Article Per Year (5 Year)
p-Index From 2021 - 2026
0.778
P-Index
This Author published in this journals
All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia Jurnal Kartika Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia
Muhamad Salman Fareza
Departement Of Pharmacy, Faculty Of Mathematics And Natural Science, Udayana University, Bali 80361, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Molecular Docking of 6-shogaol and Curcumin on DNMT1 and LSD1 As Potential Agents for Thalassemia Treatment Joko Setyono; Sekar Cahyo Nurani; Muhamad Salman Fareza; Arif Fadlan; Sarmoko Sarmoko
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 6, No 3 (2021): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v6i3.54346

Abstract

Beta-thalassemia therapy is developed by increasing γ-globin production which binds to α-globin to form haemoglobin fetal (HbF). Meanwhile, DNA methyltransferase 1 (DNMT1) and lysine specific demethylase 1 (LSD1) play an important role in silencing the HbF gene by inhibiting the production of HbF and inducing haemoglobin subunit alpha (HbA) expression. 6-Shogaol and curcumin induce HbF by inhibiting signal transducer and activator of transcription 3 (STAT3) expression. Therefore, this study predicts the interaction between 6-shogaol and curcumin on DNMT1 and LSD1. The protein structure of DNMT1 (3SWR) and LSD1 (6KGP) was prepared by removing the water molecules, while the validation step was performed by separating protein from native ligands (sinefungin for 3SWR and flavine-adenine dinucleotide (FAD) for 6KGP) in new protein data bank files. Furthermore, the protein was docked with a native ligand to obtain grid box coordinates, while the root means standard deviation (RMSD) was calculated from the conformation results of the validation process. 6-Shogaol and curcumin were docked with coordinates of the validation results, and the best conformation was visualized with Discovery Studio. The validation step results in the RMSD value of 0.861Å and 1.410Å for DNMT1 and LSD1, respectively. The binding affinity of 6-shogaol and curcumin on DNMT1 was -6.5 kcal/mol and -8.0 kcal/mol, respectively. Furthermore, the binding affinity of 6-shogaol and curcumin on LSD1 was -8.2 kcal/mol and -10.1 kcal/mol, respectively. Amino acid residues found in DNMT1 interaction include Gly1147, Phe1145, Glu1168, Asn1278, Pro1225, Leu1151, Val1580, Ala1579, Asn1578, Trp1170, and Ala1579; meanwhile, Val288, Ser289, Arg310, Gly285, Thr624, Leu659, Lys661, Arg316, Leu625, Tyr761, Trp751, Gly330, and Leu659 were found in LSD1. This study showed that curcumin has the potential to inhibit DNMT1 as well as LSD1 proven by lower bonding energy and stronger bond types compared to sinefungin and FAD native ligands and other DNMT1 and LSD1 inhibitors.
Free Chlorine Determination in Disinfectant Product using Visible Spectrophotometry based on Prussian Blue Degradation Hendri Wasito; Defi Srium Siagian; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5371

Abstract

Disinfectant products with excessive chlorine could be dangerous for health and need quality control. It is important to develop an analytical method for monitoring product quality. The main objective of this work is to develop an alternative method and evaluate the analytical performance of visible spectrophotometry for determining free chlorine in disinfectant products based on the Prussian blue decomposition process. The capability of chlorine to oxidize ferrous to ferric ions makes the Prussian blue generated by ferrosulfate and potassium ferricyanide is decomposed and measured by spectrophotometer. The formation of Prussian blue was improved by optimizing some reaction conditions and assessing incubation time. Linearity, analytical concentration range, precision, accuracy, detection limit, and quantitation limit parameters were among the examined analytical parameters. The results showed that the optimum concentration of ferrosulfate, potassium ferysianide, and hydrochloric acid for Prussian blue formation was 2.0 mmol L-1, 3.0 mmol L-1, and 0.5 mol L-1, respectively, with 15 minutes incubation time after chlorine addition. Analytical performance parameters seemed appropriate for routine analysis purposes. The developed method can also be applied as an alternative analytical method to determine the free chlorine concentration of disinfection products in the market.
TRANSFORMATION OF ETHYL-P-METHOXYCINNAMATE TO P –METHOXYCINNAMIC ACID FROM KENCUR (Kaempheria galanga L.) AND THEIR ANTIBACTERIAL ACTIVITY Muhamad Salman Fareza; Rehana Rehana; Nuryanti Nuryanti; Didin Mujahidin
ALCHEMY Jurnal Penelitian Kimia Vol 13, No 2 (2017): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.13.2.8472.176-190

Abstract

This study aimed to evaluate the antibacterial properties of ethyl-p-methoxycinnamate and p-methoxycinnamate acid from Kaempheria galanga L. Ethyl-p-methoxycinnamate was isolated from the n-hexane rhizome extract of Kaempheria galanga L. Separation and purification of this compound was carried out with vacuum liquid chromatography and column chromatography. Hydrolysis of ethyl-p-methoxycinnamic under alkaline conditions obtained p-methoxycinnamic acid with a good yield of 85 %. The structure of the compounds were charactrized with IR, NMR spectrophotometer (1H-NMR and 13C-NMR) and mass spectrophotometer. The antibacterial properties of the compounds were evaluated using microdilution methods against B. cereus ATCC 11778, L. monocytogenes ATCC 7644, E. coli ATCC 25922, S. enterica sv Typhimurium ATCC 14028, and E. aerogenes ATCC 13048. The compounds showed weak antibacterial properties. Only ethyl p-methoxycinnamate showed the strongest antibacterial activity, especially against B. cereus ATCC 11778 bacteria with MIC values of 62.5 mg /mL. The change of the functional groups provided no significant impact on the antibacterial activity.
Phytochemical Screening and Antibacterial Activity of Ethanolic Extract of Syzygium samarangense Leaves Nur Amalia Choironi; Muhamad Salman Fareza
Jurnal Kartika Kimia Vol 1 No 1 (2018): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.629 KB) | DOI: 10.26874/jkk.v1i1.2

