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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Riset Kimia Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia JPSCR : Journal of Pharmaceutical Science and Clinical Research Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat International Journal of Basic and Applied Science Journal of Science and Technology Research for Pharmacy Pharmaceutical Sciences and Research (PSR) Pharmaqueous Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Gizi dan Kesehatan Masyarakat
Triyadi Hendra Wijaya
Department Of Pharmacy, Faculty Of Health Sciences, Universitas Jenderal Soedirman, Jl. Dr. Soeparno, Purwokerto, Indonesia, 53122.
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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The Antibacterial Activity of Acanthus ilicifolius L. n-Hexane Fraction warsinah, warsinah; Wijaya, Triyadi Hendra; Ekowati, Nuraeni
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.49615

Abstract

Background: Recently, with the high prevalence of diarrhoea caused by bacterial infection, the usage of antibiotics has increased. Antibiotic overuse might lead to several side effects and resistance, suggesting the development of an alternate antibacterial agent. A mangrove plant, Acanthus Illinois, contained triterpenoid, which has antibacterial properties. Aim: This study aimed to evaluate the antibacterial effect of the Acanthus Illinois n-hexane fraction against Escherichia coli and Shigella dysenteriae. Method: The Acanthus Illinois was fraction using n-Hexane, identification of secondary metabolite compound using GC-MS, and evaluation of antibacterial activity against Escherichia coli and Shigella dysenteriae under paper disc methods. This study was designed using a fully randomized design (CRD) with concentrations of fractions 1%, 2%, and 4%. The GC-MS results were compared to the WILEY 9 library and analysed. A prism graph was used to measure the inhibition zone of antibacterial activity. Result: The n-hexane fraction yield is 3.3% and contains sesquiterpene compounds (trans (beta.)-caryophyllene, alpha humulene, naphthalene decahedron-4A-methyl), terpenoid alcohol (3,7,11,15-tetramethyl -2-hexadecane-1-ol), and fatty acids (hexadecanoic acid methyl ester. Acanthus Illinois n-hexane fraction has antibacterial activity against Escherichia coli and Shigella dysenteriae in a dose-dependent manner. Conclusion: The n-hexane fraction of leaves Acanthus ilicifolius contains sesquiterpene, alcohol terpenoids, and fatty, and has antibacterial activity against Escherichia coli and Shigella dysenteriae
Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Abstract

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.
Pengujian Mutu Sediaan Kapsul Minyak Hati Ikan Cucut Botol Dalam Beberapa Produk yang Beredar di Pasaran Wijaya, Triyadi Hendra; Kartawinata, Tutus Gusdinar; Nugrahani, Ilma
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

National standard agency of Indonesia has set the quality standard of shark liver oil through the Indonesian national standard which consists of sensory test, moisture content, free fatty acid as well as squalene concentration. The purpose of this study is to evaluate quality of shark liver oil capsule on market. As many as 6 samples were tested for the quality in accordance to SNI through organoleptic test (< 7), moisture content (max 0.3%), free fatty acid content (max 1.5%) and squalene concentration (min 70%). The results showed that the level of squalene in all samples do not meet the standard requirement, however all samples meet the free fatty acid content requirements. One sample does not fit the standard criteria in the term of organoleptic test and moisture content.
The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system Beti Pudyastuti; Triyadi Hendra Wijaya
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.461 KB) | DOI: 10.12928/pharmaciana.v12i3.18881

Abstract

Kencur (Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility of the extract in water. The purpose of this study was to determine the effect of surfactant combination on the kencur rhizome extract in the SNEDDS system. The SNEDDS formulations were carried out by selecting the surfactant ratio of Tween 80:Span 80 and Tween 80:Chremophor RH 40, followed by selecting the ratio of surfactant mixtures to polyethylene glycol 400 as co-surfactant, and to virgin coconut oil as the oil phase. The clarity, transmittance, emulsification time, particle size, and polydispersity index were evaluated. The stability test was carried out in aquadest, artificial gastric fluid, and artificial intestinal fluid for 4 hours at 37°C. The results showed that the combination of Tween 80: Chremophor RH 40 produced better SNEDDS than Tween 80:Span 80. The combination of surfactant-cosurfactant of Tween 80:Chremophor RH 40:PEG 400 at ratio 3:1 and 1:1 could produce homogenous dispersed SNEDDS showing droplet size of 23,0 and 21,8 nm; transmittance of 95.63% and 93.83%, and SNEDDS preconcentrate emulsified less than 35 seconds. The single surfactant Tween 80:PEG 400 at the ratio 3:1 produce better dispersed SNEDDS than the combined surfactant with droplet size 16.3 nm, transmittance 97.85%, and SNEDDS preconcentrate emulsified less than 45 seconds. The SNEDDS system could produce a smaller droplet size than the extract in aquadest.
Efek Ukuran Partikel terhadap Disolusi Ibuprofen Yosephine, Samuella; Intan, Nur; Anjani, Sabrina; Rahma, Shesa; Pudyastuti, Beti; Wijaya, Triyadi Hendra; Kurniawan, Dhadhang Wahyu
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.3409

