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All Journal Jurnal Farmasi Indonesia Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Sanitas: Journal of Health, Medical, and Psychological Studie
Annora Rizky Amalia
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Aerospace Engineering Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Social Sciences Transportation

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Analisis Biayariil Dan Kesesuaian Dengan Tarif INA-CBG’S Pada Pasien Kanker Kolorektal Di RSUD Dr. Moewardi Surakarta Tahun 2018 Annora Rizky Amalia
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.823

Abstract

Colorectal cancer is cancer that starts from the colon or rectum. Colorectal cancer occurs when tumors form in the lining of the large intestine. The high real cost of colorectal cancer chemotherapy is a major factor in creating a national health insurance program through the INA-CBG package. The purpose of this study was to determine the suitability of real costs with INA-CBG package rates and factors that affect real costs in colorectal cancer patients hospitalized in Dr. Moewardi Surakarta. This study uses observational cross-sectional methods. Data taken retrospectively. The subjects of this study were colorectal cancer patients who were hospitalized at Dr. Moewardi Surakarta in 2018. Subjects and objects of this study were colorectal cancer chemotherapy patients who hospitalization and medical record data and inpatient claim service files at Dr. Moewardi general hospital of Surakarta for the period of January - December 2017. The analysis used is one-sample t-test to determine the suitability between real costs and INA-CBG rates and bivariate correlation analysis to determine the relationship of real costs with factors that affect real costs. The results showed the complex intestinal procedure (K-1-20-I / II / III) had an average cost that was higher than the other procedures which was Rp. 20,889,414.64. This relates to the increase in costs for medical treatment and also pharmaceutical costs. Based on the magnitude of the difference between the real rates with the INA-CBG package in colorectal cancer patients in Dr. Moewardi Surakarta in 2018 the procedure that has the highest cost difference in chemotherapy procedures at the severity of C-4-13-I with a total difference of Rp - 671,021,073,14 (negative difference). The most influential factor is Length of Stay (LOS) in anal procedures with INA-CBG's K-1-50 code with a value of p <0.05 (0,000) and in digestive tumor procedures with INA-CBG's K-4-10 code with p-value <0.05 (0.001).
Analysis of Ethnopharmaceutical Studies of Traditional Medicine for the Management of Jaundice Due to Hepatic Disorders by the Mandar Tribe of West Sulawesi, Indonesia Sari, Dewi Weni; Kharisma Jayak Pratama; Annora Rizky Amalia
Eureka Herba Indonesia Vol. 5 No. 2 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i2.120

Abstract

Jaundice, or icterus, is a medical condition characterized by yellowing of the skin and whites of the eyes. This is caused by a buildup of bilirubin in the blood, which is a waste product of the breakdown of red blood cells. Liver disorders, such as hepatitis, are the most common cause of jaundice. The Mandar tribe in West Sulawesi Indonesia has a traditional healing tradition that has been passed down from generation to generation. This traditional medicine is often used to treat various diseases, including jaundice. This study aims to analyze the ethnopharmaceutical traditional treatment for jaundice in the Mandar tribe in West Sulawesi. This research used a descriptive observational method with traditional healthcare respondents. Data was collected through interviews and observations of traditional healers and patients who used traditional medicine. The data was analyzed descriptively to determine the type of plant, part of the plant used, processing methods, and how traditional medicines are used. This research found 14 plant species from 13 families that were used as medicine for jaundice. Two types of plants are typically used by the Mandar tribe, namely lapo-lapo (Melanolepis multiglandulosa) and barorang (Blumea balsamifera). The parts of the plant most commonly used as medicine are leaves (43%), followed by fruit (29%), stems (14%), roots (7%), rhizomes (4%), and herbs (3%). Plant processing by pressing and boiling is the most widely used (50% each). The most common method of use is boiling (70%), followed by pounding (20%) and eating directly (10%). This research found 14 plant species from 13 families that were used by the Mandar tribe as medicine for jaundice. Two types of plants are typically used, namely lapo-lapo and barorang. This research provides important information about the Mandar tribe's ethnopharmacology for jaundice and can be a basis for the development of more effective and safer traditional medicines.
Formulation and Physicochemical Evaluation of Spray Gel Containing Cordyline fruticosa L. Leaf Extract for Topical Delivery Alfina Nurrahman; Annora Rizky Amalia; Andany Oktamia Ningtyas Hartoyo
Natural Sciences Engineering and Technology Journal Vol. 4 No. 2 (2024): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v4i2.57