Abstract

The ethanolic extracts of S. samarangense leaves were examined for antibacterial activity in vitro using broth microdillution method. The extracts showed effective against Bacillus cereus, Salmonella enterica with MIC (minimum inhibition concentration) value 78 µg/ml and against multi strains of Escherichia coli, Enterobacter aerogenes, Kocuria rhizophila with MIC value 2500 µg/mL, 2500 µg/mL and 156 µg/mL. Phytochemical screening of S. samarangense was observed for the presence of tannins, alkaloids, flavonoids, and terpenoids.
ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF DARI DAUN JAMBU MAWAR (SYZYGIUM JAMBOS (L.) Alston) Soenarto Soetomo; Eviyana Eviyana; Nur Amalia Choironi; Nilta Dizzania; Muhamad Salman Fareza; Ade Martinus
Jurnal Sains dan Terapan Kimia Vol 13, No 2 (2019)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.079 KB) | DOI: 10.20527/jstk.v13i2.5884

Abstract

Syzygium jambos (jambu mawar) merupakan salah satu tumbuhan tropis khas Indonesia. Tumbuhan ini secara empiris telah digunakan sebagai tumbuhan obat tradisional. Kajian fitokimia tumbuhan ini yang berasal dari Indonesia masih terbatas.Tujuan penelitian ini adalah mengisolasi dan mengidentifikasi senyawa fenolik dari bagian daun S. jambos asal Purwokerto. Proses ektraksi daun S. jambos dilakukan dengan menggunakan metode maserasi. Fraksinasi dan pemurnian ektrak menggunakan metode kromatografi vakum cair dan kromatografi gravitasi. Identifikasi isolat dilakukan menggunakan metode spektroskopi 1H-NMR dan 13C-NMR. Berdasarkan hasil isolasi yang dilakukan telah diperoleh satu senyawa fenolik yaitu asam anakardat dengan rantai samping alkil diena.
Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Abstract

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.
Optimasi Formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) Etil-p-metoksisinamat (EPMS) Nur Amalia Choironi; Beti Pudyastuti; Giri Gumelar; Muhamad Salman Fareza; Triyadi Hendra Wijaya; Joko Setyono
ALCHEMY Jurnal Penelitian Kimia Vol 18, No 2 (2022): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.18.2.56847.205-213

Abstract

Penelitian ini bertujuan untuk menentukan formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) menggunakan zat aktif etil-p-metoksisinamat (EPMS). Formula SNEDDS terdiri dari cremophor RH 40 sebagai surfaktan, propilen glikol sebagai ko-surfaktan, Virgin Coconut Oil (VCO) sebagai fase minyak dan EPMS sebagai zat aktif. Penentuan perbandingan surfaktan dan ko-surfaktan menggunakan metode Simplex Lattice Design (SLD) dengan software Design-Expert versi 13.0. Formula optimum SNEDDS EPMS memiliki komposisi EPMS 100 mg/mL, cremophor RH 40 53,6%, propilen glikol 26,4% dan VCO 20% sesuai dengan rekomendasi dari SLD menghasilkan SNEDDS dengan transmitan 95,43%, waktu emulsifikasi dalam aquadest 8,33 menit, ukuran partikel 30,16 nm, zeta potensial -61,03 mV dan indeks polidispersitas 0,160. Penelitian ini menunjukkan bahwa dengan formula SNEDDS 53,6% cremophor RH 40; 26,4% propilen glikol dan EPMS dapat meningkatkan nilai transmitan dan waktu emulsifikasi.Formula Optimization of the Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Ethyl-p-methoxycinnamate (EPMC). This research aimed to optimize the Self-Nanoemulsifying Drug Delivery System (SNEDDS) formula of the ethyl-p-methoxycinnamate (EPMS). The SNEDDS formula was prepared using cremophor RH 40 as a surfactant, propylene glycol as a co-surfactant, VCO as an oil phase, and EPMS as an active ingredient. Proportion surfactant and co-surfactant were determined using the simplex lattice design (SLD) method using the Design-Expert software version 13.0. The optimum formula of EPMC SNEDDS are EPMC cremophor RH 40, propylene glycol, VCO and EPMS was 100 mg/ml, 53.6%, 26.4%, and 20% based on SLD data. The formulation was a transmittance of 95.43%, an emulsification time of 8.33 minutes, a particle size of 30.16 nm, a zeta potential of -61.03 mV, and polydispersity index of 0.160. The result showed that the proportion of cremophor RH 40; 26,4% propylene glycol, and EPMC were able to increase the value of transmittance and emulsification time.
Co-Authors Ade Martinus Agnes Yuliasari Beti Pudyastuti Defi Srium Siagian Didin Mujahidin Eviyana Eviyana Fadlan, Arif Giri Gumelar Hendri Wasito Joko Setyono Joko Setyono Nilta Dizzania Nur Amalia Choironi Nuryanti Nuryanti Rehana Rehana Sarmoko Sarmoko Sekar Cahyo Nurani Soenarto Soetomo Sri Sutji Susilowati Sunarto Sunarto Triyadi Hendra Wijaya