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Neni Sawitri

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Author-ID : 374832

Humanities Medicine & Pharmacology Nursing Public Health

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Asthma symptoms improvement in moderate persistent asthma patients with gastroesophageal reflux disease (GERD): the role of proton-pump inhibitor Susanto, Agus D.; Yunus, Faisal; Wiyono, Wiwien H.; Sawitri, Neni; Lelosutan, Syafruddin A.R.
Medical Journal of Indonesia Vol 17, No 3 (2008): July-September
Publisher : Faculty of Medicine Universitas Indonesia

This study aimed to evaluate effect of proton pump inhibitor (esomeprazole) on asthma symptoms, use of inhaled bronchodilator and peak expiratory flow rate (PEFR) in moderate persistent asthma with gastroesofageal refluks disease (GERD). This randomized single blind, controlled clinical trial study was conducted at Persahabatan Hospital, Jakarta from July 2004 until October 2005. Samples were moderate persistent asthma patients with GERD. GERD is diagnosed GERD symptoms and proof of oesophagitis from endoscopy and or histapatologic examination from oesophagus biopsy. Phase 1:2 week run-in period patient received inhaled budesonide 2x200 ug/day. Phase 2: patient randomised to receive inhaled budesonide 2 x 400 ug/day with esomeprazole 40 mg/day or without esomeprazole (control group) for 8 weeks. Phase 3: 4 week wash out period, patient receive inhaled budesonide 2 x 200 ug/day. Diary cards were assessed at run-in periode, after treatment 4 weeks, 8 weeks and wash out. There were 32 patients (23 female and 9 male) completed the study. Mean total asthma symptoms score daily were significantly decreased on esomeprazole vs without esomeprazole after 8 weeks (-2.29 vs -0.90; p < 0.05). Mean use of inhaled bronchodilator was significantly decreased on esomeprazole vs without esomeprazole after 8 weeks (-1.09 vs -0.42; p < 0.05). Morning and evening PEFR improved higher on esomeprazole than without esomeprazol but were not significantly difference. In conclusion, administration esomeprazole 40 mg daily improved asthma symptoms and lower the use of inhaled bronchodilator in moderate persistent asthma patients with GERD. (Med J Indones 2008; 17: 169-74)Keywords: Asthma symptoms, inhaled bronchodilator, moderate persistent asthma, GERD, esomeprazole

Hubungan Antara Usia dan Jenis Kelamin dengan Kejadian Multidrugs-Resistant Tuberculosis (MDR-TB) di Rumah Sakit Paru Dr. M. Goenawan (RSPG) Cisarua Bogor Siti Fatimah Az'zahra; Nurhayati, Eka; Hartati, Julia; Sawitri, Neni
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12431

Abstract. Tuberculosis (TB) is a chronic infectious disease caused by Myobacterium tuberculosis. TB is considered the second top killer infectious disease and is the 13th cause of death worldwide. Long treatment and uncertain times of onset pose a challenge to compliance in the TB treatment process. Non-adherence to treatment results in multi-drug-resistant (MDR-TB). This condition occurs when TB patients experience resistance to the drugs isoniazid (H) and rifampicin (R), which are anti-tuberculosis drugs (OAT). This research is a cross sectional study conducted at RSPG Cisarua Bogor on 299 patients. Data was obtained from medical records in the form of age and gender characteristics. Data were analyzed using univariate and bivariate tests and then carried out the Chi-Square test. The results of this study show that the average age of MDR-TB patients is 39 years and more males. The Chi-Square test shows an age p-value of 0.014 (<0.05) and a gender p-value of 0.605 (>0.05). MDR-TB patients are more common in male than female, but there is no significant relationship because the location of the rpOB gene and KatG gene which are mutated are in bacteria, not humans. MDR-TB is more vulnerable in productive age because high productivity can cause treatment errors that result in MDR-TB. It was found from this study that there was a relationship between age and the incidence of MDR-TB and there was no relationship betweensex and the incidence of MDR-TB. Abstrak. Tuberkulosis (TB) merupakan penyakit infeksi menular kronis yang disebabkan oleh Myobacterium tuberculosis. TB dianggap sebagai penyakit infeksi pembunuh teratas kedua dan menjadi penyebab kematian ke-13 di seluruh dunia. Pengobatan yang lama dan onset waktunya tidak pasti menjadi tantangan kepatuhan dalam proses pengobatan TB. Ketidakpatuhan pengobatan mengakibatkan terjadinya multidrugs-resistant tuberculosis (MDR-TB). Kondisi ini terjadi ketika pasien TB mengalami resistensi terhadap obat isoniazid (H) dan rifampisin (R) yang merupakan obat anti-tuberkulosis (OAT). Penelitian ini merupakan penelitian cross sectional yang dilakukan di RSPG Cisarua Bogor pada 299 pasien. Data diperoleh dari rekam medis berupa karakteristik usia dan jenis kelamin. Data dianalisis dengan uji univariat dan bivariate lalu dilakukan uji Chi-Square. Hasil penelitian ini menunjukkan rerata usia pasien MDR-TB adalah 39 tahun dan lebih banyak pada laki – laki. Uji Chi-Square menunjukkan p-value usia sebesar 0,014 (<0,05) dan p-value jenis kelamin sebesar 0,605 (>0,05). Pasien MDR-TB lebih banyak terjadi pada laki – laki dibandingkan perempuan namun tidak terdapat hubungan bermakna karena letak gen rpOB dan gen KatG yang mengalami mutasi terletak pada bakteri bukan pada manusia. MDR-TB lebih rentan pada usia produktif karena produktivitas yang tinggi dapat menyebabkan kelalaian pengobatan yang mengakibatkan MDR-TB. Didapatkan dari penelitian ini bahwa terdapat hubungan antara usia dengan kejadian MDR-TB dan tidak terdapat hubungan antara jenis kelamin dengan kejadian MDR-TB.

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