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All Journal Molekul: Jurnal Ilmiah Kimia Mandala of Health : A Scientific Journal
Viva Ratih Bening Ati
Faculty Of Medicine, Universitas Jenderal Soedirman
Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Public Health

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Protective Effect of Ethanol Extract of Celery (Apium graveolens L) on Kidney Damage in Ischemia/ Reperfusion Injury Rats Model Afifah Afifah; Khusnul Muflikhah; Viva Ratih Bening Ati; Rizki Maulana Tsani; Dairotul Khasanah; Watub Maulana
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.741 KB) | DOI: 10.20884/1.jm.2019.14.1.448

Abstract

Ischemia/ reperfusion injury (IRI) is marked by the sudden decrease of blood supply to the kidney followed by restoration of blood flow. Ischemic acute kidney injury (AKI) is the leading cause of morbidity and mortality. Therefore, the prevention strategy for decreasing the damage due to IRI is required. Celery (Apium graveolens L) is often consumed as food. Celery has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of the celery on kidney damage in the kidney ischemia/ reperfusion injury rat model.  Twenty-five rats male, 2-3 months old Sprague Dawley were divided into 5 groups: Group 1  was sham operation, group 2 was ischemia/ reperfusion injury (IRI), group 3, 4, 5 were IRI and 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW of ethanol extract of celery respectively for 14 days before and 3 days after operation. Blood serum sample was taken 3 days after the operation for measuring urea, creatinine, superoxide dismuthase (SOD) and nitrite oxide (NO). Hematoxylin-eosin (HE) staining was utilized to examine kidney tubular injury score. Data were analyzed using One-way ANOVA (p<0,05). The ethanol extract of celery at dose 1000 mg/kgBW prevented the increase of urea, creatinine serum, kidney tubular injury score and prevented the decrease of SOD, NO in the kidney ischemia/ reperfusion injury rat model (p<0,05). In conclusion, the ethanol extract of celery has a protective effect on kidney damage in the ischemia/ reperfusion injury rat model.  
RISK FACTORS ASSOCIATED WITH THE EVENT OF PROSTATE CANCER (CASE STUDY IN Prof. Dr. MARGONO SOEKARJO PURWOKERTO HOSPITAL) Viva Ratih Bening Ati
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.447 KB) | DOI: 10.20884/1.mandala.2021.14.2.5116

Abstract

The incidence of prostate cancer (PCa) is closely related to increasing age and other factors such as family history, obesity, smoking habits, vasectomy history, and alcohol consumption. As the number of cases increases, understanding the risk factors associated with the incidence of PCa becomes very important. Therefore, this study was conducted to determine the risk factors for PCa in Prof. Dr. Margono Soekarjo Purwokerto’s Hospital as an approach to the identification and prevention of PCa events. Observational research using cased control was conducted at the Urology Surgery Polyclinic of Prof. Dr. Margono Soekarjo Purwokerto Hospital. 15 PCa patients and controls in the form of participants diagnosed with other cancers as many as 8 people. Univariate analysis using SPSS was conducted to determine the relationship of risk factors to the incidence of PCa with a significance of p<0.05. The results showed that some of the prominent characteristics of PCa respondents were age >60 years (66.7%), married (80%), not suffering from diabetes mellitus (93.3%), normal lifestyle (80%), and not consuming alcohol (100%). In the control group, age >60 years (62.5%), no family history of prostate cancer (100%), normal lifestyle (100%), and smoking (50%). From the results of the study, it was concluded that the characteristics of respondents in the case group were mostly aged > 60 years, had low education, worked as farmers, and had no history of prostate cancer in their family.
Co-Authors Afifah Afifah Dairotul Khasanah Khusnul Muflikhah Rizki Maulana Tsani Watub Maulana