Abstract

Spray gel is a gel system applied through a spray pump, producing small or large liquid droplets. Cordyline fruticosa (L.) A. Cheval, commonly known as Andong Merah, is a plant with various medicinal properties, including wound healing activity attributed to its flavonoid content. This research aimed to formulate and evaluate the physicochemical properties of a spray gel containing Cordyline fruticosa leaf extract for topical delivery, focusing on the effects of different concentrations of Carbopol 940 as a gelling agent and sorbitol as a humectant. Cordyline fruticosa leaf extract was obtained by maceration using 96% ethanol. Three spray gel formulations were prepared, varying the concentrations of Carbopol 940 (0.4 g, 0.6 g, and 0.8 g) and sorbitol (5 ml, 7.5 ml, and 10 ml). The prepared spray gels were then subjected to physicochemical evaluation, including organoleptic tests (color, odor, and consistency), homogeneity tests, pH measurements, viscosity measurements, spray pattern analysis, and adhesion tests. All spray gel formulations exhibited acceptable physicochemical properties. The formulations were homogeneous, with a pH within the acceptable range for topical applications. The viscosity and adhesion properties varied with the concentrations of Carbopol 940 and sorbitol. The spray pattern analysis revealed a circular spread pattern, with the pressure required for spraying influenced by the viscosity of the formulation. The spray gel formulations containing Cordyline fruticosa leaf extract demonstrated good physicochemical qualities, indicating their potential suitability for topical delivery. Further studies are recommended to optimize the formulation for enhanced stability and therapeutic efficacy.
Uji Potensi Fraksi n-Heksan Daun Keji Besi (Hemigraphis repanda L.) Sebagai Antibakteri Terhadap Escherichia Coli dan Bacillus Cereus Beserta Penentuan Konsentrasi Hambat Minimum (KHM) Alfina Nurrahman; Rahmat Hidayat; Annora Rizky Amalia
Journal of Health, Medical, and Psychological Studies Vol 1 No 2 (2025): December: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/29v9p164

Abstract

This study aimed to evaluate the antibacterial potential of the n-hexane fraction of Keji Besi leaves (Hemigraphis repanda L.) against Escherichia coli and Bacillus cereus, as well as to determine its Minimum Inhibitory Concentration (MIC). Keji Besi leaves were extracted by maceration using 96% ethanol, followed by liquid–liquid fractionation with n-hexane. The antibacterial activity was assessed using the disc diffusion method, while MIC values were determined using the broth dilution method. Phytochemical screening revealed that the n-hexane fraction predominantly contained steroid and triterpenoid compounds. The disc diffusion assay showed that the n-hexane fraction exhibited stronger inhibitory activity against B. cereus than E. coli, with the largest inhibition zone observed at an 80% concentration. MIC determination indicated that the MIC value for B. cereus was 40% (w/v), whereas E. coli required a higher concentration of 80% (w/v) to inhibit bacterial growth. These findings suggest that the n-hexane fraction of Keji Besi leaves demonstrates selective antibacterial activity, particularly against Gram-positive bacteria. Therefore, this fraction has promising potential to be developed as a natural antibacterial agent, especially for infections caused by Gram-positive pathogens.
Co-Authors Alfina Nurrahman Andany Oktamia Ningtyas Hartoyo Kharisma Jayak Pratama Rahmat Hidayat Sari, Dewi Weni