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Craniofacial morphology of children with complete unilateral cleft lip and palate following labioplasty and palatoplasty Sigit Handoko Utomo; Krisnawati Krisnawati; Benny M. Soegiharto
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 2 (2012): June 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: A complete unilateral cleft lip and palate generally results in asymmetry of the midface. The lack of continuity in the perilabial musculature through the midline contributes to a malpositioning of the underlying osseus structures which are often underdeveloped. Purpose: The purpose of this study was to determine whether there are differences in the craniofacial morphology among children with complete unilateral cleft lip and palate following labioplasty and palatoplasty as compared with children without cleft lip and palate at the same pubertal age. Methods: A series of 14 consecutively treated subjects with complete unilateral cleft lip and palate following labioplasty and palatoplasty were compared with 14 pubertal stage-matched controls with normal craniofacial structure. Pubertal stage was determined with cervical vertebral maturation (CVM) method improved by Baccetti et al, 2002. Lateral cephalograms were used for comparison. An unpaired t-test was run for 14 subjects with complete unilateral cleft lip and palate and 14 normal subjects. Results: There were significant cephalometric differences in anterior cranial base length (p = .002), cranial base length (p = .001), maxillary length (p = .000), mandibular length (p = .000), mandibular ramus height (p = .000), mandibular body length (p = .002), and upper anterior face height (p = .004). There was no significant cephalometric difference in posterior cranial base length (p = .051), lower anterior face height (p = .206), posterior face height (p = .865), growth pattern/ facial type (p = .202). Conclusion: There were craniofacial morphology differences between children with complete unilateral cleft lip and palate post labioplasty and palatoplasty and children without cleft lip and palate at the age of pubertal. Children with complete unilateral cleft lip and palate post labioplasty and palatoplasty had shorter length of the anterior cranial base, cranial base, maxilla, mandible, mandibular ramus height, mandibular body, and upper anterior face height as compared with children without cleft lip and palate at the age of pubertal.Latar belakang: Celah bibir dan langit-langit unilateral komplit umumnya menghasilkan asimetri wajah bagian tengah. Berkurangnya kontinuitas otot di sekitar bibir yang melewati garis tengah wajah mengakibatkan malposisi struktur tulang di bawahnya yang seringkali kurang berkembang. Tujuan: Tujuan penelitian ini adalah untuk menentukan apakah terdapat perbedaan morfologi kraniofasial anak dengan celah bibir dan langit-langit unilateral komplit pasca labioplasti dan palatoplasti dibandingkan anak tanpa celah bibir dan langit-langit pada usia pubertal. Metode Penelitian: Sejumlah subyek penelitian berupa 14 orang anak penderita celah bibir dan langit-langit pasca labioplasti dan palatoplasti dibandingkan dengan 14 orang anak yang normal pada masa pubertal yang sama. Masa pubertal ditentukan menggunakan metode cervical vertebral maturation (CVM) yang dikembangkan oleh Baccetti dkk, 2002. Dilakukan perbandingan hasil pengukuran sefalogram lateral dari kedua kelompok. Uji-t tidak berpasangan dilakukan untuk mengetahui perbedaan gambaran kraniofasial antara kelompok anak dengan celah bibir dan langit-langit unilateral komplit pasca labioplasti dan palatoplasti dan kelompok anak normal. Hasil: Terdapat perbedaan bermakna pada panjang basis kranium anterior (p = .002), panjang keseluruhan basis kranium (p = .001), panjang maksila (p = .000), panjang mandibula (p = .000), tinggi ramus mandibula (p = .000), panjang badan mandibula (p = .002), tinggi wajah anterior atas (p = .004). Tidak terdapat perbedaan bermakna pada panjang basis kranium posterior (p = .051), tinggi wajah anterior bawah (p = .206), tinggi wajah posterior (p = .865), pola pertumbuhan/tipe wajah (p = .202). Kesimpulan: Terdapat perbedaan morfologi kraniofasial antara anak dengan celah bibir dan langit-langit unilateral komplit pasca labioplasti dan palatoplasti dibandingkan anak tanpa celah bibir dan langit-langit pada masa pubertal. Anak dengan celah bibir dan langit-langit unilateral komplit pasca labioplasti dan palatoplasti memiliki panjang basis kranium anterior, panjang keseluruhan basis kranium, panjang maksila, panjang mandibula, tinggi ramus mandibula, panjang badan mandibula, dan tinggi wajah anterior atas yang lebih pendek dibandingkan anak tanpa celah bibir dan langit-langit pada masa pubertal.

