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All Journal Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Mandala of Health : A Scientific Journal

Muhammad Ilyas

Bagian Radiologi, Fakultas Kedokteran, Universitas Hasanuddin, Makassar

Author-ID : 3687732

Dentistry Health Professions Medicine & Pharmacology Public Health

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Karakteristik morfologi penderita karsinoma payudara dengan reseptor estrogen positif dan negatif berdasarkan duplex ultrasound Wenda Anastasia; Mirna Muis; Muhammad Ilyas; Andi Alfian Zainuddin; Sri Asriyani; Ni Ketut Sungowati
Majalah Kedokteran Andalas Vol 42, No 3 (2019): Published in September 2019
Publisher : Faculty of Medicine, Universitas Andalas

Tujuan: Penelitian ini bertujuan mengetahui karakteristik morfologi dan vaskularisasi karsinoma payudara dengan reseptor estrogen positif dan negatif berdasarkan ultrasonografi grayscale dan doppler. Metode: Penelitian ini dilakukan di Bagian Radiologi RS Wahidin Sudirohusodo dan RS Pendidikan Universitas Hasanuddin Makassar pada Oktober 2018 sampai dengan Februari 2019. Penelitian ini merupakan jenis penelitian deskriptif dengan metode kajian potong lintang. Analisis data menggunakan statistik melalui uji diagnostik chi-square dan Mann-Whitney. Sampel penelitian sebanyak 40 orang dengan karsinoma payudara. Hasil: Hasil penelitian menunjukkan terdapat perbedaan rata-rata yang signifikan (p<0,05) pada morfologi akustik posterior antara reseptor estrogen positif dan negatif karena akustik posterior shadowing dominan pada reseptor estrogen positif, sedangkan akustik posterior enhancement dominan pada reseptor estrogen negatif. Morfologi akustik posterior ini hanya dapat dinilai dengan menggunakan ultrasonografi grayscale. Simpulan: Terdapat perbedaan yang signifikan pada morfologi akustik posterior dimana akustik posterior shadowing dominan pada reseptor estrogen positif, dan akustik posterior enhancement dominan pada reseptor estrogen negatif.

Kesesuaian ukuran kanalis spinalis lumbal berdasarkan Ultrasonografi dengan MR-Myelografi pada penderita nyeri punggung bawah Emilya Jufianti; Muhammad Ilyas; Bachtiar Murtala; Andi Alfian Zainuddin; Cahyono Kaelan; Mirna Muis
Majalah Kedokteran Andalas Vol 42, No 3 (2019): Published in September 2019
Publisher : Faculty of Medicine, Universitas Andalas

Tujuan: Penelitian ini bertujuan menilai kesesuaian ukuran kanalis spinalis lumbal berdasarkan ultrasonografi dengan MR myelografi lumbosakral pada penderita Nyeri Punggung Bawah (NPB). Metode: Penelitian ini menggunakan desain observasi cross-sectional dan dilakukan di Bagian Radiologi RSUP Dr. Wahidin Sudirohusodo Makassar dari November 2018 - Februari 2019. Sampel penelitian sebanyak 54 dengan 22 sampel eksklusi dan 32 sampel inklusi. Dari 32 sampel pada level L3-L4 sebanyak 27 sampel normal dan 5 sampel stenosis, level L4-L5 sebanyak 21 sampel normal dan 11 sampel stenosis, level L5-S1 sebanyak 28 sampel normal dan 4 sampel stenosis. Data dianalisis dengan analisis statistik melalui uji korelasi Person. Hasil: Hasil penelitian menunjukkan terdapat kesesuaian ukuran kanalis spinalis lumbal berdasarkan ultrasonografi dengan MR myelografi lumbosakral pada penderita NPB pada level L3-L4 dengan nilai p=0,001 (<0,05) dan memiliki kekuatan hubungan kuat dengan nilai r=0,985. Data juga menunjukkan bahwa terdapat kesesuaian antara hasil MR myelografi dengan Ultrasonografi lumbosakral pada level L4-L5 dengan nilai p=0,001 (<0,05) dan memiliki kekuatan hubungan kuat dengan nilai r=0,987. Data juga menunjukkan bahwa terdapat kesesuaian antara hasil MR myelografi dengan Ultrasonografi lumbosakral pada level L5-S1 dengan nilai p=0,001 (<0,05) dan memiliki kekuatan hubungan kuat dengan nilai r=0,973. Simpulan: Terdapat kesesuaian ukuran kanalis spinalis lumbal berdasarkan ultrasonografi dengan MR myelografi lumbosakral pada penderita NPB.

