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All Journal Hydrogen: Jurnal Kependidikan Kimia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Siti Maesarah
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Chemistry Education Medicine & Pharmacology Nursing Public Health

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PENGARUH PRAKTIKUM BERWAWASAN LINGKUNGAN DENGAN MODEL INKUIRI TERHADAP SIKAP ILMIAH DAN HASIL BELAJAR Siti Maesarah; Baiq Asma Nufida
Hydrogen: Jurnal Kependidikan Kimia Vol 5, No 2 (2017): Hydrogen: Jurnal Kependidikan Kimia
Publisher : Universitas Pendidikan Mandalika Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.845 KB) | DOI: 10.33394/hjkk.v5i2.1591

Abstract

This study aims to determine the effect of the experiment based environmentalon scientific attitude of the student and learning achievement on acidandalkali subject. This study was quasi-experimental with Posttest-Only ControlGroup Design. The sample consists of two intact group, experimental group(learning by experiment based environmental method) and control group(learning by traditional method) choosen by purposive sampling technic. Datacollection of scientific attitude using questionnaires and observation sheets,while learning outcomes data collected by an objective test. Data analyzedwith descriptive statistic and non parametric statistic (Mann Whitney test).The result show that student’s scientific attitude score of experiment group is83.35 at very high category while the control group is 77.82 at the highcategory. The average score of learning achievement 86.40 for experimentalgroup higher than control groupis 70.87. Beside that Mann-Whitney testobtained sig. less than 0.05 (p <0.005). Thus, it can be concluded that theexperiment based environmental methods affect the scientific attitude andstudent learning achievement on acid-base subject.
Review Artikel: Pengaruh Sistem Emulsi Lipid terhadap Farmakokinetika Obat Lipofili Ghina Salsabila; Candra Dwipayana Hamdin; Karlina Dwi Febrianingsih; Naya Wahyu Anindiya; Febriana Putri Rohmayani; Haulya Razkianita; Siti Maesarah; Sabila Rosyada; Puji Elok Dzakirah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 3 (2026): September: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i3.6945

Abstract

Lipophilic drugs have low water solubility and often exhibit inconsistent absorption profiles, which can lead to suboptimal therapeutic outcomes in clinical use. Lipid-based drug delivery systems have emerged as a promising and widely studied formulation strategy because they are able to significantly enhance the solubility, bioavailability, and systemic distribution of lipophilic drugs. This study aims to identify how various lipid emulsion systems modify the pharmacokinetic profile of lipophilic drugs, compare the differences in effects among different types of emulsions, and highlight the key formulation characteristics that contribute to these pharmacokinetic parameter changes. The study was conducted through a comprehensive literature review of national and international scientific articles published between 2015 and 2025. The results indicate that lipid emulsion systems modify pharmacokinetics primarily through increased drug dissolution, accelerated absorption processes, reduced first-pass metabolism, and facilitation of lymphatic transport pathways. These mechanisms consistently result in increased Cmax, AUC, and overall bioavailability. The formulation characteristics that strongly influence these outcomes include nano-sized droplet distribution, lipid type selection, surfactant and co-surfactant composition, amorphous drug form, and the physical stability of the emulsion system.
Co-Authors Baiq Asma Nufida Candra Dwipayana Hamdin Febriana Putri Rohmayani Ghina Salsabila Haulya Razkianita Karlina Dwi Febrianingsih Naya Wahyu Anindiya Puji Elok Dzakirah Sabila Rosyada