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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya MANDALA of Health Disease Prevention and Public Health Journal Jurnal Penelitian Pendidikan Prosiding 2nd Seminar Nasional IPTEK Terapan (SENIT) 2017 Universa Medicina Jurnal Gizi Klinik Indonesia Journal Of Holistic Nursing Science Herb-Medicine Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Evy Sulistyoningrum
Department Of Histology, Faculty Of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PERUBAHAN SELULER DAN MOLEKULER PADA NEFROPATI DIABETIK Sulistyoningrum, Evy
MANDALA of Health Vol 7, No 1 (2014): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Diabetic nehropathy is the most prevalent complication of diabetes mellitus. Hiperglycemia in diabetes mellitus activates several pathways leading to PKC activation. This activation then induce molecular changes involving many growth factors and cytokines. Various growth factors and cytokines further induce extracellular matrix accumulation and mesangial cell expansion leading to glomerular hypertrophy and sclerosis. This changes affects renal function in filtering albumin and further damage can cause abnormal renal function and lead to renal failure
TINJAUAN HISTOLOGIS PEMBULUH DARAH TIKUS PUTIH (Rattus norvegicus) DIABETES YANG DIBERI REBUSAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpha (Scheff.) Boerl.) Sulistyoningrum, Evy; Kautsari, Septina; Susatyo, Priyo
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Prevalence of Diabetes Mellitus among adult in Indonesia reached 4,1% in 1995 and projected to 6,5% in 2025. Complication of diabetes mellitus which come earlier and widely distributed yis atherosclerosis.Atherosklerosis can lead to other serious complications such as gangrene, stroke, cardiomiopathy, andcoronary artery diseases. This research was aimed to know the effect of Mahkota dewa (Phaleriamacrocarpha (Scheff.) Boerl.) boiled water to regeneration of aorta’s atherosclerosis post diabetic inductionwith alloxan. The research was conduct in four weeks to 25male albino rats (Rattus norvegicus) 3 monthaged, 120-180 grama weighed. The subjects was divided into five groups:positive control, negative control,A, B and C. A, B and C groups was treated Mahkota dewa boiled water with 4,5%, 9%, and 13,5%concentration respectively. The drug was administered orally. III, IV, and V groups are injected by alloxan toinduce diabetes. Atherosclerosis frequency was counted from histological section stained with Haematoxylineosin.Statistical analysis using Chi square analysis showed that Mahkota Dewa boiled water significantlyreduced atherosclerosis frequency in aorta. It can be concluded that Mahkota dewa (P.macrocarpha(Scheff.) Boerl.) regenerates atherosclerosis injury in diabetic blood vessel.
TINJAUAN MOLEKULAR DAN ASPEK KLINIS RESISTENSI INSULIN Sulistyoningrum, Evy
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Insulin resistance is defined by an unresponsive condition in the target organ that normallyresponded to insulin hormone. Insulin resistance play a major role in many serious health problem such asmetabolic syndrome, type II diabetes, polycistic ovarii syndrome, cancer and cardiovascular diseases. Themechanism of insulin resistance is still unclearly understood. Researchers postulated two mechanism ofinsulin resistance, based on inflammatory theory and obesity theory. These two causes of insulin resistancehave different mechanism of action. Clinical diagnosis of insulin resistance can be performed by clampmethod and minimal model of frequency sampled intravenous glucose tolerance test (FSIVGTT) but thesegold standard diagnosis are very invasive. Non-invasive methods for diagnosing insulin resistance can beperformed by using various formulas derived from base examination in glucose and insulin plasma level.One of the formulas which have high sensitivity and specificity is HOMA-IR index (Homeostasis ModelAssessment-Insulin Resistance). Different characteristic of population required different cut-off fordetermining insulin resistant condition.
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
Pengaruh Pemberian Kafein Selama Kehamilan Terhadap Berat Lahir Dan Gambaran Histologis Uterus Dan Plasenta Tikus Putih (Rattus Norvegicus) Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
Journal Of Holistic Nursing Science Vol 1 No 2 (2014)
Publisher : Universitas Muhammadiyah Magelang

