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Radical Scavenging Activity and Quercetin Content of Muntingia calabura,L Leave extracted by Various Ethanol Concentration Pertiwi, Ratih Dyah
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

ABSTRACTÂ Muntingia calaburais broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract ofÂ Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colourimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated thatMuntingia calaburaleaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solventÂ Keywords: DPPH,Â Muntingia calabura, phenolic total, antiradical activity, TLC densitometryÂ

Formulasi dan Evaluasi sediaan Balsam Bibir Menggunakan ekstrak Bunga Kembang Sepatu (Hibiscus rose sinensis L ) sebagai Pewarna Alami Pertiwi, Ratih Dyah; Pertiwi, Ratih Dyah
Archives Pharmacia Vol 2, No 2 (2020): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Ekstrak bunga Kembang Sepatu (Hibiscus rosa sinensisÂ L) memiliki kandungan senyawa antosianin yang dapat dimanfaatkan sebagai pewarna alami.Â Salah satu pewarna yang bisa dimanfaatkan adalah pewarna sediaan balsam bibir.Â Pembuatan ekstrak bunga kembang sepatu menggunakan metode maserasi dengan menggunakanÂ Â pelarut etanol 96%. Formulasi sediaan balsam bibirÂ dibuat denganÂ penambahanÂ pewarna alami dengan menggunakanÂ ekstrak bunga kembang sepatu dengan konsentrasi yang berbeda.Â EvaluasiÂ sediaan meliputi uji organoleptis, homogenitas, titik lebur , uji stabilitas selama empat minggu penyimpanan pada suhu kamardan uji oles. Hasil formulasi sediaan balsam bibir menggunakan ekstrak bunga kembang sepatu menunjukkan bahwa sediaan yang dibuat homogen, titik lebur antara 51,6 â€“ 53,6ËšC, pH 5, dan stabil dalam penyimpanan suhu kamar selama empat minggu.Balsam bibir yang diformulasikan dengan ekstrak bunga kembang sepatu diharapkan dapat digunakan sebagai kosmetik pilihan yang ramah lingkungan dan memiliki efek samping minimal dibandingkan dengan balsam bibir yang beredar di pasaran saat ini.

Formulasi dan Evaluasi sediaan Balsam Bibir Menggunakan ekstrak Bunga Kembang Sepatu (Hibiscus rose sinensis L ) sebagai Pewarna Alami Pertiwi, Ratih Dyah; Pertiwi, Ratih Dyah
Archives Pharmacia Vol 2, No 2 (2020): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Ekstrak bunga Kembang Sepatu (Hibiscus rosa sinensisÂ L) memiliki kandungan senyawa antosianin yang dapat dimanfaatkan sebagai pewarna alami.Â Salah satu pewarna yang bisa dimanfaatkan adalah pewarna sediaan balsam bibir.Â Pembuatan ekstrak bunga kembang sepatu menggunakan metode maserasi dengan menggunakanÂ Â pelarut etanol 96%. Formulasi sediaan balsam bibirÂ dibuat denganÂ penambahanÂ pewarna alami dengan menggunakanÂ ekstrak bunga kembang sepatu dengan konsentrasi yang berbeda.Â EvaluasiÂ sediaan meliputi uji organoleptis, homogenitas, titik lebur , uji stabilitas selama empat minggu penyimpanan pada suhu kamardan uji oles. Hasil formulasi sediaan balsam bibir menggunakan ekstrak bunga kembang sepatu menunjukkan bahwa sediaan yang dibuat homogen, titik lebur antara 51,6 â€“ 53,6ËšC, pH 5, dan stabil dalam penyimpanan suhu kamar selama empat minggu.Balsam bibir yang diformulasikan dengan ekstrak bunga kembang sepatu diharapkan dapat digunakan sebagai kosmetik pilihan yang ramah lingkungan dan memiliki efek samping minimal dibandingkan dengan balsam bibir yang beredar di pasaran saat ini.

