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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Jurnal Kesehatan Jurnal Penelitian Kesehatan Suara Forikes Jurnal Kesehatan Komunitas Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Majalah Kedokteran Andalas Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Sains, Teknologi dan Kesehatan
Malinda Meinapuri
Universitas Andalas
Agriculture, Biological Sciences & Forestry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Hubungan antara Kadar Troponin T dengan Luas Infark Miokard yang Diukur dengan Menggunakan Metode Skoring QRS Selvester pada Pasien Infark Miokard Akut Muhammad Lingga Primananda; Masrul Syafri; Malinda Meinapuri
Jurnal Kesehatan Andalas Vol 5, No 3 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i3.562

Abstract

AbstrakDalam kriteria diagnosis IMA oleh WHO salah satunya apabila ditemukan peningkatan kadar enzim jantung. Troponin T merupakan salah satu enzim jantung yang akan meningkat apabila terjadi kerusakan sel miokardium. Tujuan penelitian ini adalah menentukan hubungan antara kadar Troponin T dan luas infark miokard yang diukur dengan metode skoring QRS Selvester. Ini merupakan penelitian analitik dengan desain cross sectional yang dilaksanakan dari Oktober 2013 sampai September 2014 di Subbagian Rekam Medis RS Khusus Jantung YJI Cabang Utama Sumatera Barat.  Analisis data menggunakan uji Kolmogorov-Smirnov dengan p ≤ 0,05 jika bermakna.  Sampel penelitian adalah data rekam medis semua pasien dengan diagnosis IMA di RS Khusus Jantung YJI Cabang Utama Sumatera Barat periode Juli 2013 – Juni 2014 yang diambil dengan teknik total sampling. Penyeleksian data menghasilkan 81 data pasien dengan diagnosis IMA dan 37 data yang memiliki hasil pemeriksaan troponin T dan EKG. EKG digunakan untuk menentukan luas infark dengan menggunakan metode skoring QRS Selvester dengan hasil luas infark rendah, sedang, dan tinggi. Hasil penelitian menunjukkan tidak terdapat hubungan yang signifikan antara kadar Troponin T dengan luas infark pada pasien IMA dengan nilai p = 0,097 (p > 0,05). Kesimpulan penelitian ini adalah tidak terdapat hubungan antara kadar Troponin T dan luas infark miokard.Kata kunci: troponin T, luas infark miokard, infark miokard akut, skoring QRS Selvester AbstractThe one of WHO criteria for the diagnosis of AMI is the elevated levels of cardiac enzymes. Troponin T is one of cardiac enzyme that will increase if  there is a myocardial cells damage. The objective of this study was to determine the correlation between troponin T level and myocardial infarction size that measured by using Selvester QRS scoring method. This research was an analytic research with cross sectional design that conducted in October 2013 to September 2014 in the sub-section of Medical Record of Khusus Jantung YJI Cabang Utama Sumatera Barat hospital. Analysis of the data was using the Kolmogorov-Smirnov test to determine the correlation with p ≤ 0.05 was significant. Samples of the research were medical record data of all patients with diagnosis of AMI in the Khusus Jantung YJI Cabang Utama Sumatera Barat hospital period July 2013 - June 2014 that were selected with a total sampling technique. The result of data selection was 81 patients with diagnosis of AMI and 37 data with the results of Troponin T and ECG Examination. ECG results were used to determine infarction size by using Selvester QRS scoring method with results low, medium, and high of infarction size. The results shown that there was no significant correlation between Troponin T level and myocardial infarction size with p value was 0.097 (p> 0.05). The conclusion of this research is there is no correlation between Troponin T level and myocardial infarction size.Keywords: troponin T, myocardial infarction size, acute myocardial infarction, Selvester QRS scoring
Polimorfisme Gen Apolipoprotein E Pada Penderita Sindrom Down Trisomi 21 Malinda Meinapuri
Jurnal Kesehatan Andalas Vol 2, No 1 (2013)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v2i1.57

