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All Journal Jurnal Biologi Udayana Jurnal Sains dan Teknologi Farmasi Indonesia
Nur Asni Setiani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Potensi Bacillus cereus dalam produksi biosurfaktan Nur Asni Setiani; Nia Agustina; Irma Mardiah; Syarif Hamdani; Dewi Astriany
Jurnal Biologi Udayana Vol 24 No 2 (2020): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBIOUNUD.2020.v24.i02.p09

Abstract

Biosurfactants from microorganisms have stable physical and chemical properties, environment friendly, biodegradable, renewable, cheaper and low toxicity that can be used in the pharmaceutical industry as antibacterial. The aim of this study was to examine the emulsification and characterization of biosurfactant from Bacillus cereus. Hemolysis and spreading oil tests was performed as an initial screening. Biosurfactant production was carried out by growing bacteria on oil-enriched media with shaker system for 7 days. The supernatant was measured for biosurfactant activity through an emulsification index and characterized using thin layer chromatography and antibacterial qualitative testing. The emulsification index on days 0, 1, 3, 5, and 7 showed percentage in sequence 44,83%, 48,28%, 51,72%, 46,43%, and 51,50%. The formation of red stains on TLC plates with ninhydrin appearance showed lipopeptide groups. Antibacterial testing using Escherichia coli and Staphylococcus aureus showed the formation of clear zones around the disk paper. Bacillus cereus can produce biosurfactants of the lipopeptide group with the largest emulsification index of 51.72% and has antibacterial activity against both gram positive and gram negative.
KANDUNGAN KIMIA DAN AKTIVITAS ANTIOKSIDAN PADA UMBI BAWANG DAYAK (Eleutherine palmifolia (L.) Merr.) HASIL FERMENTASI Sani nurlaela fitriansyah; Naimah Puteri; Nur Muthmainnah; Nur Asni Setiani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 10, No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.389 KB) | DOI: 10.58327/jstfi.v10i2.181

Abstract

Umbi bawang dayak (Eleutherine palmifolia (L.) Merr.) memiliki kandungan fenol dan flavonoid yang berkhasiat sebagai antioksidan. Kandungan kimia dalam suatu tumbuhan dapat dipengaruhi dengan adanya proses pengolahan bahan baku. Salahsatu proses pengolahan baku tumbuhan yaitu dengan adanya fermentasi menggunakan pemanasan. Penelitian ini bertujuan mengetahui pengaruh fermentasi pada kandungan kimia dan aktivitas antioksidan pada ekstrak umbi bawang dayak. Penelitian ini dilakukan dengan fermentasi umbi bawang dayak dengan pemanasan selama 10, 20 dan 30 hari. Ekstraksi dilakukan menggunakan maserasi dengan pelarut etanol 70%. Penetapan kadar fenol total, flavonoid total dan aktivitas antioksidan menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan, ekstrak umbi bawang dayak hasil fermentasi selama 30 hari memiliki kadar fenol total, kadar flavonoid total dan aktivitas antioksidan tertinggi, ditunjukkan secara berurutan (3,721 g GAE/100 g ekstrak ± 0,210; 0,378 g QE/100 g ekstrak ± 0,189, IC50 peredaman DPPH 28,689 µg/mL± 0,144). Adanya proses fermentasi dan lama proses fermentasi dapat mempengaruhi kandungan kimia dan aktivitas antioksidan ekstrak umbi bawang dayak.
PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana, L.) TERHADAP PENURUNAN KADAR LOGAM MERKURI PADA GINJAL MENCIT GALUR SWISS WEBSTER Nela Simanjuntak; Marwatul Zamil; Tiara Berliani; Nur Asni Setiani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 10, No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.009 KB) | DOI: 10.58327/jstfi.v10i2.174

Abstract

Mangosteen (Garcinia mangostana L.) is known as a plant rich in antioxidants and has various pharmacological activities. This study aims to determine the activity of the ethanolic extract of G. mangostana L. to decrease mercury levels in the kidneys. Mangosteen rind was extracted using 96% ethanol using the maceration method to form a thick extract. The experimental animals used in this study were Swiss Webster strain mice which were grouped into normal group (CMC suspension 0.5%), negative control (induction of HgCl2 solution), positive control (induction of HgCl2 solution followed by administration of curcumin at a dose of 100mg/KgBW). , and the test group was given mangosteen peel extract at a dose of 200mg/kgBW, 400mg/kgBW, 600mg/kgBW. In the test group, mice were induced using HgCl2 for 14 days, followed by administration of ethanol extract of mangosteen rind for 24 days. Observations were made with kidney organ surgery and observations were made using Atomic Absorption Spectrophotometry (AAS) and analyzed using ANOVA. The test results showed mercury accumulation in the negative, positive control group, and the test doses of 200, 400 and 600mg/kgBW, respectively, were 44.3mg/kg, 7.3mg/kg, 36.46mg/kg, 35.7mg/kg. kg and 31.34mg/kgBW with an effective dose of 600mg/KgBW.
Co-Authors Dewi Astriany Hamdani, Syarif Irma Mardiah Marwatul Zamil Naimah Puteri Nela Simanjuntak Nia Agustina Nur Muthmainnah Sani nurlaela fitriansyah Tiara Berliani