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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sains dan Praktis
Teguh Widodo
UNIVERSITAS KATOLIK WIDYA MANDALA
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efek Gel Putih Telur terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus novergicus) Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Chintya Wandasari; Putu Mirah Risata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.513 KB) | DOI: 10.35814/jifi.v16i2.532

Abstract

Egg whites traditionally used for the treatment of burns. In this research, egg white was formulated as gel dosage form for easy to use and covered unpleasant odor. The aim of the study was to determined effectivity of egg white in gel dosage form against the healing of superficial partial thickness burns (second degree) on white rats (Rattus novergicus) Wistar strain with parameters were macrophages, fibroblasts, collagen deposit density and wound healing. Research subject were male white rats aged 3 months. Second degree burns on the back of rat with a diameter of 2 cm were made by using a hot coin with temperature 80 ° C for 20 seconds. 18 white rats divided into 3 groups of treatment that is negative control using 0.9% NaCl, positive control using Bioplacenton®, and 40% egg white gel as treatment. Based on the experimental results, white egg gel given topically decreased the number of macrophages and increase the number of fibroblasts, increase the density of collagen deposits and speed up wound healing on second degree burns. White egg gel had significantly difference with negative control of NaCl 0.9% and no significantly difference with Bioplasenton as positive control.
ANALGESIC ACTIVITY OF TRANSDERMAL PATCH ETHANOL EXTRACT PIPER NIGRUM L FRUCTUS WITH SOME ENHANCERS ON MICE Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Regiskha Hermandanie Surya; Alif Ekacahya Wahyudi; Dwi Damayanti Rasdianto
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4033

Abstract

Piper nigrum L fructus with active compound piperin had been known have an analgesic effect. Ethanol extract of Piper nigrum formulated to transdermal patch to reduce side effect of analgesic oral. The aim of this research was to know the effect of sodium lauryl sulphate, Tween 80, isopropyl myristate as enhancer of transdermal patch ethanolic extract of Piper nigrum L. Analgesic effect of Piper nigrum L. carried out by writhing method after acetic acid induction in mice. Parameters used were the number of writhing and macrophage from peritoneal fluid of mice at the end of this study. Based on this study, ethanol extract of Piper nigrum had an analgesic effect. The used of sodium lauryl sulphate 5%, Tween 80 5%, isopropyl myristate6% as enhancer increased the analgesic effect of Piper nigrum L.
Co-Authors Alif Ekacahya Wahyudi Chintya Wandasari Dwi Damayanti Rasdianto Iwan Sahrial Hamid Lucia Hendriati Lucia Hendriati Putu Mirah Risata Regiskha Hermandanie Surya