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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Pro Food Jurnal Penelitian Kesehatan Suara Forikes Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Ilmu Kefarmasian Indonesia Scripta Biologica Jurnal Gema Ngabdi Jurnal Abdi Insani Jurnal Kesehatan Tambusai Journal of Multidisciplinary Applied Natural Science Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Warta Desa (JWD) Prosiding Konferensi Nasional PKM-CSR Jurnal Pijar MIPA Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Kefarmasian Indonesia Lombok Medical Journal Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan

Candra Dwipayana Hamdin

Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia

Author-ID : 3495039

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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KETOKSIKAN AKUT ORAL ZAT PEWARNA MAKANAN DAUN JATI (Tectona grandis L. f.) PADA TIKUS WISTAR Candra Dwipayana Hamdin; Dheni Cahyo; Dandiko Galanova
Pro Food Vol. 3 No. 2 (2017): Pro Food
Publisher : Fakultas Teknologi Pangan dan Agroindustri, Universitas Mataram

Jati leaf becomes one of the alternative natural food coloring in some food producers. A research is needed to determine the potential of acute ketoxicity (LD50) and determine the clinical symptoms that arise also to see the groos patologi of organs resulting from single oral dosage of jati leaf extract. This research was conducted with complete randomized design using OECD 423 method. The test animal used was Wistar strain female rats. In this study, the test animals were divided into 2 groups, namely the control and treatment groups, each consisting of 3 test animals. Control group given Na CMC 0.5% and treatment group given jati leaf extract with a single dose of 2000 and 5000 mg/kg bw. Dosage starts from 2000 mg/kg bw, then increased to 5000 mg / kg bw in different rat. Observations were made for 14 days because single dose administration did not cause death. Test animals were sacrificed for gross observation of the vital organ pathologies (liver, kidney, heart, stomach, spleen, and small intestine). The results showed the potential toxicity (LD50) jati leaf extract using Wistar female rat test animal included in V category (not classified). The dosage of 2000 mg/kg bw did not show any change in behavior, the dosage of 5000 mg/kg bw gave clinical symptom on the central and somatomotor nerves in the form of increased aggressiveness and vocalization and gastrointestinal disturbances in the form of singultus in the test animals. Keywords: Acute toxicity (LD50), gross pathology, histopathology, jati leaf extract (Tectona grandis L. f.), OECD 423. ABSTRAK Daun jati menjadi salah satu alternatif pewarna alami makanan pada sebagian produsen makanan. Perlu dilakukan penelitian untuk menentukan potensi ketoksikan akut (LD50) untuk mengetahui gejala-gejala klinik yang timbul dan melihat gambaran gross patologi organ akibat pemberian oral dosis tunggal ekstrak daun jati. Penelitian ini dilakukan dengan rancangan acak lengkap pola searah menggunakan metode OECD 423. Hewan uji yang digunakan adalah tikus betina galur Wistar. Pada penelitian ini, hewan uji dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan perlakuan yang masing-masing terdiri dari 3 hewan uji. Kelompok kontrol dipejani Na CMC 0,5% dan kelompok perlakuan dipejani ekstrak daun jati dengan dosis tunggal 2000 dan 5000 mg/kg BB. Dosis pemejanan dimulai dari 2000 mg/kg BB, kemudian dinaikkan menjadi 5000 mg/kg BB pada tikus yang berbeda. Pengamatan dilakukan selama 14 hari karena pemejanan dosis tunggal tidak menyebabkan kematian. Hewan uji dikorbankan untuk pengamatan gross patologi organ vitalnya (hati, ginjal, jantung, lambung, limpa, dan usus halus). Hasil penelitian menunjukkan potensi ketoksikan (LD50) ekstrak daun jati menggunakan hewan uji tikus betina galur Wistar termasuk dalam kategori V (tidak terklasifikasikan). Pemejanan dosis 2000 mg/kg BB tidak menunjukkan perubahan tingkah laku, pada pemejanan dosis 5000 mg/kg BB memberikan gejala klinis pada saraf pusat dan somatomotor berupa peningkatan agresifitas dan vokalisasi serta gangguan pada saluran cerna berupa singultus pada hewan uji. Keywords: ekstrak daun jati (Tectona grandis L. f.), gross patologi, histopatologi, OECD 423, toksisitas akut (LD50)

