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SRI NINGSIH
BADAN PENGKAJIAN dan PENERAPAN TEKNOLOGI
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Analisis Urea-Kreatinin Tikus Putih pasca Pemberian Ekstrak Buah Mahkota Dewa dan Herba Pegagan WAHONO SUMARYONO; AGUNG ERU WIBOWO; SRI NINGSIH; KURNIA AGUSTINI; ROS SUMARNY; FITRIANIAR AMRI; HENDIG WINARNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The evaluation of toxicity of a mixed herbal extract containing mahkota dewa fruits (Phaleria macrocarpa Scheff. Boerl) and pegagan leaves (Centella asiatica L. Urban) on Wistar-strain rats had been carried out by the determination of the urea and creatinine content in urine and plasma after feeding. Oral doses of 100 mg, 500 mg, and 2500 mg of the mixed extract/kg body Weight were administered for 16 consecutive weeks to three groups of rats. Each treated group consisted of 15 males and 15 females, and the control group was represented by 10 males and 10 females. Samples of urine and plasma of the treated groups were taken at the time right before treatment (Week zero) and at Sm, 16th, 18th Week, while those of the control were taken at zero Week, 8th, and 16th Week, respectively. The result showed that theurea and creatinine contents among the treated and control groups were not signihcantly different. It could be concluded that oral administration ofthe mixed extract by a dose up to 2500 mg/kg body weight for 16 Weeks did not influence the urea and creatinine contents both in urine and plasma of the treated animals. Based on this result, it could be assumed that the use of the mixed extract is safe.
Efek Peningkat Respon Imun dari Ekstrak Etanol Pegagan (Centella Asiatica Urban) pada Tikus SRI NINGSIH; AGUNG ERU WIBOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This research had been conducted to verify the activity of ethanolic extract of Pegagan or Centella asiatica Urban (CA) from Indonesia as immune enhancing with the activity and capacity of peritoneal macrophages as parameters tested. Sprague Dawley male rats were divided into 4 groups of 5 rats each. Dose 1, dose 2 and dose 3 groups were treated with extract at the dose of 10, 20 and 40 mg/200 g b.w. p.o. for 15 consecutive days, respectively, and the control group was supplemented with carrier. One day after the last treatment, all rats were sacrificed after induced by Staphylococcus epidermidis (109 CFU per rat) i.p. and then the activity and capacity of peritoneal macrophages were examined with giemsa staining microscopically. The results showed that the immune-enhancing effect of the extract was a dose dependent manner. Based on statistical analysis (ANOVA, p < 0.05), the administration of CA extract at the dose of 40 mg/200 g bw demonstrated the highest result and differed from control group significantly (96% of macrophage activity and 61 bacteria of macrophage capacity). From these experiments could be concluded that the ethanolic extract of CA had potential to be developed as immune-enhancing agent. However, it was still needed to conduct further study for elaborating the mechanism of immune enhancer completely.
Co-Authors AGUNG ERU WIBOWO FITRIANIAR AMRI HENDIG WINARNO KURNIA AGUSTINI ROS SUMARNY Wahono Sumaryono