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Diki Prayugo
Sekolah Tinggi Farmasi Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa Nela Simanjuntak; Umi Yuniarni; Diki Prayugo
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.448 KB) | DOI: 10.15416/pcpr.v1i2.15202

Abstract

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion
KADAR TOTAL FLAVONOID PADA BERBAGAI VARIETAS BIJI KEDELAI (Glycine max) INDONESIA Siti Uswatun Hasanah; Diki Prayugo; Nitta Nurlita Sari
Jurnal Ilmiah Farmako Bahari Vol 10, No 2 (2019): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.533 KB) | DOI: 10.52434/jfb.v10i2.654

Abstract

Kedelai merupakan salah satu komoditi tanaman pangan terbesar di Indonesia setelah padi dan jagung. Beberapa penelitian menunjukkan kandungan flavonoid dalam kedelai memberikan perubahan efek profilaktik pada pengobatan menggunakan kedelai, diantaranya menurangi resiko kanker prostat, kanker payudara,dan perkembangan kanker usus besar. Penelitian ini bertujuan untuk mengetahui kadar total flavonoid pada beberapa varietas biji kedelai serta mengetahui variaetas biji kedeai yang memiliki flavonoid tinggi. Penelitian ini dilakukan terhadap Sembilan varietas biji kedelai, yang diekstraksi dengan cara panas. Ekstrak yang dihasilkan dianalisis dengan menggunakan spektrofotometer, dan penentuan kadar total flavonoid didasarkan pada kurva kalibrasi kuersetin. Kadar total flavonoid pada Sembilan varietas biji kedelai bervriasi satu sama lain. Kadar total flavonoid tertinggi didapat dari biji kedelai varietas Argomulyo, yaitu 0,354 mg/gram biji kedeai kering. Kata kunci : Kedelai, varietas, flavonoid
Co-Authors Nela Simanjuntak Nitta Nurlita Sari Siti Uswatun Hasanah Umi Yuniarni