Runx2 rs59983488 polymorphism in class II malocclusion in the Indonesian subpopulation Fadli Jazaldi; Benny M. Soegiharto; Astrid Dinda Hutabarat; Noertami Soedarsono; Elza Ibrahim Auerkari
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 4 (2021): December 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i4.p216-220

Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations. Variation in skeletal profile is mainly controlled internally by a regulatory gene. Runt-related transcription factor-2 (Runx2) plays a role in osteoblast differentiation and is highly expressed during development. Purpose: This study aimed to evaluate the relation of regulatory gene variation in the Runx2 promoter with class II malocclusion. Methods: DNA samples were acquired from 95 orthodontic patients in Jakarta, Indonesia, who were divided into two groups: class I skeletal malocclusion (control group) and class II malocclusion. A single nucleotide polymorphism was investigated using the polymerase chain reaction and restriction fragment length polymorphism techniques. The distribution of alleles was assessed using the Hardy-Weinberg test. The relationship between polymorphism and skeletal variation was assessed with the Chi-Square test and logistic regression. Results: The frequency distributions of genotypes and alleles were tested for Hardy-Weinberg equilibrium and found to be slightly deviated. There was an equal distribution of G and T alleles throughout class II and class I skeletal malocclusions and the Chi-Square test showed that this relationship was not significant (p=0.5). Conclusion: Runx2 rs59983488 polymorphism was found in the Indonesian subpopulation; however, an association between Runx2 rs59983488 polymorphism and class II skeletal malocclusion was not found.

Efektivitas hyaluronic acid 0,1% terhadap penyembuhan luka trauma akibat piranti ortodontik cekat Effectivity of 0.1% hyaluronic acid toward to healing of trauma injury due to fixed orthodontics Hanna Silvia Debora; Nada Ismah; Benny Mulyono Soegiharto
Journal of Dentomaxillofacial Science Vol. 11 No. 1 (2012): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v11i1.286

Treatment with a fixed orthodontic aims to improve malocclusion and enhance the aesthetic. Traumatic injury to themucosa of the mouth is one of the risks that often occur and can be addressed among others by using mouthwashthat contains hyaluronic acid. This study aimed to determine the effectiveness of 0.1% hyaluronic acid on woundhealing caused by trauma of fixed rthodontic appliance in terms of size wound, redness and pain. Twenty twopatients who had a traumatic injury caused by fixed appliance on buccal or labial mucosa were divided into 2groups: K1, was instructed to rinse 10 ml solution containing 0.1% hyaluronic acid for 2 minutes after brushingteeth, 2 times a day for 4 days; K2, used the K1â€™s instruction but using a placebo solution. Examination of size areused caliper and reddish wounds are used index measuring wound redness performed before and after treatment,and pain measurement used questionnaires. Based on the statistical analysis of t-test, the percentage of size changes and redness traumatic injury were more significant in K1 than in K2 (p<0.05). While the pain of traumatic changesin K1 than in K2 were not significant (p>0.05). The use of mouthwash containing 0.1% hyaluronic acid wasconcluded proved effective to accelerate the wound healing process, but does not prove effective reducing paincaused by traumatic injury due to fixed orthodontic appliance.

The role of fibroblast growth factor receptor-3 as a negative regulator in late mandibular growth: Peran fibroblast growth factor receptor-3 sebagai regulator negatif di akhir pertumbuhan mandibula Pratiwi, Dwita; Suniarti, Dewi Fatma; Soedarsono, Nurtami; Soegiharto, Benny M.
Makassar Dental Journal Vol. 14 No. 1 (2025): Volume 14 Issue 1 April 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i1.1207

Assessment of mandibular growth status has been done using cephalometric radiographs by looking at cervical bone maturation. Recent studies suggest that this method is not good at identifying the final period of growth. In recent years, biomolecular re-search has been conducted to look at the potential of proteins as growth indicators. It is important to comprehensively understand the mandibular growth process in order to determine which proteins have the potential to be used as indicators. Mandibular growth is a complex biological process that is regulated by various proteins through various signalling pathways. The centre of growth is at the mandibular condyle which has a unique cartilage and plays a dual role as articular cartilage and growth plate. This review discusses the role of fibroblast growth factor receptor-3 (FGFR-3) in the mandibular growth process and its signalling pathways. The FGFR-3 was shown to act as a negative regulator of mandibular growth by reducing the proliferation and hypertrophic dif-ferentiation of chondrocytes in mandibular condylar cartilage. It is concluded that the regulation of FGFR-3 is localised due to pre-vious studies on condylar cartilage of experimental animals, so further research needs to be done to see the role of FGFR-3 in human mandibular growth.