Surfactant Protein D Level in Cement Workers Nurlinah Jalil; Sita Laksmi Andarini; Muhammad Ilyas; Feni Fitriani Taufik
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.280

Background: Pneumoconiosis occurs almost all over the world. Pneumoconiosis is a threat to cement workers. Serological abnormalities are observed in pneumoconiosis. Surfactant protein D (SP-D) levels were increased in workers exposed to silica. SP-D may be useful as a biomarker for the early diagnosis of pneumoconiosis but it has not been studied in Indonesia.Methods: This cross-sectional study was conducted with consecutive sampling technique. The number of subjects was 61 people, consisting of 44 workers exposed to cement and 17 controls from September 2017 to March 2018. Serum level of SP-D was measured using ELISA method. Cement exposed workers were workers in the production area and workers in quarry areas.Results: All of the study subjects were male (100%) with mean age of 42.5 years old. The youngest and oldest subjects were 21 and 55 years old, respectively. Majority of the subjects was in the normal weight group (47.7%). Based on smoking history, there were 26 subjects (59.1%) had never smoked, 12 subjects (27.3%) as smokers, and 6 subjects (13.6%) as former smokers. Duration of exposure <10 years was found in 9 subjects (20.5%) while exposure ≥10 years was observed in 35 subjects (79.5%). Good category of using self-respiratory safety instrument was observed in 5 subjects (11.4%), moderate category in 36 subjects (81.8%) and poor category in 3 subjects (6.8%). Mean serum SP-D levels in the exposed group was 111.027 ng/ml and in control group was 67.648 ng/ml. Serum SP-D levels were significantly higher in the exposed group than control group (P=0.014).Conclusion: Serum SP-D levels was statistically higher in the exposed group than in control group.

Surfactant Protein A Serum Level in Cement Worker Gunawan Gunawan; Sita Laksmi Andarini; Muhammad Ilyas; Arif Santoso; Ahmad Hudoyo; Irawaty Djaharudin; Harun Iskandar; Nur Ahmad Tabri
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.363

Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia.Methods: The design of this study was observational with cross-sectional. A sampling of cement-exposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017 – March 2018 and 17 healthy people as control. The serum level of SP-A was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area.Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SP-A level in the study subject group or the exposed group was 6.02 ng/ml, and the mean SP-A level in the control group was 4.50 ng/ml. The difference in SP-A levels between the exposed and control groups was different but not significant, with value of P=0.084.Conclusion: SP-A levels in the exposed and control groups were different but not statistically significant.

