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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina Medika Kartika : Jurnal Kedokteran dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Rosmelia Rosmelia
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Phototoxicity inhibition effect of vitamin c and glutathione against several photosensitizers Rosmelia, Rosmelia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 3 (2003)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Ultraviolet B radiation on the skin, in the presence of photosensitizers such as quinolones, sulfacetamide, and non-steroid antiinflammatory.could induce phototoxicity due to cell membrane photo-oxidation. Antioxidants, such as vitamin C and glutathione, have been reported capable to neutralize free radicals and prevent oxidative reactions. Scientific report about the role of such antioxidants in the prevention of phototoxicity due to photosensitizers on above, is still limited.Objectives: To compare phototoxicity inhibition effect between vitamin C and glutathione and phototoxicity potency of several photosensitizersMaterials and Methods: A simple experimental design is used to compare phototoxicity potency of 0.08 mg/ml ofloxacin, 0.004 mg/ml furosemide, and 0.02 mg/ml ketoprofen, and effects of 0.2 mg/ml vitamin C, and 0.12 mg/ml glutathione on phototoxicity reactions of erythrocytes exposed to 1.6 J/cm2 UVB. Phototoxicity reaction was measured by hemoglobin released by targeted erythrocytes using spectrophotometer.Results: Hemoglobin released by photosensitizers were ofloxacin 6.760±.1.669, furosemide 6.532±1.271, ketoprofen 6.710 ±1.826 g/dI respectively. There was no significant difference of haennoglobine released among them (p>0.051. Addition of vitamin C could reduce phototoxicity of photosensitizer very significantly (p
Social Demography Study of Gonorrhea and Syphilis at RSUD dr. Soedono Madiun Musy, Rahajeng; Widyasari, Vita; Rosmelia, Rosmelia
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190227

Abstract

An understanding of the socio-demographic characteristics is the first step to conduct preventive and promotive measures to reduce the number of sexually transmitted infections. This study described the socio-demographic cha-racteristics of gonorrhea and syphilis in dr. Soedono Hospital Madiun. A descripttive study with a quantitative approach used secondary data from outpatient medical records. This research was conducted in dr. Soedono Hospital Madiun, East Java. The samples used in this study were 61 patients who had been diagnosed with gonorrhea and syphilis in the period from July 2013 - June 2016. The data consisted of 50 (82%) medical records with the diagnosis of gonorrhea and 11 (18%) medical records with a diagnosis of syphilis. Characteristics of patients/respondents are the highest age group of 21-30 years, 22 female patients (36.1%), 55 male patients (90.2%), unmarried status 33 people (54.1%), work as private employees 37 people (60.7%), pay without insurance 48 people (78.7%), and live around Madiun 52 (86.0%). The socio-demographic factors were dominant in patients with gonorrhea and syphilis in dr. Soedono Hospital period of 2013-2016 was 21-30 years old, male, unmarried, living as private sector employees, pay without insurance, and Madiun origin.
Phototoxicity inhibition effect of vitamin c and glutathione against several photosensitizers Rosmelia Rosmelia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 3 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Ultraviolet B radiation on the skin, in the presence of photosensitizers such as quinolones, sulfacetamide, and non-steroid antiinflammatory.could induce phototoxicity due to cell membrane photo-oxidation. Antioxidants, such as vitamin C and glutathione, have been reported capable to neutralize free radicals and prevent oxidative reactions. Scientific report about the role of such antioxidants in the prevention of phototoxicity due to photosensitizers on above, is still limited.Objectives: To compare phototoxicity inhibition effect between vitamin C and glutathione and phototoxicity potency of several photosensitizersMaterials and Methods: A simple experimental design is used to compare phototoxicity potency of 0.08 mg/ml ofloxacin, 0.004 mg/ml furosemide, and 0.02 mg/ml ketoprofen, and effects of 0.2 mg/ml vitamin C, and 0.12 mg/ml glutathione on phototoxicity reactions of erythrocytes exposed to 1.6 J/cm2 UVB. Phototoxicity reaction was measured by hemoglobin released by targeted erythrocytes using spectrophotometer.Results: Hemoglobin released by photosensitizers were ofloxacin 6.760±.1.669, furosemide 6.532±1.271, ketoprofen 6.710 ±1.826 g/dI respectively. There was no significant difference of haennoglobine released among them (p>0.051. Addition of vitamin C could reduce phototoxicity of photosensitizer very significantly (p
Wound healing activity of topical Phaleria macrocarpa extract in type 2 diabetic rats Sulistyoningrum, Evy; Rosmelia, Rosmelia; Fidianingsih, Ika; Narantika, Shindy Galuh; Cleopatra, Neysa Nurprahutri; Azzahra, Fathimah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.136-147

