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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Indonesia Sari Pediatri Journal of Maternal and Child Health
Evi Rokhayati
Puskesmas Margaharja, Ciamis
Health Professions Medicine & Pharmacology Public Health

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Hubungan antara Neutropenia dan Mortalitas pada Neonatus dengan Sepsis, dengan MengendalikanPengaruh Umur Gestasi dan Berat Badan lahir Rokhayati, Evi
Jurnal Kedokteran Indonesia Vol 2, No 1 (2011)
Publisher : Jurnal Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.188 KB)

Abstract

Background: Sepsis in neonates (newborns) remains a major cause of public health concern. Sepsismay cause neutropenia due to hematological system dysfunction, which suggests poor prognosis.Decreased neutrophil function will increase mortality in neonates. In addition, the health care costimplication of residual symptoms in children who survive is quite high.This study aimed to estimatethe association between neutropenia and mortality in neonates with sepsis.Methods: A prospective cohort study was conducted at Dr. Moewardi Hospital, Surakarta. A sample of85 neonates was selected by consecutive sampling, i.e. all of the newborns aged <1 month at thePedicatric Intensive Care Unit at this hospital during April 2011 to July 2011 period were taken as thestudy subjects. The dependent variable was time to mortality. The independent variabel wasneutropenia. The confounding factors were gestational age (prematurity) and low birth weight. Theassociation between neotropenia and time to mortality while controlling for gestational age and birthweight was analyzed by Cox-regression model on SPSS 17.0Results: The sample consisted of 54 (63.5%) male and 31 (36.5%) female newborns. There were 40(47.10%) newborns with gestational age <37 weeks, and 45 (52.90%) with weight <2500g. As many as44 (51.80%) newborns experienced neutropenia while 41 (48.20%) did not experience neutropenia.The death toll of these newborns was 27 (31.80%). Cox regression analysis showed a weak associationbetween neotropenia and mortality, and it was not statistically signficant (Hazard Ratio = 1.28; 95% CI0.55 to 2.94; p=0.568). This estimate has controlled for the effects of gestational age and birth weight.Prematurity showed strong association with the risk of mortality in neonates with sepsis (HR = 3.12;95% CI 1.07 to 9.68; p=0.037).Conclusion: Neutropenia and in addition low birth weight show weak and unreliable predictors formortaity in neonates with sepsis. Prematurity shows a strong and reliable predictor for mortality inneonates with sepsis.Keywords: sepsis, neutropenia, mortality, neonates.
Increased Plasma Caspase-3 in Children with Down Syndrome is Associated with an Increasing Risk of Pulmonary Hypertension Prasanti, Damayanti Ika; Widjaja, Sri Lilijanti; Rokhayati, Evi
Journal of Maternal and Child Health Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.549 KB) | DOI: 10.26911/thejmch.2023.08.01.03

Abstract

Background: Pulmonary hypertension (PH) is the one of the comorbidities in children with Down syndrome. The pathogenesis of this pulmonary hypertension remains to be investigated, although endothelial dysfunction and apoptotic activity are among the proposed mechanisms. Caspase-3 is a key regulator of apoptosis and appears to be an attractive predictor of pulmonary hypertension in children with Down syndrome. Subjects and Method: A cross-sectional observational clinical study was performed in Dr. Moe­wardi General Hospital in Surakarta-Indonesia between January and March 2021 involving clini­cally diagnosed children with Down syndrome. Sampling method was using a consecutive sampling. The independent variable was plasma caspase-3 level and the dependent variable were the presence of pulmonary hypertension and congenital heart defects (CHD). Clinical data documentation, blood collection and echocardiography were performed on enrollment day. We first determined the plasma level of caspase-3 in 36 children with Down syndrome and CHD (n=18) or without CHD (n=18) and further determined the risk of having pulmonary hypertension using the plasma caspase-3 level. We also determined the biomarker performance of caspase-3 using a receiver-operating characteristic (ROC) analysis Results: Children with Down syndrome with PH had a higher plasma caspase-3 compared to those without PH (p<0.001). In those with both CHD and PH, the plasma caspase-3 level was also high although not statistically significant (p=0.145). The highest plasma caspase-3 level was observed in subjects with PH without CHD (p<0.01). Relative risk and ROC analysis demonstrated that increased plasma caspase-3 level increased the risk to have PH 5 times (RR=5.00, 95% CI 1.74 to 14.34; p<0.001) and predicted the incidence of PH in children with Down syndrome (AUC 0.88, CI 0.76 to 0.99). Conclusion: An elevation in plasma caspase-3 level of Down syndrome children is associated with the increasing risk of having PH regardless the presence of CHD. Keywords: pulmonary hypertension; down syndrome; caspase-3; pathogenesis; apoptosis. Correspondence: Damayanti Ika Prasanti. Department of Pediatrics, Faculty of Medicine, Universitas Sebelas Maret / Dr. Moewardi General Hospital. Jl. Kolonel Sutarto 132, Surakarta 57126, Indonesia. Email: damayanti_ip@yahoo.com. Mobile: 081215683462.
HUBUNGAN INFEKSI SALURAN PERNAPASAN AKUT BERULANG DENGAN KEJADIAN STUNTING PADA BALITA A’yuny, Adinda Elsyira Qurroty; Sari, Atriany Nilam; Maulina, Rufidah; Rokhayati, Evi; Kusmawati, Iffah Indri
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P18

