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All Journal Global Medical and Health Communication Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Nanggroe: Journal Of Scholarly Service Nanggroe: Journal of Scholarly Service
Julia Hartati
Fakultas Kedokteran, Universitas Islam Bandung
Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY Triyani, Yani; Herliani, Irna; Patrisia, Nurul; Achmad, Sadiah; Hendyanny, Eka; Hartati, Julia
Global Medical & Health Communication (GMHC) Vol 3, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Angka kejadian penyakit infeksi di Indonesia masih tinggi, dengan angka mortalitas 230 kematian per 100.000 populasi. Dampak hal tersebut adalah penggunaan antibiotik yang tidak terkendali menyebabkan resistensi obat dan multidrug resistant bahkan extensive drug resistant. Konsumsi substansi yang berfungsi imunomodulator menjadi salah satu alternatif pemecahan. Tujuan penelitian ini untuk mengetahui apakah ekstrak etanol ceplukan (Physalis angulata) yang memiliki efek imunomodulator berpengaruh pada aktivitas fagositosis makrofag intraperitoneal mencit jantan galur DDY, serta menilai optimasi dosis ekstrak etanol ceplukan dan membandingkan efeknya dengan obat herbal imunomodulator terstandar. Penelitian ini merupakan eksperimental laboratorik dengan subjek 25 ekor mencit jantan galur DDY yang dibagi lima kelompok. Setiap kelompok diberi perlakuan yang sama selama tujuh hari. Kelompok I (kontrol negatif) tidak diberikan ekstrak etanol ceplukan, kelompok II, III, dan IV diberikan ekstrak etanol ceplukan dengan dosis 12,5%, 25%, dan 50%, serta kelompok V (kontrol positif) diberikan obat herbal imunomodulator terstandar dosis 50 µL. Pada hari ke-8, dilakukan pengukuran aktivitas fagositosis makrofag intraperitoneal dengan melihat jumlah makrofag yang memfagosit biji lateks. Uji statistik yang digunakan adalah Kruskal-Wallis, Mann-Whitney, dan independent t-test. Hasil penelitian ini menunjukkan bahwa ekstrak etanol ceplukan dosis 12,5% (rata-rata: 10, SD: 11,5) dan 25% (rata-rata: 14, SD: 8,5) secara signifikan meningkatkan aktivitas fagositosis makrofag dibanding dengan kontrol negatif. Ekstrak etanol ceplukan dosis 25% tidak berbeda bermakna dibanding dengan obat imunomodulator (rata-rata: 13, SD: 8,26) (p=0,05). Simpulan, ekstrak etanol ceplukan meningkatkan aktivitas fagositosis makrofag intraperitoneal dengan dosis optimum 25% dan memiliki efek yang sama dengan obat herbal  imunomodulator terstandar.   Kata kunci: Aktivitas fagositosis, biji lateks, ekstrak etanol ceplukan, mencit jantan galur DDY   Dossage Optimation and Comparison of Ethanol Extract of Ceplukan (Physalis angulata) to Standardized Immunomodulator Herbal Medicine on Intraperitoneal Macrophage of Male Mice DDY Strain   Abstract Number of infection disease are still in Indonesia. There were 230 people died from 100,000 population. The impact is Indonesia still face uncontrolled use of antibiotic which cause multidrug resistant even  extensive drug resistant. The use of immunomodulator became the alternative solutions. This study aims was to describe whether there were an ability of Physalis angulata as an immunomodulator for the activity in macropag phagocytosis in DDY male rats. It also aim to identify extract optimation and compare it with the standard herbal immunomodulator. This was an experimental study with 25 male DDY rats divided into 5 groups. Group I as control negative was not given any ceplukan ethanol extract, group II, III and IV were given ceplukan ethanol extract with 12.5%, 25% and 50% dosage respectively and group V acted as positive control fed by standard herbal immunomodulator. On the 8th day intraperitoneal macrophage phagocytosis were measured by counting the number of macrophage which consumed the latex seeds. Statistical analysis used was Kruskal-Wallis, Mann-Whitney, and independent t-test.The resuts from this study showed that ceplukan ethanol extracts with the dosage of 12.5% (mean: 10, SD: 11.5) and 25% (mean: 14; SD: 8.5) significantly increased the phagocyte activity of macrophage compared to negative control. However 25% ceplukan ethanol extracts had no significant difference compared to standar herbal immunomodulator (mean: 13; SD: 8.25, p>0.05). The conclusions are ceplukan ethanol extract increases the phagocyte activity of macrophage with optimum dosage of 25% and possess the same effect with standard herbal immunomodulator. Key words: Latex seeds, male DDY rats, phagocytes activities, physalis angulata
Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY Yani Triyani; Irna Herliani; Nurul Patrisia; Sadiah Achmad; Eka Hendyanny; Julia Hartati
Global Medical & Health Communication (GMHC) Vol 3, No 1 (2015)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3095.419 KB) | DOI: 10.29313/gmhc.v3i1.1543