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Abstract

  Kafein sering digunakan secara luas oleh masyarakat baik untuk konsumsi harian maupun pengobatan. Kafein dapat melewati sawar plasenta, masuk ke fetus dalam kadar yang seimbang dengan kadar maternal.  Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian kafein selama kehamilan terhadap berat lahir fetus serta gambaran histologis uterus dan plasenta. Penelitian ini adalah eksperimen dengan menggunakan  tigapuluh ekor tikus putih galur Sprague-Dawley hamil, berumur sekitar 2 bulan dan berat 150-200 gram dibagi dalam enam kelompok, diobservasi sampai kelahiran kemudian dilakukan penimbangan berat lahir fetus dan pengamatan gambaran histologis uterus dan plasenta.Pada penelitian ini didapatkan hasil bahwa   pemberian  kafein selama kehamilan menurunkan rerata berat lahir fetus dan memberikan gambaran oedema, perdarahan dan peradangan pada jaringan uterus dan plasenta 
Peningkatan Pengetahuan Warga Bromonilan untuk Mencegah Kejadian dan Komplikasi Diabetes Melitus Tipe II Kharisma, Muhammad; Fidianingsih, Ika; Sulistyoningrum, Evy
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 11, No 1 (2017): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.109 KB) | DOI: 10.12928/kesmas.v11i1.5213

Abstract

Background: Almost 80% of Diabetes Mellitus (DM) in the world is found in developing countries, and incidence of diabetes mellitus continues to increase, including in Indonesia. This disease will lead to decreased productivity and increased the economic burden in patient DM.  Bromonilan who suffer from DM is found the death of DM while the mortality rate of Bromonilan was unreported. The purpose of the study was to know the prevalence of Bromonilan’s DM. Method: A study was carried out in 80 of Bromonilan Villagers. All of the samples were measured the level of knowledge of DM through pretest and posted. Measuring glucose levels were also performed on 80 Bromonilan using rapid tests. Result: The prevalence of Bromonilan affected by DM was 10%. The level knowledge of DM increased 39.3% by intervention test. Conclusion: The prevalence of DM in Bromonilan was quite high. Integrated health services in community serve simultaneously to improve their knowledge such DM.
CASE-BASED LEARNING MENINGKATKAN CLINICAL REASONING PADA BLOK PENYAKIT INFEKSI TROPIS MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS ISLAM INDONESIA Sulistyoningrum, Evy; Lusiyana, Novyan
Jurnal Penelitian Pendidikan Vol 35, No 2 (2018): Oktober 2018
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpp.v35i2.15253

Abstract

Case-based learning (CBL) is a newer modality of teaching healthcare, combining medical theory and practices. Many researchs reported effectivity of CBL to improve student-centered learning. The aim of this study is to evaluate how CBL improved students’ clinical reasoning compared with other method such as problem-based learning. An interventional research involved 4th grade medical students receiving PBL and CBL methods supervised by a tutor or instructure. An alternative method combining CBL and structured role play (in an Integrated-Patient Management method) also performed using clinical scenario with medical practice setting. The result showed that student received CBL had better clinical reasoning indicated from better miniquizz result compared with PBL students (p < 0,05, Mann Whitney U test. Students exposed with CBL had final MCQ and essay exam grade compared with unexposed students. Students exposed with CBL also had better clinical skill indicated from Objective Structure Clinical Examination (OSCE) result (p < 0,05, independent t test). Students’ acceptance level on CBL method is 79, 4%. It is concluded that compared with PBL, CBL is more effective in improved students’ performance, learning outcomes and clinical reasoning and also had high acceptance among medical students.
Peningkatan Pengetahuan Warga Bromonilan untuk Mencegah Kejadian dan Komplikasi Diabetes Melitus Tipe II Fidianingsih, Ika; Sulistyoningrum, Evy; Kharisma, Muhammad
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 11, No 1 (2017): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.109 KB) | DOI: 10.12928/kesmas.v11i1.5213

Abstract

Background: Almost 80% of Diabetes Mellitus (DM) in the world is found in developing countries, and incidence of diabetes mellitus continues to increase, including in Indonesia. This disease will lead to decreased productivity and increased the economic burden in patient DM.  Bromonilan who suffer from DM is found the death of DM while the mortality rate of Bromonilan was unreported. The purpose of the study was to know the prevalence of Bromonilan’s DM. Method: A study was carried out in 80 of Bromonilan Villagers. All of the samples were measured the level of knowledge of DM through pretest and posted. Measuring glucose levels were also performed on 80 Bromonilan using rapid tests. Result: The prevalence of Bromonilan affected by DM was 10%. The level knowledge of DM increased 39.3% by intervention test. Conclusion: The prevalence of DM in Bromonilan was quite high. Integrated health services in community serve simultaneously to improve their knowledge such DM.
Pengaruh Pemberian Kafein Selama Kehamilan Terhadap Berat Lahir Dan Gambaran Histologis Uterus Dan Plasenta Tikus Putih (Rattus Norvegicus) Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
Journal of Holistic Nursing Science Vol 1 No 2 (2014)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.535 KB)

