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All Journal International Journal of Electrical and Computer Engineering e-GIGI Dentika Dental Journal Bulletin of Electrical Engineering and Informatics Journal of Dentistry Indonesia Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Eksakta : Berkala Ilmiah Bidang MIPA Padjadjaran Journal of Dental Researchers and Students MDJ (Makassar Dental Journal) JOURNAL LA MEDIHEALTICO Journal La Lifesci Journal of Health and Dental Sciences Jurnal Kedokteran Gigi Terpadu

Nurtami Soedarsono

Department Of Oral Biology, Faculty Of Dentistry, Universitas Indonesia

Author-ID : 1157428

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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PATOFISIOLOGI BARODONTALGIA PADA PENERBANGAN SIPIL : PATHOPHYSIOLOGY OF BARODONTALGIA ON CIVIL AVIATION Cecilia Monika Shinta Nova Andarmawanti; Achmad Hidayat; Nurtami Soedarsono
Dentika: Dental Journal Vol. 17 No. 4 (2013): Dentika Dental Journal
Publisher : TALENTA

Barodontalgia merupakan nyeri gigi yang disebabkan oleh perubahan tekanan barometrik akibat perubahan ketinggian. Sebagai individu yang biasa hidup didarat, saat terbang diketinggian selama penerbangan sipil akan memungkinkan mengalami keluhan nyeri pada gigi akibat perubahan tekanan barometrik. Barodontalgia adalah suatu gejala pada suatu kondisi patologis, dan pada kebanyakan kasus merupakan hal yang erat hubungannya dengan kondisi patologis gigi yang sudah ada sebelumnya. Kondisi patologis yang paling sering dilaporkan sebagai penyebab barodontalgia adalah karies gigi, pulpitis, nekrosis pulpa, adanya tambalan yang rusak atau tidak sempurna serta impaksi gigi molar ketiga, namun patofisiologi barodontalgia belum sepenuhnya dipahami. Intensitas dan saat terjadinya barodontalgia dapat berbeda-beda pada tiap individu tergantung pada kondisi patologis yang ada dan fase saat terbang (ascent, descent atau cruise). Dalam artikel ini akan mengulas mengenai pengertian,etiologi dan patofisiologi barodontalgia serta hubungan antara faktorfaktor patofisiologis dari gigi penyebab barodontalgia dengan perubahan tekanan yang terjadi pada ketinggian selama penerbangan sipil.

EFFECT OF CORAL GONIOPORA IN COMPARISON WITH CORAL APATITE TOWARDS HUMAN DENTAL PULP STEM CELLS MINERALIZATION ACTIVITIES: EFEK CORAL GONIOPORA DIBANDINGKAN DENGAN CORAL APATITE TERHADAP AKTIVITAS MINERALISASI SEL STEM PULPA GIGI Rachmi Fanani Hakim; Endang Winiati Bachtiar; Nurtami Soedarsono
Dentika: Dental Journal Vol. 17 No. 1 (2012): Dentika Dental Journal
Publisher : TALENTA

Challenging approach in tissue engineering for dentin regeneration is focused upon the application of a scaffold on anopen pulp enabling odontoblast-like cells to grow into the scaffold and to convert them into dentin-like substance. Coralwas chosen as a scaffold because of its good biocompatibility and resorbability. The species of marine invertebratesexploited in medical applications are Members of Porites and Goniopora. Coral goniopora is most marine invertebratafound in Indonesia's marine. Coral apattite, an osteoconductive synthetic bone graft substitute material, is manufacturedby the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapattite in the presence ofammonium phosphate preserving the original porous structure which is similar to that of bone. The aim of study was toinvestigate the effect of Coral goniopora and coral apattite as a potential scaffold on dental pulp mineralization activity. Invitro DPSCs mineralization activity was measured by von Kossa staining for calcium deposit identification. The resultthat Coral apattite increased more calcium deposited identification than coral goniopora. Calcium deposited on dentalpulp stem cells are marker for mineralized dental pulp stem cells (DPSCs). Mineralized DPSCs are marker forodontoblast diferentiation and maturation. In conclusion, these observations demonstrated that co-cultured coral apattiteand DPSCs induced a better mineralization activity than those cultured with Coral goniopora.