Abstract

AbstrakLatar Belakang: Sindrom Down merupakan suatu kelainan kromosom yang ditandai dengan adanya baik seluruhnya (trisomi 21) maupun sebagian (translokasi) suatu salinan tambahan kromosom ke 21. Apolipoprotein E (APOE) merupakan suatu bentuk protein polimorfik yang disandikan oleh suatu gen yang berlokasi pada lengan panjang kromosom 19 pada posisi 13.2 (19q13.2). Polimorfism gen APOE berkaitan dengan meningkatnya frekuensi alel ε4 yang berakibat terjadinya hambatan dalam percabangan dan pertumbuhan neuron. Dimungkinkan, penderita Sindrom Down Trisomi 21 memiliki gen APOE yang berbeda dengan kontrol sebagai faktor yang dapat mengakibatkan penuaan dini otak. Metode : Penelitian ini merupakan penelitian kasus kontrol untuk mengamati perbedaan distribusi dan frekuensi alel dan genotip gen APOE pada penderita Sindrom Down trisomi 21 dibandingkan dengan kontrol. Kasus Sindrom Down dan kontrol diambil dari data sekunder yang tersimpan di Center for Biomedical Research (CEBIOR) Semarang Indonesia. Ekstraksi DNA dilakukan dengan menggunakan metode yang terdapat di (CEBIOR) Semarang Indonesia. Kegiatan selanjutnya adalah pemeriksaan polimorfisme gen Apolipoprotein E dengan mengunakan teknik PCR dan RFLP. Hasil : Sebanyak 33 sampel dari penderita Sindrom Down, 18 laki-laki dan 15 perempuan dan 33 sampel kontrol, 18 laki-laki dan 15 perempuan. Baik sampel Sindrom Down maupun kontrol memiliki frekuensi alel ε3 paling tinggi dibandingkan dengan alel ε2 dan ε4. Pada Sindrom Down didapatkan alel ε4 4 sampel (6,1%) dan alel ε2 8 sampel (12,1%). Baik sampel Sindrom Down maupun kontrol memiliki genotip ε3/ε3 paling tinggi dibandingkan dengan genotip gen APOE lainnya. Pada Sindrom Down didapatkan genotip ε2/ε4 4 sampel (12,1%) dan genotip ε2/ε2 2 sampel (6,1%). Simpulan : Terdapat perbedaan distribusi alel dan genotip gen APOE pada penderita Sindrom Down trisomi 21 dibandingkan dengan kelompok kontrol. Diperlukan analisis sampel yang lebih banyak untuk mengkonfirmasi hasil penelitian ini.Kata kunci: Sindrom Down, Polimorfisme, Apolipoprotein E.AbstractBackgrounds :Down syndrome is an abnormal chromosomal condition, characterized by the presence of all (trisomy 21) or part (such as due to translocations) of a third copy of chromosome 21. Apolipoprotein E (APOE) is a polymorphic protein coded by a gene located on the long arm (q) of chromosome 19, positioning at 13.2 (19q13.2). Polymorphism of APOE gene is related with the increasing of allele ε4’s frequency thus cause obstruction in neuron ramification and development. In previous study, Down Syndrome groups are having different type of APOE gene compared with control. That why it can be considered as one of the caused premature aging of brain. Methods : This is a case control study to observe the difference of distribution and frequency of APOE gene allele and genotype in Down Syndrome Trysomi 21 compared to control. Down Syndrome and control samples was taken as secondary data from Center for Biomedical Research (CEBIOR) Semarang Indonesia. DNA extraction was done by using the commonly used salting out method in CEBIOR Semarang Indonesia. Subsequently polimorphism of APOE gene analysis has been done by using PCR and RFLP.Result : Thirty three samples were Down Syndrom patients, consist of 18 male and 15 female. Thirty three samples are control, consist of 18 male and 15 female. Both groups were having the highest frequency of allele ε3 compared to allele ε2 and ε4. In Down Syndrome, frequency of ε4 allele was found in 4 samples (6,1%) while allele ε2 was found in 8 samples (12,1%). Genotype ε3/ε3 were the highest frequency on both group compared to the other. In Down Syndrome group identified ε2/ε4 genotype in 4 samples (12,1%) and ε2/ε2 genotype in 2 samples (6,1%).Conclusion : There is slight difference distribution of APOE gene allele and genotype in Down Syndrome Trysomi 21 compared to control. More samples should be analyzed to confirm this finding.Keywords:Down Syndrome, Polymorpism, Apolipoprotein E.
Penyuluhan Penanganan Kegawat daruratan Rumah Tangga Di Puskesmas Anak Air Padang Malinda Meinapuri
Jurnal Pengabdian Warta Andalas Vol 23 No 4 (2016): Warta Pengabdian Andalas
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

