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All Journal Jurnal Respirologi Indonesia Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Masrul Basyar
Universitas Andalas
Health Professions Medicine & Pharmacology Nursing Public Health

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Coal Workers' Pneumoconiosis at PT. A Sawahlunto and The Influencing Factors Ulfahimayati Ulfahimayati; Deddy Herman; Masrul Basyar; Fenty Anggrainyi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.157

Abstract

Background: Coal workers’s pneumoconiosis (black lung disease) is an interstitial lung disease caused by chronic inhalation of coal dust. The incidence of coal workers’s pneumoconiosis increased globally from the 1990s to the 2000s by 3.2%. Indonesia is the country which has many coal mining, but national prevalence of coal workers pneumoconiosis was not discovered. PT. A is one of mining companies in Sawahlunto. The aims of this study was to determine the incidence of coal workers’ pneumoconiosis at PT. A Sawahlunto and it’s influencing factors. Methods: This study is an analytic study with cross sectional design, conducted from November 2019 to April 2020. There were 90 coal miners participated in this study. All subjects were performed chest X-ray examination with ILO standard to asses the incidence of pneumoconiosis. Spirometr examination, dust level measurement with portable low volume air sampler, interview, and validated questionnare were performed to evaluate it’s influencing factors. Statistical analysis used Chi-square test and double logistic regression test. Results: This study found 12 workers (13.3%) had pneumoconiosis. From the statistical test results obtained age >50 years (P=0.035), duration of exposure (P=0.040), mask usage (P=0.029), restrictive lung function (P=0.004), and the mixed abnormality lung function (P=0.006) is associated with pneumoconiosis. The most dominant factor was mask usage (P=0.049) with OR=5.026 Conclusion: The most dominant factor that influence coal workers’ pneumoconiosis was mask usage. Others related factors were age, duration of exposure and abnormality lung function.
Correlation between N-Acetyltransferase 2 (NAT2) Polymorphism Genotype with Plasma Isoniazid (INH) Concentration in MDR TB Patients Receiving Short Regimen in West Sumatera Mega Senja; Masrul Basyar; Yessy Susanty Sabri; Afriani Afriani
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.283

Abstract

Background: Isoniazid (INH) is one of the most potent TB drug. High dose INH is used in short regimen MDR TB drugs. The genetic polymorphism of NAT2 affects the acetylation status. Awareness of the patients’ acetylator status is important to determine the risk of toxicity, treatment failure and drug resistance. The aim of this study was to demonstrate NAT2 genotype association with INH plasma concentration after 2 hours of oral INH therapy. Methods: This was a cross sectional study of MDR TB patients who received short term combination therapy at RSUP Dr. M.Djamil Padang, Achmad Muchtar Hospital Bukittinggiand West Sumatra Pulmonary Hospital from September 2019 to February 2020. Patients were examined for NAT2 genotype and plasma INH concentration. The results of the plasma INH concentrations obtained were evaluated based on the NAT2 acetylator phenotype group.Results: The majority of the subjects weremen (62.5%), aged 40-64 years (50%), had the most common comorbid of diabetes mellitus (31.25%), were normoweight (75%) and had negative HIV status (93.8%). A total of 7 alleles consisting of 7 SNPs and 7 variations of the NAT2 genotype were found in MDR TB patients who received short-term therapy. The NAT2*12A alleles (56.25%) was the most common allele and was a fast acetylator. Based on the bimodal distribution, the median concentration of INH in the fast and slow acetylator were 1.25 µg/ml and 5.24 µg/ml, respectively. The median values of INH concentration based on the trimodal distribution for fast, intermediate, and slow acetylators were 1.25 µg/ml, 2.17 µg/ml and 5.24 µg/ml. Conclusion: There were no correlations between the type of NAT2 acetylator phenotype and plasma INH concentrations.
Association of the Vaccination Status of Health Workers of COVID-19 Survivors with The Outcomes of Treatment of COVID-19 At General Hospital in Padang City Kornelis Aribowo; Masrul Basyar; Yessy Susanty Sabri
Jurnal Respirologi Indonesia Vol 43, No 3 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i3.351

