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Manajemen Anestesia pada Operasi Reseksi Malformasi Arteri Vena Otak Januarrifianto, Desy; Auerkari, Aino Nindya; Firdaus, Riyadh
Majalah Anestesia dan Critical Care Vol 32 No 2 (2014): Juni
Publisher : Perdatin Pusat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

AbstrakMalformasi arteri-vena otak, atau cerebral arteriovenous malformation (AVM) merupakan kondisi yang jarang, namun morbiditas neurologis dan mortalitasnya bermakna. Salah satu pilihan terapi untuk AVM adalah operasi reseksi dengan bedah mikro. Perhatian khusus untuk ahli anestesia pada operasi ini adalah upaya mencegah iskemia sekunder jaringan otak dengan mempertahankan hemodinamik stabil agar tekanan perfusi otak sedekat mungkin dengan nilai normal, mengupayakan agar tidak terjadi pembengkakan otak dan mengantisipasi perdarahan. Di laporan ini, kami menjabarkan manajemen anestesia pada laki-laki 22 tahun dengan AVM simtomatik yang menjalani operasi reseksi AVM pada tanggal 10 April 2012 di Instalasi Bedah Pusat RS dr. Cipto Mangunkusumo, dan mengalami perdarahan akibat ruptur arteri intraoperasi. Kata kunci: Anestesia, AVM, malformasi arteri-vena, operasi reseksi Cerebral arteriovenous malformation (AVM) is a rare vascular condition carrying significant neurologic morbidity and mortality. Among the treatment options are surgical resection using microsurgery technique. Special anesthetic consideration in this type of surgery is on preventing secondary ischemia of brain tissue by maintaining stable haemodynamics to achieve as normal cerebral perfusion pressure as possible, preventing cerebral edema and anticipating hemorrhage. In this report, we describe the anaesthetic management of a 22 year-old male presenting with symptomatic AVM, who underwent surgical resection on April 10th 2012 in Central Operating Theater of RS dr. Cipto Mangunkusumo, and experienced intraoperative bleeding from an arterial rupture. Key words: Anesthesia, arteriovenous malformation, AVM, surgical resection
EFFECTIVENESS OF LAWSONIA INERMIS LINNEAUS LEAVES INFUSION IN GINGIVITIS HEALING: EFEKTIFITAS INFUSA DAUN LAWSONIA INERMIS LINNEAUS TERHADAP PENYEMBUHAN GINGIVITIS Lies Zubardiah; Dewi Nurul Mustaqimah; Elza Ibrahim Auerkari
Dentika: Dental Journal Vol. 17 No. 2 (2012): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.767 KB) | DOI: 10.32734/dentika.v17i2.1824

Abstract

Gingivitis is one type of periodontal disease and it is chronic in nature. The main etiological factor of gingivitis is bacterialplaque. Untreated gingivitis can spread to underlying tissues and it can become periodontitis and produce tissuedestruction. One of the treatments for gingivitis is plaque removal, helped by antibacterial mouthrinsing to reducebacterial plaque. Lawsonia inermis L. leaves have been used by Indonesian villagers for healing skin wounds andreported to show antibacterial effect in vitro and in vivo. This study aimed to determine the effect of Lawsonia inermis L.leaves infusion in gingivitis healing. A total of 63 gingivitis patients devided into 5 groups were instructed to rinse with 3concentrations (50000 µg/mL, 10000 µg/mL, 5000 µg/mL) of Lawsonia inermis L. leaves infusion; 0.1% hexetidinesolution, and placebo as control. Papilla Bleeding Index (PBI) used in measurement for bleeding on probing. The resultshowed that decreasing of PBI in Lawsonia inermis L. leaves infusion at 10000 µg/mL concentratation (80%), wasstronger than hexetidine 0.1% (76%). In conclusion, Lawsonia inermis L. leaves infusion effective to reduce PBI betterthan hexetidine. In conclusion, Lawsonia inermis L. leaves is effective to treat gingivitis.
ALKALINE PHOSPHATASE LEVEL MEASUREMENT TO DIFFERENTIATE MILD AND SEVERE AGGRESSIVE PERIODONTITIS: PENGUKURAN TINGKAT ALKALIN FOSFATASE UNTUK MEMBEDAKAN PERIODONTITIS AGRESIF RINGAN DAN BERAT Mustaqimah Dewi Nurul; Auerkari Elza Ibrahim
Dentika: Dental Journal Vol. 15 No. 2 (2010): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2555.135 KB) | DOI: 10.32734/dentika.v15i2.1913