Academic Stress Influences Periodontal Health Condition and Interleukin-1 beta Level Kuswandani, Sandra O.; Masulili, Sri LC.; Soedarsono, Nurtami; Kemal, Yulianti
Journal of Dentistry Indonesia Vol. 21, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Stress is a risk factor for periodontal disease, causing increase levels of interleukin-1 beta that involve in periodontal destruction. Objective: To analyze the relationship between academic stress in residency program students conditions and levels of interleukin-1 beta in gingival crevicular fluid. Methods: Thirty eight subjects filled the questionnaire of Graduate Dental Environtmental Stress (GDES), periodontal examination and samples of gingival crevicular fluid were tested for interleukin-1 beta with the Enzyme-linked Immunosorbent Assay (ELISA) test. Results: There were significant differences between academic stress to periodontal tissue in oral hygiene (p=0.038), bleeding on probing index (p=0.02), but no significant differences in pocket depth and loss of attachment (p=0.972). There were significant differences between academic stress to levels of interleukin-1 beta (p=0.03), but no significant differences between levels of interleukin-1 beta to periodontal tissue in oral hygiene (p=0.465), bleeding on probing index (p=0.826), pocket depth (p=0.968), and loss of attachment (p=0.968). Conclusion: Academic stress influences the periodontal risk factor and level of interleukin-1 beta.

A Novel Human STR Similarity Method using Cascade Statistical Fuzzy Rules with Tribal Information Inference M. Rahmat Widyanto; Reggio N. Hartono; Nurtami Soedarsono
International Journal of Electrical and Computer Engineering (IJECE) Vol 6, No 6: December 2016
Publisher : Institute of Advanced Engineering and Science

A novel human STR (Short Tandem Repeat) similarity method using cascade statistical fuzzy rules with tribal information inference is proposed. The proposed method consists of two cascade Fuzzy Inference Systems (FIS). The first FIS is to discriminate the tribal similarity, and the second FIS is to calculate the STR similarity. By using the allele marker’s statistical distribution probability density function as the membership function in the Fuzzy Rules of the first FIS, the new method makes it possible to tell the tribal similarity between two STR profiles. A 727 data acquired from tribal groups of Indonesia is used to examine the method produced promising result, being able to indicate higher tribal similarity score within a tribal group and lower similarity between tribal groups. In the light of Indonesia’s diverse tribal groups, these properties are able to be leveraged as a new way to improve the versatility of existing DNA matching algorithm.

Family relation and STR-DNA matching using fuzzy inference Maria Susan Anggreainy; M. Rahmat Widyanto; Belawati Widjaja; Nurtami Soedarsono; Putut Tjahjo Widodo
International Journal of Electrical and Computer Engineering (IJECE) Vol 9, No 2: April 2019
Publisher : Institute of Advanced Engineering and Science

Deoxyribose Nucleic Acid (DNA) are the basic elements that make up a whole section of an individual. The basic elements store information that is unique to each individual and will be passed down the generations. DNA also helps in identifying the father in paternity testing, locating missing person investigations, identifying victims in mass disasters. Identiﬁcation of the victims has a problem if the comparison the father and mother no instance the victim’s parents have died or are very far away from where the victim. Therefore, it is necessary to try to identify Short Tandem Repeat (STR) Inference of live family such as sibling, grandfather/grandmother, uncle/aunt, cousin and nephew. In this paper, we performed a method to measure the similarity of human DNA proﬁles using fuzzy similarity. In this fuzzy system, DNA profile data is used as an input that stores human identity along with its DNA profile. The data entered is the result of polymerase chain reaction (PCR) identification which is an electropherogram consisting of 16 loci with two alleles for each locus. Output in this fuzzy system is the value of individual similarity with reference and with similarity levels, namely small, medium and high.

Perbedaan kadar enzim α-amylase saliva pada penerbang sipil Indonesia yang mengalami stress dan tidak stress karena faktor kelelahanDifferences in the salivary α-amylase levels in Indonesian civil aviators with and without fatigues stress experience Meta Yunia Candra; Dewi Fatma Suniarti; Febriana Setiawati; Nurtami Soedarsono
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.28063