Efektivitas Sediaan Salep Limbah Kulit Singkong Sebagai Penyembuh Luka Widia Nila Risnadewi; Nadya Arianita Turisia; Alsifah Nurhidayati; Candra Dwipayana Hamdin
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 5 No. 2 (2019): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

The skin is an important organ that functions to receive stimuli such as touch, pain and other influences from the outside. Some problems that occur on the skin can becaused because the skin is very vulnerable to trauma and injury. Wound is a condition of the breakdown of tissue integrity caused by violence both mechanical, physical and chemical in nature. In general, wound care in the community is done with a dressing accompanied by compresses betadine and normal saline because these materials are easily available. However, long-term use of the dressing can cause slow wound healing and various infections can appear. This causes people to look for other alternative treatments, one of them with herbal plants, namely cassava plants have the potential to be used as a wound healing and is able to inhibit bacteria because they are suspected to contain phenolic compounds. This study was a true experimental study, the group of test animals was divided into 6 groups, after that the making of wounds and smeared with bacteria were given ointments with 3 concentrations namely 5%, 10%, and 15%. Ointment extract of cassava skin waste gives effect to the wound healing process seen from the length of the wound. The ethanol extract ointment which has a good effect on wound healing is an ointment with a concentration of 10% and 15%.

Anticoagulant Activity of Mangrove (Avicennia alba) Leaves Extract in Vitro Riza Rusyiana; Ima Arum Lestarini; Candra Dwipayana Hamdin; Handa Muliasari
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 26, No 2 (2021): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.26.2.110-116

Anti-coagulants are substances used to prevent the formation of thromboembolism, one of the causes of cardiovascular disease. Since cardiovascular is a disease as the leading cause of death in the world, exploration of novel and more effective anticoagulant is very needed. Mangroves contain flavonoid and sulphated polysaccharide compounds that potential as anti-coagulants. This study aimed to determine the anti-coagulant activity of ethanol extract and fractions of mangrove leaves (Avicennia alba) in human blood cells in vitro. A. alba leaves were collected at Teluk Ekas, East Lombok, Indonesia. The leaves were macerated with 96% ethanol (3x24h) and then evaporated. The extract was then fractionated to obtain the n-hexane, chloroform, and residual fractions. Anti-coagulant activity of ethanol extract and the three fractions were tested in vitro to five human blood samples by the method of Lee-White and Eustrek, compared to heparin as a positive control. Phytochemical screening of the ethanol extract indicated that A. alba leaves extract contains alkaloids, tannin, saponin, flavonoids, sulphated polysaccharide, and terpenoid. The results of Lee-White method were the ethanol extract (1 mg.mL-1), and three fractions (0.5 mg.mL-1) have anti-coagulant activity. Statistical analysis showed that the anti-coagulant activity of the ethanol extract was significantly different (P<0.05) compared to the normal group and fractions and were not significantly different (P>0.05) compared to heparin. Ethanol extract and the three fractions of A. alba leaves have anti-coagulant activity in vitro. The anti-coagulant activity of ethanol extract (1 mg.mL-1) was comparable to heparin (25 IU) and was better than the three extract fractions (0.5 mg.mL-1). Further research is needed to test the anticoagulant activities of isolated sulphated polysaccharides and flavonoid that can be developed as anticoagulant agents.

“PERAK” (PERANTI PEMURNI AIR KERUH) UNTUK MENGATASI KEKURANGAN AIR BERSIH DI DESA SENGGIGI Candra Dwipayana Hamdin; Handa Muliasari; Retno Zahara; Mujiburrohman Mujiburrohman; Devy Shandra Purwati; Romi Juniawan; Baiq Ressa Puspita Rizma
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 25, No 4 (2019): OKTOBER - DESEMBER
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v25i4.15094

