Claim Missing Document
Check
Articles

Found 7 Documents
Search

Proportion of Mutation of Epidermal Growth Factor Receptor (EGFR) Genes from Tissue Biopsy and Liquid Biopsy ctDNA in Lung Adenocarcinoma Hendra Taufik; Noni Novisari Soeroso; Setia Putra Tarigan; Erna Mutiara
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.118

Abstract

Backgrounds: In recent years, circulating tumor DNA (ctDNA) has emerged as a specific and sensitive blood-based biomarker to detect EGFR mutations. This study aims to determine the diagnostic accuracy of ctDNA in detecting EGFR gene mutations in adenocarcinoma lung cancer. Methods: This study was a cross-sectional study with the subjects were adenocarcinoma lung cancer patients from histopathology or cytology examination and examined EGFR mutations from plasma tissue biopsy and ctDNA specimens from April 2018 to February 2019 in several hospitals in the Medan City. Results: There were 100 data have been collected, with male were 71 subjects and female were 29 subjects. Found 20 mutations, single mutations of tissue biopsy were 19 cases, del exon 19 were 12 cases, mutation in exon 21 (L858R) were 6 cases, mutation exon 21 (L861Q) was 1 case, del exon 19 and 21 (L861Q double mutations) was 1 case. From plasma ctDNA examination EGFR mutations were found 15 cases, del exon 19 were 12 cases and del exon 21 (L858R) were 3 cases. Conclusions: The highest proportion of EGFR mutations by sex were women from tissue biopsy or ctDNA, the most often frequency of EGFR mutations from tissue biopsy and ctDNA in single mutations and exons19. (J Respir Indo. 2020; 40(3): 150-5)
Diagnostic Accuracy of Pleural Fluid Adenosine Deaminase Level Test in Tuberculous Pleural Effusion Puspa Rosfadilla; Widirahardjo Widirahardjo; Fajrinur Syarani; Erna Mutiara
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.468 KB) | DOI: 10.36497/jri.v37i4.81

Abstract

Background: Tuberculous pleural effusion is a paucibacillary manifestation of tuberculosis, so isolation of Mycobacterium tuberculosis is difficult, biomarkers being an alternative for diagnosis. Adenosine deaminase has the potential to optimize the diagnostic approach of tuberculous pleural effusion. Methods: This study is a diagnostic test observational (cross-sectional), which included 35 inpatient samples that meet inclusion and exclusion criteria from H. Adam Malik Medan General Hospital. Research began on February 1st until July 31st 2016 to examine 10 cc of pleural fluid specimens for the levels of Adenosine deaminase. Results: There are significant differences in the levels of adenosine deaminase from tuberculous and non-tuberculous pleural effusion (P=0.001). In the cut-off point 36.55 IU/L, level of sensitivity 95.8%, specificity 90.99%, positive predictive value 95.8%, negative predictive value 90.99%, and accuracy 94.2% of pleural fluid adenosine deaminase level test in tuberculous pleural effusion. Conclusion: Adenosine deaminase pleural fluid can be a diagnostic modality that is easy, fast, relatively affordable and applicable in the diagnosis of tuberculous pleural effusion. (J Respir Indo. 2017; 37(4): 278-82)
Effects of Lower Limb Endurance Training on Maximal Oxygen Uptake (VO2 max) in Chronic Obstructive Pulmonary Disease Andika Pradana; Amira P Tarigan; Tari Mediyanti; Erna Mutiara; Pandiaman Pandia
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.517 KB) | DOI: 10.36497/jri.v37i4.82

