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All Journal Jurnal Kesehatan Andalas Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal Of Bionursing JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Ika Murti Harini

Department Of Histology, Faculty Of Medicine, Universitas Jenderal Soedirman, Purwokerto

Author-ID : 3836074

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Other

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Articles

The Hepatotoxic and Nephrotoxic Effects of Purwoceng (Pimpinella pruatjan Molk.) Roots Ethanol Extract Administration in Subchronic Dose Fitranto Arjadi; Nur Signa Aini Gumilas; Ika Murti Harini; Vitasari Indriani; Lantip Rujito
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Purwoceng (Pimpinella pruatjan Molk) is an original Indonesian herb which is known to have an aphrodisiac effect. The active compounds in Purwoceng potentially have hepatotoxic and nephrotoxic effects.This study was aimed to analyze the effect of subchronic administration of Purwoceng roots ethanol extract to Wistar Strain of Rattus norvegicus rats. The method of this subchronic toxicity study was an experimental post test only with control group design. Forty male Rattus norvegicus were randomly divided into four groups and get 28-days treatment. Group A as control received aquadest and 1% CMC (carboxymethyl cellulose), group B, C, and D were given Purwoceng roots ethanol extract of 42, 84, and 168 mg/KgBW/day and 1% CMC. Parameters tested were the levels of urea, creatinine, SGPT (serum glutamic pyruvic transaminase), SGOT(serum oxaloacetic pyruvic transaminase), kidney and hepar histopatology.The results showed a statistically significant for the liver histopathological in group B, creatinine, urea, and kidney histopathology in group C. Our study concluded that subchronic administration of Purwoceng (Pimpinella pruatjan Molk) roots ethanol extract could induce hepatotoxicity at the 42 mg/KgBW/day dose level and nephrotoxicity at the 84 mg/KgBW/day dose level.

Sub-chronic hepatotoxicity test of Plantago mayor L. extract Eman Sutrisna; Setia Wati; Farissa Utami; Rahayu Nurmalia Fauziah; Dara AisyahRahayu Abdurrachman; Ika Murti Harini; Thianti Silviningrum
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

The aim of this study was to examine hepatotoxicity of Plantago mayor L. extract on rat by using effective dosage. By experimental study and post test only with control group design. 15 rats (Rattus norvegicus) were divided in to 3 group. Group A as a natural control was given aquades. Group B and C were given extract of Plantago major L. 50mg, and 100mg/200g BW rat/day per oral. Liver function was determined with measurement of Aspartate aminotransferase (AST) level, Alanine aminotransferase (ALT), total bilirubin, and histopathological feature of liver. Blood sampling and Liver organ were taken after 28 days of intervention. The average of AST levels, ALT and total bilirubin among groups A, B and C were AST levels (145.40±52.92, 129.00±34.89, and 115.60±13.24 U/l), ALT (76.40±18.87, 83.20±18.71, and 61.00±8.45 U/l) and total bilirubin (0.56±0.03, 0.77±0.22, and 0.58±0.08 mg/dL). Statistical analysis showed that there were not significantly differences of AST levels (p=0,63; CI95%), ALT (p=0,47; CI95%) and total bilirubin (p=0,0,09; CI95%) between the groups. In histopathological features, the average Scheuer score between groups A, B and C is 1.79 ± 0.74, 3.30 ± 0.66 and 2.84 ± 0.77. There is a significant difference in Scheuer scores between the groups (p=0,005; CI95%) that show that there is a difference in the effect of giving extract of Plantago major L. to hepatocyte cells leading to a piecemeal necrosis. This study can be concluded that in effective dosage, Plantago major L. extract able to induce hepatocytes injury although it cannot cause liver disfunction yet.

