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All Journal Majalah Kedokteran Bandung Indonesian Journal of Tropical and Infectious Disease Jurnal Pembelajaran dan Biologi Nukleus International Journal of Science and Society (IJSOC) Jurnal MedScientiae
Monica Puspa Sari
Universitas Kristen Krida Wacana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal MedScientiae

 1 
E Efektivitas Albendazol Dosis Tunggal terhadap Infeksi Soil Transmitted Helminths (STH) Sari, Monica Puspa
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3110

Abstract

The problems of worm’s infection is still a problem for Indonesian people, especially children who live in endemic areas with a lack of sanitation and clean water. The two recommended treatment regiments are Albendazole 400 mg and Mebendazole 500 mg. Several studies report that the efficacy of albendazole varies. The aims of literature review is to assess the efficacy of albendazole against STH infections, and the factors that influence the efficacy of albendazole, factors that can increase efficacy and reduce efficacy. The research method used is a literature review with a descriptive approach based on literature from relevant research articles or journals. Library searches were searched via Google scholar, Pubmed, E-journal. The keywords and boolean operators used in the research are albendazole AND Soil transmitted helminths OR cure rate OR egg reduction rate. The CR of a single dose of albendazole against A. lumbricoides reaches 80-100%. 50-54% of hookworm infections occur due to frequent recurrent infections. There were differences in results regarding the CR of T. trichiura 12,8%-66,7% and 80-90%. This difference occurs due to differences in the degree of unfections. Single dose albendazole base on CR and ERR is less effective against T. trichiura infection. Albendazole should be given in combination with other drugs or in extra doses to eliminate STH infections.
Prevalensi dan Hubungan Infeksi Protozoa Usus dengan Kejadian Diare di RSUD Kemayoran Tahun 2020-2021 Sari, Monica Puspa; Pandapotan, Roy Akur; Agustina, Nurul Fitria
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3464

Abstract

Infeksi protozoa usus masih menjadi permasalahan di dunia, terutama di negara berkembang seperti Indonesia dengan angka prevalensi 10-18%. Infeksi protozoa usus dapat menyebabkan diare pada anak. Tujuan penelitian adalah ingin mengetahui prevalensi dan hubungan protozoa usus pada penderita diare yang dirawat di RSUD Kemayoran Jakarta. Metode penelitian yaitu analitik deskriptif dengan pendekatan cross sectional menggunakan data rekam medik penderita diare pada tahun 2020-2021 di RSUD Kemayoran. Hasil penelitian ini menunjukkan dari 76 responden didapatkan bahwa kejadian diare di RSUD Kemayoran pada tahun 2020 sampai 2021 paling banyak terjadi pada anak laki laki dengan prevalensi protozoa usus (10,5%). Entamoeba histolytica merupakan protozoa usus yang paling sering menyebabkan diare pada anak. Gejala mual ditemukan sebanyak 5,3%, tanpa dehidrasi sebanyak 6,6% dengan lama rawat 3 hari (9,2%). Hasil uji Fisher menunjukkan bahwa terdapat hubungan yang bermakna antara infeksi protozoa usus dengan gejala mual yang timbulkan (p=0,044), terdapat hubungan antara infeksi protozoa usus dengan karakteristik tinja yang cair (p=0,048) dan berlendir (p=0,045). Hasil uji Mann Whitney menunjukkan bahwa terdapat hubungan antara infeksi protozoa usus dengan usia, pekerjaan dan tingkat pendidikan (p=0,000) serta kadar hemoglobin (p=0,013). Kesimpulan terdapat hubungan antara infeksi protozoa usus dengan gejala mual, konsistensi tinja, usia, pekerjaan, tingkat pendidikan dan kadar hemoglobin.
The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Co-Authors Agustina, Nurul Fitria Didi Kurniadhi Esther Sri Majawati Masiku, Gabriela Limbong Nathasaria, Tabita Pangaribuan, Helena Ullyartha R. Sapto Hendri Boedi Soesatyo Roy Akur Pandapotan, Roy Akur Sabini, Jasmine Harumi Santoso, Adit Widodo Susilowati, Rina Priastini