Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kefarmasian Indonesia
JOSHITA DJAJADISASTRA
UNIVERSITAS INDONESIA
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
(Formulation and In Vitro Penetration Evaluation of Transfersome Gel Preparation Contains Caffeine as an Anticellulite) RINI SUGIYATI; ISKANDARSYAH ISKANDARSYAH; JOSHITA DJAJADISASTRA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2311.318 KB)

Abstract

Transfersom merupakan vesikel nano yang bersifat deformabel sehingga mampu berpenetrasi sampai ke lapisan kulit yang lebih dalam. Kofein memiliki khasiat sebagai antiselulit. Penelitian ini bertujuan untuk formulasi dan mengetahui kemampuan daya penetrasi gel transfersom kofein dibandingkan dengan gel kofein tanpa transfersom. Empat formula transfersom dibuat dengan konsentrasi kofein yang berbeda (1; 2; 3; 5%) menggunakan metode hidrasi lapis tipis. Suspensi formula 4 dengan ukuran partikel 202,35 nm, indeks polidipersitas 0,1090 dan efisiensi jerapan 58,91% dipilih untuk sediaan gel. Uji penetrasi dilakukan secara in vitro dengan sel difusi Franz. Hasil yang diperoleh adalah jumlah kumulatif kofein yang terpenetrasi dari gel transfersom lebih tinggi yaitu 1218,34+358,71 μg cm-2, persentase jumlah kumulatif 8,53+2,55% dan fluks 360,91+86,50 μg cm-2 jam-1. Sementara gel kofein tanpa transfersom memiliki jumlah kumulatif terpenetrasi 369,29+231,57 μg cm-2, persentase jumlah kumulatif 2,61+1,37% dan fluks 70,96+73,39 μg cm-2 jam-1. Dapat disimpulkan bahwa gel transfersom kofein menghasilkan daya penetrasi yang lebih baik dibandingkan gel kofein tanpa transfersom.
Pembuatan, Karakterisasi dan Uji In Vitro Nanopartikel Emas Berbasis Konjugat Gom Arab-Vinkristin Ratih Dyah Pertiwi; Joshita Djajadisastra; ABDUL MUTALIB; Anung Pujiyanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.237 KB) | DOI: 10.35814/jifi.v16i1.486

Abstract

Gold nanoparticles (AuNP) are potentially developed as nanomedicine because AuNP is easily synthesized, functionalized, and biocompatible. With gum arabic as a stabilizer, vincristine was conjugated with gold nanoparticles. As a reducing agent, it used 0.02 M Natrium Boro Hidrat (NaBH4) solution. Gold nanoparticles (AuNP) coated with conjugated gum Arabic (GA) and vincristine (VCR) were successfully synthesized and characterized. The conjugation of GA-VCR and AuNP displayed a narrow hydrodynamic particle size distribution with average size < 100 nm by TEM and PSA (particle size analyzer). We investigated the cytotoxic activity of conjugated vincristine-gum arabic-gold nanoparticle by tetrazolium salt assay (MTT) using cancer cell line CCR-CEM. Cytotoxic activity of conjugated VCR-GA-AuNP before and after purification by Size Exclusion Chromatography (SEC), against leukemia cell line CCRF-CEM, was described by IC50 value. All formulation had a cytotoxic of activity with IC50 <20 μg/ml. The IC50 of samples against CCRF cell line were 1,026 μg/mL and 2,607 ug/mL, respectively.
Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol Untia Kartika Sari Ramadhani; Joshita Djajadisastra; Iskandarsyah Iskandarsyah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (673.545 KB) | DOI: 10.35814/jifi.v15i2.501

Abstract

Carvedilol is β-blocker antihypertensive drug with low oral bioavaibility and short half time which causes the frequency of oral drug used more often or the oral dose might be increased. Transdermal patch with the matrix system can deliver drug through skin in controlled within specifi c time period and hopefully it can improve carvedilol bioavaibility and convenience for patients.The aim of research was to fi nd out the effect of polymer and penetration enhancer toward penetration characteristic of carvedilol transdermal patch matrix seen from kinetics release data and penetration data of carvedilol. The polymer ratio of Polyvinyl Alcohol (PVA) : Ethyl cellulose (ES) polymers and Sorbitan Monolaurate (SM) as penetration enhancer concentrations used were F1 (1:1) / 8%, F2 (1: 1) /10%, F3 (2:1) /8%, F4 (2:1)/10%. Formula F1 did not pass in the organoleptictes so next test only carried out for formula F2, F3 and F4. The in vitro release of carvedilol showed formula F2, F3 and F4 lasted for 24 hours and the released kinetics of carvedilol followed the order of 0 and Higuchi. Carvedilol % cumulative from penetration test in vitro showed for F2, F3 and F4 formulas respectively were 15,384%, 16,495% and 18,287%.
Formulasi dan Uji Penetrasi In-Vitro Sediaan Topikal Nanoemulsi Genistein dari Tanaman Sophora japonica Linn SANDRA AULIA MARDIKASARI; MAHDI JUFRI; JOSHITA DJAJADISASTRA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1111.271 KB)

Abstract

Tujuan penelitian ini adalah memformulasi genistein menjadi nanoemulsi dan membandingkan penetrasinya dengan produk Gen90 Nano. Dibuat sebanyak 3 jenis formula dengan perbandingan komposisi antara genistein dan lesitin soya menggunakan metode emulsifikasi spontan. Hasilnya formula 3 merupakan formula terpilih yang menghasilkan nanoemulsi berukuran 191,7 nm dengan indeks polidispersitas 0,171 dan potensial zeta -47,5 mV. Uji penetrasi secara in-vitro menggunakan sel difusi Franz menunjukkan jumlah kumulatif terpenetrasi dari nanoemulsi genistein sebesar 18,29 ± 0,16 (μg/cm2) dibandingkan dengan produk Gen90 Nano sebesar 24,60 ± 0,57 (μg/cm2). Perbandingan ini dilakukan untuk melihat kualitas penetrasi dari formula nanoemulsi genistein, karena Gen90 Nano merupakan produk paten dari kompleks inklusi hidroksipropil siklodekstrin-genistein
Co-Authors . Iskandarsyah ABDUL MUTALIB Anung Pujiyanto Mahdi Jufri Pertiwi, Ratih Dyah RINI SUGIYATI SANDRA AULIA MARDIKASARI Untia Kartika Sari Ramadhani