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Abstract

Background : In a complex -paced life in modern times it is quite possible emergencies occur in the household environment . Along with the times , the flow of life in the household is becoming increasingly complex , in terms of number of members , the more diverse activities , as well as equipment used to support the passage of life . This can lead to various kinds of accidents in the home , including some circumstances that require immediate relief are classified into a state of emergency , some of choking , burns in children and fever in children . Method : Counseling will be held 1 time meeting ± 2 hours , which cover topics simple handling emergencies Overcoming household burns in children , Fever in children and choking . Extension activities will be preceded by asking cadres and mother - mother Posyandu Charge Sheet kuosioner Mini ( pre -test ) . As well as discussions continued with counseling . At the end of event , cadres and mother - mother Posyandu Requested Back kuosioner Mini Fill the ( post-test ). Result : Extension activities held on Wednesday September 3 , 2014. This event was attended by the extension 27 health cadres who are working in the region of Anak Air Health Center Padang. Material presented on handling emergencies in the household , which on this occasion focused on the handling of fever , burns and choking in children . This material was presented by dr . Malinda Meinapuri , Msi.Med . Furthermore, given the additional material submitted by dr . Nita Afriani , M.Biomed with the topic Breast Self Examination (SADARI) . Conclusion : There was an increased knowledge of health cadres who are working in the region of Anak Air Health Center Padang regarding the handling of emergencies in the household , which on this occasion focused on the treatment of fever , burns and choking in children . There was an increased knowledge of health cadres could be assessed objectively from the increased value kuosioner post-test compared to the pre-test value kuosioner .
DIAGNOSA DINI PADA INFEKSI HIV TIPE 1 DENGAN MENGGUNAKAN TES DOUBLE-DETECT PROTEIN Crisdina Suseno; Carlo Prawira Azali; Reynaldo Rahima Putra; Malinda Meinapuri
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (81.924 KB) | DOI: 10.22338/mka.v38.i1.p41-48.2015

Abstract

AbstrakTujuan yang ingin dicapai dalam penulisan gagasan tertulis ini adalah menjelaskan kajianbiologi molekuler, imunologi dan aspek genetik pada infeksi HIV-1 serta memaparkandiagnosa yang efektif untuk mengetahui infeksi HIV-1 yang dapat diterapkan. Pengumpulandata dan informasi didapatkan melalui buku dan jurnal-jurnal ilmiah hasil penelitian. Datadan informasi yang diverifikasikan lebih lanjut terbatas pada bukti yang menunjukkanjenis-jenis diagnosa HIV-1 dan membuat jenis diagnosa yang lebih efektif. Setelah semuadata yang dibutuhkan terkumpul, dilakukan pengelolaan data dengan menyusun secarasistematis dan logis. Tes Double-detect Protein kemungkinan memiliki keefektifan lebihtinggi dari tes yang mendeteksi antigen p24 ataupun tes yang mendeteksi antibodi.Diagnosa dini pada infeksi HIV merupakan diagnosa yang dapat membantu pendeteksianHIV pada fase awal infeksi hingga sebelum masuknya fase serokonversi. Pada saat inilahtes Double-Detect Protein dapat dilakukan. Namun, perlu dilakukan tes NASBA sebagai followup test.AbstractThe objectives of this writing were to explain the topic of molecular biology,immunology, and the genetic aspect of HIV infection type I. And also to give out a moreeffective diagnose of HIV type I that can be applied. The data and information werecollected from various books and scientific journals resulted from research. Data andinformation was verified further limited to the evidence that shows the types of diagnosesof HIV-1 and created a more effective type of diagnoses. Once all the required datacollected, data management was done by arranging a systematic and logical manner. TheProtein Double-Detect test had the possibility of having a higher effectiveness compared to p24antigen test or antibody detection tests. Early diagnosis of HIV infection is a diagnosis thatcan help the detection of HIV in the early phase of infection prior to the entry phase ofseroconversion. At this time Double-Detect Proteins Test can be done. However, NASBA testsneeded as a follow-up test.
Hubungan kadar imunoglobulin a sekretori air susu ibu dengan berat badan bayi yang mendapat air susu ibu eksklusif Malinda Meinapuri; Biomechy Oktomalio Putri
Majalah Kedokteran Andalas Vol 41, No 1 (2018): Published in January 2018
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22338/mka.v41.i1.p1-9.2018