Efektivitas Repelan Losion Minyak Atsiri Daun Zodia (Evodia Suaveolens) Terhadap Nyamuk Aedes aegypti Linnaeus Aprilita Rina Yanti Eff; Ratih Dyah Lestari Ayu Pertiwi; Tyas Putri Utami
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25868

Zodia (Evodia suaveolens) merupakan salah satu tanaman yang mempunyai aroma yang tajam pada bagian bunga dan daunnya dan dipercaya dapat mengusir nyamuk. Daun Zodia mengandung minyak atsiri evodiamine dan rutaecarpine yang tidak disukai oleh nyamuk. Tujuan penelitian ini untuk menilai efektivitas repelen losion mengandung minyak atsiri daun Zodia pada konsentrasi 1%, 1.5% dan 2%. Metodenya dengan iosion yang dibuat dengan mencampurkan minyak atsiri hasil isolasi dari daun Zodia pada konsentrasi 1%, 1,5% dan 2% ke dalam formulasi sediaan losion yang terdiri dari asam stearat, setil alkohol, parafin cair, dimetikon, vaselin kuning, trietanolamin dan asam sitrat. Pengujian dilakukan dengan cara memasukkan lengan secara bergantian antara lengan yang diberi perlakuan (losion) dan kontrol (tidak diberi perlakuan) ke dalam kurungan nyamuk yang berisi 25 ekor nyamuk Aedes aegypti, kemudian dihitung jumlah nyamuk yang hinggap setiap jam selama enam jam. Efikasi repelan ditentukan berdasarkan daya proteksi yang dihitung dengan rumus : Daya proteksi (DP) =( K - R)/K x 100%; K = banyaknya hinggapan pada lengan control; R = banyaknya hinggapan pada lengan pelakuan. Hasil penelitian losion mengandung minyak atsiri daun zodia pada konsentrasi 1%, 1,5% dan 2% berpotensi sebagai pengusir nyamuk (repelan) Aedes aegypti dengan daya proteksi rata-rata selama enam jam berturut-turut adalah sebesar 74,50%, 75,39% dan 82,45%. Tidak terdapat perbedaan yang signifikan pada daya proteksi antara ke 3 konsentrasi losion (p>0.05) Losion mengandung minyak atsiri daun zodiac pada konsetrasi 1%, 1,5% dan 2% memiliki efektivitas sebagai repelen. Daya proteksi tertinggi ditunjukkan oleh losion yang mengandung minyak atsiri daun Zodia 2% yaitu sebesar 82.45%.

Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.

Pembuatan, Karakterisasi dan Uji In Vitro Nanopartikel Emas Berbasis Konjugat Gom Arab-Vinkristin Ratih Dyah Pertiwi; Joshita Djajadisastra; ABDUL MUTALIB; Anung Pujiyanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Gold nanoparticles (AuNP) are potentially developed as nanomedicine because AuNP is easily synthesized, functionalized, and biocompatible. With gum arabic as a stabilizer, vincristine was conjugated with gold nanoparticles. As a reducing agent, it used 0.02 M Natrium Boro Hidrat (NaBH4) solution. Gold nanoparticles (AuNP) coated with conjugated gum Arabic (GA) and vincristine (VCR) were successfully synthesized and characterized. The conjugation of GA-VCR and AuNP displayed a narrow hydrodynamic particle size distribution with average size < 100 nm by TEM and PSA (particle size analyzer). We investigated the cytotoxic activity of conjugated vincristine-gum arabic-gold nanoparticle by tetrazolium salt assay (MTT) using cancer cell line CCR-CEM. Cytotoxic activity of conjugated VCR-GA-AuNP before and after purification by Size Exclusion Chromatography (SEC), against leukemia cell line CCRF-CEM, was described by IC50 value. All formulation had a cytotoxic of activity with IC50 <20 μg/ml. The IC50 of samples against CCRF cell line were 1,026 μg/mL and 2,607 ug/mL, respectively.

THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR Aprilita Rina Yanti Eff; Erika Noviyanti; Ratih Dyah Pertiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4874

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors. This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.

