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All Journal Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Crown: Journal of Dentistry and Health Research Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Sanitas: Journal of Health, Medical, and Psychological Studie Jurnal Kesehatan Tujuh Belas (Jurkes TB)
Alfina Nurrahman
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Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus Amalia, Annora Rizky; Alfina Nurrahman; Dewi Weni Sari; Muhammad Firdaus
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.123

Abstract

Diabetes mellitus (DM) is characterized by chronic hyperglycemia and increased oxidative stress, contributing to disease complications. Red gedi leaves (Abelmoschus manihot L. Medik) are rich in bioactive compounds, including tannins, saponins, alkaloids and flavonoids, with antioxidant potential. This study aims to evaluate the effect of ethanol extract of red gedi leaves on endogenous antioxidant activity in rat model of DM induced by STZ-NA. Male rats were induced with DM with streptozotocin (STZ)-NA. Rats were divided into five groups: normal control (KN), DM control (KDM), glibenclamide positive control (KPG), and group treated with red gedi leaf extract at a dose of 100 mg/kgBW (GEDI 100), 200 mg/kgBW (GEDI 200), and 400 mg/kgBW (GEDI 400). The parameters observed included blood glucose levels, malondialdehyde (MDA) as a marker of oxidative stress, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue. Data analysis used one-way ANOVA and Tukey's post hoc test (p<0.05). The results showed that the yield of ethanol extract from red gedi leaves was 6.984%. Administration of red gedi leaf extract at a dose of 400 mg/kgBW (GEDI 400) significantly reduced blood glucose levels (p<0.05) and MDA (p<0.05), and increased the activity of SOD (p<0.05), CAT (p<0.05), and GPx (p<0.05) in DM rats compared to the DM control group (KDM). The effect of GEDI 400 was comparable to the effect of glibenclamide as a positive control. The ethanol extract of red gedi leaves at a dose of 400 mg/kgBW was effective in increasing endogenous antioxidant activity and reducing oxidative stress in STZ-NA-induced DM rats, showing potential as an antioxidant and antidiabetic agent.
Antibacterial Test of Cherry Leaves Ethanol Extract (Muntingia calabura L.) Against Streptococcus mutans Amalia, Annora Rizky; Riyan Setiyanto; Alfina Nurrahman; Ariska Rahmawati Utami; Dewi Weni Sari
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.128

Abstract

Introduction: Streptococcus mutans is a bacteria that plays an important role in the occurrence of dental caries. Use of antibiotics to treat infections Streptococcus mutans often causes side effects. Cherry leaves (Muntingia calabura L.) contain active compounds that have the potential to have antibacterial effects. This research aims to determine the inhibitory power of cherry leaf ethanol extract against Streptococcus mutans in vitro. Methods: This research uses an experimental method with a post-test-only control group design. Cherry leaf ethanol extract was made by maceration method using 96% ethanol solvent for 5 days. The antibacterial test was carried out using the paper disc diffusion method with varying concentrations of cherry leaf extract, namely 20%, 40%, and 60% w/v dissolved in 10% DMSO. The positive control used was the amoxicillin antibiotic disc, while the negative control used 10% DMSO. Results: The results of the antibacterial test of the ethanol extract of cherry leaves in this study showed that at a concentration of 20% it had an average inhibitory power of 9.16 mm, the extract with a concentration of 40% had an inhibitory power of 11.33 mm, and at a concentration of 60% it had an inhibitory power of 12. 16mm. The positive control amoxicillin had an inhibitory power of 18.67 mm. Conclusion: Cherry leaf ethanol extract has potential as an alternative therapy to overcome Streptococcus mutans bacterial infections.
Formulation and Physicochemical Evaluation of Spray Gel Containing Cordyline fruticosa L. Leaf Extract for Topical Delivery Alfina Nurrahman; Annora Rizky Amalia; Andany Oktamia Ningtyas Hartoyo
Natural Sciences Engineering and Technology Journal Vol. 4 No. 2 (2024): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v4i2.57

Abstract

Spray gel is a gel system applied through a spray pump, producing small or large liquid droplets. Cordyline fruticosa (L.) A. Cheval, commonly known as Andong Merah, is a plant with various medicinal properties, including wound healing activity attributed to its flavonoid content. This research aimed to formulate and evaluate the physicochemical properties of a spray gel containing Cordyline fruticosa leaf extract for topical delivery, focusing on the effects of different concentrations of Carbopol 940 as a gelling agent and sorbitol as a humectant. Cordyline fruticosa leaf extract was obtained by maceration using 96% ethanol. Three spray gel formulations were prepared, varying the concentrations of Carbopol 940 (0.4 g, 0.6 g, and 0.8 g) and sorbitol (5 ml, 7.5 ml, and 10 ml). The prepared spray gels were then subjected to physicochemical evaluation, including organoleptic tests (color, odor, and consistency), homogeneity tests, pH measurements, viscosity measurements, spray pattern analysis, and adhesion tests. All spray gel formulations exhibited acceptable physicochemical properties. The formulations were homogeneous, with a pH within the acceptable range for topical applications. The viscosity and adhesion properties varied with the concentrations of Carbopol 940 and sorbitol. The spray pattern analysis revealed a circular spread pattern, with the pressure required for spraying influenced by the viscosity of the formulation. The spray gel formulations containing Cordyline fruticosa leaf extract demonstrated good physicochemical qualities, indicating their potential suitability for topical delivery. Further studies are recommended to optimize the formulation for enhanced stability and therapeutic efficacy.
Antioxidant Lotion Formulation with a Combination of Ethanol Extracts of Black Soybean and Pigeon Pea Rekha Aulia Istikhomah; Rifkarosita Putri Ginaris; Alfina Nurrahman
Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Vol. 1 No. 5 (2025): Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah (Bulan November 2025)
Publisher : PT. Saha Kreasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64788/ar-rasyid.v1i5.45