Desa Senggigi merupakan salah satu daerah yang kekurangan pasokan air bersih, khususnya di Dusun Senggigi RT 04.Kondisi ini sangat memprihatinkan, sebab ketika musim kemarau tiba sangat sulit untuk memperoleh air bersih.Adapun air PDAM maupun air sungai sangatlah keruh sehingga tidak layak untuk digunakan.Oleh karena itu,dibutuhkan sebuah solusi terkait pengelolaan air keruh menjadi air bersih, yaitu PERAK (Peranti Pemurni Air Keruh).Tujuan dibuatkan program ini adalah terciptanya suatu alat pemurni air keruh (PERAK),terbentuk masyarakat yang terampil dalam mengelola air keruh menjadi air bersih, dan terbentuknya KelompokSwadaya Masyarakat di Dusun Senggigi. Metode yang digunakan dalam program ini adalah sosialisasi dan pelatihan pembuatan PERAK. Adapun hasil yang didapatkan pada pelaksanaan program ini adalah PERAK telah dapat menghasilkan air bersih yang dapat digunakan untuk keperluan kehidupan sehari-hari.Selain itu warga Dusun Seggigi juga telah mampu membuat PERAK dan telah dibentuknya Kelompok Swadaya Masyarakat yang bertugas memonitoring pelaksanaan program sehingga tercipta kemandirian dalam pelaksanaan program tersebut.Dengan demikian PERAK telah berhasil menjadi solusi bagi permasalahan kekurangan air bersih bagi Dusun Senggigi.Kata kunci: Air Bersih; Air Keruh; Pemurni Air; PERAK; Senggigi.AbstractSenggigi Village is one of the areas that lack of clean water supply, especially in Dusun Senggigi RT 04. This condition is very concerning, because when the dry season comes, it is very difficult to obtain clean water. The PDAM water or river water is very muddy so it is not feasible to use. Therefore, it takes a solution related to the management of turbid water into clean water, which is PERAK (Refrigerant Water Purifier). The purpose of this PERAK program is to create a turbid water purification tool (PERAK), to form a skilled community in managing turbid water into clean water, and forming Self-Help Groups in Senggigi Village. The methods used in this program are socialization and training on making PERAK. As for the results obtained in the implementation of this program is PERAK has been able to produce clean water that can be used for the purposes of everyday life. In addition, residents of Dusun Senggigi has also been able to make PERAK and has formed a Self-Help Group which is tasked to monitor the implementation of the program so as to create independence in the implementation of the program. Thus PERAK has successfully become the solution for the problem of water shortage for Dusun Senggigi.Keywords: Clean Wate; Cloudy Water; Water Purifier; PERAK; Senggigi.

Studi In Silico Bioaktivitas Antikanker Senyawa Aktif Dalam Minyak Biji Buah Wali [Brucea javanica (L.) Merr] Agus Dwi Ananto; Handa Muliasari; Candra Dwipayana Hamdin
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Insilico study of anticancer bioactivity in oil of “buah wali” [Brucea javanica (L.) Merr] has been successfully carried out. “Buah Wali” (Brucea javanica (L.) Merr) is known to treat various diseases such as diabetes, diarrhea, and malaria. In addition, “buah wali” seeds are supported to have antidiabetic, antioxidant, and anticancer activities. The stages of the study began by taking a sample of “buah wali”seeds, then extracted to get oil of “buah wali”. While GC-MS analysis resulted Octadec-9-enoic acid (56.25%), palmitic acid (13.82%), stearic acid (10.57%), and acids -9-octadecanoate (5.91%) were found as the major components of the seed oil. Based on these compounds, docking molecular was carried out to find anticancer bioactivity. The results obtained are compounds that have lower binding energy than the native ligands [Octadec-9-enoic acid (-72.4518), hexadecanoic acid (-70.2136), octadecanoic (-72.2362).

Edukasi Pengelolaan Obat Melalui DAGUSIBU untuk Mencapai Keluarga Sadar Obat Wahida Hajrin; Candra Dwipayana Hamdin; Dyke Gita Wirasisya; Gusti Ayu Putu Sri Erwinayanti; Raisya Hasina
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Abstract: The high ratio of population in Pamenang, Tanjung, and Gangga sub-districts compared to existing facilities and health workers is a very principle problem related to health education for the community, including information about medicine. One of whichis about the correct methods of how to get, use, save, and dispose medicines which is abbreviated with the DAGUSIBU program, including how to use special medicines. The aim of this socialization was to educate the patients in the public health center in Pemenang, Tanjung, and Gangga sub-districts about DAGUSIBU. The DAGUSIBU socialization program was carried out through the delivery of material, discussions, questions and answers, and demonstration by the audience and Pharmacists. Participants that incidentally were patients in public health centrewere very enthusiastic about this program as evidenced by the activeness of the participants in asking questions and answering questions about DAGUSIBU. Keywords: DAGUSIBU, socialization, Pemenang, Tanjung, Gangga, medicine