Promoting a healthy and smart living community in rational use of medicine at RW 05 Kebun Jeruk, West Jakarta Ratih Dyah Pertiwi; Anisa Uswatun Khasanah; Yolanda Yolanda; Novi Andriani; Teti Maharani; Tasya Nurmila Devi; Dwi Evi Indriani; Wahyu Darmawan; Dewi Puji Astuti
Community Empowerment Vol 7 No 9 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.6971

Omicron is a large family of corona viruses that can cause illness ranging from mild to severe symptoms. This severe symptom of Covid-19 will be worrying if it afflicts erderly and toddlers. Lack of knowledge about proper medication use, health precautions, and the importance of handwashing are some of the issues that exist in the community of RW 05 Kebon Jeruk. Based on the survey, it is necessary to carry out community service which aims to determine public knowledge in responding to the Covid-19 pandemic. In addition, it also monitors public knowledge about the rational use of drugs and children's knowledge about the importance of keep healthy. The methods used in this program are door-to-door counseling and education, question and answer and discussion, coloring competition and socialization of little pharmacists, posyandu, morning exercise, delivery of family medicinal plants, and distribution of new normal kit packages. According to questionnaires, education, and other activities, the public's understanding of rational medicine, children's understanding of the importance of keep healthy, and the public's understanding of how to respond to the pandemic period have all increased.

PELATIHAN PEMBUATAN DAN PEMANFAATAN ECO-ENZYME DARI SAMPAH ORGANIK (BUAH DAN SAYURAN) DI RW. 12 KELURAHAN DURI KOSAMBI CENGKARENG JAKARTA BARAT Hermanus Ehe Hurit; Inherni Marti Abna; Ratih Dyah Pertiwi; Alvianto Gautama; Winda Amelia Sari; Dimas Inggar Pramudya; Alno Kaldicson; Miftahul Hassanahl
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 9: February 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v2i9.4785

Penanganan sampah di kota-kota besar khususnya di DKI Jakarta selalu menjadi masalah utama dari segi kesehatan lingkungan, karena jumlah penduduk yang sangat padat yang berkontribusi besar dalam menghasilkan sampah terutama dari rumah tangga. DKI Jakarta setiap harinya memproduksi 7.000 ton sampah, tentunya memberikan dampak yang buruk bagi kesehatan masyarakat jika tidak dikelola dengan baik. Dampaknya bisa menyebabkan polusi udara, tanah dan air, serta penularan penyakit dengan lalat sebagai vektornya. Tempat Pembuangan Akhir (TPA) tentunya menjadi penuh jika sebagian sampah tersebut tidak dikelola dan dimanfatkan secara maksimal. Dalam skala kecil khususnya rumah tangga, jika dibiasakan untuk memilah sampah dan mengolah serta memanfaatkan untuk kebutuhan rumah tangga, tentunya akan berdampak langsung dalam mereduksi pembuangan sampah ke TPA dan memperbaiki kualitas dari udara, tanah dan air yang tentunya berdampak sangat bagi kesehatan manusia. Metode yang digunakan adalah melakukan sosialisasi dan edukasi serta pelatihan secara langsung kepada masyarakat terkait pemilahan sampah dan pengolahannya menjadi Eco-enzyme. Hasil yang didapatkan bahwa peningkatan perilaku dalam pemilahan sampah dari 0% menjadi 100%, pengetahuan tentang dampak sampah terhadap kesehatan dan lingkungan dari 76,92% menjadi 100%, kesediaan responden untuk mengikuti ceramah dan pelatihan terkait eco-enzyme dari 15,31% menjadi 100%, pengetahuan tentang eco-enzyme dari 38,36% menjadi 100%, dari 23,81% menjadi 100%, pengetahuan tentang bahan dasar pembuatan eco-enzyme dari 0% menjadi 100% dan kesediaan responden untuk mengikuti pelatihan pengolahan hasil eco-enzyme menjadi produk yang bermanfaat dari 15,31% menjadi 76,19%. Kegiatan pengabdian masyarakat yang dilakukan oleh Program Studi Farmasi Universitas Esa Unggul sangat bermanfaat bagi masyarakat dalam dalam meningkatan kualitas kesehatan dan lingkungan dan bermanfaat secara ekonomi.

Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.

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