Abstract

Indonesia’s tropical climate with high sun exposure increases the risk of oxidative stress on the skin due to free radicals. Synthetic antioxidants in skincare products are proven effective but may cause long-term side effects. Natural ingredients offer a safer and more promising alternative. This study aimed to formulate an antioxidant lotion using ethanol extracts of black soybean and pigeon pea. Extraction was carried out by maceration using 70% ethanol as solvent. The extracts were formulated into five lotion formulas, consisting of three extract combinations, one positive control, and one negative control. Evaluation included antioxidant activity using the DPPH method and physical stability tests. Formula 3, containing 11,31% black soybean extract and 3,75% pigeon pea extract, shows the highest antioxidant activity with a strong category (IC₅₀ = 73,5 µg/mL). All formulas show good physical stability during 21 days of storage and form oil-in-water emulsions. The combination of black soybean and pigeon pea extracts demonstrates strong antioxidant potential with good formulation stability and is suitable for development in natural cosmetic products.
Formula Gel Ekstrak Daun Andong Merah (Cordyline Fruticose L.) Dengan Kombinasi Gelling Agent Karbopol 940 Dan HPMC Sebagai Antioksidan Irfan Bagus Setyawan; Alfina Nurrahman; Rifkarosita Putri Ginaris
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 5 No. 1 (2024): November 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Radikal bebas adalah atom atau molekul dengan elektron tidak berpasangan, dan yang paling reaktif adalah radikal hidroksil (OH). Tanaman Andong Merah (Cordyline fruticosa L.) dikenal memiliki efek antioksidan, berkat kandungan saponin, tanin, flavonoid, polifenol, steroida, polisakarida, kalsium oksalat, dan zat besi. Flavonoid, salah satu senyawa dalam tanaman ini, efektif sebagai penangkap radikal bebas. Penelitian ini menilai efek kombinasi karbopol 940 dan HPMC sebagai agen pengental dalam gel ekstrak etanol daun andong merah terhadap sifat fisiknya. Metode penelitian yang digunakan yaitu maserasi menggunakan etanol 70%. Hasil pengamatan menunjukkan bahwa gel stabil baik secara organoleptis maupun homogen sebelum dan setelah penyimpanan. Viskositas gel mengalami perubahan selama penyimpanan. Formula I dengan kombinasi karbopol 940 dan HPMC pada konsentrasi 1,50% dan 3,50% menunjukkan pH yang stabil dalam rentang fisiologis kulit (4,5-6,5). Daya sebar gel, baik pada Formula I, II, III, dan IV, juga stabil dengan diameter 3-5 cm. Kesimpulan analisis spektrofotometri UVVis FI menunjukkan absorbansi yang sesuai dengan hukum Lambert-Beer, dengan grafik linear dan nilai R² mendekati 1, menandakan hasil yang akurat.
Uji Potensi Fraksi n-Heksan Daun Keji Besi (Hemigraphis repanda L.) Sebagai Antibakteri Terhadap Escherichia Coli dan Bacillus Cereus Beserta Penentuan Konsentrasi Hambat Minimum (KHM) Alfina Nurrahman; Rahmat Hidayat; Annora Rizky Amalia
Journal of Health, Medical, and Psychological Studies Vol 1 No 2 (2025): December: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/29v9p164

Abstract

This study aimed to evaluate the antibacterial potential of the n-hexane fraction of Keji Besi leaves (Hemigraphis repanda L.) against Escherichia coli and Bacillus cereus, as well as to determine its Minimum Inhibitory Concentration (MIC). Keji Besi leaves were extracted by maceration using 96% ethanol, followed by liquid–liquid fractionation with n-hexane. The antibacterial activity was assessed using the disc diffusion method, while MIC values were determined using the broth dilution method. Phytochemical screening revealed that the n-hexane fraction predominantly contained steroid and triterpenoid compounds. The disc diffusion assay showed that the n-hexane fraction exhibited stronger inhibitory activity against B. cereus than E. coli, with the largest inhibition zone observed at an 80% concentration. MIC determination indicated that the MIC value for B. cereus was 40% (w/v), whereas E. coli required a higher concentration of 80% (w/v) to inhibit bacterial growth. These findings suggest that the n-hexane fraction of Keji Besi leaves demonstrates selective antibacterial activity, particularly against Gram-positive bacteria. Therefore, this fraction has promising potential to be developed as a natural antibacterial agent, especially for infections caused by Gram-positive pathogens.
Co-Authors Amalia, Annora Rizky Andany Oktamia Ningtyas Hartoyo Annora Rizky Amalia Ariska Rahmawati Utami Dewi Weni Sari Irfan Bagus Setyawan Muhammad Firdaus Rahmat Hidayat Rekha Aulia Istikhomah Rifkarosita Putri Ginaris Riyan Setiyanto