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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal) Heart Science Journal Journal of Psychiatry Psychology and Behavioral Research (JPPBR) Engagement: Jurnal Pengabdian Kepada Masyarakat
Novi Kurnianingsih
Brawijaya Cardiovascular Research Center Department Of Cardiology And Vascular Medicine Faculty Of Medicine, Universitas Brawijaya Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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TARGETING DNA METHYLATION ON TRANSGENERATIONAL CONSEQUENCES OF PRENATAL STRESS-INDUCED DEPRESSION Nia Kurnianingsih
Journal of Psychiatry Psychology and Behavioral Research Vol. 3 No. 2 (2022): Mental Health and Application of Applied Therapy
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.95 KB) | DOI: 10.21776/ub.jppbr.2022.003.02.8

Abstract

Background: Depression is a common mental disorder with disabilities and mortalities burden. Maternal stress during pregnancy has a strong correlation with the depression of children event in their adulthood phase. Abundant maternal cortisol transfer to the fetus generates blunted hypothalamus-pituitary-adrenal axis response. Objective: To understand the mechanism of targeting DNA methylation on transgenerational consequences of prenatal stress-induced depression.   Methods: This review provides a comprehensive explanation of the DNA methylation changes as well as the occasion of new potential therapy that focused on DNA methylation inhibitors in depression from 33 trusted sources. Results: Higher fetal circulation of cortisol led to epigenetic changes during fetal development in an antenatal stress situation. DNA methylation of crucial genes such as brain-derived neurotrophic factor (BDNF) and nuclear receptor subfamily 3 group C member 1 (NR3C1) are responsible for the molecular mechanism of depression progression into the next generation through transcriptional inhibition. Conclusion: Demethylation is becoming a potential target to reduce the risk of depression in children who has a risk of prenatal stress mother. The role of plant bioactive compound as demethylation agent is promising and need further exploration. Keywords: depression, DNA methylation, prenatal stress.
Aortic Intramural Hematoma Mimicking Acute Coronary Syndrome Zainal Fathurohim; Novi Kurnianingsih; Djanggan Sargowo; Heny Martini
Heart Science Journal Vol 4, No 2 (2023): Dealing with the Complexity of the Wide Spectrum of Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.02.5

Abstract

Abstract :Type A Aortic intramural haematoma (IMH), a variant form of classic aortic dissection, has been accepted as an increasingly recognised and potentially fatal entity of acute aortic syndrome.It is a very dangerous, fatal, and emergency condition. It is very important to recognize the symptoms of acute aortic syndrome related to appropriate management Case IllustrationA 52 year old man patient  suffered from chest pain with moderate intensity while he was working at home. It was sharp , tear-like sensation, in the middle of the chest radiated to the back, accompanied with cold sweating, and did not relieve by rest. Because of this condition he brought to hospital. From examination at Emergency room, he had cardiomegaly, aortic dilatation. From the Electrocardiography an st elevation at V1-V2 and T inverted V4-V6 precordial lead,I aVL extremities lead  and slightly elevated cardiac enzymes with risk factors for active smoking and uncontrolled hypertension. Initially he was suspected of having acute coronary syndrome with differential diagnose acute aortic syndrome. To exclude the diagnose he had underwent cardiac catheterization, the cardiologist in charge suspicious this patient with aortic dissection because of trapping contrast durante procedure and coronary minor disease. For a better diagnosis, transtransthoracic echocardiography and Aortic Computed Tomography angiography was performed on the patient which confirmed the evidence of dissection. After being diagnosed, we treat the patient as an acute aortic syndrome and we stabilize the patient's condition. The patient was planned for cardiac surgery DiscussionAcute aortic syndrome, which includes Acute Aortic Dissection, Intramural Hematoma and penetrating aortic ulcer, is difficult to diagnosed. Aortic intramural hematoma, which is one of the acute aortic syndromes, is characterized by the presence of a hematoma in the medial layer of the aortic wall without the appearance of an intimal tear. The incidence of intramural hematoma differs slightly from that of aortic dissection syndrome. Patients with intramural hematomas often occur in older patients, more often with aortic aneurysmsThe patient  receive treatment aggressively to control blood pressure by administering a non-dihydropyridine calcium channel blocker intravenously and then beta blocker, angiotensin II receptor blockers, was also needed. Acute aortic syndrome, where an intramural aortic hematoma can present with varying symptoms of varying severity, which can lead to misdiagnosis and delay in cases of life-threatening disease. In the case of our patient, who had strong cardiac risk factors, His initial presentation described an acute myocardial infarction; the diagnosis was made after CT scan was performed and the patient remained stable  ConclussionComplaints of chest pain due to symptoms of acute aortic syndrome are very important to be recognized immediately because they need proper management. Complaints in this syndrome have similarities with complaints in acute coronary syndrome, pulmonary embolism and others. Patients with aortic intramural hematoma are at high risk for developing periaortic hematoma and hemorrhagic pericardial effusion. In patients with an intramural aortic hematoma, Stanford A, the most appropriate management is surgical technique. Initial management of blood pressure control, heart rate and anti-pain can be given. In this case, the choice of a combination of surgery with endovascular may be a logical choice of therapyKeywordAortic Intramural Hematoma, Acute aortic syndrome
Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice: Purple Sweet Potatoes on Psychological Stress Nia Kurnianingsih; Dian Artamevia; Antania Kashira Winarta; Andini Putri Wulandari; Dian Hasanah; Edwin Widodo; Retty Ratnawati
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.18

