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All Journal Jurnal Ilmu Kefarmasian Indonesia JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)
ACHMAD FUDHOLI
UNIVERSITAS GADJAH MADA
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Purifikasi n-Heksana pada Serbuk Simplisia terhadap Kadar Asiatikosida, Penangkapan Radikal Bebas dan Kadar Fenol Total Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urban) AGATHA BUDI SUSIANA LESTARI; ACHMAD FUDHOLI; AKHMAD KHARIS NUGROHO; ERNA PRAWITA SETYOWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

It has been proven that gotu kola (Centella asiatica (L.) Urban) have an antioxidant activity that make it possible to use in preventing degenerative illness. The aims of this study are to find the effect of n-hexane purification before maceration on asiaticoside content, free radical scavenging activity and total phenolic content of gotu kola ethanolic extract. The gotu kola extract was made by maceration process using the mix of ethanol and aquadest as solvents in different proportion, which are 100%:0% (E100), 75%:25% (E75), 50%:50% (E50), 25%:75% (E25), and 0%:100% (E0). The determination of asiaticoside content in gotu kola ethanolic extract was measured using Thin Layer Chromatography (TLC) Densitometry method, free radical scavenging activity was measured using diphenylpicryl hydrazyl (DPPH) and defined by parameter of IC , and total phenolic content was defined by equivalency of galic acid using Folin-Ciocalteau. The results show that the hexane purification would increasing total phenolic content significantly in ethanolic extract which extracted with solvents in proportion of ethanol:aquades 75%:25% (E75), 50%:50% (E50), and 25%:75% (E25), but not significant in decreasing of IC . Statistically, n-hexane purification was also not significant to increasing asiaticoside content in gotu kola ethanolic extract.
Pemodelan Farmakokinetika Tablet Floating Aspirin pada Kelinci dengan PKSolver AGUS SISWANTO; ACHMAD FUDHOLI; AKHMAD KHARIS NUGROHO; SUDIBYO MARTONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Aspirin selain sebagai analgetik juga efektif digunakan sebagai antiplatelet untuk profilaksis stroke. Aspirin diabsorpsi secara cepat di saluran pencernaan bagian atas terutama di bagian pertama usus halus. Formulasi dalam bentuk tablet floating diharapkan mampu memperbaiki profil farmakokinetika aspirin. Tujuan penelitian ini adalah untuk menentukan model farmakokinetika tablet floating aspirin pada kelinci dengan PKSolver. Penentuan model dengan PKSolver berdasarkan parameter: 1) visual goodness of fit (GOF) dan 2) parameter statistik yang meliputi Akaike’s information criteron (AIC) dan Schwarz criterion (SC). Berdasarkan kedua parameter tersebut menunjukkan bahwa model multiple site absorption (MAS) merupakan model terbaik untuk menjelaskan farmakokinetika tablet floating aspirin. Pelepasan dan absorpsi aspirin dari tablet floating terjadi melalui 2 tahap sehingga menghasilkan profil farmakokinetika dengan puncak ganda akibat absorpsi yang terjadi secara paralel di dalam lambung.
Optimasi Formula Sediaan Fast Disintegrating Tablet (FDT) Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urb.) Agatha Budi Susiana Lestari; Achmad Fudholi; Akhmad Kharis Nugroho; Erna Prawita Setyowati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.036 KB) | DOI: 10.35814/jifi.v16i1.423

Abstract

It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.
ANALISIS KINERJA IFRS X PURWOKERTO DARI PERSPEKTIF PERTUMBUHAN DAN PEMBELAJARAN BALANCED SCORECARD Fithria Dyah Ayu Suryanegara; Achmad Fudholi; Satibi Satibi
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol. 1 No. 1 (2012): January 2012
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.v1i1.153

Abstract

IFRS X is an integral part of the hospital, and has a strategic role in the professional development of hospitals and hospital economics. IFRS X in order to enter the business environment in the future an increasingly competitive, requiring the measurement of performance in order to survive and compete. Therefore, the performance measured in terms of IFRS X from the perspective of growth and learning balanced scorecard. Methods in cross-sectional study was conducted, and data collected in the form of quantitative data obtained by observation and dissemination of data questionnaire. The results showed that from the perspective of growth and learning, the performance of IFRS X has shown good results, judging from the 80.77% level of employee satisfaction, employee productivity levels 93.59% and 42.31% level of employee training.
Co-Authors Agatha Budi Susiana Lestari Agus Siswanto Akhmad Kharis Nugroho ERNA PRAWITA SETYOWATI Fithria Dyah Ayu Suryanegara Satibi Satibi SUDIBYO MARTONO