Pengembangan media edukasi diabetes mellitus untuk tenaga kefarmasian di puskesmas wilayah Mataram Ni Made Amelia Ratnata Dewi; Iman Surya Pratama; Candra Dwipayana Hamdin
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Adherence in using drugs is one of the factors that determine the success of therapy, especially for chronic diseases such as diabetes mellitus. Efforts that can be made by health workers in increasing adherence to diabetes mellitus sufferers in undergoing treatment are to pay attention to providing information and education to patients. The purpose of this community service activity is to develop educational media for type II diabetes mellitus for pharmaceutical workers in the Mataram regional health center. Making diabetes education media is done by making a pocket book which aims to make it easier for health workers to carry out counseling related to diabetes mellitus and its treatment.

Efek Hipoglikemik Ekstrak Biji Buah Wali (Brucea Javanica L. Merr) Pada Tikus Wistar Yang Diinduksi Aloksan Ida Bagus Putra Manuaba; Faturrahman Faturrahman; Candra Dwipayana Hamdin
Jurnal Pijar Mipa Vol. 15 No. 1 (2020): Januari
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Buah wali (Brucea javanica L. Merr) telah lama digunakan sebagai obat penyakit diabetes oleh masyarakat di daerah Sesaot. Tujuan penelitian ini adalah mengetahui efek hipoglikemik ekstrak biji buah wali terhadap kadar gula darah puasa (GDP) tikus wistar yang mengalami diabetes. Penelitian ini menggunakan metode experimental dengan rancangan acak lengkap (RAL). Terdapat delapan kelompok perlakuan yaitu kelompok kontrol positif (K+) dengan terapi glibenklamid 0.5 mg/kgBB, kelompok kontrol negatif (K-) yaitu hewan diabetes dengan pemberian cmc na 0.5%, kelompok N adalah hewan tidak diabetes danÃÂ kelompok pemberian variasi dosis ekstrak biji buah wali (D1, D2, D3, D4, dan D5). Pembuatan hewan model diabetes dilakukan dengan cara induksi aloksan (125 mg/kgBB) secara intravena pada setiap kelompok kecuali pada kelompok N. Analisis data dilakukan dengan uji Anova dan LSD. Hasil penelitian ini menunjukkan persentase penurunan rata-rata gula darah selama 15 hari pengamatan sebesar 4% (D1), 10% (D2), 22% (D3), 6% (D4), 6% (D5), 14% (K+), 4% (K-), dan 2% pada kelompok N. Hasil uji Anova menunjukan bahwa p <0,05 yang berarti ada pengaruh pemberian ekstrak biji buah wali terhadap penurunan kadar gula darah tikus. Uji LSD menunjukkan pengaruh signifikan terjadi pada kelompok K+ dan kelompok variasi dosis ekstrak terhadap kelompok K- dengan nilai LSD p <0.05. Berdasarkan hasil penelitian ini, esktrak biji buah wali dapat menurunkan kadar gula darah puasa pada hewan uji diabetes dengan penurunan terbesar (22%) pada kelompok D3 dengan dosis 25 mg/kgBB

Efek Pemberian Eugenol Isolat Bunga Cengkeh (Syzygium aromaticum) terhadap Histologi Pankreas Tikus Diabetes Sinta wahyu utami; I Made Sudarma; Candra Dwipayana Hamdin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diabetes mellitus is disease with a high prevalence rate and continuously increase in Indonesia. So some researchers began to glance at natural rescource for prevention and treatment of diabetes mellitus. Clove Flower (Syzygium aromaticum) contains eugenol that can chemically lower blood sugar levels. The aimed of this research is to know the effect of eugenol on pancreas histology of diabetic rats. Clove flowers was extracted used maseration method use n-hexan and eugenol was isolated tested with TLC. Alloxan-induced rats were dosed 125 mg / kg BW IP and then the eugenol was administered in dosage 10 mg / kg BW compared with glibenclamid 1,35 mg /Kg BW orally for 14 days. Observation of pancreatic histology results were made pancreatic preparations using Hematoxilin Eosin (HE) staining. The results showed that alloxan-induced rats had pancreatic cell damage. How ever, after being treated with Glibenclamide and Eugenol showed the improvement of damage organs. Giving the eugenol at a dose of 15 mg / kg BW showed the most significant improvement.