Abstract

Individuals with aggressive periodontitis (AP) can have a heritable risk factors related to the bacterial floras, immunological responses and leukocyte functions. This study aimed to characterize indicators and differences between the two subclasses of AP. A series of clinical parameters and full mouth dental radiographs was obtained from 27 consenting AP patients. After sampling of gingival crevicular fluid (GCF) and peripheral blood, the activity of alkaline phosphatase (ALP) was measured from GCF by enzymatic method. The proportion of lymphocyte subpopulations was measured from blood by flow cytometry, and titter of immunoglobulin G against Porphyromonas gingivalis (Pg) fimbriae was determined from serum by ELISA. The results classified the subjects into eight subjects with mild AP (AP1) and 19 subjects with severe AP (AP2). From all indicators tested, we concluded that the GCF ALP was the one which was 100% specific for AP2, though with 76.9% sensitivity and 77.8% accuracy; and that AP1 and AP2 are different types of early-onset periodontitis (EOP), of which AP1 does not progress into AP2.
Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients Antonius Winoto Suhartono; Benso Sulijaya; Niniarty Zeiroeddin Djamal; Sri Lelyati Chaidar Masulili; Christopher Talbot; Elza Ibrahim Auerkari
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 3 (2015): September 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.612 KB) | DOI: 10.20473/j.djmkg.v48.i3.p113-118

Abstract

Background: Periodontitis is an inflammatory disease caused by periodontal pathogens and influenced by multiple risk factors such as genetics, smoking habit, age and systemic diseases. The inflammatory cascade is characterized by the release of C-reactive protein (CRP). Periodontitis has been reported to have plausible links to increased level of CRP, which in turn has been associated to elevated risk of  cardiovascular disease (CVD). Purpose: The purpose of this study was t o investigate the relationship amongst the severity of periodontitis, CRP level in blood and CRP (-717 C>T) gene polymorphism in male Indonesian smokers and non-smokers. Method: The severity of periodontitis was assessed for 97 consenting male Indonesian smokers and non-smokers. The CRP level of the subjects was determined by using immuno-turbidimetric assay performed in PARAHITA Diagnostic Center Laboratory ISO 9001: 2000 Cert No. 15225/2. The rate of CRP (-717C>T) gene polymorphism was determined by using PCR-RFLP in Oral Biology Laboratory, Faculty of Dentistry, Universitas Indonesia. Result: The results suggest that the CRP protein level is not significantly associated with the tested CRP gene polymorphism (p>0.05). Also, while the severity of periodontitis increased significantly with subject age, the CRP level in blood serum was not significantly related to the severity of  periodontitis. The genotypes of the tested polymorphism did not show significant association with the severity of periodontitis either in smokers or in the combined population including smokers and non-smokers. The results naturally do not exclude such associations, but suggest that to discern the differences the sample size must be considerably increased. Conclusion: The CRP (-717C>T) gene polymorphism and CRP level in blood serum were not found to be associated with the severity of periodontitis in male smokers or in the combined population of smokers and non-smokers.
Runx2 rs59983488 polymorphism in class II malocclusion in the Indonesian subpopulation Fadli Jazaldi; Benny M. Soegiharto; Astrid Dinda Hutabarat; Noertami Soedarsono; Elza Ibrahim Auerkari
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 4 (2021): December 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i4.p216-220

Abstract

Background: Class II malocclusion is one of the main orthodontic issues for patients in seeking treatment. The prevalence of class II malocclusion varies in different populations. Variation in skeletal profile is mainly controlled internally by a regulatory gene. Runt-related transcription factor-2 (Runx2) plays a role in osteoblast differentiation and is highly expressed during development. Purpose: This study aimed to evaluate the relation of regulatory gene variation in the Runx2 promoter with class II malocclusion. Methods: DNA samples were acquired from 95 orthodontic patients in Jakarta, Indonesia, who were divided into two groups: class I skeletal malocclusion (control group) and class II malocclusion. A single nucleotide polymorphism was investigated using the polymerase chain reaction and restriction fragment length polymorphism techniques. The distribution of alleles was assessed using the Hardy-Weinberg test. The relationship between polymorphism and skeletal variation was assessed with the Chi-Square test and logistic regression. Results: The frequency distributions of genotypes and alleles were tested for Hardy-Weinberg equilibrium and found to be slightly deviated. There was an equal distribution of G and T alleles throughout class II and class I skeletal malocclusions and the Chi-Square test showed that this relationship was not significant (p=0.5). Conclusion: Runx2 rs59983488 polymorphism was found in the Indonesian subpopulation; however, an association between Runx2 rs59983488 polymorphism and class II skeletal malocclusion was not found.
Clinical Implications of Dental Injury Analysis in Forensic Odontology: A Review Article Khan, Muhammad S.; Suhartono, Antonius W.; Auerkari, Elza I.
e-GiGi Vol. 13 No. 1 (2025): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v13i1.54118