Promosi Kesehatan Untuk Mencegah Miopi dan Komplikasinya Pada Murid SDN 2 Berkoh, Purwokerto Alfi Muntafiah; Afifah Afifah; Octavia Permata Sari; Ika Murti Harini; Qodri Santosa
Jurnal Pengabdian Pada Masyarakat Vol 3 No 1 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

HEALTH PROMOTION FOR PREVENTING AND COMPLICATIONS MYOPIA IN STUDENTS OF SDN 2 BERKOH, PURWOKERTO. Myopia is the most common refractive disorder in school-aged children. These visual disorders need attention, because they can interfere with life and daily work, and also their intellectual development. This health promotion activity is conducted to improve knowledge and understanding about myopia and the efforts that must be done to maintain eye health. This activity was conducted on 140 students of 4th, 5th, and 6th grade of SDN 2 Berkoh Purwokerto, through counseling, training, giving module, leaflet and poster. Based on the T-test of the pre-post and post-test in each class, the p values obtained in grades 4,5 and 6 respectively p = 0.058; 0.588; and 0.074. Conclusion: this activity can increase students' knowledge of myopia, although the increase is not significant.

Hubungan antara Profil Lipid dengan Kejadian Retinopati Diabetika pada Pasien Diabetes Melitus Tipe 2 di Fasilitas Kesehatan Tingkat Pertama Klinik Tanjung Purwokerto Ika Murti Harini; Muhamad Rifqy Setyanto; Nur Signa Aini Gumilas; Dwi Arini Ernawati
Jurnal Kesehatan Andalas Vol 11, No 1 (2022): Online March 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1932

Diabetic retinopathy is a major microvascular complication due to diabetes mellitus (DM) and prolonged hyperglycemia. One of the risk factors for the development and progression of diabetic retinopathy is lipid profile levels in DM patients. Objectives: To determined the relationship between lipid profile and the incidence of diabetic retinopathy in DM patients who follow the Chronic Disease Management Program at the first level health facilities Klinik Tanjung Purwokerto. Methods: The number of respondents in this study was 49 people. The independent variables assessed were lipid profiles, including levels of total cholesterol, triglycerides, LDL, and HDL. The dependent variable is the incidence of diabetic retinopathy determined by an ophthalmologist. Statistical analysis to determine the relationship between lipid profile and the incidence of diabetic retinopathy used the Chi-square test and calculated the odds ratio (OR). Results: The results showed that there was no relationship between levels of total cholesterol (p=0.586), triglycerides (p=1), and LDL (0.719) with the incidence of diabetic retinopathy. The statistical analysis results of the relationship between HDL levels and the incidence of diabetic retinopathy were known to have a p-value = 0.046 (OR 4.83; 95% CI 1.23-18.98). Conclusion: There is a significant relationship between HDL levels and the incidence of diabetic retinopathy in Type 2 DM patients at the FKTP Klinik Tanjung Purwokerto. DM patients with abnormal HDL levels are 4.83 times more likely to develop diabetic retinopathy than DM patients whose HDL levels are normal.Keywords: diabetes mellitus, lipid profile, diabetic retinopathy

The decrease of histomorphometry and function of pancreas in male albino rats after induced by sleep deprivation Fitranto Arjadi; Nur Signa Aini Gumilas; Ika Murti Harini; Pugud Samodro; Andromeda Andromeda
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art3

