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AGUNG ERU WIBOWO
BADAN PENGKAJIAN DAN PENERAPAN TEKNOLOGI
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Karakterisasi Senyawa Utama Ekstrak Daun Aglaia elliptica Blume dan Uji Sitotoksisitas pada Sel Kanker Payudara AGUNG ERU WIBOWO; FRANS SUYATNA; WAHONO SUMARYONO; NURYATI CHAERANI SIREGAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

AIglaia elliptica Blume is one of plant species from the genus of Aglaia, belonging to the family of Meliaceae. This group of plants is known to have powerful cytotoxic effect. This research was conducted to isolate and characterize major compound(s) from ethanol extract of Aglaia elliptical leaf that can be used as marker compound(s) for extract standardization. Approximately 1000 g of Aglaia elliptica Blume leaf dry powder was extracted with ethanol using maceration method. Ethanol extract was then fractionated using n-hexane and ethyl acetate. Six sub-fractions were obtained from the Vacuum Liquid Chromatography (VLC) process of ethyl acetate fraction. Based on the HPLC profile and separation process using column chromatography and preparative HPLC, a major compound (with the weight of 36.80 mg) was successfully isolated from sub-fraction H. Analyses on its UV absorbance pattern, mass spectra, and proton NMR identified the isolated compound as a compound with molecular weight of 300, C18H24N2O2, known as odorin. Cytotoxicity test showed that odorin has inhibition effect against MCP-7 cell line with IC5O of 153.32 ppm.
Aktivitas Antikanker Ekstrak Daun Aglaia elliptica Blume pada Tikus Betina yang Diinduksi 7,12 dimethylbenz[a] antracene AGUNG ERU WIBOWO; FRANS D. SUYATNA; WAHONO SUMARYONO; NURYATI CHAIRANI SIREGAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Aglaia elliptica Blume is one of plants that contain cyclopenta[b] tetrahydrobenzofuran compound with strong cytotoxic effect on various types of cancer cell lines. The objective of this study is to determine the inhibition effect of ethanol extract of A. elliptica leaves on mammary tumor growth in Sprague Dawley female rats induced by 7.12-dimethylbenz[a]anthracene (DMBA). The study was conducted with induction of 50 female rats with DMBA at a dose of 20 mg/kg orally for 11 times. Twenty-five female rats suffering mammary tumor were divided into 5 groups. Three groups were treated with ethanol extract at a dose of 50, 100 and 200 mg/200 g BW one day after the tumor appeared for 30 days, 1 group as a negative control and 1 group as a positive control (doxorubicin 2 μg/200 g BW). The results showed that the induction of DMBA resulting tumor incidence by 74% and tumor multiplicity of 2 nodules/rat. Histopathological analysis of mammary tumor, suggested that the carcinogenesis has reached the level of ductal carcinoma invasive (DCIV). The administration of ethanol extract at dose of 50, 100 and 200 mg/200 g BW suppressed the growth of mammary tumor volume by 30 %, 33.5% and 37.4%, respectively.
Analisis Urea-Kreatinin Tikus Putih pasca Pemberian Ekstrak Buah Mahkota Dewa dan Herba Pegagan WAHONO SUMARYONO; AGUNG ERU WIBOWO; SRI NINGSIH; KURNIA AGUSTINI; ROS SUMARNY; FITRIANIAR AMRI; HENDIG WINARNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The evaluation of toxicity of a mixed herbal extract containing mahkota dewa fruits (Phaleria macrocarpa Scheff. Boerl) and pegagan leaves (Centella asiatica L. Urban) on Wistar-strain rats had been carried out by the determination of the urea and creatinine content in urine and plasma after feeding. Oral doses of 100 mg, 500 mg, and 2500 mg of the mixed extract/kg body Weight were administered for 16 consecutive weeks to three groups of rats. Each treated group consisted of 15 males and 15 females, and the control group was represented by 10 males and 10 females. Samples of urine and plasma of the treated groups were taken at the time right before treatment (Week zero) and at Sm, 16th, 18th Week, while those of the control were taken at zero Week, 8th, and 16th Week, respectively. The result showed that theurea and creatinine contents among the treated and control groups were not signihcantly different. It could be concluded that oral administration ofthe mixed extract by a dose up to 2500 mg/kg body weight for 16 Weeks did not influence the urea and creatinine contents both in urine and plasma of the treated animals. Based on this result, it could be assumed that the use of the mixed extract is safe.
Efek Peningkat Respon Imun dari Ekstrak Etanol Pegagan (Centella Asiatica Urban) pada Tikus SRI NINGSIH; AGUNG ERU WIBOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This research had been conducted to verify the activity of ethanolic extract of Pegagan or Centella asiatica Urban (CA) from Indonesia as immune enhancing with the activity and capacity of peritoneal macrophages as parameters tested. Sprague Dawley male rats were divided into 4 groups of 5 rats each. Dose 1, dose 2 and dose 3 groups were treated with extract at the dose of 10, 20 and 40 mg/200 g b.w. p.o. for 15 consecutive days, respectively, and the control group was supplemented with carrier. One day after the last treatment, all rats were sacrificed after induced by Staphylococcus epidermidis (109 CFU per rat) i.p. and then the activity and capacity of peritoneal macrophages were examined with giemsa staining microscopically. The results showed that the immune-enhancing effect of the extract was a dose dependent manner. Based on statistical analysis (ANOVA, p < 0.05), the administration of CA extract at the dose of 40 mg/200 g bw demonstrated the highest result and differed from control group significantly (96% of macrophage activity and 61 bacteria of macrophage capacity). From these experiments could be concluded that the ethanolic extract of CA had potential to be developed as immune-enhancing agent. However, it was still needed to conduct further study for elaborating the mechanism of immune enhancer completely.
Co-Authors FITRIANIAR AMRI FRANS D. SUYATNA FRANS SUYATNA HENDIG WINARNO KURNIA AGUSTINI NURYATI CHAERANI SIREGAR NURYATI CHAIRANI SIREGAR ROS SUMARNY SRI NINGSIH Wahono Sumaryono