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All Journal Jurnal Respirologi Indonesia Respiratory Science Indonesian Journal of Cancer
Sita Laksmi Andarini
Department Of Pulmonology And Respiratory Medicine Faculty Of Medicine, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and D-Dimer in Predicting the Outcome of Confirmed COVID-19 patients Fathiyah Isbaniah; Tomu Juliani; Triya Damayanti; Dewi Yenita; Faisal Yunus; Budhi Antariksa; Wahyu Aniwidyaningsih; Sita Laksmi Andarini; Diah Handayani
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.215

Abstract

Background: Cytokine storm or hyperinflammation condition in COVID-19 patients could result in fatal outcomes. Inflammation could also result in coagulation disorders. The Neutrophil-Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) have been known as inflammation markers in several diseases. D-dimer value can be used to assess a patient's coagulation status. Further study on thromboinflammation biomarkers in COVID-19 patients is needed. Therefore, we conducted a study to assess the association between NLR, PLR, and d-dimer on the clinical outcome of confirmed COVID-19 patients at Persahabatan Central Hospital.Methods: Observational cohort retrospective analysis was conducted on 214 medical records of confirmed COVID-19 patients who meet the inclusion criteria in Persahabatan Central Hospital from March to July 2020.Results: The mean patient’s age in this study is 54.35 years, dominated by male patients (60.7%). Most of the patients had normal nutritional status (54.7%). The proportion of patients with comorbidities is 65.4%. The most common comorbid is hypertension, followed by diabetes mellitus. 76.1% of patients have severe-critically ill disease, followed by moderate (20.1%) and mild disease (3.7%) The length of hospitalization median were 12 days. Sixty patients (28%) have died during hospitalization. The median of initial value of NLR, PLR, and d-dimer is 5.75 (0.68–81.5), 243.5 (44.7–1607), and 1140 (190–141300) respectively. We found significant associations between NLR (p = 0.000), PLR (p=0.013) and d-dimer (p = 0.032) on clinical outcome. Conclusion: Initial value of NLR, PLR, and D-dimer of confirmed COVID-19 patients at Persahabatan Central Hospital were associated with clinical outcome. 
Lung Diffusion Capacity of X Fighter Pilot in Madiun Ririn Astuty Ningsih; Faisal Yunus; Triya Damayanti; Flora Ekasari; Sita Laksmi Andarini; Dicky Soehardiman; Ratnawati Ratnawati; Fathiyah Isbaniah; Erlang Samoedro
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1007.037 KB) | DOI: 10.36497/jri.v40i1.96

Abstract

Background: Pilot works in the high environment that exposed by G force. Increasing G force led to linear decreases in cardiac output and blood oxygenation of the brain. Thus, likely due to decreased lung gas exchange capacity in hypergravity. This study aims to investigate the pulmonary diffusing capacity test among Fighter pilots in Madiun. Methods: This study used cross sectional method conducted on February 2019 in Madiun. The total subjects consist of 44 Fighter pilots based on total sampling. Interview was done to fill out question about sociodemografic and smoking habit, flight hour data and physical fitness. Lung function measurement was done using portable spirometry and DLCO equipment (Easyone TM Pro Lab). Result: Spirometri result was found in the standard normal range in 41 subjects (93,2%) only 3 subject (6,8%) get obstruction abnormalities and none of them get restriction result. Average VEP1 prediction was 103,3±10,60 % and median range for VEP1/KVP was 84,5(63,5-92,5) %. Lung diffusion capacity measurement was found to be normal in 41 subject (93,2%) and to be deficient in 3 subject (6,8%) in smoker. Conclusion: This study demosntrated that diffusion capacity and spirometry test in Fighter pilots generally in normal range. Lung diffusion capacity has no association with age, BMI, flight hour, physical fitness, Brinkman index and spirometry parameters. (J Respir Indo. 2020; 40(1): 39-47)
The Surfactant Protein D (SP-D) Serum Levels in Limestone Mining Worker Sita Laksmi Andarini; Anna Yusrika; Sri Wening Pamungkasningsih; Farhan Hilmi Taufikulhakim; Ahmad Hudoyo; Widhy Yudistira Nalapraya; Agus Dwi Susanto
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.301

Abstract

Background: Limestone is sedimentation rocks consist of minerals calcite and aragonite, often contains silica, and fossils, commonly used in building materials. Limestone mining workers are at high risk to pneumoconiosis. Surfactant protein D(SP-D) is part of collectin family, and served as innate immune system of pathogen recognition receptor (PRR). SP-D level were usually increased in fibrotic lung disease. In this study, we sought the serum level of SP-D as marker for early pneumoconiosis in limestone worker in Indonesia.Method: This study was cross-sectional observational study. Participant of the study were 65 limestone workers, willing to participate in this study by signing informed consent, were questionnaire, and blood sample were collected to measure SP-D level by ELISA.Results: This study found that characteristic subjects dominated by male with the median of age was 42 years old and last education mostly elementary school. Majority duration of working <6 years and time working in a day >8 hours per day. The limestone mining workers mostly did not wear mask and had normal weight group. Majority limestone mining workers ever smoker, mean SP-D level in limestone workers was (66.3±5.5ng/mL), slightly higher than normal subject. Smoking status, gender, working hour were correlated with higher SP-D level.Conclusion: Although not statistically significant, the SP-D serum levels in limestone mining workers might be used as monitoring for early screening for pneumoconiosis in limestone workers.
Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta Astari Pranindya Sari; Ratnawati Ratnawati; Wahju Aniwidyaningsih; Sita Laksmi Andarini; Faisal Yunus
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.38