Abstract

The dissolution rate is an important characteristic to consider when designing a pharmaceutical dosage form, particularly for oral medications. Ibuprofen is an oral medication with a low dissolution rate. The common solution to this problem is to increase the dose to improve drug absorption and effectiveness in order to achieve therapeutic concentration. Some methods to increase dissolution rates have been explored, such as salt formation, prodrug formation, particle size reduction, crystal modification, micellar solubilization, complex formation, solid dispersion, and self-emulsifying. This review focuses on a strategy for increasing ibuprofen dissolution rate by reducing the particle size of the drug. Reduced particle size could improve ibuprofen solubility, allowing it to be absorbed more easily and achieve the desired therapeutic effect.
Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto, Sunarto; Yuliasari, Agnes; Susilowati, Sri Sutji; Wasito, Hendri; Wijaya, Triyadi Hendra; Fareza, Muhamad Salman
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Abstract

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.
Upaya Promotif Untuk Meningkatkan Status Gizi Siswa Sekolah Dasar Melalui Pendidikan Sarapan Sehat Kepada Siswa dan Guru Prasetyo, Teguh Jati; Khoiriani, Izzati Nur; Wijaya, Triyadi Hendra; Wicaksari, Sifa Aulia
Jurnal Pengabdian Gizi dan Kesehatan Masyarakat Vol 2 No 1 (2024): Agustus
Publisher : Ikatan Sarjana Gizi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53823/jpgkm.v2i1.79

Abstract

Sarapan merupakan kegiatan makan di pagi hari yang dilakukan sebelum melakukan aktivitas dengan komposisi makanan yang mencakup zat tenaga, zat pembangun, dan zat pengatur. Sarapan merupakan sumber energi bagi anak sekolah untuk melakukan aktivitas dan belajar di sekolah. Kegiatan ini dilakukan di SDN Kemiri 03 dengan melibatkan 10 guru dan 33 siswa kelas 5 dan 6. Kegiatan ini terdiri atas 3 kegiatan utama yaitu penyusunan Media dan Materi pelatihan untuk guru dan siswa, Traning of Trainer bagi Guru SD dan Edukasi dan Demo Sarapan Sehat kepada Siswa. Berdasarkan hasil kegiatan diketahui bahwa hanya ada 15 dari 33 siswa yang terbiasa melakukan sarapan. Sementara untuk guru sudah terbiasa sarapan namun belum memenuhi kategori sarapan sehat. Kegiatan ini diharapkan mampu meningkatkan kebiasaan sarapan sehat baik bagi guru maupun siswa.
Forced Degradation and Stability Testing of Chloramphenicol Ear Drops Using Derivative Spectrophotometry Combining with Chemometrics Rahmah, Annisa; Wijaya, Triyadi Hendra; Wasito, Hendri
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art5

Abstract

Background: Chloramphenicol eye drops have a lower stability than solid dosage forms. Hence, it is necessary to assess their stability. One stability test that can be conducted is the forced degradation approach, which involves applying stress conditions that are more severe than those used in accelerated stability testing.Objective: This study used forced degradation to explore the stability profile of chloramphenicol ear drops.Methods: Stability analysis was carried out using a derivative spectrophotometric instrument combined with chemometric analysis. The forced degradation study was conducted by exposing the sample to three conditions: acidic (0.1 N HCl at 80°C for 2 hours), alkaline (0.1 N NaOH at 80°C for 2 hours), and heat (90°C for 4 hours). Principal Component Analysis (PCA) and Partial Least Squares–Discriminant Analysis (PLS-DA) were utilized for the chemometric analysis. Results: Sequential chloramphenicol observations with a zero to third derivative show a maximum wavelength of 278, 260, 234, and 292 nm. According to stability studies with forced degradation, chloramphenicol tended to degrade under alkaline and thermal conditions compared to acidic conditions. A typical grouping pattern amongst forced degradation treatments is revealed by chemometric analysis, which characterizes chloramphenicol's stability profile under different experimental settings.Conclusion: The UV-Vis spectrophotometric approach, both non-derivative and derivative, can describe changes in chloramphenicol degradation profiles, although the specific degradation products generated remain unknown.
Nephroprotective effect and untargeted metabolomic analysis of celery extract against diethylene glycol induced nephrotoxicity in rats Wijaya, Triyadi Hendra; Ekowati, Heny; Wasito, Hendri; Maryellen, Geeta; Silitonga, Tasya Melinda; Oktavian, Firdaus
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.190-200