Abstract

Menyusui adalah cara terbaik dalam memberikan nutrisi ideal untuk pertumbuhan dan perkembangan bayi. Air Susu Ibu (ASI) mengandung protein dengan fungsi imunologis yaitu Immunoglobulin A (IgA) sekretori, laktoferin, dan lisozym. IgA sekretori dalam ASI berfungsi melindungi bayi dari infeksi bakteri, virus, maupun parasit. Tujuan: Untuk mengetahui hubungan kadar imunoglobulin A sekretori dalam ASI dengan berat badan bayi yang mendapat ASI eksklusif. Metode: Penelitian ini menggunakan desain potong lintang yang diselenggarakan di RSUP M Djamil, beberapa puskesmas, dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas. Subjek penelitian adalah ibu dan bayi yang melaksanakan ASI eksklusif, berumur 4-6 bulan, dan bersedia ikut penelitian. Jumlah sampel minimal 59 subjek dan diambil secara consecutive sampling. Analisis statistik dengan Analisis Bivariat Korelasi Pearson. Didapatkan 60 subjek ikut serta dalam penelitian. Hasil: Jenis kelamin terbanyak perempuan yaitu 51,67% dengan usia bayi rata-rata 4,5 bulan. Berat badan rata-rata 6,75 kg SD +0,95. Kadar IgA sekretori rata-rata 17,3 ng/ml, SD +3,14. Didapatkan nilai p hubungan kadar IgA sekretori dalam ASI dan berat badan 0,908. Kesimpulan: Kadar imunoglobulin A sekretori dalam ASI tidak berhubungan dengan berat badan pada bayi yang mendapat ASI eksklusif.
PELATIHAN SATGAS COVID DI SDN 10 LAMBUNG BUKIT DESA BINAAN FAKULTAS KEDOKTERAN UNAND Nita Afriani; Biomechy Oktomalio Putri; Eryati Darwin; Malinda Meinapuri; Tuti Handayani; Dina Arfiani; Fathiya Juwita Hanum; Novita Ariani; Yulia Kurniawati
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 7 No 1 (2023)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.7.1.148-151.2023

Abstract

Kota Padang memberlakukan pendidikan luring dengan pembatasan jam waktu pendidikan dengan tetap memperhatikan promosi kesehatan. Anak-anak peserta didik diminta untuk menggunakan masker, menjaga jarak, dan mencuci tangan sebelum memasuki kelas masing-masing. Salah satu upaya untuk meningkatkan promosi kesehatan adalah dengan membuat siswa menjadi well educated mengenai covid dan penularannya. Kegiatan pengabdian masyarakat dilaksanakan di SDN 10 Lambung Bukit Desa Binaan FK Unand pada kelas 3A,4A,5A SD sebagai kelas percontohan bagi kelas lainnya. Kegiatan dilaksanakan secara berkesinambungan selama 6 minggu. Kegiatan berupa edukasi menggunakan video dan pelatihan pembentukan satgas covid. Pengetahuan, sikap, dan tindakan dinilai sebelum pemberian materi dan dinilai kembali pada akhir minggu ke 4. Pada minggu ke 5 dan 6 dilakukan penilaian pengetahuan, sikap, dan tindakan terhadap pencegahan covid. Kegiatan ini disimpulkan telah terbentuk satgas covid di SDN 10 Lambung Bukit sehingga diharapkan terbentuk pola sikap dan tindakan yang sudah menjadi budaya dalam menghadapi new normal di era pandemi ini. Kata kunci: new normal, pengetahuan, sikap, tindakan, covid, murid SD ABSTRACT Padang enforces offline education by limiting the hours of education while still paying attention to health promotion. Students are asked to wear masks, keep their distance, and wash their hands before entering their respective classes. One of the efforts to improve health promotion is to make students well educated about COVID and its transmission. Community service activities were carried out at SDN 10 Lambung Bukit in the fostered village of Medical Faculty Universitas Andalas (FK Unand) in grades 3A, 4A, 5A SD as a pilot class for other classes. Activities are carried out continuously for 6 weeks. Activities in the form of education using videos and training on the formation of the Covid task force. Knowledge, attitudes, and actions are assessed before giving the material and reassessed at the end of week 4. At week 5 and 6 an assessment of knowledge, attitudes, and actions towards covid prevention is carried out. This activity was concluded to have formed a covid task force at SDN 10 Lambung Bukit so that it was hoped that a pattern of attitudes and actions that had become a culture in dealing with the new normal in this pandemic era was expected. Keywords: new normal, knowledge, attitude, action, covid, elementary school students
Promosi Kesehatan Periksa Payudara Sendiri (SADARI) pada Ibu-Ibu Majelis Taklim Mesjid Baitul Chair Komplek Bea Cukai Teluk Bayur Kota Padang Nita Afriani; Biomechy Oktomalio Putri; Malinda Meinapuri; Sheila Diana; SM Rezvi; Eryati Darwin; Roza Silvia; YN Zuhal Chaisart Chaniago; Tegar Abdillah
Warta Pengabdian Andalas Vol 30 No 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.2.297-303.2023

