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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Jurnal MedScientiae
Roy Akur Pandapotan, Roy Akur
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Modulasi Mikrobiota untuk Memperbaiki Laju Filtrasi Glomerulus, Toksin Uremik, dan Penanda Inflamasi pada Gagal Ginjal Kronik: Telaah Sistematik dan Meta-Analisis Gunawan, Burhan; Purwata, Raymond Sebastian; Hidayat, Syarif; Pandapotan, Roy Akur; Jennifer, Jennifer
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients. Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic Review and Meta-Analysis). Only randomized controlled trial (RCT) articles investigating the effect of symbiotic, prebiotic, of probiotic for CKD were included in the analysis. Effect size quantify from Standardized Mean Difference (SMD), using a continuous random effect model and described in the forest plot model. Results. A total of 17 RCT studies with a total 867 CKD stage 1-5 subjects (440 subjects in the intervention group and 427 subjects in the control group). The intervention duration ranging from 1-12 months. The studies included had varied on methodologies, with significant heterogenicity (I296,96%, p Conclusions. The administration of probiotic/prebiotic/symbiotic supplements to CKD patients resulted in significant improvements in e-GFR and reductions in total pCS. These results suggest the potential of symbiotic, prebiotic, and probiotic supplementation to improve CKD outcome. Keywords: Chronic kidney disease, e-GFR, hs-CRP, prebiotic, probiotic, uremic toxin
Approach to Diagnosis and Treatment of Drug Allergy Pandapotan, Roy Akur; Rengganis, Iris
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Drug allergy is a serious medical problem. Drug allergy can be defined as an adverse drug reaction involving immunological mechanism. However, it is not easy to decide whether an adverse drug reaction is an allergic reaction, and it requires a systematically diagnostic approach. Beside a thorough history taking and physical examination, there are general and specific laboratory examination to investigate drug allergy which can be done in vivo, in vitro, or biopsy. The management of drug allergy include the avoidance of the precipitating event, and specific methods to reduce the drug reaction which include threating through, dosing test, desensitization, and the administration of premedication for certain drugs.
Prevalensi dan Hubungan Infeksi Protozoa Usus dengan Kejadian Diare di RSUD Kemayoran Tahun 2020-2021 Sari, Monica Puspa; Pandapotan, Roy Akur; Agustina, Nurul Fitria
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3464

Abstract

Infeksi protozoa usus masih menjadi permasalahan di dunia, terutama di negara berkembang seperti Indonesia dengan angka prevalensi 10-18%. Infeksi protozoa usus dapat menyebabkan diare pada anak. Tujuan penelitian adalah ingin mengetahui prevalensi dan hubungan protozoa usus pada penderita diare yang dirawat di RSUD Kemayoran Jakarta. Metode penelitian yaitu analitik deskriptif dengan pendekatan cross sectional menggunakan data rekam medik penderita diare pada tahun 2020-2021 di RSUD Kemayoran. Hasil penelitian ini menunjukkan dari 76 responden didapatkan bahwa kejadian diare di RSUD Kemayoran pada tahun 2020 sampai 2021 paling banyak terjadi pada anak laki laki dengan prevalensi protozoa usus (10,5%). Entamoeba histolytica merupakan protozoa usus yang paling sering menyebabkan diare pada anak. Gejala mual ditemukan sebanyak 5,3%, tanpa dehidrasi sebanyak 6,6% dengan lama rawat 3 hari (9,2%). Hasil uji Fisher menunjukkan bahwa terdapat hubungan yang bermakna antara infeksi protozoa usus dengan gejala mual yang timbulkan (p=0,044), terdapat hubungan antara infeksi protozoa usus dengan karakteristik tinja yang cair (p=0,048) dan berlendir (p=0,045). Hasil uji Mann Whitney menunjukkan bahwa terdapat hubungan antara infeksi protozoa usus dengan usia, pekerjaan dan tingkat pendidikan (p=0,000) serta kadar hemoglobin (p=0,013). Kesimpulan terdapat hubungan antara infeksi protozoa usus dengan gejala mual, konsistensi tinja, usia, pekerjaan, tingkat pendidikan dan kadar hemoglobin.
Pola Pasien Anemia yang dirawat Inap di RS UKRIDA Tahun 2021-2023 Allotodang, Thiessa Gabriel; Pandapotan, Roy Akur; Suhayanly, Nella
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3653

Abstract

Anemia is when hemoglobin levels fall below normal levels and are unable to provide oxygen to body tissues. Symptoms may include lethargy, fatigue, weakness, ringing in the ears, cold feet, shortness of breath, eye strain, and dyspepsia. Several processes, including decreased red blood cell production, increased red blood cell destruction, and blood loss, can cause anemia. The number of anemia cases in Indonesia ranks fifth in Southeast Asia. Three types of anemia are normocytic normochrome, microcytic hypochrome, and macrocytic. This study aims to determine the pattern of anemia patients hospitalized at UKRIDA Hospital in 2021-2023. This research is a descriptive study with a cross-sectional design. The results showed that anemia is more common in the 18-60 age group (60%), but quite a lot also occurs in geriatrics due to nutritional deficiencies and chronic diseases. Anemia was more common in women (80%). The majority of patients (93.8%) had comorbid diseases, with the most common conditions including type 2 diabetes mellitus, hypertension and chronic kidney disease. Only 13.8% of patients underwent surgery while 61.5% of patients received blood transfusions. The most common type of anemia experienced was normocytic normochrome anemia.
Platelet to White Blood Cell Ratio (PWR) to Predict Mortality in Acute on Chronic Liver Failure of Cirrhosis Patient: A Systematic Review Pandapotan, Roy Akur; Gunawan, Burhan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022180-187

Abstract

Background: Liver cirrhosis (LC) is still being important public health concern, due to the rising of global incidence and mortality. There is risk progression in LC patients to acute-on-chronic liver failure (ACLF) patients with high incidence of complication and high short-term mortality rate. It needs rapid and simpler predictor to immediate and accurate triage of the patient. The aim of this study is to review systematically the role of PWR to predict the mortality in ACLF cirrhosis patient.Method: This systematic review study was identified by searching Pub-Med, Cochrane library, and EMBASE database (2016-2022). Only observational studies were included. ACLF patient was selected as the main subject in each study, and PWR was added as short-term mortality predictor. The Cochran seven step model was used to perform the review.Results: Six cohort retrospective studies met inclusion criteria, including total 1,348 patient ACLF. Half of studies included had high level of evidence. The non-survivor ACLF patient had significantly lower PWR values than survivor. The range of HR of PWR to predict mortality in ACLF was 0.665-0.995, with p value 0.0001. Whereas the cutoff range of PWR value to predict non survivor in ACLF patient was 7.83-14.2.Conclusion: PWR had a predictive efficacy, similar to CLIF-SOFA and MELD score in terms of predicting short-term mortality in ACLF patients. PWR showed significantly independent risk factor of short term mortality in ACLF cirrhotic patient.
Co-Authors Agustina, Nurul Fitria Allotodang, Thiessa Gabriel Gunawan, Burhan Iris Rengganis Jennifer Jennifer Monica Puspa Sari Purwata, Raymond Sebastian Suhayanly, Nella Syarif Hidayat