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Hilwan Y. Teruna
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Medicine & Pharmacology

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Anti-Bacterial and Anti-Fungal Activities from Macaranga bancana Leaves Extract Rianti Putri; Rudi Hendra; Hilwan Y. Teruna
Pharmacology and Clinical Pharmacy Research Vol 4, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.746 KB) | DOI: 10.15416/pcpr.v4i1.21376

Abstract

Macaranga bancana is one of the Indonesian medicinal plants that is empirically used to treat infectious disease. The aim of this study was to evaluate anti-bacterial and anti-fungal  activities of  M. bancana against human pathogenic microbes, i.e., Escherichia coli, Staphylacoccus aureus, and Candida albicans. The dried leaves of M. bancana were extracted using cold extraction method with n-hexane, dichloromethane, ethylacetate, methanol, and ethanol solvents. The evaluation of anti-microbial activity from these extracts at the concentration of  1000 µg/ml was conducted using microdilution method. Amoxicillin, cephadroxil, and ketoconazole were used as positive controls. All extracts showed 100% inhibitory activity against S. aureus, with the exception of ethanol extract which was 72.8%. Nevertheless, methanol and ethanol extracts showed 100%  inhibitory activity against E. coli, while the lowest activity was shown by n-hexane extract ( 45.2%). All extracts exhibited 100% inhibitory activity against C. albicans.  In conclusion, leaves extract of M. bancana is a potential source of anti-bacterial and anti-fungal agents.  Keywords:  anti-bacterial, anti-fungal, M. bancana, microdilution
Physicochemical Properties of Phosphate Pregelatinized Musa balbisiana Starch as Pharmaceutical Excipient Deni Anggraini; Anita Lukman; Hilwan Y. Teruna
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (676.153 KB) | DOI: 10.15416/pcpr.v1i3.15398

Abstract

Starch is among the important pharmaceutical excipient, which is particularly used as filler in the tablet formulation and suspending agent. Starch from natural source has a potential to be developed as pharmaceutical excipient with comparable characteristics, including starch from Musa balbisiana (M. balbisiana). This study aimed to synthesize and evaluate physicochemical properties of phosphate pregelatinized M. balbisiana starch. We isolated the starch from M. balbisiana and performed pregelatinization. Since pregelatinized starch still could experience retrogradation which cause syneresis, chemical modification of pre-gelatinized starch was conducted using 5% of sodium tripolyphosphate at pH of 9-10. Physicochemical properties of phosphate pregelatinized starch were then investigated. It included the assessment of its organoleptic, pH, water content, particle size distribution, angle of repose, swelling power, amylose content, adsorbs isotherm, and particle analysis using Scanning Electron Microscope (SEM). Phosphate-pregelatinized M. balbisiana starch had low swelling power, better flow properties and viscosity. It can be used particularly in the formulation of slow released tablets and suspending agents in suspension formula.Keywords: pregelatinized starch, Musa balbisiana, psychochemical properties, excipients
Co-Authors Anita Lukman Deni Anggraini Rianti Putri Rudi Hendra