Public Elementary School Bumi Agung Lampung Students' Perceptions About Maloclusions and The Need for Orthodontic Treatment Krisnawati, Krisnawati; Widayati, Retno; Adiwirya, Muhammad Sulaiman Kusumah; Soegiharto, Benny Mulyono; Kusumadewy, Widya; Pratiwi, Dwita
Journal of Indonesian Dental Association Vol 7 No 1 (2024)
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v7i1.1107

Introduction: Based on Indonesia Basic Health Research in 2018, it is known that 47% of Lampung people experience tooth decay and only 51% of them regularly go to the dentist. The need for orthodontic treatment is quite high among students. Epidemiological studies in Japan show that around 40% of teenagers aged 15-18 years need orthodontic treatment, 27%-36% in England aged 10-15 years, while in South Jakarta (2004) is 48.5%. Brook and Shaw introduced the Index of Orthodontic Treatment Need (IOTN), to assess the need for orthodontic treatment in England. IOTN has been applied by Agusni, T to measure the treatment needs of urban and rural children in Surabaya. Objective: Aims to determine the perceptions of elementary school students in Lampung regarding Malocclusion and the need for Orthodontic treatment. Method: A cross-sectional study was conducted in May 2023, carried out on students at public Elementary School Bumi Agung who met the inclusion criteria, namely aged 9-13 years, had never and were not currently undergoing orthodontic treatment, and were willing to take part in the research. 130 people were selected using a purposive sampling technique. Questionnaires were used to obtain sociodemographic data and general knowledge about Dental and Oral Health and Malocclusion. Assessment of the need for orthodontic treatment was carried out using the AC IOTN by the subject and operator. Results: 90% of students answered the questionnaire correctly, and 42% of students needed orthodontic treatment. A Pearson Chi-Square analysis test was carried out and found that there was a statistical difference in the perception of the need for orthodontic treatment by students and operators (p-value <0.05). Conclusion: Students at SDN Bumi Agung, Kalianda, Lampung, have very good general knowledge about Dental and Oral Health and Malocclusion. However, this is unsubstantiated by the perception of the need for orthodontic treatment.

Public Elementary School Bumi Agung Lampung Students' Perceptions About Maloclusions and The Need for Orthodontic Treatment Krisnawati Krisnawati; Retno Widayati; Muhammad Sulaiman Kusumah Adiwirya; Benny Mulyono Soegiharto; Widya Kusumadewy; Dwita Pratiwi
Journal of Indonesian Dental Association Vol. 7 No. 1 (2024)
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v7i1.1107

Introduction: Based on Indonesia Basic Health Research in 2018, it is known that 47% of Lampung people experience tooth decay and only 51% of them regularly go to the dentist. The need for orthodontic treatment is quite high among students. Epidemiological studies in Japan show that around 40% of teenagers aged 15-18 years need orthodontic treatment, 27%-36% in England aged 10-15 years, while in South Jakarta (2004) is 48.5%. Brook and Shaw introduced the Index of Orthodontic Treatment Need (IOTN), to assess the need for orthodontic treatment in England. IOTN has been applied by Agusni, T to measure the treatment needs of urban and rural children in Surabaya. Objective: Aims to determine the perceptions of elementary school students in Lampung regarding Malocclusion and the need for Orthodontic treatment. Method: A cross-sectional study was conducted in May 2023, carried out on students at public Elementary School Bumi Agung who met the inclusion criteria, namely aged 9-13 years, had never and were not currently undergoing orthodontic treatment, and were willing to take part in the research. 130 people were selected using a purposive sampling technique. Questionnaires were used to obtain sociodemographic data and general knowledge about Dental and Oral Health and Malocclusion. Assessment of the need for orthodontic treatment was carried out using the AC IOTN by the subject and operator. Results: 90% of students answered the questionnaire correctly, and 42% of students needed orthodontic treatment. A Pearson Chi-Square analysis test was carried out and found that there was a statistical difference in the perception of the need for orthodontic treatment by students and operators (p-value <0.05). Conclusion: Students at SDN Bumi Agung, Kalianda, Lampung, have very good general knowledge about Dental and Oral Health and Malocclusion. However, this is unsubstantiated by the perception of the need for orthodontic treatment.

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