Abstract

Abstract: Dental trauma is a common occurrence in forensic investigations and may provide important clues about the amount of damages and when they occurred, both of which are vital in court cases. Forensic pathologists and dentists work hand in hand to assess and diagnose oral injuries accurately, which is crucial for those who are alive and those who have passed away. In order to guarantee accurate forensic results, the need of standardizing procedures used in dental trauma analysis, such as clinical and radiographic tests, and the need of thorough documentation are very crucial. The many kinds of dental injuries, their causes, and how forensic applications help to identify victims and piece together are very important to be discussed. This article provides a comprehensive overview of the importance of dental injury analysis, procedures and their implications in various cases within the scope of forensic odontology for efficient practice, highlighting the vital role of forensic odontology in medico-legal investigations via an in-depth review of the existing literature. Keywords: dental trauma; forensic odontologist; clinical examination; radiographic assessment; legal context
Pola Fraktur Kraniomaksilofasial Akibat Trauma Tumpul Terkait Identifikasi Forensik Meilana, Andi N. S. T.; Auerkari, Elza I.
e-GiGi Vol. 13 No. 1 (2025): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v13i1.54227

Abstract

Abstract: Blunt trauma has high morbidity and mortality rates worldwide. Traffic accidents, assaults or fights, falls, and accidents during sports are the leading cause of this trauma. The head and face areas are frequently the targets of blunt force attacks, and fatal cases are often attributed to trauma to these areas. The magnitude of the velocity and the surface area of ​​the blunt object will produce different oral craniofacial fracture patterns. This study aimed to obtain the pattern of craniomaxillofacial fracture patterns caused by blunt trauma and their relationship to various forensic cases. Craniomaxilofacial fractures divided into cranial, maxilofacial, and mandibular fractures are series of injuries resulting from blunt trauma that may present alone or in a combination of the three of them. This is due to the proximity of the anatomy of these three types of bones. Fracture patterns can be present around the trauma, and can also present far from the trauma area since the trauma will be directly transmitted to areas with lowest weak point. By knowing a fracture pattern, various forensic problems can be solved. Keywords: blunt trauma; fracture pattern; craniomaxillofacial fracture; forensic cases    Abstrak: Trauma tumpul memiliki tingkat morbiditas dan mortalitas yang cukup tinggi di dunia. Kecelakaan lalu lintas, perkelahian, Tindakan kekerasan, jatuh, serta kecelakaan saat berolahraga merupakan faktor-faktor utama penyebab jenis trauma ini. Area kepala dan wajah merupakan area yang paling sering menjadi target serangan benda tumpul, dan beberapa kasus fatal sering ditemukan akibat trauma pada daerah tersebut. Bentuk dan luas permukaan benda tumpul serta kecepatan hantaman akan menghasilkan pola fraktur kraniomaksilofasial yang berbeda. Penelitian ini bertujuan untuk mendapatkan pola fraktur kraniomaksilofasial akibat trauma tumpul dan hubungannya pada berbagai kasus forensik. Fraktur kraniomaksilofasial yang terbagi atas fraktur kranial, maksilofasial, dan mandibula merupakan serangkaian cedera akibat trauma tumpul yang dapat hadir sendiri ataupun kombinasi ketiganya. Hal ini dikarenakan kedekatan anatomi dari ketiga jenis tulang ini. Pola fraktur dapat hadir di sekitar trauma, dan juga dapat hadir jauh dari area trauma. Hal ini dikarenakan dampak dari trauma akan langsung diteruskan ke daerah yang memiliki titik lemah paling rendah. Dengan mengetahui suatu pola fraktur maka berbagai masalah forensik dapat terpecahkan seperti merekonstruksi suatu kejadian, identifikasi jenis senjata, serta membantu proses pengadilan. Kata kunci: trauma tumpul; pola fraktur; fraktur kraniomaksilofasial; kasus forensik
Estimation of Time of Death through Observation of Microbiota Changes in the Oral Cavity Oktaviana, Fahriza R.; Gultom, Ferry P.; Pasaribu, Roben S.; Auerkari, Elza I.
e-GiGi Vol. 13 No. 1 (2025): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v13i1.54461