Abstract

Background: Patients with COPD exhibit muscle atrophy and dysfunction which lead into decondition state. This will in turn decrease maximal oxygen uptake (VO2 max) in tissues. Considered as the best predictor of cardiorespiratory endurance and survival, VO2max can be attenuated by aerobic training. This study aimed to assess the effects of lower-limb endurance training on VO2 max in COPD patient. Methods: An experimental study was conducted on 20 COPD patients in group C and D in June–July 2017 at USU Hospital. Patients were prescribed lower-limb exercise by stationary cycling with individualized dose, twice a week for 4 weeks, ranging from 5-20 minutes/session. VO2 max measurement was calculated pre-and post-intervention using Nury’s Formula specifically designed for Indonesian (r=0,68; P
The Association Between Vitamin D Receptor Gene FokI Polymorphism and Pulmonary Tuberculosis Dina Octafrida Marpaung; Bintang Yinke Magdalena Sinaga; Parluhutan Siagian; Erna Mutiara
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.29

Abstract

Backgrounds: There is a wide range of individual responses to mycobacterium infection. However, the reason why certain people suffers from a disease when they are infected with mycobacterium while others remain healthy is still unknown. Genetic susceptibility is thought to be one of the important explanatory factors for individuals with the risk of developing pulmonary tuberculosis (TB). FokI polymorphism was one of the genetic variations within the vitamin D receptor (VDR) gene associated with pulmonary TB. In the present study, we investigated the association between VDR gene FokI polymorphism and pulmonary TB. Conclusion: There was no significant association between the VDR gene FokI polymorphism and pulmonary TB.
Karakteristik Penderita TB Resistan Obat (RO) dan Persepsi Lingkungan Sekitar terhadap Penderita, di Kota Medan Syarifah Syarifah; Erna Mutiara; Sri Novita
Berita Kedokteran Masyarakat (BKM) Vol 34, No 11 (2018): Proceedings of the 4th UGM Public Health Symposium
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (672.13 KB) | DOI: 10.22146/bkm.40622

Abstract

Kasus TB RO saat ini semakin meningkat baik di tingkat global maupun Indonesia. Indonesia merupakan negara dengan urutan ke delapan terbesar kasus TB RO di dunia, di Sumatera Utara Kota Medan merupakan penderita TB RO tertinggi. Telah  dilakukan berbagai upaya untuk menangani kasus TB RO namun kasus TB RO di Kota Medan masih tetap tinggi. Penelitian ini bertujuan untuk menggambarkan karakteristik penderita TB RO dan persepsi lingkungan sekitar terhadap penderita.Desain penelitian crossectional study, populasi penelitian adalah penderita TB RO tahun 2017 sampai April 2018. Sampel ditentukan secara purposive yaitu pasien yang memulai menjalani pengobatan bulan Juli 2017 sampai April 2018 dan bersedia dikunjungi ke rumah dan mendapat sms reminder untuk meningkatkan kepatuhan berobatnya, diperoleh sampel 24 orang dari 60 pasien yang menjalani pengobatan dari tahun 2017 sampai April 2018. Data dikumpulkan dengan wawancara kepada responden dan dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa ; laki-laki lebih banyak dari perempuan, umur pada usia produktif, tingkat pendidikan dominan SLTA, suku terbanyak suku Batak dan status perkawinan menikah. Umumnya responden mengalami efek samping obat dari yang ringan sampai berat.  Setengah dari responden mengalami gangguan penyerta lebih dari satu jenis seperti asam urat, hipertensi, DM maupun HIV. Persepsi lingkungan terhadap penderita hanya sebagian kecil 1 orang (4,2%) mengalami perubahan status perkawinan, sebanyak 12 orang (50%) mengalami perubahan pekerjaan, perubahan status ekonomi 10 orang (41,7%), perubahan sikap keluarga 5 orang (20,8%), perubahan sikap masyarakat 1 orang (4,2%) dan  mendapatkan bantuan 12 orang (50%).Disarankan agar penderita patuh minum obat sampai sembuh, berkomunikasi dengan petugas kesehatan jika mengalami efek samping obat yang berat agar dapat berkonsultasi dengan Tim Ahli Klinis, dapat mencegah penularannya pada keluarga dan lingkungan.  Diharapkan dukungan psikologis, sosial dan ekonomi  dari keluarga dan lingkungan sekitar agar penderita dapat menjalani pengobatannya sampai sembuh. 
Pelatihan Komunikasi Terapeutik Medik di RSUD Dr. Pirngadi Kota Medan Arfah Mardiana Lubis; Surya Utama; Erna Mutiara; Siti Khadijah Nasution; Juanita Juanita; Raden Kintoko Rochadi; Taufik Ashar; Tukiman Tukiman; Hiswani Hiswani
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 7, No 1 (2026): Edisi Januari
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jpmik.v7i1.6694