Pendahuluan: Penerbang Sipil Indonesia beresiko mengalami stres yang disebabkan karena faktor kelelahan dengan rute penerbangan jarak dekat antara pulau-pulau di Indonesia. Enzim α-amylase saliva dapat digunakan sebagai biomarker stress. Penelitian ini bertujuan untuk menganalisis perbedaan kadar enzim α-amylase saliva pada penerbang sipil Indonesia yang mengalami stres karena faktor kelelahan dengan penerbang sipil Indonesia yang tidak mengalami stress karena faktor kelelahan. Metode: Jenis penelitian adalah cross-sectional, membandingkan tingkat kelelahan yang menjadi penyebab stress pada penerbang sipil Indonesia dengan metode pengukuran Fatigue Severity Scale (FSS) dan membandingkan kadar enzim α-amylase saliva yang dianalisa dengan metode ELISA pada dua kelompok penerbang sipil Indonesia yang memiliki jam terbang total lebih dari 6624 jam dan melakukan penerbangan sektor sebanyak 24 subjek dengan kelompok penerbang sipil Indonesia yang memiliki jam terbang total kurang dari 6624 jam dan tidak melakukan penerbangan sektor sebanyak 16 subjek dengan uji analisis data bivariat komparatif. Hasil: Kelompok penerbang sipil Indonesia dengan jam terbang total lebih dari 6624 jam dan melakukan penerbangan sektor menunjukkan nilai enzim α-amylase sebesar 0,899 dan kelompok penerbangan sipil Indonesia dengan jam terbang kurang dari 6624 jam dan tidak melakukan penerbangan sektor menunjukkan nilai enzim α-amylase sebesar 0,689. Terdapat perbedaan bermakna p = 0,006 (p<0,05) antara kedua kelompok penerbang. Simpulan : Stres yang disebabkan karena faktor kelelahan pada penerbang sipil Indonesia menghasilkan kadar enzim α-amylase yang lebih tinggi dibandingkan dengan penerbang sipil Indonesia yang tidak mengalami stress karena faktor kelelahan.Kata kunci: Enzim α-amylase saliva, fatigue severity scale, stres, penerbang. ABSTRACT Introduction: Indonesian civil aviators have a risk of experiencing stress due to fatigue factor with high-frequency intersection routes between islands of Indonesia. Salivary α-amylase is an enzyme that can be used as a stress biomarker. This study was aimed to analyse the differences of salivary α-amylase levels in Indonesian civil aviators with and without fatigues stress experience. Methods: This research was cross-sectional, comparing the level of fatigue as the cause of stress for Indonesian civil aviators with the Fatigue Severity Scale (FSS) measurement method. The level of the salivary α-amylase enzyme was analysed using the ELISA method in two groups: Indonesian civil aviators with more than 6624 flight hours and performed sector flights (24 subjects); Indonesian civil aviators with less than 6624 flight hours and did not perform sector flights (16 subjects). All data then analysed with comparative bivariate data analysis. Results: The group of Indonesian civil aviators with more than 6624 flight hours and performed sector flight showed an α-amylase enzyme value of 0.899; while the group of Indonesian civil aviators with less than 6624 flight hours and did not perform sector flights showed an α-amylase enzyme value of 0.689. There was a significant difference p=0.006 (p < 0.05) between the two groups of pilots. Conclusion: Indonesian civil aviators with fatigues stress experience of increases the α-amylase enzyme value compared to Indonesian civil pilots without fatigues stress experience. Keywords: Salivary α-amylase, fatigue severity scale, stress, aviator.

