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All Journal Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Jurnal Riset Ilmiah Biosaintifika: Journal of Biology & Biology Education

Yulia Kurniawati

Bagian Radiologi Fakultas Kedokteran Universitas Andalas/RS Dr. M. Djamil Padang

Author-ID : 3690598

Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Articles

Hypertrophic pulmonary osteoarthropathy with primary lung cancer Yulia Kurniawati; A.H.S. Kartamihardja
Majalah Kedokteran Andalas Vol 40, No 1 (2017): Published in May 2017
Publisher : Faculty of Medicine, Universitas Andalas

Hipertrophic Pulmonary Osteoarthropathy (HPO) merupakan sindrom paraneoplastik yang disebabkan oleh kelainan pada paru-paru. Angka kejadian HPO sangat rendah yaitu kurang dari 1%, dimana penyebab yang tersering (90%) adalah karsinoma bronkogenik. Gambaran klinis HPO timbul akibat kelainan sistemik pada sendi dan jaringan lunak berupa pembengkakan pada jari-jari, pembentukan tulang baru terutama pada tulang panjang ekstremitas bawah, serta gambaran menyerupai artristis pada sendi dan jaringan periartikuler (pergelangan kaki, lutut, pergelangan tangan dan siku). Beberapa penelitian telah melaporkan manfaat sidik tulang (bone scintigraphy) untuk penegakkan diagnosis dan penilaian pasca terapi pada HPO. Sidik tulang selain untuk menegakkan diagnosis dan mengetahui adanya metastasis, juga dapat menggambarkan secara lebih jelas keberadaan dan luasnya aktivitas sub-periosteal dibandingkan pemeriksaan radiologi. Berikut dilaporkan kasus HPO yang awalnya didiagnosis sebagai osteoarthritis dari pemeriksaan radiologi, selanjutnya didiagnosis dengan karsinoma bronkogenik dengan HPO dari pemeriksaan sidik tulang.

Uptake and effect of radioiodine exposure on SKBR-3 cell lines Miftah Irramah; Yulia Kurniawati; VY Susilo; S Setiyowati; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020
Publisher : Faculty of Medicine, Universitas Andalas

Radioiodine has been known as an adjuvant therapy for thyroid cancer. Beside for thyroid cell, radioiodine is reported to be taken up by breast cell. It may be proposed as an alternative for breast cancer therapy. Objective: The study aim was to analyze an uptake of radioiodine and cell proliferation rate of breast cancer cell after the exposure of radioiodine. Methods: This study used SKBR-3 cell line as representative of Human Epidermal Growth Factor Receptor (HER2+) subtype. The cells were planted in DMEM medium added 10% fetal bovine serum (FBS), panstrep 1% and amphotericin B. The cells were grown until 80% confluent and then stripped. Subsequently the cells were sub-cultured on plates 12 and 6 wells respectively for measured uptake of radioiodine and cell proliferation rate after the exposure. Radioiodine uptake was calculated by sum efflux of 125 Iodine (125I) and the amount of uptake after the addition of 95% ethanol. Cell proliferation rate was measured by calculated by using clonogenic assay after iodine-131 (131I) exposure. Results: The average of iodine uptake was 194±50 cpm/106 cell. The average cell proliferation after radioiodine exposure was 54%±5%; Conclusions: Radioiodine is taken by SKBR-3 cells and it reduced cell proliferation rate. This finding shows an opportunity for radioiodine as an alternative therapy for breast cancer. Another studies are needed to understand of cell death the mechanism.

PELATIHAN SATGAS COVID DI SDN 10 LAMBUNG BUKIT DESA BINAAN FAKULTAS KEDOKTERAN UNAND Nita Afriani; Biomechy Oktomalio Putri; Eryati Darwin; Malinda Meinapuri; Tuti Handayani; Dina Arfiani; Fathiya Juwita Hanum; Novita Ariani; Yulia Kurniawati
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No 1 (2023)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.7.1.148-151.2023

