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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Indonesia Sari Pediatri Journal of Maternal and Child Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Avicenna : Journal of Health Research
Evi Rokhayati
Puskesmas Margaharja, Ciamis
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Journal of Maternal and Child Health

 1 
Increased Plasma Caspase-3 in Children with Down Syndrome is Associated with an Increasing Risk of Pulmonary Hypertension Prasanti, Damayanti Ika; Widjaja, Sri Lilijanti; Rokhayati, Evi
Journal of Maternal and Child Health Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.549 KB) | DOI: 10.26911/thejmch.2023.08.01.03

Abstract

Background: Pulmonary hypertension (PH) is the one of the comorbidities in children with Down syndrome. The pathogenesis of this pulmonary hypertension remains to be investigated, although endothelial dysfunction and apoptotic activity are among the proposed mechanisms. Caspase-3 is a key regulator of apoptosis and appears to be an attractive predictor of pulmonary hypertension in children with Down syndrome. Subjects and Method: A cross-sectional observational clinical study was performed in Dr. Moe­wardi General Hospital in Surakarta-Indonesia between January and March 2021 involving clini­cally diagnosed children with Down syndrome. Sampling method was using a consecutive sampling. The independent variable was plasma caspase-3 level and the dependent variable were the presence of pulmonary hypertension and congenital heart defects (CHD). Clinical data documentation, blood collection and echocardiography were performed on enrollment day. We first determined the plasma level of caspase-3 in 36 children with Down syndrome and CHD (n=18) or without CHD (n=18) and further determined the risk of having pulmonary hypertension using the plasma caspase-3 level. We also determined the biomarker performance of caspase-3 using a receiver-operating characteristic (ROC) analysis Results: Children with Down syndrome with PH had a higher plasma caspase-3 compared to those without PH (p<0.001). In those with both CHD and PH, the plasma caspase-3 level was also high although not statistically significant (p=0.145). The highest plasma caspase-3 level was observed in subjects with PH without CHD (p<0.01). Relative risk and ROC analysis demonstrated that increased plasma caspase-3 level increased the risk to have PH 5 times (RR=5.00, 95% CI 1.74 to 14.34; p<0.001) and predicted the incidence of PH in children with Down syndrome (AUC 0.88, CI 0.76 to 0.99). Conclusion: An elevation in plasma caspase-3 level of Down syndrome children is associated with the increasing risk of having PH regardless the presence of CHD. Keywords: pulmonary hypertension; down syndrome; caspase-3; pathogenesis; apoptosis. Correspondence: Damayanti Ika Prasanti. Department of Pediatrics, Faculty of Medicine, Universitas Sebelas Maret / Dr. Moewardi General Hospital. Jl. Kolonel Sutarto 132, Surakarta 57126, Indonesia. Email: damayanti_ip@yahoo.com. Mobile: 081215683462.
Relationship Between Stress Levels and Functional Constipation Incidence in Adolescents in Surakarta Putri, Amanda Rizma Devyka; Rokhayati, Evi; Aditya, Aisya Fikritama; Wulandari, Agustina
Journal of Maternal and Child Health Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2025.10.03.06

Abstract

Background: Adolescence is a time when physical and mental changes occur. They experience various mental pressures and can affect digestive health. One of the common digestive problems in adolescents is constipation. Constipation is a condition of bowel movement disorders characterized by infrequent or less than three times a week defecation or painful defecation due to hard or large-caliber feces. The purpose of this study was to determine the relationship between stress levels and functional constipation incidence among 10th grade adolescents at SMA Negeri 1 Surakarta.              Subjects and Method: This was a cross-sectional study conducted at SMA Negeri 1 Surakarta. A total of 308 students of Class X selected with the conseutive sampling method. The dependent variable was constipation. The independent variables was stress levels. Te data were collected by questionairre. The sample results of the study were analyzed using SPSS software using univariate tests and chi-square bivariate tests. Results: The incidence of stress level did not have a significant relationship to the incidence of functional constipation in adolescents (OR= 0.77; 95% CI = 0.25 to 2.37; p = 0.551). Conclusion: There is no relationship between stress levels and functional constipation incidence in adolescents in Surakarta.
Co-Authors Agustina Wulandari Aisya Fikritama Aditya Andieny, Pramudya Dwi Anggara Putra, David A’yuny, Adinda Elsyira Qurroty Hani, Yulistya Kusmawati, Iffah Indri Maulina, Rufidah Prasanti, Damayanti Ika Putri, Amanda Rizma Devyka Sari, Atriany Nilam sebastian, reza Sri Lilijanti Widjaja, Sri Lilijanti Sukamto, Ika Sumiyarsi