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All Journal Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia International Journal of Science Technology and Health al Kimiya : Jurnal Ilmu Kimia dan Terapan
SITTI HADIJAH SABARWATI
Departement Of Chemistry, Faculty Of Mathematics And Science, Halu Oleo University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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Isolasi dan Identifikasi Senyawa (-)-Asam Usnat dari Lichen Usnea sp. serta Aktivitas Sitotoksiknya terhadap Sel Murine Leukemia P388 MAULIDIYAH MAULIDIYAH; THAMRIN AZIS; SITTI HADIJAH SABARWATI; MUHAMMAD NURDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1685.306 KB)

Abstract

Lichen is a symbiotic organism composed by algae and fungi that already known produces spesific secondary metabolites having bioactivities. The aim of this study were to isolate and determine the structure of secondary metabolites of Lichen Usnea sp. and to examine the cytotoxic activity against murine leukemia P388 cells. Isolation was carried out by utilizing colom chromatography using silica gel 60 stationary phase with eluent mixtures of n-hexane and ethyl acetate in a gradient elution. Isolates compounds were identified using UV-Vis spectroscopy, IR, 1H-NMR and 13C-NMR. The identification result obtained was (-)-usnic acid compound with molecular weight (MW) of 344 g/mol, needle-shaped yellow crystals. Test results cytotoxic compound of (-)-usnic acid against murine leukemia P388 cells were derived IC50 5.738 ± 0.61 µg/mL.
Functionalization of Chitosan with Maleic Anhydride for Proton Exchange Membrane Muhammad Ridwan Septiawan; Dian Permana; Sitti Hadijah Sabarwati; La Ode Ahmad; La Ode Ahmad Nur Ramadhan
Indonesian Journal of Chemistry Vol 18, No 2 (2018)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.615 KB) | DOI: 10.22146/ijc.33141

Abstract

Chitosan was modified by maleic anhydride, and it was then functionalized using heterogeneous and blending method to obtain the membrane. The results of the reaction between chitosan with maleic anhydride were signed by the new peak appears around 1475 cm-1 which attributed to C=C bending of alkene. The new peak also appears at 1590 cm-1 which attributed to N-H bending of amide. Chitosan-maleic anhydride membranes show microstructure of chitosan membrane with high porous density and rigidity while chitosan-maleic anhydride membranes have clusters. In addition, the thermal tenacity of membranes reached 500 °C. Modified membrane by heterogeneous and blending method have higher water uptake, ion exchange capacity, and proton conductivity than chitosan membrane. Moreover, the blending method is much more effective than the heterogeneous method that can be exhibited from ion exchange capacity and proton conductivity values of 1.08–6.38 meq g-1 and 1x10-3–1x10-2 S cm-1, 0.92–2.27 meq g-1 and 1.53x10-4–3.04x10-3 S cm-1, respectively. The results imply that modification of chitosan membrane with the addition of maleic anhydride using heterogeneous and blending method can be applied to proton exchange membrane.
Microwave Assisted Extraction of Banana Stem Waste and its Antifungal Activity against Fusarium Oxysporum Mashuni Mashuni; muhammad Natsir; Sudirman Sudirman; Sitti Hadijah Sabarwati; Fitri Handayani Hamid; M. Jahiding
International Journal of Science Technology and Health Vol 1 No 1 (2023): Science Technology and Health
Publisher : LPPM ISTEK 'Aisyiyah Kendari