Kota Padang memberlakukan pendidikan luring dengan pembatasan jam waktu pendidikan dengan tetap memperhatikan promosi kesehatan. Anak-anak peserta didik diminta untuk menggunakan masker, menjaga jarak, dan mencuci tangan sebelum memasuki kelas masing-masing. Salah satu upaya untuk meningkatkan promosi kesehatan adalah dengan membuat siswa menjadi well educated mengenai covid dan penularannya. Kegiatan pengabdian masyarakat dilaksanakan di SDN 10 Lambung Bukit Desa Binaan FK Unand pada kelas 3A,4A,5A SD sebagai kelas percontohan bagi kelas lainnya. Kegiatan dilaksanakan secara berkesinambungan selama 6 minggu. Kegiatan berupa edukasi menggunakan video dan pelatihan pembentukan satgas covid. Pengetahuan, sikap, dan tindakan dinilai sebelum pemberian materi dan dinilai kembali pada akhir minggu ke 4. Pada minggu ke 5 dan 6 dilakukan penilaian pengetahuan, sikap, dan tindakan terhadap pencegahan covid. Kegiatan ini disimpulkan telah terbentuk satgas covid di SDN 10 Lambung Bukit sehingga diharapkan terbentuk pola sikap dan tindakan yang sudah menjadi budaya dalam menghadapi new normal di era pandemi ini. Kata kunci: new normal, pengetahuan, sikap, tindakan, covid, murid SD ABSTRACT Padang enforces offline education by limiting the hours of education while still paying attention to health promotion. Students are asked to wear masks, keep their distance, and wash their hands before entering their respective classes. One of the efforts to improve health promotion is to make students well educated about COVID and its transmission. Community service activities were carried out at SDN 10 Lambung Bukit in the fostered village of Medical Faculty Universitas Andalas (FK Unand) in grades 3A, 4A, 5A SD as a pilot class for other classes. Activities are carried out continuously for 6 weeks. Activities in the form of education using videos and training on the formation of the Covid task force. Knowledge, attitudes, and actions are assessed before giving the material and reassessed at the end of week 4. At week 5 and 6 an assessment of knowledge, attitudes, and actions towards covid prevention is carried out. This activity was concluded to have formed a covid task force at SDN 10 Lambung Bukit so that it was hoped that a pattern of attitudes and actions that had become a culture in dealing with the new normal in this pandemic era was expected. Keywords: new normal, knowledge, attitude, action, covid, elementary school students

GAMBARAN KADAR TIROGLOBULIN PADA PASIEN KARSINOMA TIROID BERDIFERENSIASI POST TOTAL TIROIDEKTOMIDI RSUP DR. M. DJAMIL PADANG Muhammad Furqan; Yulia Kurniawati; Zelly Dia Rofinda
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 4 (2026): SINERGI : Jurnal Riset Ilmiah, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i4.2488

Thyroid carcinoma is the most common malignancy found in the endocrine glands and accounts for 1% of all malignancies. The average incidence of thyroid carcinoma cases according to the National Cancer Institute (NCI) from 2012-2017 was 14.3 per 100,000 total population per year, with an average mortality rate of 0.5 per 100,000 population per year. In Indonesia in 2000, thyroid carcinoma ranked ninth out of the ten most common carcinomas (4.3%) and covered 90% of all endocrine carcinomas. Based on medical record data at Dr. M. Djamil Padang General Hospital, the incidence of thyroid carcinoma in 2015 was 373 people and increased in 2016 to 850 people. Based on the problems described above, and there has not been much research on Thyroglobulin levels as a prognostic factor for recurrence of thyroid carcinoma in Indonesia, especially Padang. Encourage the author to conduct research on differentiated thyroglobulin levels after total thyroidectomy at Dr. M. Djamil Padang General Hospital.

Antiproliferative and Apoptosis-Inducing Effects of Iodine Molecule in Differentiated Primary Thyroid Cancer Cells: In Vitro Study Yulia Kurniawati; Jihan Atiqah; Malinda Meinapuri; Daan Khambri; Achmad Hussein Kartamihardja; Aisyah Elliyanti
Biosaintifika: Journal of Biology & Biology Education Vol. 18 No. 1 (2026): April 2026
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v18i1.42523

Thyroid cancer poses a persistent clinical challenge, particularly when conventional therapies fall short. Growing evidence suggests that molecular iodine (I₂) may exert direct antitumor effects beyond its classical role in thyroid hormone synthesis. This study evaluated the antiproliferative and apoptosis-inducing effects of I₂ on primary cell cultures derived from differentiated thyroid cancer tissue and established dose- and time-response relationships. Primary cultures were exposed to I₂ at concentrations of 5, 10, 20, 40, 80, and 100 µM for 24, 48, and 72 hours. Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, with IC₅₀ calculated accordingly. Apoptosis was characterized by acridine orange/propidium iodide (AO/PI) double-staining, analyzed by fluorescence microscopy and ImageJ software. I₂ demonstrated clear antiproliferative and apoptotic activity in a dose- and time-dependent manner. The strongest effect appeared at 100 µM after 72 hours, reducing viability to 1.39% (p < 0.001). At the IC₅₀ of 2.09 µM, iodine significantly suppressed proliferation and induced apoptosis, with an apoptosis rate of 81.77% ± 12.24% (p = 0.004). These findings confirm the meaningful antineoplastic potential of I₂ against differentiated thyroid cancer cells. This study supports SDG 3 (Good Health and Well-Being), contributing to efforts to develop more equitable, effective cancer treatment options and to reduce cancer-related morbidity globally.

Co-Authors A.H.S. Kartamihardja Achmad Hussein Kartamihardja Aisyah Elliyanti Daan Khambri Dia Rofinda, Zelly Dia Dina Arfiani Eryati Darwin Hanum, Fathiya Juwita Jihan Atiqah Malinda Meinapuri Malinda Meinapuri Miftah Irramah Muhammad Furqan Nita Afriani Novita Ariani Putri, Biomechy Oktomalio S Setiyowati Tuti Handayani VY Susilo

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