Abstract

Abstract: Various methods for estimating post-mortem (PMI) have been investigated such as rigor mortis, livor mortis, molecular, chemical, and forensic entomology (insect) methods. However, these methods have weaknesses, therefore researchers are looking for more accurate methods in determining the time of death of a person. Molecular methods are unreliable due to the degradation of DNA, RNA, and proteins in corpses over time. In different parts of the body, the amount of diversity of microbes will be different. The oral cavity is the most abundant microbial area among other parts of the body due to its continuous exposure to the respiratory and digestive systems. This area has great potential in estimating time intervals of death because of its ease of access and the types of microbiomes that predominate at any given time. Therefore, this narrative review was conducted to describe studies that used oral microbiota communities to estimate post-mortem intervals. Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes are the dominant microbial types found in corpses. Firmicutes became one of the dominant bacterial phyla in the early stages of decomposition. Actinobacteria were found to decrease as PMI increased. Studies have shown that the oral microbiome has excellent potential as a parameter to determine the post-mortem interval. However, further research is needed with more complex environmental conditions such as different humidity and temperature. In addition, further research requires more samples of human remains to obtain more valid results. Keywords: oral microbiome; post-mortem interval; human identification; forensic odontology
DNA Profiling, Bioinformatics and Databases in Forensics: Human Identification Purposes Meilana, Andi Nur Sakina Tri; Auerkari, Elza Ibrahim
Journal La Lifesci Vol. 5 No. 1 (2024): Journal La Lifesci
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallalifesci.v5i1.1171

Abstract

Individual identification is an essential element in establishing truth the forensic investigation process, be it in criminal, medico-legal, or mass disasters case. When ante-mortem data are not available, the only thing that can be used is identification trough DNA. Alec Jeffrey, a geneticist (1984), found that certain regions of DNA contain repetitive sequences and the number of repetitions in individuals differs from one another. This identification method known as DNA profiling. DNA profiling is described as an important and significant discovery in forensics and has been considered as the standard in modern human identification. Until now, the recommended DNA profiling method must be based on the PCR to analyze degraded DNA and short-sized DNA (Short Tandem Repeats) through PCR amplification. In profiling, the result DNA amplification are analyzed through genetic markers (DNA Markers) and then matched into the database or compared with the collected reference samples. In the human genome, the genetic markers most frequently used in forensics are autosomal STR, Y-STR, mtDNA, X-STR, SNPs, and Amelogenin. Accomplishment of proving the suitability of DNA profiles, an application of bioinformatics in forensics is carried out. Bioinformatics is a combination of molecular biology and computer informatics that aims to manage and analyze data and store biological (genetic) information. DNA database is an application of bioinformatics in the form of special software which has become an important tool for biologists and forensics. This genetic database will predict the similarities between one DNA profile and another.
Radiographic Techniques For Estimating Dental Age: A Comparative Study Khan, Muhammad Salman; Auerkari, Elza Ibrahim; Suhartono, Antonius Winoto
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.574

Abstract

The determination of dental age using radiographic techniques has become a crucial method in forensic dentistry for estimating the chronological age of individuals, particularly in cases involving children and adolescents. This study aims to compare various radiographic techniques in estimating dental age based on tooth development. A comparative research method was employed, analyzing radiographic data from individuals aged 6 to 18 years. The data were collected using two primary techniques: panoramic and intraoral periapical, and analyzed using well-established methods such as the Demirjian and Nolla methods. The results showed that the Demirjian method had a higher accuracy rate compared to other methods, particularly in age estimation for individuals under 12 years old. The discussion highlights that differences in accuracy between techniques are due to better visualization of dental anatomical structures in some techniques. The conclusion of this study is that radiographic methods, especially the panoramic technique and the Demirjian method, are optimal choices for dental age estimation with high accuracy.