Abstract

Latar Belakang: Balita yang mengalami stunting pada lima tahun pertama kehidupannya, memiliki kapasitas belajar dan produktivitas rendah, serta berisiko tidak mencapai potensi fisik dan mental/ kecerdasan yang maksimal sehingga berdampak pada prestasi buruk di sekolah yang mengakibatkan produktifitas ekonomi rendah saat dewasa. Penyakit infeksi merupakan faktor penyebab langsung stunting bergantung pada frekuensi kambuh atau berulang. Infeksi saluran pernafasan akut (ISPA) merupakan penyakit infeksi yang paling sering menyerang balita, dengan 3-6 episode setiap tahunnya. Penelitian ini bertujuan untuk mengetahui hubungan infeksi saluran pernapasan akut berulang dengan kejadian stunting pada balita. Metode: Penelitian observasional analitik dengan pendekatan cross-sectional pada 88 ibu balita usia 24-59 bulan yang terdiagnosis infeksi saluran pernapasan akut di Puskesmas Sibela dalam 1 tahun terakhir yang dipilih dengan purposive sampling. Pengambilan data dilakukan pada bulan Juni 2023. Ibu diwawancarai dengan kuesioner dan balita ditimbang dan diukur tinggi badannya, status imunisasi diperoleh dari buku kesehatan ibu dan balita. Hasil: Berat badan kurang berkontribusi terhadap kejadian stunting (p-value=0,001), sedangkan status pekerjaan ibu (p-value=0,015) dan status imunisasi yang tidak lengkap (p-value=0,005) berkontribusi terhadap infeksi saluran pernapasan akut berulang berulang. Uji chi-square menunjukkan bahwa infeksi saluran pernapasan akut berulang secara signifikan berhubungan dengan kejadian stunting (p-value=0,001). Kesimpulan: Terdapat hubungan yang signifikan antara infeksi saluran pernapasan akut berulang dengan kejadian stunting, serta ditemukan bahwa kelebihan berat badan berkontribusi terhadap kejadian stunting, sementara memiliki ibu yang bekerja dan status imunisasi yang tidak lengkap berkontribusi terhadap infeksi saluran pernapasan akut berulang pada balita.
Hubungan Status Gizi dan Aktivitas Fisik dengan Menarche Dini pada Anak Sekolah Dasar di Surakarta Andieny, Pramudya Dwi; Sukamto, Ika Sumiyarsi; Sari, Atriany Nilam; Rokhayati, Evi; Kusmawati, Iffah Indri
Sari Pediatri Vol 27, No 1 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.1.2025.26-31

Abstract

Latar belakang. Usia menarche bagi seorang anak perempuan sangat penting karena hal ini dapat menjadi prediksi kesehatan pada saat dewasa. Seiring berjalannya waktu, usia menarche secara signifikan semakin dini. Menarche dini ditemukan menjadi faktor risiko berkembangnya kanker payudara, kanker endometrium, leiomyomata uterus, penyakit kardiovaskular, diabetes mellitus type 2, dan obesitas. Faktor yang dapat memengaruhi menarche dini, di antaranya status gizi dan aktivitas fisik. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara status gizi dan aktivitas fisik dengan menarche dini pada anak sekolah dasar di Surakarta.Metode. Penelitian dilakukan di SDIT Insan Mulia Surakarta. Desain penelitian ini adalah observasional analitik dengan pendekatan cross-sectional. Sampel penelitian ini menggunakan teknik total sampling dengan jumlah 65 orang. Data dianalisis secara bivariat dengan chi-square dan analisis multivariat dengan regresi logistik biner. Hasil. Terdapat hubungan signifikan antara status gizi dengan menarche dini (p-value 0,013). Tidak terdapat hubungan signifikan antara aktivitas fisik dengan menarche dini (p-value 0,402). Status gizi (p-value 0,005) lebih berhubungan dengan menarche dini dibandingkan aktivitas fisik (p-value 0,477).Kesimpulan. Status gizi lebih berhubungan dengan menarche dini pada anak SDIT Insan Mulia. Oleh karena itu, diharapkan anak perempuan dapat menerapkan gaya hidup sehat untuk mencegah terjadinya menarche dini.
Relationship Between Stress Levels and Functional Constipation Incidence in Adolescents in Surakarta Putri, Amanda Rizma Devyka; Rokhayati, Evi; Aditya, Aisya Fikritama; Wulandari, Agustina
Journal of Maternal and Child Health Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2025.10.03.06

Abstract

Background: Adolescence is a time when physical and mental changes occur. They experience various mental pressures and can affect digestive health. One of the common digestive problems in adolescents is constipation. Constipation is a condition of bowel movement disorders characterized by infrequent or less than three times a week defecation or painful defecation due to hard or large-caliber feces. The purpose of this study was to determine the relationship between stress levels and functional constipation incidence among 10th grade adolescents at SMA Negeri 1 Surakarta.              Subjects and Method: This was a cross-sectional study conducted at SMA Negeri 1 Surakarta. A total of 308 students of Class X selected with the conseutive sampling method. The dependent variable was constipation. The independent variables was stress levels. Te data were collected by questionairre. The sample results of the study were analyzed using SPSS software using univariate tests and chi-square bivariate tests. Results: The incidence of stress level did not have a significant relationship to the incidence of functional constipation in adolescents (OR= 0.77; 95% CI = 0.25 to 2.37; p = 0.551). Conclusion: There is no relationship between stress levels and functional constipation incidence in adolescents in Surakarta.
Co-Authors Agustina Wulandari Aisya Fikritama Aditya Andieny, Pramudya Dwi A’yuny, Adinda Elsyira Qurroty Kusmawati, Iffah Indri Maulina, Rufidah Prasanti, Damayanti Ika Putri, Amanda Rizma Devyka Sari, Atriany Nilam Sri Lilijanti Widjaja, Sri Lilijanti Sukamto, Ika Sumiyarsi