Abstract

Komunikasi terapeutik medik adalah proses interaksi tenaga medik dan pasien secara individual dengan tujuan membantu pasien merasa nyaman dan tidak takut untuk mengungkapkan perasaan dan pikiran mereka. Hanya saja, ada indikasi komunikasi terapeutik medik di RSUD Dr. Pirngadi Kota Medan belum efektif. Salah satu penyebabnya adalah tingkat pengetahuan dan keterampilan yang rendah dari dokter mengenai cara menyamankan dan meyakinkan pasien. Agar dokter dapat meningkatkan keterampilannya mengenai bagaimana memprioritaskan kenyamanan dan keyakinan pasien saat berkomunikasi dengan pasien, maka diperlukan pelatihan mendengar aktif, mendengar dengan empati, komunikasi persuasif, dan komunikasi asertif. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan dokter mengenai cara menyamankan dan meyakinkan pasien berobat di rumah sakit. Pelatihan ini menggunakan metode ceramah, games, dan role play. Peserta pelatihan yang mengikuti sampai akhir hanya 12 orang. Berdasarkan evaluasi pelatihan dengan pre-test dan post-test, pengetahuan peserta tentang cara menyamankan dan meyakinkan pasien berobat di rumah sakit RSUD Dr. Pirngadi Kota Medan meningkat dari 0% menjadi 83,3%. Berdasarkan hasil evaluasi pelatihan dengan simulasi, seluruh peserta mendapatkan nilai 70 ke atas. Disimpulkan bahwa pelatihan komunikasi terapeutik medik yang telah dilakukan dapat meningkatkan pengetahuan dan keterampilan dokter mengenai cara menyamankan dan meyakinkan pasien berobat di rumah sakit RSUD Dr. Pirngadi Kota Medan. Diharapkan pelatihan ini dapat dilanjutkan secara mandiri oleh mitra dan didukung oleh pihak terkait, serta ke depan pelatihan serupa dapat diperluas ke rumah sakit lain dengan pemantauan berkelanjutan.
Eye and Neck Relaxation Training Using the 20-20-20 Rule to Prevent Computer Vision Syndrome and Text Neck Syndrome Due to Binge- Watching Namora Lumongga Lubis; Arfah Mardiana Lubis; Surya Utama; Isyatun Mardhiyah Syahri; Maya Fitria; Asfriyati; Erna Mutiara
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 10 No. 2 (2025): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v10i2.18187

Abstract

Binge-watching is an activity of watching between two and six episodes of a TV show in one sitting. This activity is mostly carried out by students and teenager. At FKM USU, many students binge-watch, and most of them do it because they want to overcome stress. Binge-watching that is done incorrectly will increase a person's risk of suffer various non-communicable diseases due to reduced activity and snacking while binge-watching. This activity can also increase a person's risk of suffering from Text Neck Syndrome and Computer Vision Syndrome because when someone binge-watches they tend to watch with the wrong posture and are reluctant to stop staring at the screen of an electronic device for hours. Programs or activities must be held within FKM USU to prevent students from suffering from Computer Vision Syndrome and Text Neck Syndrome due to binge-watching. This community service activity was carried out at FKM USU, by giving Eye and Neck Relaxation Training Using the 20-20-20 Rule to 27 participants with lecture and demonstration methods. Participants were also given pre-tests and post-tests and also carried out simulations to assess participants' understanding. Based on the pre-test and post-test results, of the 27 participants, only 19 (70.37%) increased their knowledge. Based on the simulation results, all participants got a score of 100, it can be concluded that the eye and neck relaxation training using the 20-20-20 rule that has been implemented can increase students’ knowledge and skills about the eyes and neck relaxation training using the 20-20-20 rule.