Abstract

Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status. Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed. Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation. Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.
The Role of miRNA in Non-Small Cell Lung Carcinoma Ahmad Arfan; Sita Laksmi Andarini
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.39

Abstract

Micro Ribonucleic Acids, or miRNAs, are short non-coding RNAs. Their length, on average, is 22 nucleotides, and they function in post-transcriptional regulation of gene expression. MiRNAs have their own nomenclature, and the same miRNAs can be found across different species. MiRNAs play important roles in many physiological and pathological processes in the human body. Regarding cancer, miRNAs are involved in carcinogenesis. MiRNAs work by binding completely or incompletely with messenger RNAs (mRNAs). Complete binding with mRNA produces mRNA degradation, while incomplete binding produces translational inhibition. Eventually, miRNAs decreased gene expression. In cancer, miRNAs show unique and different expression profiles. Based on their role in activating or deactivating intracellular signaling pathways, miRNAs can be classified as oncomiR or tumor suppressor miRNA. In non-small cell lung cancer (NSCLC), miRNAs are associated with gene mutation status, and they have important roles as diagnostic, prognostic, and predictive biomarkers.  
Surfactant Protein D Level in Cement Workers Nurlinah Jalil; Sita Laksmi Andarini; Muhammad Ilyas; Feni Fitriani Taufik
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.280

Abstract

Background: Pneumoconiosis occurs almost all over the world. Pneumoconiosis is a threat to cement workers. Serological abnormalities are observed in pneumoconiosis. Surfactant protein D (SP-D) levels were increased in workers exposed to silica. SP-D may be useful as a biomarker for the early diagnosis of pneumoconiosis but it has not been studied in Indonesia.Methods: This cross-sectional study was conducted with consecutive sampling technique. The number of subjects was 61 people, consisting of 44 workers exposed to cement and 17 controls from September 2017 to March 2018. Serum level of SP-D was measured using ELISA method. Cement exposed workers were workers in the production area and workers in quarry areas.Results: All of the study subjects were male (100%) with mean age of 42.5 years old. The youngest and oldest subjects were 21 and 55 years old, respectively. Majority of the subjects was in the normal weight group (47.7%). Based on smoking history, there were 26 subjects (59.1%) had never smoked, 12 subjects (27.3%) as smokers, and 6 subjects (13.6%) as former smokers. Duration of exposure <10 years was found in 9 subjects (20.5%) while exposure ≥10 years was observed in 35 subjects (79.5%). Good category of using self-respiratory safety instrument was observed in 5 subjects (11.4%), moderate category in 36 subjects (81.8%) and poor category in 3 subjects (6.8%). Mean serum SP-D levels in the exposed group was 111.027 ng/ml and in control group was 67.648 ng/ml. Serum SP-D levels were significantly higher in the exposed group than control group (P=0.014).Conclusion: Serum SP-D levels was statistically higher in the exposed group than in control group.
Primary Pulmonary Sarcoma Coinfected with Pulmonary Tuberculosis: A Case Report Dea Putri Audina; Sita Laksmi Andarini; Hana Khairina Putri Faisal; Prasenohadi Prasenohadi; Jamal Zaini; Herawati Hidajat
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.991

Abstract

Introduction: Pulmonary tuberculosis (TB) and malignancy are conditions with similar respiratory diseases and they are even known to coexist simultaneously. Therefore, accurate diagnosis of each disease is crucial to ensure precise treatment. This case study showed the coexistence of pulmonary TB and primary pulmonary sarcoma.Case Presentation: A 62-year-old male presented with a 3-month history of dyspnea, which worsened within 3 days. Before hospitalization, there were complaints of left chest pain, fatigue, loss of appetite, weight loss within 5 months, and night sweats. The patient who was a heavy smoker had experienced hemoptysis in the past 5 months. Upon physical examination, an increased respiratory rate and decreased oxygen saturation level. Furthermore, there were asymmetrical thorax movements, dull percussion on the left side, and decreased vesicular breathing sound on the left hemithorax, with no rhonchi or wheezing. A chest x-ray showed a destroyed left lung, while scanning confirmed left lung atelectasis and indicated a suspected mass within or around the left bronchus causing total obstruction in the main left bronchus. The bronchoscopy procedure identified a mass blocking the left main bronchus. However, a biopsy yielded inconclusive results. A rapid molecular test of TB detected Mycobacterium tuberculosis, which was discovered to be Rifampicin sensitive. As a result, the patient was treated daily with 4 fixed drug combinations for anti-TB. Despite the treatment, the complaint was not resolved within the next 3 months, as there was still a disease of cough in the form of mass-like phlegm, which uncovered a malignancy focus cell with differential diagnosis of pleomorphic sarcoma and sarcomatoid carcinoma.Conclusions: Lung malignancy not only overlapped with but also occurred simultaneously alongside lung TB. Therefore, it was crucial to establish a clear diagnosis in patients with chronic respiratory disease.
Co-Authors Agus Dwi Susanto Ahmad Arfan Ahmad Hudoyo Aniwidyaningsih, Wahju Anna Yusrika Astari Pranindya Sari Budhi Antariksa Damayanti, Triya Dea Putri Audina Dewi Yenita Faisal Yunus Faisal Yunus Faisal, Hana Khairina Putri Farhan Hilmi Taufikulhakim Flora Ekasari Herawati Hidajat Isbaniah, Fathiyah Muhammad Ilyas Nurlinah Jalil Prasenohadi Raden Rara Diah Handayani Ratnawati Ratnawati Ririn Astuty Ningsih Samoedro, Erlang Soehardiman, Dicky Sri Wening Pamungkasningsih Taufik, Feni Fitriani Tomu Juliani Wahyu Aniwidyaningsih Widhy Yudistira Nalapraya Zaini, Jamal