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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal EduHealth
Erfan Tri Prasongko
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Veterinary

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Aktivitas Penghambat Reseptor-β Adrenergik Ekstrak Air Kulit Batang Taya (Nauclea subdita (Korth) Steud) Pada Tikus Wistar Jantan Erfan Tri Prasongko; Finna Setiawan; Christina Avanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.157 KB) | DOI: 10.35814/jifi.v18i1.792

Abstract

Beta-adrenergic receptor blockers (β-blockers) are an appropriate treatment for patients with hypertension who have concomitant ischemic hearat disease, heart failure, obstructive cardiomyopathy, aortic dissection or certain cardiac arrhythmias. Taya (Nauclea subdita (Korth) Steud) is a local natural potential of Kalimantan that is empirically believed to have antihypertensive activities. This study aims to determine the activity of β-adrenergic receptor inhibitors of stem bark water extract in male wistar rats. Tests were carried out on male Wistar rats by the Non Invasive Blood Pressure method using the CODA® tool. Test animals were divided into 5 groups: normal group, induction group (Epinephrine 1.2 µg/kgBW), 100 mg/kgBW extract group, 200 mg/kgBW extract group, and 4,5 mg/kgBW atenolol group. The induction group showed an increase in systolic blood pressure, diastolic blood pressure, and heart rate that were significantly different from the normal group, the 100 mg/kgBW extract group, the 200 mg/kgBW extract extract group, and the 4.5 mg/kgBW atenolol group (p<0,05). The 100 mg/kgBW extract group was not significantly different from systolic blood pressure, diastolic blood pressure, and heart rate with the normal group, the 200 mg/kgBW extract group, and the 4.5 mg/kgBW atenolol group (p> 0.05). The results of this study showed that taya bark water extracts 100 mg/kgbw had inhibitory activity of β-adrenergic receptors in male wistar rats.
Formulation And Physical Quality Test Of Lip Balm Rosella Flower Extract (Hibiscus Sabdariffa L.) As A Lip Moisturizer And Natural Color Lailiyah, Munifatul; Sony Andika Saputra; Erfan Tri Prasongko; Ida Kristianingsih
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

Background: Lip balm, also known as lip balm, functions to moisturize the lips so they don't get dry and chapped by sunlight, pollution, temperature, and weather. One natural ingredient that functions as a lip moisturizer is the rosella flower (Hibiscus sabdariffa L.), which has many cosmetic benefits such as vitamin C, antioxidants, and anthocyanins, which can moisturize the lips and give them a natural color. Objective: This research is to determine how the concentration of rosella flower extract (Hibiscus sabdariffa L.) impacts the physical quality test and moisture test of rosella flower extract lip balm preparations with concentrations of 0%, 6%, 8%, and 10%. Results: Physical quality tests showed that the formulation was stable. The results of organoleptic, homogeneity, pH, irritation, stability, and moisture tests did not show significant differences in varying extract concentrations. In the moisture test, the percentage of moisture test for formulation 0 was 15.5%, formulation I was 22.4%, formulation II was 28.7%, and formulation III was 35.4%. Conclusion: The results of the physical quality test were not influenced by differences in the concentration of rosella flowers in each formulation. Formulation III has a concentration of 35.4%, which is the most moist.
Co-Authors Christina Avanti Finna Setiawan Ida Kristianingsih Lailiyah, Munifatul Sony Andika Saputra