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All Journal Pharmacology and Clinical Pharmacy Research Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Sains dan Teknologi Farmasi Indonesia
Nela Simanjuntak
Program Studi Sarjana Famasi, Sekolah Tinggi Farmasi Indonesia, Jawa Barat, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa Nela Simanjuntak; Umi Yuniarni; Diki Prayugo
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.448 KB) | DOI: 10.15416/pcpr.v1i2.15202

Abstract

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion
VALIDASI METODE ANALISIS SENYAWA ETIL p-METOKSISINAMAT DALAM PLASMA DARAH TIKUS PUTIH JANTAN GALUR WISTAR MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI Revika Rachmaniar; Natalia Suryanata; Nela Simanjuntak
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 1 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i1.2332

Abstract

Ethyl p-methoxycinnamate (EPMC) isolated from the rhizome of kencur (Kaempferia galanga L) is being developed at STFI. Validation of EPMC analysis in blood plasma using High-Performance Liquid Chromatography (HPLC) needs to be conducted to perform in vivo EPMC analysis. This study aims to validate the EPMC analysis method in blood plasma using HPLC. The HPLC column used is column C18, with methanol : phosphoric acid 70:30 and 80:20 mobile phases, a flow rate of 1.0 mL/min, and a maximum wavelength of 310 nm. The blood plasma used was the blood plasma of white male rats of the Wistar strain. EPMC was added to blood plasma and analyzed using HPLC. Parameter validation used is system suitability test, linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). The results showed that the optimum mobile phase for analyzing EPMS in plasma was methanol : phosphoric acid with a ratio of 70:30. Based on the validation, the linear regression was 0.998. In the accuracy test, the average value range for the percent recovery is 98% - 102%. In the precision test, the average value of the RSD percentage was 4.10% - 68.83%. The LOD value is 2.747 g/mL, and the LOQ value is 9.158 g/mL. Based on this research, it can be concluded that EPMC in blood plasma can be analyzed using KKKT with column C18 and mobile phase methanol : phosphoric acid 70:30.
PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana, L.) TERHADAP PENURUNAN KADAR LOGAM MERKURI PADA GINJAL MENCIT GALUR SWISS WEBSTER Nela Simanjuntak; Marwatul Zamil; Tiara Berliani; Nur Asni Setiani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 10, No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.009 KB) | DOI: 10.58327/jstfi.v10i2.174

Abstract

Mangosteen (Garcinia mangostana L.) is known as a plant rich in antioxidants and has various pharmacological activities. This study aims to determine the activity of the ethanolic extract of G. mangostana L. to decrease mercury levels in the kidneys. Mangosteen rind was extracted using 96% ethanol using the maceration method to form a thick extract. The experimental animals used in this study were Swiss Webster strain mice which were grouped into normal group (CMC suspension 0.5%), negative control (induction of HgCl2 solution), positive control (induction of HgCl2 solution followed by administration of curcumin at a dose of 100mg/KgBW). , and the test group was given mangosteen peel extract at a dose of 200mg/kgBW, 400mg/kgBW, 600mg/kgBW. In the test group, mice were induced using HgCl2 for 14 days, followed by administration of ethanol extract of mangosteen rind for 24 days. Observations were made with kidney organ surgery and observations were made using Atomic Absorption Spectrophotometry (AAS) and analyzed using ANOVA. The test results showed mercury accumulation in the negative, positive control group, and the test doses of 200, 400 and 600mg/kgBW, respectively, were 44.3mg/kg, 7.3mg/kg, 36.46mg/kg, 35.7mg/kg. kg and 31.34mg/kgBW with an effective dose of 600mg/KgBW.
Co-Authors Diki Prayugo Marwatul Zamil Natalia Suryanata Nur Asni Setiani Rachmaniar, Revika Tiara Berliani Umi Yuniarni