Abstract

Psychological stress generates inflammation and oxidative stress in various tissues. Visceral fat as the target site of inflammation is then correlated with stress-induced obesity. Redox imbalance following inflammation also has prominent impacts on hepatic tissue. Therefore, the development of anti-inflammatory and antioxidant properties from plant bioactive compounds is necessary to be investigated. Anthocyanin (ANC) from various plants is previously described as a powerful anti-inflammatory and antioxidant even though its effect in psychological stress remains underexplored. Purple sweet potatoes (PSP) has ANC as its natural pigment. Previous studies revealed the potential effect of ANC from PSP on behavior and an antidepressant candidate. Thus, this study was purposed to determine the effect of ANC from PSP on inflammation and oxidative stress in visceral fat and hepatic tissue respectively. A total of 25 adult male BALB/c mice were assigned into groups of control, stress, stress+ANC 10 mg/kgBW, stress+ANC 20 mg/kgBW and stress+ANC 40 mg/kgBW. Restraint stress was applied 2 hours/day for 14 days. Enzyme-linked immunoassay (ELISA) was conducted to measure level of IL-6 and IL-10 in visceral fat as well as SOD and MDA from hepatic tissue. The results demonstrated that the supplementation of ANC reduces the level of IL-6 cytokine (p=0.005), tends to increase IL-10 (p=0.612), reduces hepatic SOD (p=0.03), and does not significantly affect the level of hepatic MDA (p=0.432). Both ratios of IL-6/IL-10 and SOD/MDA were reduced following ANC administration. Total ANC extracts are suggested to have a potential role of resisting inflammation and oxidative stress in the psychologically stressed model. Further studies are necessary to evaluate the benefits of ANC from PSP in other peripheral organs under psychological stress exposure.
THE COMBINATION OF HIGH FAT DIET AND MONOSODIUM GLUTAMATE ALTERING ADIPOGENESIS, BRAIN RESISTIN AND SERUM CORTISOL LEVEL IN FEMALE RAT Aris Widayati; Dewi Mustika; Yhusi Karina Riskawati; Agustin Iskandar; Nia Kurnianingsih
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.8

Abstract

Background: The prevalence of obesity is increasing tremendously worldwide. Obesity is correlated with the consumption of a high-fat diet (HFD) and monosodium glutamate (MSG). Although the effect of MSG or HFD on inflammation has been established, lack of information about the effects of both combination on simultaneous systemic and brain inflammation that can be evaluated from cortisol serum and brain resistin level respectively. Objectives: This study aimed to investigate the effects of combining HFD and MSG on brain resistin, serum cortisol, lipid profiles, visceral weight, and body weight gain. Methods: Sixteen adult female rats were randomized into 4 groups consist of standard diet; HFD+MSG 0.05 mg/gBW, HFD+MSG 0.2 mg/gBW and HFD+MSG 0.35 mg/gBW. Lipid profiles were measured using automatic biochemical analyzer. Brain resistin and serum cortisol level were determined using enzyme-linked immunoassay. Results: The groups of HFD+MSG significantly have higher level of brain resistin (p<0.003), serum cortisol (p<0.01), total cholesterol (p<0.003) and visceral fat weight (p<0.05) than control group. Conclusion: The combination of HFD, and MSG generates obesity that led to systemic-brain alteration on inflammation.  Further study is necessary to evaluate further the functional impact of both combinations on behavioral profiles.
Pendampingan Penguatan Kompetensi Guru dan Siswa SMA Melalui Pengembangan Inovasi Sains dan Kompetisi Olimpiade Biologi di Kabupaten Sampang, Madura Eko Suyanto; Anna Safitri; Nia Kurnianingsih; Fatchiyah Fatchiyah
Engagement: Jurnal Pengabdian Kepada Masyarakat Vol 4 No 2 (2020): November 2020
Publisher : Asosiasi Dosen Pengembang Masyarajat (ADPEMAS) Forum Komunikasi Dosen Peneliti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52166/engagement.v4i2.288

Abstract

Teachers and students need more knowledge to improve their competence. The educational quality can be improved by varying learning methods and supported by competition. This community service activity aims to strengthen the competence of teachers and students through learning innovation in the Biology subject and to provide learning competition of Biology Olympiad through simulation and training. The community-based research (CBR) method was performed by workshop and training involving 60 participants. As many as 100% of the participants attended the activities. The results indicated that the participants acquired new knowledge and realized their competence skills. Learning innovation and competition were able to improve their knowledge and competence. The participants are eager to apply the methods learned at school. These new competence and skill are expected to improve the quality of education
Co-Authors Adhika Prastya Wikananda Agustin Iskandar Andini Putri Wulandari Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Antania Kashira Winarta Ardian Rizal Aris Munandar Zulkifli Ismail Aris Widayati Ayu Asri Devi Adityawati Budi Satrijo Budi Satrijo Cholid Tri Tjahjono Davy Reyhanditya Dian Artamevia Dian Hasanah Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dyah Ayu Ikeningrum Edwin Widodo Eko Suyanto Fahmy Rusnanta Fatchiyah Fatchiyah Fatchiyah Fatchiyah Heny Martini Indra Prasetya Indra Prasetya Irma Kamelia Irma Kamelia Liemena Harold Adrian Mohammad Ryan Ramadhan Mohammad Saifur Rohman Monika Sitio Muhammad Rizki Fadlan Mustika Dewi Oktafin Srywati Pamuna Putri Annisa Kamila Retty Ratnawati Riskawati, Yhusi Karina Safitri, Anna Sasmojo Widito Seprian Widasmara Veny Kurniawati Viona Faiqoh Hikmawati Zainal Fathurohim