Abstract

Kafein sering digunakan secara luas oleh masyarakat baik untuk konsumsi harian maupun pengobatan. Kafein dapat melewati sawar plasenta, masuk ke fetus dalam kadar yang seimbang dengan kadar maternal. Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian kafein selama kehamilan terhadap berat lahir fetus serta gambaran histologis uterus dan plasenta. Penelitian ini adalah eksperimen dengan menggunakan tigapuluh ekor tikus putih galur Sprague-Dawley hamil, berumur sekitar 2 bulan dan berat 150-200 gram dibagi dalam enam kelompok, diobservasi sampai kelahiran kemudian dilakukan penimbangan berat lahir fetus dan pengamatan gambaran histologis uterus dan plasenta.Pada penelitian ini didapatkan hasil bahwa pemberian kafein selama kehamilan menurunkan rerata berat lahir fetus dan memberikan gambaran oedema, perdarahan dan peradangan pada jaringan uterus dan plasenta
Senam Aerobik Meningkatkan Daya Tahan Jantung Paru dan Fleksibilitas Candrawati, Susiana; Sulistyoningrum, Evy; Prakoso, Dicky Bramantyo agung; Pranasari, Nurvita
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.327 KB) | DOI: 10.21776/ub.jkb.2016.029.01.14

Abstract

Kurang beraktivitas fisik berkaitan erat dengan risiko timbulnya penyakit tidak menular dan penyakit degeneratif. Salah satu aktivitas fisik yang saat ini banyak diminati adalah senam aerobik. Daya tahan jantung paru dan fleksibilitas sangat penting bagi produktivitas hidup dan penurunan risiko penyakit degeneratif di masa mendatang. Beberapa penelitian membuktikan adanya pengaruh latihan aerobik terhadap daya tahan jantung paru dan fleksibilitas, akan tetapi penelitian tentang senam aerobik sebagai salah satu bentuk latihan aerobik belum banyak dilakukan. Penelitian bertujuan mengetahui pengaruh senam aerobik terhadap fleksibiltas dan daya tahan jantung paru. Penelitian ini merupakan penelitian eksperimental dengan pre and post test design. Sebanyak 33 individu berusia 15–25 tahun diperiksa fleksibilitas dan daya tahan jantung paru di Laboratorium Fisiologi Kedokteran Unsoed sebelum dan sesudah melaksanakan program latihan fisik senam aerobik selama 12 minggu di Sanggar Senam Sisca Purwokerto. Fleksibilitas diukur dengan metode Sit and Reach Test, sedangkan daya tahan jantung paru diukur dengan metode Quenns Collegge Step Test. Data sebelum dan sesudah intervensi senam aerobik dianalisis menggunakan perangkat lunak komputer dengan uji t berpasangan dan uji Wilcoxon. Terdapat pengaruh bermakna senam aerobik terhadap fleksibiltas (p=0,002) dan daya tahan jantung paru (p&lt;0,001), yaitu meningkatkan fleksibilitas (33,78 cm menjadi 36,45 cm) dan meningkatkan daya tahan jantung paru (18,48 menjadi 22,08). Dapat disimpulkan senam aerobik berpengaruh terhadap fleksibilitas dan daya tahan jantung paru.
Co-Authors Adrian Nugraha Putra Agus Prastowo Agus Prastowo Ariadne Tiara Hapsari Ariadne Tiara Hapsari Aulia, Afkar Azzahra, Fathimah Cleopatra, Neysa Nurprahutri Darajati, Irene Titin Diah Krisnansari Diah Krisnansari Dicky Bramantyo agung Prakoso, Dicky Bramantyo agung Eman Sutrisna Erika Maharani Fajar Wahyu Pribadi Fitranto Arjadi Herlin Fitriana Kurniawati Herlina Nindyastuti Ika Fidianingsih Ira Puspitawati Kharisma, Muhammad Mus topa Mustofa Mustofa Muttaqqin, Habib Zahar Zaki Narantika, Shindy Galuh Novyan Lusiyana Nur Signa Aini Gumilas Nurvita Pranasari, Nurvita Panggabean, Andre Stefanus Priyo Susatyo Qurrotu Aini Rosmelia Rosmelia Septina Kautsari, Septina Setiawati Setiawati Supriyati . Supriyati, Endah Susiana Candrawati Yulia Wardhani, Yulia