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All Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Indonesian Health Journal
Andika Pradana
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Risk Factors of Prolonged QTc Interval in Patients with Drugs-Resistant Tuberculosis Andika Pradana; Katharine Katharine; Parluhutan Siagian
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.274

Abstract

Background: Drug-Resistant Tuberculosis (DRTB) is still one of the biggest health problems worldwide. In 2016, WHO published new guidelines for DRTB management using 7 second-line drugs that only required 9-11 months of treatment with a higher success rate. Unfortunately, one of the side effects was the possibility of a prolonged QT-c interval on electrocardiography. However, to date there have been no known factors which increased the risk of QTc prolongation in DRTB patients.Methods: This was a retrospective cohort study that analyzed the medical records of 50 DRTB patients who underwent treatment from August 2017 to August 2020 at the DRTB Clinic of Adam Malik Hospital Medan. Statistical analysis was performed using logistic regression to determine the factors which increased the risk of QTc prolongation in DRTB patients.Results: Of the 50 study samples consisting of 40 MDR TB patients, 9 pre-XDR TB patients and 1 XDR TB patient, 14 (28%) subjects were found to have QTc prolongation. There were no correlation between the regimen type (P = 0.51), age (P = 0.40), sex (P = 0.74), nutritional status (P = 0.35) and comorbid diseases (P = 0.31) on the prolongation of QTc interval. Patients receiving clofazimine had a greater percentage (78.6% vs 21.4%) to experience prolonged QTc interval, although not statistically significant (P = 0.41). Conclusion: Treatment regimen, age, sex, nutritional status and comorbid disease were not associated with prolonged QTc interval in DRTB. 
Effects of Lower Limb Endurance Training on Maximal Oxygen Uptake (VO2 max) in Chronic Obstructive Pulmonary Disease Andika Pradana; Amira P Tarigan; Tari Mediyanti; Erna Mutiara; Pandiaman Pandia
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.517 KB) | DOI: 10.36497/jri.v37i4.82

Abstract

Background: Patients with COPD exhibit muscle atrophy and dysfunction which lead into decondition state. This will in turn decrease maximal oxygen uptake (VO2 max) in tissues. Considered as the best predictor of cardiorespiratory endurance and survival, VO2max can be attenuated by aerobic training. This study aimed to assess the effects of lower-limb endurance training on VO2 max in COPD patient. Methods: An experimental study was conducted on 20 COPD patients in group C and D in June–July 2017 at USU Hospital. Patients were prescribed lower-limb exercise by stationary cycling with individualized dose, twice a week for 4 weeks, ranging from 5-20 minutes/session. VO2 max measurement was calculated pre-and post-intervention using Nury’s Formula specifically designed for Indonesian (r=0,68; P
Revisiting Pleural Effusion Classification: Diagnostic Utility of the Serum-Effusion Albumin Gradient Compared with Light’s Criteria Chairunnisya Chairunnisya; Ricke Loesnihari; Andika Pradana
Jurnal Respirasi Vol. 12 No. 3 (2026): September 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.3.2026.221-229

Abstract

Introduction: Pleural effusion is a common clinical condition resulting from various systemic or local diseases. Differentiating transudative from exudative effusions is essential for determining etiology and management. Light’s criteria remain the standard diagnostic method; however, their accuracy may decrease in certain conditions, such as in patients receiving diuretic therapy. The Serum–Effusion Albumin Gradient (SEAG) has been proposed as a simpler parameter with potential diagnostic value Objective: To evaluate the diagnostic performance of SEAG in differentiating transudative and exudative pleural effusions using Light’s criteria as the reference standard Methods: This cross-sectional analytic study was conducted at Adam Malik Hospital, Medan, from October to December 2025. Sixty-three patients with pleural effusion undergoing thoracentesis were enrolled consecutively. Statistical analyses included the Mann–Whitney test, Chi-square test, Cohen’s Kappa for agreement, and Receiver Operating Characteristic (ROC) curve analysis to determine the optimal cut-off, sensitivity, and specificity of SEAG Results: Based on Light’s criteria, 58.7% of effusions were classified as exudates and 41.3% as transudates. SEAG classified 60.3% as transudates and 39.7% as exudates. A significant association was found between SEAG and Light’s criteria (χ² = 23.753; p < 0.001) with moderate agreement (κ = 0.571; p < 0.001). ROC analysis showed an AUC of 0.813 (95% CI: 0.704–0.923). The optimal SEAG cut-off was 1.295 g/dL, with 92.3% sensitivity and 73% specificity Conclusion: SEAG demonstrated good diagnostic performance and may serve as an additional parameter in differentiating pleural effusions Keywords: Pleural effusion, SEAG, Light’s criteria, transudate, exudate, quality of care
Older Age and Low Body Mass Index as Predictors of Sarcopenia in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study Farizky; Andika Pradana; Amira Permatasari; Rina Amelia
Indonesian Health Journal Vol. 5 No. 3 (2026): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v5i3.920