Elderly nutritional status effection salivary anticandidal capacity against Candida albicans Ria Puspitawati; Nurtami Soedarsono; Elisabeth A Putri; Anissha D Putri; Boy M Bachtiar
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 2 (2011): June 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Elderly often suffer malnutrition and oral candidiasis. Candida albicans (C. albicans) which is the most prominent cause of oral candidiasis, is one of commensal oral micro-flora. Nutritional status affect the characteristic of saliva. Saliva is the regulator in the development of C. albicans from comensal into pathogen. Purpose: The purpose of this study was to determining the correlation between elderly nutritional status with salivary total protein and its activity in inhibiting C. albicans growth and biofilm formation. Methods: Using mini nutritional assessment 30 elderly were classified into normal and malnutrition groups. Total protein of unstimulated saliva was measured using Bradford protein assay. The colony forming unit (CFU) of C. albicans was counted on 72 hours on SDA cultures without (control) or with 2 hour saliva exposure. Biofilm formation was analyzed from the optical density of 10–5 C. albicans suspension without saliva exposure (control) or with exposure of 10.000 μg/ml saliva and incubated in 37° C for 2 days. The suspension was put into 96 well plates, stained with crystal-violet dye, and analyzed using microplate reader. Differences between groups were analyzed using independent t-test or Kruskall-Wallis. Correlation between variables was analyzed using Spearman test. Results: Salivary total protein of normal elderly (1.113.5 ± 1.1143.3) was higher than those of malnutrition (613.6 ± 253.6) but not statistically significant (p > 0.05). The CFU of C. albicans exposed to saliva of normal samples (2.060 cfu/ml) was significantly lower than control (24.100 cfu/ml) and those exposed to malnutrition saliva (5.513.3 cfu/ml). C. albicans biofilm formation is highest in controls (0.177), lower in those exposed to malnourished saliva (0.151) and lowest in those exposed to saliva of good nourished elderly (0.133). Conclusion: Although does not cause significant decrease of salivary total protein, malnutrition in elderly results in lower capacity of saliva in inhibiting the growth and declining the virulence of C. albicans.Latar belakang: Lansia sering menderita malnutrisi dan kandidiasis oral. Candida albicans yang merupakan penyebab utama terjadinya candidiasis, adalah salah satu mikroflora rongga mulut yang bersifat konvensional. Malnutrisi memengaruhi karakteristik saliva. Saliva merupakan regulator utama perkembangan Candida albicans (C. albicans) dari sifat konvensional menjadi bersifat patogen.Tujuan: Tujuan dari penelitian ini adalah untuk menentukan korelasi antara status gizi lansia dengan total protein dan aktivitas saliva dalam menghambat pertumbuhan dan pembentukan biofilm C. albicans. Metode: Menggunakan mini nutritional assessment, 30 lansia diklasifikasikan menjadi kelompok gizi baik dan gizi buruk. Total protein unstimulated saliva diukur dengan metode Bradford protein assay. Colony forming unit (CFU) dihitung pada kultur C. albicans pada saburaud dextrose agar (SDA) berusia 72 jam yang sebelumnya telah dipaparkan saliva selama 2 jam. Kontrol adalah kultur C. albicans tanpa paparan saliva. Pembentukan biofilm adalah pengukuran optical density suspensi 10–5 C. albicans tanpa paparan saliva (kontrol) atau dengan paparan saliva 10.000 μg/ml dan diinkubasi pada suhu 37° C selama 2 hari. Suspensi tersebut kemudian dimasukkan ke dalam 96 well plates, diberi pewarna crystal violet, dan diukur menggunakan microplate reader. Analisis data menggunakan uji beda t Independen atau Kruskall-Wallis, dan uji korelasi Spearman. Hasil: Total protein saliva lansia gizi baik (1.113,5 ± 1.1143,3) lebih tinggi dari lansia gizi buruk (613,6 ± 253,6) tetapi tidak bermakna secara statistik (p > 0,05). Pembentukan koloni C. albicans yang terpapar saliva lansia gizi baik (2.060 cfu/ml) secara signifikan lebih rendah dari kontrol (24.100 cfu/ml) dan daripada yang terpapar saliva lansia gizi buruk (5.513,3 cfu/ml). Pembentukan biofilm C. albicans tetinggi pada kontrol (0,177), lebih rendah pada yang terpapar saliva gizi buruk (0,151) dan terrendah pada yang terpapar saliva gizi baik (0,133). Kesimpulan: Meskipun malnutrisi tidak menyebabkan penurunan total protein saliva lansia, tetapi menurunkan kapasitasnya dalam menghambat pertumbuhan dan mengurangi virulensi C. albicans.

The Similarity Measurement of Human DNA Profile Using Fuzzy Similarity Meira Parma Dewi; Nurtami Soedarsono
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 21 No. 1 (2020): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

This research investigated the similarity of human DNA profile using fuzzy similarity measure. The similarity measurement of DNA profile had been done by measuring the similarity between query’s DNA profile and its biological family such as father, mother, brother, sister, grandmother and grandfather. The similarity measurement had been done to the short tandem repeat (STR) alleles in sixteen loci. The result of the experiment showed that each simulation gave matching result. This research is useful for Indonesian National Police (POLRI) in identifying process of disaster victim, terrorism victim and other criminal conduct.