Efek Ekstrak Petroleum Eter Daun Ara (Ficus Racemosa Linn.) pada Indeks Fagositosis Mencit (Mus musculus) Candra Dwipayana Hamdin; Andriliana Trihastuty; Siti Rahmatul Aini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Terpenoid compound from ara’s leaf is known to have immunosuppressant activity by inhibit blood cells proliferation. Immunosuppressant is a group of drugs that can suppress excessive immune responses. The aim of this research was investigated the immunosuppressant effect of petroleum ether from ara’s leaf (Ficus racemosa Linn.) on mice (Mus musculus). The immunosuppressant activity was conducted by carbon clearance method to investigate the ability of phagocytosis with carbon as an antigen that is injected intravenously, followed by determining organ index. All data was analyzed by SPSS. The result showed that at dose of 560 mg/kgbw and 1120 mg/kgbw, extract found to have immunostimulant activity with phagocytic index values respectively of 1.5 and 1.1, while the dose of 1680 mg/kgbw was immunosuppressant with phagocytic index 0.7. The lymphoid organ index showed a significantly difference between petroleum ether from ara leaf extract by dose 1680 mg/kgbw with negative control (p<0.05). Based on the results of the non-specific immune response, it can be concluded that the petroleum ether ara’s leaf extract by dose 1680 mg/kgbw has immunosuppressant activity.

Co-Authors Adila Rizkika Agus Dwi Ananto, Agus Aini, Siti Rahmatul Alamanda, Baiq Irzana Putri Alfiah Hayati Almando Geraldi Almira Amini Alsifah Nurhidayati Amini, Almira Ananta, Muhammad Naufal Farras Andriliana Trihastuty Arief Nurrochmad Baiq Citra Azzahra Qotrunnada Baiq Ressa Puspita Rizma Candra Eka Puspitasari Dandiko Galanova Dandiko Galanova Devy Shandra Purwati Dhea Syafitri Dwiyanti Dheni Cahyo Dheny Cahyo Saputro Diouf Maulana Dwi Putranto Dyke Gita Wirasisya Dzakiyyah Sulthanah Ahmad Faolananda Qurrota A'yun Faturrahman Fawwaz Aqila Putri Febriana Putri Rohmayani Febriana Putri Rohmayani Firli Rahmah Primula Dewi Ghina Salsabila Gusti Ayu Pratitha Devinta Putri Gusti Ayu Putu Sri Erwinayanti Hajar, Versa Rachmania Halimatussakdiyah Halimatussakdiyah Handa Muliasari Hasina, Raisya Haulya Razkianita Hudaynu Patya Putri I MADE SUDARMA Ida Bagus Putra Manuaba Ika Puspitasari Ima Arum Lestarini Iman Surya Pratama Ivan Mambaul Munir Jingga Rusyesyah Padli Karlina Dwi Febrianingsih Kattari, Raisah Putri Lalu Rifqi Azami Lim, Vuanghao Lisnasari, Baiq Risky Wahyu M. M. Samdya Aripansy Mahacita Andanalusia Mahdiyyah Husna Nihar Manikya Pramudya Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Nadia Magfira Nurmalasanti Nadya Arianita Turisia Naya Wahyu Anindiya Naya Wahyu Anindiya Ni Made Amelia Ratnata Dewi Ningsih, Fitriani Putri Eka Puji Elok Dzakirah Putri, Dheden Nurhani Bija Raisya Hasina Retno Zahara Ria Hapsari Risma Fitriani Riza Rusyiana Romi Juniawan Sabila Rosyada Sabita Tarinda Sabita Tarinda Saputra, Yoga Dwi Shafira Khansa Haiba Silhiyatun Mayada Sinta wahyu utami Siti Maesarah Siti Maesarah Siti Rahmatul Aini Siti Rahmatul Aini Steve Pratama Tanjaya Syahrani Febrianti Ulya, Tuhfatul Vania Aisyah Aulia Syahda Haris Vania Aisyah Aulia Syahda Haris Wahida Hajrin Widia Nila Risnadewi Windah Anugrah Subaidah Wiwin Azariani Yazid Maula Zaskia Rizky Maulana Zaskia Rizky Maulana `Mustofa, Laila Al Azizi

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