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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia
Rahmah Elfiyani
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih Anisa Amalia; Rahmah Elfiyani; Adesi Chenia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.842

Abstract

Garlic (Allium sativum L) contains allicin which has the property of reducing blood sugar levels. In previous studies, methanol extract of garlic can reduce blood sugar levels in mice at a dose of 400 mg/kg BW. Penetration of allicin can be increased by formulating extracts in the phytosome system. In this study, it will be observed the effect of making a phytosome system on the diffusion rate of allicin. Garlic extract phytosome was made using a thin layer hydration method which was then evaluated for its physicochemical properties which included testing of entrapment efficiency, density, particle size, index polydispersity, and zeta potential. Determination of the value of the diffusion rate of allicin in the extract and in the phytosome system was carried out using a modified diffusion cell for 420 minutes. The phytosome system formed has an entrapment efficiency value of 64.8789% with a density of 1.0051 g/mL, the particle size of 270 nm, the zeta potential of -32.55 mV and polydispersion index of 0.571. Diffusion rate testing indicates the diffusion rate of the phytosome system can increase the diffusion rate of allicin when compared to the diffusion rate of allicin in garlic extract.
PENGARUH PENINGKATAN KONSENTRASI PEKTIN SEBAGAI GELLING AGENT TERHADAP SIFAT FISIK MARSHMALLOW ANTISARIAWAN EKSTRAK KENTAL DAUN SAGA (Abrus precatorius L.) rahmah elfiyani; ari widayanti; budiarti rahayu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 2 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.181 KB) | DOI: 10.22236/farmasains.v3i2.3323

Abstract

Saga leaves (Abrus precatorius L.) have anti-thrush activity and contain glisirizin. Glisirizin is a compound of saponin glycosides non hemolytic, class of triterpenoid and have anti-parasitic activity. This study aims at knowing effect of increasing concentration of pectin as gelling agent on physical properties marshmallow. Saga leaves extract made in to marshmallow 4 formulas, with variations of concentrations of pectin 0.7%, 0.8%, 0.9% and 1%. The physical properties evaluations included organoleptic, uniformity of weight, uniformity of size, moisture content, and texture. The hardness test result data obtained in 859.33; 710.03; 677.13; 506.36 gf, the cohesiveness test result data 0.7375; 0.8247; 0.8780; 0.9327 gs, the springiness test result data 0.7255; 0.8142; 0.8530; 1.0236 gs. Data were analysed using one-way ANOVA followed by Tukey test. The result showed that the higher concentration of pectin will increase springiness and cohesiveness and reduce hardness of marshmallow of viscous saga leaves extract.
FORMULASI HARD MOLDED LOZENGES EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) DENGAN PENAMBAHAN KOMBINASI CORN SYRUP DAN MANITOL Kori Yati; Rahmah Elfiyani; Dessy Ayu Permatasari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 11 No. 02 Desember 2014
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.833

Abstract

ABSTRAK Kelopak bunga rosella (Hibiscus sabdariffa L.) mengandung senyawa yang memiliki aktivitas antioksidan, sehingga dapat menangkal radikal bebas. Agar lebih praktis dan efisien maka diformulasikan dalam bentuk hard molded lozenges. Penelitian ini bertujuan untuk memformulasikan hard molded lozenges ekstrak bunga rosella dengan penambahan kombinasi corn syrup dan manitol dan mengamati pengaruhnya terhadap kualitas fisik sediaan. Kombinasi corn syrup dan manitol pada sediaan hard molded lozenges dilakukan dalam beberapa perbandingan, yaitu perbandingan 1:4, 1:5, 1:6, 1:7. Pengaruh penambahan corn syrup dan manitol pada sifat fisik hard molded lozenges yang meliputi organoleptis, tekstur (kekerasan dan kelengketan), kadar air, kadar abu, dan jumlah gula reduksi dianalisis. Diperoleh data hasil uji kekerasan pada masing-masing formula yaitu 1302,1 gf, 1523,9 gf, 2033,2 gf, dan 3038,1 gf. Data hasil uji kelengketan -198,3 gf, -138,7 gf, -121,2 gf, dan -73,9 gf. Dapat disimpulkan bahwa penambahan kombinasi corn syrup dan manitol dapat meningkatkan kekerasan dan menurunkan kelengketan sediaan. Kata kunci: corn syrup, manitol, hard molded lozenges, tekstur. ABSTRACT Rosella calyxes (Hibiscus sabdariffa L.) have antioxidant activity. To be more practical and efficient in its use, it was formulated into hard molded lozenges. This study was aimed to formulate hard molded lozenges of rosella calyxes with the addition of a combination of corn syrup and mannitol and to evaluate the physical quality of the lozenges. The combination of corn syrup and mannitol are prepared in ratio of 1:4, 1:5, 1:6, and 1:7. The physical properties evaluation of the hard molded lozenges included organoleptic, texture (hardness and stickiness), moisture content, ash content, and the number of reducing sugar. The hardness of the lozenges in each formula were 1302.1 gf, 1523.9 gf, 2033.2 gf, and 3038.1 gf, respectively. The adhesiveness of the lozenges in each formula were -198.3 gf, -138.7 gf, -121.2 gf, and -73.9 gf, respectively. It can be concluded that the addition of combination of corn syrup and mannitol increased the hardness and decreased the adhesiveness of preparation. Key words: corn syrup, mannitol, hard molded lozenges, texture.
Co-Authors Adesi Chenia Anisa Amalia Ari Widayanti budiarti rahayu Dessy Ayu Permatasari Kori Yati