Abstract

Background Diethylene glycol (DEG) is known for its nephrotoxic effects as a contaminant. Recent investigations suggest that celery extract potentially protects against DEG-induced renal toxicity, warranting an exploration of the non-targeted metabolomic profile of celery in renal tissue. This study aimed to determine celery nephroprotective effects and identify potential biomarkers using an untargeted metabolomic  celery profile in DEG-induced kidney injury in male rats. Methods An experimental study was conducted involving 24 male Wistar rats, randomized into control and three treatment groups receiving DEG at doses of 1, 3, and 5 g/BW for three days. After 14 days, all rats were sacrificed. For the celery nephroprotective and metabolomic study, 27 male rats were randomized into three groups:  control, DEG group at 3g/BW, and DEG-celery group (receiving celery extract 200mg/kg BW single dose for 6 days). After 14 days, blood was tested for creatinine level and untargeted metabolomic analysis using liquid chromatography-high resolution mass spectrometry. One-way ANOVA was used to analyze creatinine data. Results Diethylene glycol at doses of 1 and 3 g/kg BW caused mild renal damage, while 5 g/kg BW resulted in moderate damage. Creatinine levels in the normal, DEG-induced, and DEG-celery groups were 0.55 ± 0.14, 0.71±0.1, and 0.86± 0.17 mg/dL, respectively, but not statistically significantly different between groups (p>0.05). DEG lead tryptophan and phenylalanine levels increased 45-fold and 123-fold, respectively. Celery reduced levels of these metabolites 21-fold and 65-fold, respectively. Conclusion Diethylene glycol led to mild to moderate renal damage. Celery effectively diminished metabolite levels associated with renal damage, specifically tryptophan and phenylalanine.
Nephroprotective and Hepatoprotective Effects of Turmeric in Diethylene Glycol Induced Toxicity in Rats Ekowati, Heny; Devitasari, Arinda; Fitriani, Novita Inawanda; Endriastuti, Nialiana Endah; Wijaya, Triyadi Hendra
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95225

Abstract

In 2022, children in Indonesia experienced acute renal failure due to antipyretic syrup contaminated with diethylene glycol (DEG). DEG is a known contaminant in pharmaceutical solvents that can induce inflammation and act as a free radical, leading to kidney and liver damage. Turmeric (Curcuma Longa) has been reported to have nephroprotective and hepatoprotective effects due to anti-inflammatory and antioxidant properties. This study aims to evaluate the protective effects of turmeric ethanol extract on rat kidneys and liver subjected to DEG toxicity. Rats were divided into five groups (n=5 per group): Group I served as the normal control, while Group II received DEG orally at 3 g/kg BW twice daily for three days. Groups III, IV, and V were treated with DEG (3 g/kg BW) along with turmeric ethanol extract at a doses of 100, 200, and 400 mg/kg BW, respectively, administered orally twice daily for six days. After 14 days, all rats were sacrificed for macroscopic and microscopic evaluation using hematoxylin-eosin (H&E) staining. The results showed that rats treated with turmeric extract exhibited significantly significantly less kidney and liver damage (p<0.05). Kidney protection was evidenced by improvements in endothelial tissue, glomeruli, and tubules, while liver protection was indicated by reduced Kupffer cell activation, sinusoidal dilatation, hepatocyte degeneration, and necrosis. In conclusion, turmeric ethanol extract effectively protects against DEG-induced kidney and liver toxicity in rats.
Co-Authors Agnes Yuliasari Agustina, Laely Triyani Ajeng Puspo Aji Anita Ratna Faoziyah, Anita Ratna Anjani, Sabrina Asrada, Syahdan Beti Pudyastuti Beti Pudyastuti Beti Pudyastuti, Beti Choironi, Nur Amalia Defa, Ines Naila Devitasari, Arinda Dhadhang Wahyu Kurniawan Elisa Issusilaningtyas Endriastuti, Nialiana Endah Faiqoh, Maziyatul Fareza, Muhamad Salman Fischellya, Dafi Fitriani, Novita Inawanda Garcella, Prilyano Giri Gumelar Hendri Wasito HENDRI WASITO Heny Ekowati Ilma Nugrahani Joko Setyono Kartawinata, Tutus Gusdinar Khoiriani, Izzati Nur Maryellen, Geeta Mubarak, Zulfikar Yusya Muslimah, Gadizza Mustikaningtyas, Ika Mutia Wulandari, Mutia Nur Amalia Choironi Nur Intan, Nur Nuraeni Ekowati, Nuraeni Oktavian, Firdaus Puteri, Adelia Rahma, Shesa Rahmah, Annisa Rehana, Rehana Rizkya, Dayna Rizqi, Titis Alvanur Salsabila, Wilda Adelia Samudra, Genta Hafied Naga Sarmoko Sarmoko Setiyabudi, Lulu Silitonga, Tasya Melinda Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Suryoputri, Masita Wulandari Tahya, Khofifah Teguh Jati Prasetyo Tuti Sri Suhesti Warsinah Warsinah Wicaksari, Sifa Aulia Yosephine, Samuella Yuliasari, Agnes yunadi, frisca dewi