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Banana stem (BS) waste is obtained in large quantities in banana production. In this work, microwave extraction (MAE) from BS was used, and the solvent concentration parameters were 50%, 60%, 70%, 80%, 96% (v/v) ethanol, and 5% HCl with a sample weight of 10 g each. The influence of solvent, time, temperature, and solid: the liquid ratio was evaluated on the extraction results. Total phenolic content (TPC) and its functional performance against Fusarium oxysporum. The effect of a high ethanol concentration on BS extraction was observed because the higher ethanol solvent concentration resulted in higher extraction results and TPC. Optimal MAE conditions were determined at 200 watts for 20 minutes, with 80% ethanol showing better TPC results than other ethanol concentrations, namely 0.7171 mg g-1. The results of chemical content analysis using gas chromatography–mass spectrometry (GC-MS) of BS extract of 80% ethanol obtained phenolic compounds, carboxylic acids, aldehydes, esters, ketones, and furans. BS extract of 80% ethanol showed antifungal activity of Fusarium oxysporum with an apparent zone diameter of 9.7 mm (moderate category). It can be concluded that MAE is an efficient technique for releasing bioactive molecules from BS with TPC and antifungal applications in the agricultural industry.
Microwave-assisted extraction of Phenolic Compounds from Pineapple Peel against Staphylococcus aureus and Escherichia coli Mashuni Mashuni; Fitri Handayani Hamid; M Jahiding; Nur Cahya Islamiati MR; Sitti Hadijah Sabarwati; Andi Muhammad Naufal Khaeri
International Journal of Science Technology and Health Vol 2 No 1 (2024): Science, Technology and Health
Publisher : LPPM ISTEK 'Aisyiyah Kendari

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Pineapple production is mostly marketed as a processed product, resulting in large amounts of industrial waste consisting of pineapple peel, core and crown. This study evaluated organic solvents for microwave-assisted extraction (MAE) of phenolic compounds from pineapple peel and their total phenolic content and antibacterial activities. The application of microwave technology in phenolic extraction provides a fast extraction process and produces higher yields. In addition, organic solvent ethanol is considered an environmentally friendly solvent characterized by low toxicity and increased capacity to extract bioactive compounds. The solvent compositions are ethanol (80%), ethanol-HCl (80%-5%), and ethanol-NaOH (80%-5%). A higher phenolic compound was obtained using ethanol-HCl (80%-5%) of 2.68 mg eq GA/g DW. The results of the antibacterial activity test against Staphylococcus aureus was 19.00 mm and Escherichia coli was 19.31 mm. These results indicate that pineapple peel extract from ethanol-HCl solvent can be an effective antibacterial agent.
Isolation and Characterization of Flavonoid Derivative of Ethyl Acetate Extract from Bauhinia latisiliqua Stem Bark and Its Activity as Antioxidant Sitti Hadijah Sabarwati; Indriani Indriani; Nurhaeni Nurhaeni; Ahmad Ridhay; Pasjan Satrimafitrah; Jaya Hardi; Rismawaty Sikanna
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 10, No 2 (2023): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v10i2.30372

Abstract

Various bioactivities on natural compounds, the antioxidant potency can provide a broad spectrum in their utilization and development into medicinal raw material. One of the plants that have potency for antioxidant activity is the Kemerakan sapenit (Bauhinia latisilqua) plant. The study aimed to isolate, characterize, and determine the antioxidant activity of a compound isolated in the ethyl acetate extract of the stem bark of B. latisilqua. This research includes extraction, fractionation, purification, and elucidation of secondary metabolite structure as well as testing its antioxidant activity. Extraction was carried out by maceration technique, fractionation, and purification using liquid vacuum chromatography and gravitation column chromatography. The elucidation of the structural compound was determined by analysis of the UV, IR, and NMR spectra. The antioxidant test was performed using the DPPH method. Based on the analysis of the spectral data, the isolated compound was catechin, a derivative of flavan-3-ol. Antioxidant test on catechin compound showed a strong antioxidant with an IC50 value of 35.01 µg /mL (IC50 for positive control, ascorbic acid, of 42.94 µg /mL).
Co-Authors Ahmad Ridhay Andi Muhammad Naufal Khaeri Dian Permana Handayani Hamid, Fitri Indriani Indriani Jaya Hardi La Ode Ahmad La Ode Ahmad Nur Ramadhan M Jahiding M. Jahiding Mashuni Mashuni MAULIDIYAH MAULIDIYAH Muhammad Natsir Muhammad Nurdin Muhammad Ridwan Septiawan Nur Cahya Islamiati MR Nurhaeni Nurhaeni Pasjan Satrimafitrah Rismawaty Sikanna Sudirman Sudirman THAMRIN AZIS