Abstract

Breast self-examination (BSE) is a breast examination carried out by the woman herself every month regularly. BSE as a step for early detection of breast cancer is highly recommended for women, especially those aged 40 years and over, because the higher the age, the greater the risk of developing breast cancer. This activity aimed to determine the level of knowledge and attitudes and carry out health promotion about BSE to the pilgrim women of the Baitul Chair Mosque, Teluk Bayur, Padang. 11 women of the society attended this activity. The level of knowledge and attitudes regarding BSE was assessed using a simple questionnaire consisting of five questions regarding knowledge and attitudes, respectively. The survey resulted in no history of breast cancer or family history of breast cancer; as many as 81.8% of mothers had never received information about BSE before. The level of knowledge showed that 63.6% of mothers have good knowledge and a good attitude about BSE, 55.5%. Health behaviour, knowledge and attitudes must be improved, including health promotion. Health promotion as one of the driving factors can increase the knowledge and attitudes that will manifest in BSE actions for early detection of breast cancer.
The Relationship Between Knowledge, Information Exposure, and Cadre Support with Mothers' Visits for Under-Five Weighing Coverage in the Working Area of Pegambiran Health Center, Padang City, 2024 Suherlis, Septia; Sriyanti, Roza; Meinapuri, Malinda; Ariadi, Ariadi; Afdal, Afdal; Firdawati, Firdawati
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1555

Abstract

Malnutrition is a major nutritional problem throughout the world. The highest number of nutritional problems occured in East Africa and Asia, including Indonesia. The Indonesian Ministry of Health conducted a survey and revealed that in Indonesia, 1 in 12 toddlers suffered from wasting, and 1 in 5 toddlers suffered from stunting (SSGI 2022). The scope of toddler weighing at Pagambiran health center with the indicators of (K/S) 99,84%, (N/D) 53,26% and (D/S) 13,4%, had not reached the strategic plan target which was 85%. The strategy used to reduce nutritional problems was to increase community participation through integrated health posts (posyandu). The purpose of this study was to determine the determinant factors related to mothers' visits to posyandu on the scope of weighing toddlers. The research method used was the combination method (mix method). The research was conducted from September 2023 to August 2024. The number of samples was 196 mothers who had children aged 12-59 months in the work area of Pegambiran Health Center using the sampling technique of cluster random sampling. The data were collected through questionnaires and interviews. This research data analysis was carried out using univariate and bivariate analysis. The result of statistical test, it was found out that the relationship knowledge (p-value 0.002), exposure information (p-value 0.007) and cadre support (p-value 0.000) to mothers' visits in the scope of toddler weighing.The conclusion of the research is that there is a significant relationship between knowledge, exposure information and cadre support to mothers' visits in the scope of toddler weighing at the work area of Pegambiran Health Center.
Stunting Prevention in the Preconception Period Lady Wizia; Yusrawati Yusrawati; Malinda Meinapuri; masrul masrul; Husna Yetti; Afdal Afdal
Jurnal Kesehatan - STIKes Prima Nusantara Vol 15 No 2 (2024): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v15i2.1149

Abstract

Background: The stunting rate in Indonesia in 2022 was 21.6%. I was reduced when compared to the SSGI data in 2021 of 24.4%. The stunting rate appears to be decreasing from year to year, but a joint commitment is still needed to achieve the target of reducing stunting to 14% by 2024. Stunting prevention is a much more effective step than stunting treatment itself. Prevention of stunting can be done by optimizing the role of mothers in the golden phase of child development. stunting prevention in Indonesia still focuses on pregnancy and toddlers, while prevention during the preconception period is still limited.Purpose:To synthesize and critically effective steps that can be taken to prevent stunting in the preconception periodMethods:The research method employed was a literature review, conducted by using primary studies from PubMed, google scholar, and ScienceDirect with the keywords “stunting; prevention; praconception” published between 2017-2023, in English, open access, and relevant to the topicResults:A total of 397 research articles were screened for eligibility, and 15 articles met the inclusion criteria. Based on the 15reviewed articles, devide into three themes: Nutritional status during preconception, Supplementation during preconception and Lifestyle during preconceptionConclusion: This review found that there are several efforts made in preventing stunting in the preconception period. it is recommended that health workers can optimize the prevention of stunting in the preconception period.
Analysis of Allele Frequency Distribution Apoliprotein E Gene in Patients With Down Syndrome Trisomy 21 Malinda Meinapuri; Arni Amir; Eva Chundrayetti; efrida efrida; Susmiati Susmiati
Jurnal Kesehatan - STIKes Prima Nusantara Vol 15 No 1 (2024): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v15i1.1171