Background: Sleep disturbance accelerates type 2 diabetes mellitus by reducing insulin secretion and by the occurrence of difficulty in controlling sleep behaviour in humans so that it is necessary conduct a study by using experimental animals.Objective: This study aims to determine histophotometric differences of pancreas and differences of glucose tolerance in male albino rats (Rattus norvegicus) after induced by stress paradoxical sleep deprivation (PSD) and total sleep deprivation (TSD). Methods: This study applied a post-test only with control groups consisting of 30 male albino rats (Wistar strain) divided randomly into 3 groups: control group, PSD group and TSD group. The mean number and diameter of islets of Langerhans were calculated per slide and were averaged for each group at a magnification of 400 X. The percentage of beta cells in one islet of Langerhans was (ß-p) that was a number of normal beta cells (Bn) divided for the total beta cells (Bt) (normal and damaged) x 100%. The glucose level based on the sampling time was made a curve shape, and the area under the 0-to-120-minute curves (AUC0-120) was calculated by using a trapezoidal formula.Results: The lowest AUC0-120 level of glucose was the control group (14,082 ± 955mg/dL) and the highest was the TSD group (16,293 ± 2,195 mg/dL); the Post-Hoc LSD test showed a significant difference (p<0.05) between the control-PSD group and the TSD-control group. The mean result of pancreatic ß cells mass with the lowest number was in the TSD group (76.3 ± 4.8), and the highest result was in the control group (94.3 ± 2.7); Post-Hoc LSD showed a significant difference (p <0.05) in the control-PSD group and the TSD-control group. The lowest mean in cell diameter of islets of Langerhans was in the TSD group (0.132 ± 0.031 mm), and the highest mean was in the control group (0.213 ± 0.019 mm). Conclusion: Sleep deprivation could reduce pancreatic ß cell mass and cell diameter of islets of Langerhans and increase glucose tolerance levels.

Faktor-Faktor yang Mempengaruhi Tingkat Kepatuhan Diet pada Pasien Diabetes Melitus Tipe 2 di Kecamatan Sumbang Banyumas Dwi Arini Ernawati; Ika Murti Harini; Nur Signa Aini Gumilas
Journal of Bionursing Vol 2 No 1 (2020): Journal Of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Background problem: Diabetes Mellitus (DM) prevalence in Indonesia based on the results of basic health Research (RISKESDAS) year 2013 is 2.1%, in Central Java 18.33%. Banyumas District has an incidence rate of 1,417 in 2014 and Sumbang Sub-district has the highest incidence rate of DM type 2. Management in DM sufferers is integrated, including eating arrangements, physical activity, education, and medicines. Meal arrangement for patients with type 2 DM includes setting against 3J: number, type and meal schedule in a day. Patients with DM who have already run a diet program has not been able to control blood glucose properly. Food arrangement often fails due to the disobedience of sufferers in running their diet. Many factors affect dietary compliance, among them the level of education, level of knowledge, self-motivation, family support and the role of health workers.Objective: To determine the factors that affect the compliance of diet in diabetes mellitus type 2 patients in Sumbang Sub-district of Banyumas.Methods: The studies used are cross sectional, the level of compliance seen from 3J, i.e. precise amounts, precise types and precise schedules. Samples taken from DM patients who are in Prolanis present during laboratory examination in June 2019. Sampling technique using total sampling. Bound variables are the level of dietary compliance, the free variables are education levels, knowledge levels, self-motivation, family support and the role of health workers.Results: The number of samples was 32 people, who were obedient in a diet of 15 people (46.9%), who did not obey 17 people (53.1%). The P value of the factor variable factors affecting the diet is: age p = 0.411, sex p = 0.035, Job p = 0131, long DM p = 0.261, education level p = 0.035, knowledge level p = 0.036, self motivation p = 0.464, family support p = 0.314, and P Health worker, p = 0.452. Variables that have a meaningful relationship (P < 0.05) with dietary compliance levels are gender, level of education and level of knowledge. As for the variable age, employment, old DM, self-motivation, family support, and the role of health workers have an insignificant relationship (P > 0.05Conclusion: From 32 patients DM most have a level of diet compliance in the category of disobedient 17 people (53.1%), there is a meaningful relationship between gender, education level and level of knowledge with DM dietary compliance,

Co-Authors Afifah Afifah Alfi Muntafiah Andromeda Andromeda Dara AisyahRahayu Abdurrachman Dwi Arini Ernawati Dwi Arini Ernawati Eman Sutrisna Farissa Utami Fitranto Arjadi Fitranto Arjadi Lantip Rujito Muhamad Rifqy Setyanto Nur Signa Aini Gumilas Octavia Permata Sari Pugud Samodro Qodri Santosa Rahayu Nurmalia Fauziah Setia Wati Thianti Sylviningrum Vitasari Indriani

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