NILAI DIAGNOSTIK ULTRASONOGRAFI DOPPLER DALAM MENENTUKAN KEGANASAN TUMOR OVARIUM DIBANDINGKAN HASIL HISTOPATOLOGI Nurhayati Nurhayati; Mirna Muis; Muhammad Ilyas
Mandala Of Health Vol 12 No 2 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Kanker ovarium merupakan keganasan organ viseral dan paling mematikan serta dianggap silent killer. Kanker ini umumnya baru menimbulkan keluhan bila telah menyebar ke rongga peritoneum atau organ visera lainnya. Pada tingkat ini penyakit telah mencapai stadium lanjut sehingga tindakan pembedahan dan terapi adjuvan seringkali tidak menolong. Kurangnya gejala awal maupun sensitifitas skrining serta teknik deteksi dini merupakan alasan keterlambatan dalam diagnosis. Pengenalan dini kanker ovarium stadium awal berdasarkan pemeriksaan fisik saja tidak cukup sehingga perlu dilengkapi pemeriksaan radiologi seperti Ultrasonografi (USG), Computted Tomography Scan, Magnetic Resonance Imaging (MRI). USG Doppler adalah teknik pencitraan yang sering digunakan, noninvasif, biaya relatif murah, dan ditoleransi dengan baik. Penggunaan USG Doppler dimungkinkan untuk menilai vaskularisasi tumor dan nilai resistive index. Penelitian ini bertujuan mengetahui nilai diagnostik USG Doppler dalam menentukan keganasan tumor ovarium dibandingkan hasil histopatologi. Penelitian ini dilaksanakan di Bagian Radiologi RS. Dr. Wahidin Sudirohusodo dan RS. Universitas Hasanuddin, Makassar dimulai pada bulan Juni-Agustus 2018. Desain penelitian menggunakan uji diagnostik. Sebanyak 55 sampel dengan klinis tumor ovarium umur 14-67 tahun dilakukan pemeriksaan USG Doppler untuk menilai distribusi vaskuler, jumlah vaskuler, dan nilai resistive index, dilanjutkan sistem kategori untuk menentukan sifat tumor jinak atau ganas. Ganas, jika terdapat ≥ 2 kriteria Doppler ganas, dan jinak jika terdapat < 2 kriteria Doppler ganas. Hasil diagnosis USG Doppler dibandingkan dengan hasil histopatologi. Data dianalisis secara statistik berdasarkan uji diagnostik. Hasil penelitian menunjukkan USG Doppler memiliki nilai diagnostik yang cukup tinggi dalam menilai keganasan tumor ovarium dengan sensitivitas 94,7%, spesifisitas 70,6%, nilai prediksi posistif 87,8%, nilai prediksi negatif 85,7% dan akurasi 87,2%. Ovarian cancer is a visceral organ malignancy that is lethal and is considered as “silent killer”. This cancer typically cause complaint if it has spread to peritoneum cavity or other visceral organ where the disease reached late stage, thus, surgical or adjuvant therapy is not beneficial anymore. The lack of early manifestation, screening sensitivity and difficulty in early detection technique are reasons for delay diagnosis. Early detection of ovarian cancer based on physical examination is not sufficient, and should be completed with imaging studies such as USG, CT scan, MRI and nuclear medicine. Doppler US is a technique that is non-invasive, relatively cheap and well-tolerated. This examination may assessed tumor vascularization and resistive index. This study aimed to investigate the diagnostic values of Doppler Ultrasound in determining the malignancy of ovarian tumor compared with result of histopathology. This study was conducted in Radiology Department of Dr.Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital, Makassar from June through August 2018. Design of the study was diagnostic test. Doppler Ultrasound examination was carried on 55 samples with clinical sign of ovarian tumor aged between 14-67 years to evaluate the vascular distribution, number of vascular, and values of resistive index; followed by categorical system to determine the characteristics of benign or malignant ovarian tumor. The lesion is considered malignant if two or more Doppler malignant criteria were found, and benign if less than two criteria were found. The result of Doppler was compared to the result of histopathology. Data were analyzed statistically based on diagnostic test. This study result showed that Doppler Ultrasound had diagnostic value which was high enough to evaluate tumor malignancy with sensitivity of 94.7%, specificity of 70.6%, positive predictive value of 87.8%, negative predictive value of 85.7%, and the accuracy of 87.2%.

Co-Authors Ahmad Hudoyo Andi Alfian Zainuddin Arif Santoso Bachtiar Murtala Cahyono Kaelan Emilya Jufianti Gunawan Gunawan Harun Iskandar Irawaty Djaharudin Mirna Muis Ni Ketut Sungowati Nur Ahmad Tabri Nurhayati Nurhayati Nurlinah Jalil Sita Laksmi Andarini Sita Laksmi Andarini Sri Asriyani Taufik, Feni Fitriani Wenda Anastasia

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