Abstract

Background: Down syndrome is a global health problem of particular concern because people with Down syndrome have a wide variety of clinical disorders and are one of the causes of mental retardation and serious physical growth disorders.Down syndrome can occur at all socioeconomic, ethnic and demographic levels. The incidence of Down Syndrome will increase as the mother's age increases at the time of pregnancy and the incidence varies in different populations: 1 in 319 to 1 in 1000 live births. Each year, an estimated 3,000 to 5,000 children are born with Down syndrome. The APOE gene is located in the long arm (q) of chromosome 19 at position 13.2 (19q13.2). The APOE gene consists of four exons and three introns, a total of 3597 base pairs. In melanocyte cells APOE gene expression can be regulated by MITF. APOE is a form of polymorphic, which translates into three gene alleles: normal: allele ?3 and dysfunctional: allele ?2 and allele ?4.  The polymorphism of the APOE gene had a strong effect on the level of allele production, a high concentration of APOE indicated that the production of ?4 allele was increased and a low concentration of APOE was associated with the production of ?2 allelePurpose:To Analyze of Allele Frequency Distribution Apoliprotein E Gene  in Patients With Down Syndrome Trisomy  21Methods: This research is an analitic observasional study with a comparative  study design. The sample used was the result of DNA extraction patients with Down's Syndrome Trisomy 21 as many as 33 samples and 33 controls stored in the Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang, Indonesia. The next step is to examine the APOE gene polymorphisms using PCR and sequencing techniques.Results: Samples of Down syndrome patients had variations in the distribution of alleles, where alleles ?4 and ?2 were found even though the allele frequency ?3 was still the highest allele frequency. Meanwhile, in the samples representing the normal control population, ?3 and ?2 alleles were found and no ?4 allele was found. Although the allele is not associated with Down Syndrome, Down Syndrome sufferers have a 2.26 times greater risk for e2 and e4 alleles than e3.Conclusion: There was a difference in the frequency distribution pattern of the APOE gene allele in patients with Down Trisomy Syndrome 21 compared to the control. 
Co-Authors Afdal Afdal Afdal Afdal, Afdal ALADIN ALADIN Almurdi Almurdi Amilia, Fenni Amir, Arni Andani Eka Putra Ariadi, Ariadi Aswiyanti Asri Avit Suchitra Carlo Prawira Azali Crisdina Suseno Dedy Kurnia Dessy Arisanty Dina Arfiani efrida efrida Efrida Efrida, Efrida Eka Nofita Elizabeth Bahar Eryati Darwin Eryati Darwin Eva Chundrayetti Firdawati, Firdawati Ginting, Desi Scorpinasari Hanum, Fathiya Juwita Hasmiwati Herman, Deddy Husna Yetti Husna Yetti Izzati, Ruhilda Karmia, Hudila Rifa Lili Irawati Linosefa Linosefa Masrul Masrul Syafri Muhammad Lingga Primananda Nita Afriani Nita Afriani Novita Ariani Noza Hilbertina, Noza Nur Indrawaty Lipoeto Putri Ariani Putri, Biomechy Oktomalio Rahman, Rifna Alya Ramadani, Mery Reynaldo Rahima Putra Rikarni Rikarni Rina Gustia Rinal Effendi Rinang Mariko, Rinang Rizola, Clodeya Roza Silvia Rudy Afriant Rustam, Rony Selfi Renita Rusjdi Sheila Diana SM Rezvi Sriyanti, Roza Suherlis, Septia Sukri Rahman Susmiati Susmiati Tegar Abdillah Tri Anggraini, Fika Trisuliandre, Muhammad Rizki Tuti Handayani Tyas, Syanindhita Wikanthining Wizia, Lady YN Zuhal Chaisart Chaniago Yulia Kurniawati Yulistini, Yulistini Yusrawati Yusrawati Yusri, Elfira