Oral Clinical Findings in Cadaver with Tuberculosis: A Case Report Azizah, Anna; Wahyu, Nadilla I.; Rahmadhani, Ayu; Soedarsono, Nurtami; Yuniastuti, Mindya; Suhartono, Antonius W.; Syarifudin, Mohammad A.; Fonataba, Anthon G.
e-GiGi Vol. 13 No. 1 (2025): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v13i1.54414

Abstract: Tuberculosis (TB) is a long-lasting infectious disease that usually affects the lungs (pulmonary TB), but can also affect other organs and systems (extra-pulmonary TB). Oral TB is uncommon, particularly primary oral tuberculosis which predominantly affects young adults, and the tongue is the site most frequently affected. This case report aimed to discuss the manifestation of TB in the hard palate, focusing on observation from a cadaver and providing a thorough analysis of the oral clinical symptoms. We reported a case of unidentified 42-year-old female body that was found dead and brought to Dr. Cipto Mangunkusumo Hospital for an autopsy. Poor oral hygiene was found. In the palate, there was bone defect on palatum durum regio teeth 21 22 near to the incisive foramen. Pink teeth was discovered in the anterior part of the lower jaw. Based on the autopsy report, the cause of death was tuberculosis. In conclusion, although tuberculosis of the palate is infrequent, it should be included as a potential cause of palatal perforation during diagnostic evaluations. Additionally, it is crucial to conduct a comprehensive investigation into the primary site of tuberculosis in cases involving palatal tuberculosis. Keywords: oral tuberculosis; palatal perforation; pink teeth phenomenon

Triangular fuzzy number for similarity measurement of Y chromosome DNA profile Dewi, Meira Parma; Arymurthy, Aniati Murni; Setiawan, Suryana; Soedarsono, Nurtami
Bulletin of Electrical Engineering and Informatics Vol 13, No 1: February 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/eei.v13i1.5304

This study measures the similarity of the short tandem repeat (STR) profile of human DNA. The similarity measurement had been done to the STR value of the allele loci in DNA profile between the query’s DNA to the reference’s DNA profile. The measurements were conducted on 27 DNA profile loci including the Y chromosome loci (YSTR). The YSTR loci were used as the main comparison of similarity measurements to determine the biological kinship relationship between the query DNA profile and the alleged male biological family. To measure the similarity of two STR values that have shifted due to several factors in the DNA source extraction process, a fuzzy similarity measure was used. The STR values of the DNA profile loci are described as triangular fuzzy numbers. Similarity value of the STR is the intersection of two isosecle that been compared. To conclude that the query has a biological relationship with the male reference, the similarity of the YSTR locus is equal or more than 0.75 and the similarity value of the other 24 DNA profile loci is greater or equal to 0.5. From the trial that have been done, 90% give the right results.

Co-Authors Achmad Hidayat Aniati Murni Arymurthy Anissha D Putri Antonius Winoto Suhartono, Antonius Winoto Asdiana, Andi Eka Auerkari, Pertti Azizah, Anna Belawati Widjaja Benny M. Soegiharto, Benny M. Boy M Bachtiar Cecilia Monika Shinta Nova Andarmawanti Dedek Yunus, Aditia Dewi Fatma Suniarti Eko Prastyo Elisabeth A Putri Elza Ibrahim Auerkari Endang Winiati Bachtiar Febriana Setiawati Fonataba, Anthon G. Gultom, Ferry Pergamus Ibrahim Auerkari, Elza Kaurow, Farah P. Kaurow, Farah Primadani M. Rahmat Widyanto M. Rahmat Widyanto Maria Susan Anggreainy Masulili, Sri LC. Meira Parma Dewi Meira Parma Dewi Meta Yunia Candra Mindya Yuniastuti Nur Azizah, Anna Pasaribu, Roben Suhadi Pratiwi, Dwita Putut Tjahjo Widodo Rachmi Fanani Hakim Rachmi Fanani Hakim Rahmadhani, Ayu Reggio N. Hartono Ria Puspitawati Rijaldi, Ferdy Rizki Tanjung Sandra O. Kuswandani, Sandra O. Sari, Fitri Ambar Satriyo, Juanda Setiawan, Suryana Suhartono, A. Winoto Suhartono, Antonius W. Syarifudin, Mohammad A. Wahyu, Nadilla I. Winoto Suhartono, A. Wulan Purnama Sari Yatma, Debby Yudy, Yudy Yulianti Kemal Yunus, Aditia Dedek Zevrianty, Dieci

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