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All Journal Jurnal Respirologi Indonesia Respiratory Science
Parluhutan Siagian
Universitas Sumatera Utara
Health Professions Medicine & Pharmacology

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The Association Between Vitamin D Receptor Gene FokI Polymorphism and Pulmonary Tuberculosis Dina Octafrida Marpaung; Bintang Yinke Magdalena Sinaga; Parluhutan Siagian; Erna Mutiara
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.29

Abstract

Backgrounds: There is a wide range of individual responses to mycobacterium infection. However, the reason why certain people suffers from a disease when they are infected with mycobacterium while others remain healthy is still unknown. Genetic susceptibility is thought to be one of the important explanatory factors for individuals with the risk of developing pulmonary tuberculosis (TB). FokI polymorphism was one of the genetic variations within the vitamin D receptor (VDR) gene associated with pulmonary TB. In the present study, we investigated the association between VDR gene FokI polymorphism and pulmonary TB. Conclusion: There was no significant association between the VDR gene FokI polymorphism and pulmonary TB.
Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients' Sputum Conversion During Intensive Phase Category I Treatment in Medan Elok Ariyani Safitri; Parluhutan Siagian; Bintang Yinke Magdalena Sinaga; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.30

Abstract

Background: Many factors influence the success of the acceleration of Acid-Fast Bacilli (AFB) sputum conversion in the treatment of the intensive phase of pulmonary tuberculosis (TB). One of these factors is the nutritional status or nutrition of pulmonary TB patients. Through a fenton reaction, Vitamin C is known to be able to sterilize Mycobacterium tuberculosis. This study aims to determine the effect of giving vitamin C on the conversion of AFB sputum in the intensive phase of pulmonary TB treatment. Method: This study was an inferential, quasi-experimental evaluation of the acceleration of AFB sputum conversion following vitamin C supplementation in patients with category I pulmonary TB. The study group was separated into two groups: 40 TB patients getting Anti Tuberculosis Treatment (ATT) with vitamin C, and 40 TB patients receiving ATT with placebo. Every two weeks, AFB sputum was examined, and vitamin C levels were measured before and after two months of therapy. Results: Conversion of AFB occurred sooner in the vitamin C group of pulmonary TB patients, with as many as 29 patients (72.5%) experiencing conversion of AFB sputum at the end of the second week of therapy, whereas there was no conversion in the placebo group. At the end of the fourth week, all patients (100%) given vitamin C showed AFB sputum conversion, whereas only eight patients (20%) in the placebo group had conversion at the end of the fourth week of treatment. Vitamin C levels increased significantly in the group of pulmonary tuberculosis patients who received vitamin C supplementation. Conclusion: Vitamin C supplementation in the treatment of pulmonary TB can accelerate the conversion of AFB sputum, which is statistically significant.
Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera Dyana Destylya; Bintang YM Sinaga; Parluhutan Siagian; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.53

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The increase in the number of COVID-19 cases was happening quite quickly and has spread between countries so that COVID-19 has become a pandemic in the world. This study aimed to determine the characteristics of COVID-19 patients at Haji Adam Malik General Hospital Medan. Method: This was a descriptive study. Data were taken from the medical records of 110 hospitalized patients with positive RT-PCR results for COVID-19 from December 2020 to April 2021. The inclusion criteria for the case samples were patients diagnosed with COVID-19 based on RT-PCR and the exclusion criteria were incomplete medical records. Characteristic analysis was carried out using the Kruskal Wallis test. Results: The most common comorbidities found in patients with severe COVID-19 were diabetes mellitus and HIV. The most common comorbidity found in moderate-level COVID-19 patients was pregnant women. The most common chest X-rays finding in severe and critical levels was bilateral infiltrates. Recovered patients were mostly obtained at moderate level, while deceased patients were mostly observed at critical levels. Conclusion: Characteristics of COVID-19 patients at Haji Adam Malik General Hospital were classified based on the degree of disease by age, lymphocyte value, N/L ratio, levels of CRP, D-dimer, procalcitonin, fibrinogen, ferritin, and comorbidities as well as the appearance of infiltrates in both lung fields.
Co-Authors Andika Pradana Bintang Yinke Magdalena Sinaga Bintang YM Sinaga Budi Jefri Dana Jauhara Layali Diana Santy Dina Octafrida Marpaung Dyana Destylya Elok Ariyani Safitri Erna Mutiara Ganda M. Leonard Samosir Indra Barata Katharine Katharine Putri C Eyanoer Putri Chairani Eyanoer, Putri Chairani Putri Eyenoer Rizka Helmi Zainuddin Amir Zulfikar Lubis