Abstract

Background: Health workers are on the front lines of treating and fighting the COVID-19 pandemic. Health workers face COVID-19 patients at work. Health workers are at increased risk of infection if they are not properly protected. Increased risk for health workers can be caused by contact with patients without personal protective equipment (PPE) and surfaces contaminated with the virus. Infected health workers can infect other people around them and will increase the workload of other health workers. One of the efforts to reduce the risk of transmission to health workers is vaccination. Vaccines against COVID-19 are considered very important to prevent and control COVID-19. The aim is to determine the relationship between the COVID-19 vaccine status and the outcomes of healthcare workers treated for confirmed COVID-19 at hospitals throughout Padang.Methods: This observational study was conducted using a retrospective cohort method. The study was conducted from August 2021 to May 2022 in hospitals across Padang by completing a questionnaire in the form of a Google form link. Results: Vaccination status of health workers who survived COVID-19 who were treated at Padang City General Hospital (66.97%) were not vaccinated, aged 26–35 years (57.80%), female (80.73%), worked as paramedics (63, 55%), symptom onset 3 to 7 days (44.95%), number of symptoms 3 (55.96%), most fever (24.68%), number of comorbid 1 to 2 (66.06%), obesity (66.67%), length of stay <21 days (84.40%), and mild clinical (55.96%) and recovered (92.66%). The highest degree of COVID-19 severity for health workers who were not vaccinated was moderate clinical, 42 samples (57.53%), and vaccinated, predominantly mild clinical, 34 samples (94.44%). The duration of stay of health workers vaccinated was higher than that who were not vaccinated (97.22% vs. 78.08%).Conclusion: The vaccination status of health workers who have survived COVID-19 relates to a clinical degree, length of stay, and outpatient treatment.
HUBUNGAN FAKTOR KESEHATAN LINGKUNGAN DENGAN KEJADIAN TUBERKULOSIS DI KOTA PADANG TAHUN 2023 finy marsyah; Yuniar Lestari; Masrul Basyar
Jurnal Endurance Vol. 8 No. 3 (2023): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jen.v8i3.2523

Abstract

Tuberculosis is still a public health problem both in Indonesia and internationally so that it is the goal of the SDGs. In 2021 the number of tuberculosis cases in Padang City was 1,656 cases, the cure rate decreased from 1009 to 457. The death toll increased from 75 to 93. This study aims to analyze environmental health factors associated with tuberculosis. The type of research is quantitative, comparative cross sectional study design. Respondents of the tuberculosis group were tuberculosis sufferers who had lived in the same house with the patient. The non-TB group is not a patient who has been at home with TB sufferers. Data was analyzed using chi square and logistic regression. This research was conducted at 5 Puskesmas in Padang City from June-July 2023. The study showed that 52.8% occupancy density, 45.8% ventilation, 37.5% lighting, 40.3% humidity respondents did not qualify, 98.6% of respondents' house floors were qualified. There are relationships between density (p = 0.034), ventilation (p = 0.005), lighting (p = 0.003), humidity (p = 0.04). The lighting variable is the most dominant variable related to the incidence of tuberculosis in Padang City in 2023. The variable most associated with tuberculosis incidence is lighting. This study found that ventilation is related to tuberculosis, so it needs to be considered in PBG (building approval) to establish rules on the minimum ventilation area requirements as one of the requirements in granting construction approval so that the house becomes healthy and protected from infectious diseases
Co-Authors Afriani Afriani Fenty Anggrainy finy marsyah Herman, Deddy Kornelis Aribowo Mega Senja Ulfahimayati Ulfahimayati Yessy Susanty Sabri Yuniar Lestari