Abstract

BackgroundHyperglycemia interrupts wound healing, causing persistent and non-healing wounds. Phaleria macrocarpa extract (PME) has anti-diabetic, anti-inflammatory, antimicrobial, and antioxidant properties. This study aimed to assess P. macrocarpa activity on skin wound healing in diabetic rats. MethodsAn experimental study performed on 25 male Wistar rats. Ointments were prepared by adding vehicle (w/w) to PME at the desired concentration. Diabetes was induced by injecting rats with nicotinamide (NAD) 230 mg/kg and streptozotocin (STZ) 65 mg/kg. After hyperglycemia was confirmed, animals were randomly grouped into: i) normal rats, ii) diabetic rats; iii) diabetic rats + 2.5% ointment; iv) diabetic rats +5% ointment; and v) diabetic rats +10% ointment. Full-thickness skin wounds were induced on the dorsum and treatment was applied daily for 3 and 7 days, respectively. On days 4 and 8, wound closure was measured and animals were sacrificed for tissue samples. Wound healing was evaluated by measuring malondialdehyde (MDA) in tissue homogenates of the dermal wounds and analyzing histological changes by hematoxylin-eosin and Sirius-red staining. ResultsPME 10% ointment improved MDA levels and wound closure of inflammatory and proliferation phases. In inflammatory phase, 5% and 10% ointment reduced inflammation severity compared with diabetic rat group (p<0.05). In proliferation phase, PME 10% ointment group had a higher wound histological score (characterized by epidermal regeneration, fibroblast count, granulation tissue, and angiogenesis), and higher collagen bundle density compared with untreated groups (p<0.05).  ConclusionsTopical P. macrocarpa improves inflammatory and proliferation phases of excision wound healing in type 2 diabetes.
PEMANFAATAN MONOTERAPI DAN TERAPI KOMBINASI VITAMIN C TOPIKAL DAN DERIVATNYA SEBAGAI AGEN PENCERAH KULIT: A SCOPING REVIEW Sakinah, Olivia Puteri; Rohmah, Restu Nur; Suryaningsih, Betty Ekawati; Rosmelia, Rosmelia
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 2 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Sebagai salah satu agen pencerah kulit, vitamin C maupun derivatnya digunakan dalam industri kosmetik dalam beragam konsentrasi dan bentuk topikal. Formulasi kosmetik dengan kandungan vitamin C seharusnya efektif dalam mencapai manfaat vitamin C pada kulit. Telaah ini bertujuan untuk mengetahui jenis, besar konsentrasi, dan bentuk vitamin C topikal dan derivatnya sebagai agen pencerah kulit manusia. Seleksi artikel dilakukan berdasarkan alur PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). Kata kunci yang digunakan dalam pencarian artikel pada database yaitu “(vitamin C OR ascorbic acid OR asam askorbat) AND (brightening OR lightening OR whitening OR pencerah)” pada database Google Scholar, ScienceDirect, PubMed, ProQuest, dan EBSCOHost, “vitamin C” pada database Neliti, serta “vitamin C DAN kulit” pada database GARUDA. Jenis artikel yang dipilih merupakan artikel yang terbit pada tahun 2011–2021 dengan metode RCT dan non-RCT, baik original article maupun grey literature. Didapatkan hasil vitamin C (L-ascorbic acid) dan derivatnya (palmitoyl-KVK-L-ascorbic acid, tetrahexadecyl ascorbate, dan magnesium ascorbyl phosphate) digunakan sebagai pencerah kulit pada kondisi normal, melasma, atau amyloidosis makular. Ditemukan beragam besar konsentrasi yang digunakan dari 2% hingga 30% dalam bentuk losio, krim, atau serum; serta disimpulkan bahwa penggunaan vitamin C topikal atau derivatnya dapat mencerahkan kulit wajah. Kata kunci: pencerah kulit, topikal, vitamin C DOI : 10.35990/mk.v7n2.p198-208
CORRELATIONS BETWEEN LIPID PROFILE AND DIET WITH SEBUM PRODUCTION AND ACNE SEVERITY Rosmelia, Rosmelia; Absari, Nurmala Widya; Fairuz, Ratna Amalia; Fidianingsih, Ika
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3011

Abstract

Acne vulgaris (AV) bersifat kronis dan kambuhan, dan mengenai  mengenai hampir 85% orang dewasa muda. Memahami patogenesis AV dapat mencegah terjadinya acne. Hubungan antara profil lipid dan diet dengan AV masih kontroversial. Penelitian ini bertujuan untuk apakah ada perbedaan status profil lipid dan frekuensi diet dengan produksi sebum dan total lesi AV. Penelitian dilakukan dengan desain cross sectional dengan responden sebanyak 57 orang mahasiswa Universitas Islam Indonesia. Responden dilakukan pemeriksaan keparahan AV, produksi sebum, kadar profil lipid darah, dan wawancara menggunakan semi qualitative food frequency questionnaire yang sudah tervalidasi. Analisis statistik dilakukan untuk melihat hubungan dan korelasi antar variabel dengan tingkat kepercayaan 95%. Hasil uji korelasi tidak menemukan adanya hubungan yang signifikan (p>0,05) antara profil lipid dengan tingkat produksi sebum dan derajat keparahan acne, kecuali antara kadar trigliserida dan tingkat produksi sebum (p=0,017). Terdapat perbedaan bermakna lesi acne total antara responden dengan produksi sebum normal dan rendah (25,7±20,7 vs 15,7±12,2, p=0,032). Hasil uji korelasi Spearman antara pola diet dengan produksi sebum dan total lesi acne adalah p>0,05 kecuali konsumsi kacang tanah dan sereal terhadap total lesi acne berturut-turut (p=0,023; r=0,317 dan p=0,043; r=-0,285). Kesimpulan adalah kadar trigliserida yang lebih tinggi berkaitan dengan peningkatan produksi sebum, yang berkorelasi dengan jumlah lesi acne yang lebih tinggi. Terdapat korelasi yang lemah antara frekuensi konsumsi kacang tanah dan sereal dengan total lesi acne.
Co-Authors Absari, Nurmala Widya Azzahra, Fathimah Cleopatra, Neysa Nurprahutri Evy Sulistyoningrum Fairuz, Ratna Amalia Ika Fidianingsih Musy, Rahajeng Narantika, Shindy Galuh Rohmah, Restu Nur Sakinah, Olivia Puteri Suryaningsih, Betty Ekawati Widyasari, Vita