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder frequently accompanied by systemic complications, including sarcopenia, which may reduce physical capacity and worsen clinical outcomes. This study aimed to determine the prevalence of sarcopenia and identify its associated predictors among patients with stable COPD. A cross-sectional study was conducted among 67 patients with stable COPD who attended the Pulmonology Outpatient Clinic at Universitas Sumatera Utara Hospital. Muscle mass was assessed using bioelectrical impedance analysis and expressed as the skeletal muscle index, while muscle strength was measured using a handgrip strength test. Descriptive, bivariate, and receiver operating characteristic (ROC) analyses were performed. The results showed that 55.2% of participants had reduced muscle strength, 38.8% had low muscle mass, and 29.9% met the diagnostic criteria for sarcopenia. Older age and lower body mass index (BMI) were significantly associated with sarcopenia. An age threshold of >66 years predicted sarcopenia with 75.0% sensitivity and 66.0% specificity, whereas a BMI threshold of <23 kg/m² demonstrated 76.6% sensitivity and 85.0% specificity. In conclusion, sarcopenia was prevalent even among clinically stable COPD patients. Routine assessment of age, BMI, muscle mass, and handgrip strength may support early detection and facilitate timely nutritional and rehabilitative interventions to prevent functional decline and improve patient outcomes.
Correlation Between Exposure to Cement Dust and Lung Function Values and The Incidence of Chronic Obstructive Lung Disease Among Workers at The X Cement Factory Company Medan Audhy Alivia Rambe; Amira Permatasari Tarigan; Andika Pradana; Yuki Yunanda
Indonesian Health Journal Vol. 5 No. 3 (2026): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v5i3.928

Abstract

Cement industry workers are continuously exposed to airborne cement dust, which may contribute to respiratory impairment and increase the risk of chronic obstructive pulmonary disease (COPD). Occupational exposure to particulate matter can induce oxidative stress, airway inflammation, and a progressive decline in lung function. However, evidence regarding the relationship between cement dust exposure, pulmonary function, and COPD incidence among cement workers in Indonesia remains limited. This study aimed to determine the correlation between cement dust exposure, lung function values, and the incidence of COPD among workers at X Cement Factory in Medan. This research employed a cross-sectional study design and was conducted from January to November 2024. The study involved 72 cement factory workers selected through consecutive sampling. Data were collected using the PUMA questionnaire and spirometry to assess lung function parameters, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and the FEV1/FVC ratio. Statistical analyses were performed to evaluate the associations of occupational and individual risk factors with COPD prevalence. Among the 72 respondents, 15 workers (20.8%) were identified as having COPD. The analysis showed that smoking history was significantly associated with COPD prevalence (PR = 1.875; p = 0.031). Meanwhile, work placement, age, personal protective equipment use, inhaler use, duration of employment, and working hours were not significantly associated with COPD prevalence. Lung function assessment revealed variations in spirometric parameters among workers, indicating the importance of respiratory monitoring in occupational settings. Cement dust exposure represents an important occupational respiratory health concern; however, COPD prevalence among cement workers is influenced by multiple factors, particularly smoking history. Continuous respiratory surveillance, exposure control, and preventive occupational health programs are recommended to reduce respiratory risks among cement industry workers.
Co-Authors Amira Permatasari Audhy Alivia Rambe Chairunnisya Chairunnisya Erna Mutiara Farizky Katharine Katharine Pandiaman Pandia Parluhutan Siagian Ricke Loesnihari Rina Amelia Tari Mediyanti Tarigan, Amira Permatasari Yunanda, Yuki