Abstract

Angka kejadian penyakit infeksi di Indonesia masih tinggi, dengan angka mortalitas 230 kematian per 100.000 populasi. Dampak hal tersebut adalah penggunaan antibiotik yang tidak terkendali menyebabkan resistensi obat dan multidrug resistant bahkan extensive drug resistant. Konsumsi substansi yang berfungsi imunomodulator menjadi salah satu alternatif pemecahan. Tujuan penelitian ini untuk mengetahui apakah ekstrak etanol ceplukan (Physalis angulata) yang memiliki efek imunomodulator berpengaruh pada aktivitas fagositosis makrofag intraperitoneal mencit jantan galur DDY, serta menilai optimasi dosis ekstrak etanol ceplukan dan membandingkan efeknya dengan obat herbal imunomodulator terstandar. Penelitian ini merupakan eksperimental laboratorik dengan subjek 25 ekor mencit jantan galur DDY yang dibagi lima kelompok. Setiap kelompok diberi perlakuan yang sama selama tujuh hari. Kelompok I (kontrol negatif) tidak diberikan ekstrak etanol ceplukan, kelompok II, III, dan IV diberikan ekstrak etanol ceplukan dengan dosis 12,5%, 25%, dan 50%, serta kelompok V (kontrol positif) diberikan obat herbal imunomodulator terstandar dosis 50 µL. Pada hari ke-8, dilakukan pengukuran aktivitas fagositosis makrofag intraperitoneal dengan melihat jumlah makrofag yang memfagosit biji lateks. Uji statistik yang digunakan adalah Kruskal-Wallis, Mann-Whitney, dan independent t-test. Hasil penelitian ini menunjukkan bahwa ekstrak etanol ceplukan dosis 12,5% (rata-rata: 10, SD: 11,5) dan 25% (rata-rata: 14, SD: 8,5) secara signifikan meningkatkan aktivitas fagositosis makrofag dibanding dengan kontrol negatif. Ekstrak etanol ceplukan dosis 25% tidak berbeda bermakna dibanding dengan obat imunomodulator (rata-rata: 13, SD: 8,26) (p=0,05). Simpulan, ekstrak etanol ceplukan meningkatkan aktivitas fagositosis makrofag intraperitoneal dengan dosis optimum 25% dan memiliki efek yang sama dengan obat herbal  imunomodulator terstandar. DOSSAGE OPTIMATION AND COMPARISON OF ETHANOL EXTRACT OF CEPLUKAN (PHYSALIS ANGULATA) TO STANDARDIZED IMMUNOMODULATOR HERBAL MEDICINE ON INTRAPERITONEAL MACROPHAGE OF MALE MICE DDY STRAINNumber of infection disease are still in Indonesia. There were 230 people died from 100,000 population. The impact is Indonesia still face uncontrolled use of antibiotic which cause multidrug resistant even extensive drug resistant. The use of immunomodulator became the alternative solutions. This study aims was to describe whether there were an ability of Physalis angulata as an immunomodulator for the activity in macropag phagocytosis in DDY male rats. It also aim to identify extract optimation and compare it with the standard herbal immunomodulator. This was an experimental study with 25 male DDY rats divided into 5 groups. Group I as control negative was not given any ceplukan ethanol extract, group II, III and IV were given ceplukan ethanol extract with 12.5%, 25% and 50% dosage respectively and group V acted as positive control fed by standard herbal immunomodulator. On the 8th day intraperitoneal macrophage phagocytosis were measured by counting the number of macrophage which consumed the latex seeds. Statistical analysis used was Kruskal-Wallis, Mann-Whitney, and independent t-test.The resuts from this study showed that ceplukan ethanol extracts with the dosage of 12.5% (mean: 10, SD: 11.5) and 25% (mean: 14; SD: 8.5) significantly increased the phagocyte activity of macrophage compared to negative control. However 25% ceplukan ethanol extracts had no significant difference compared to standar herbal immunomodulator (mean: 13; SD: 8.25, p>0.05). The conclusions are ceplukan ethanol extract increases the phagocyte activity of macrophage with optimum dosage of 25% and possess the same effect with standard herbal immunomodulator.
Analisis In Sillico Mekanisme Cell Survival Zat Aktif Daun Sirsak (Annona Muricata Linn) pada Kanker Kolorektal Hur'iynazzahra Kariima Romli; Lelly Yuniarti; Julia Hartati
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1316

Abstract

Abstract. Colorectal cancer (CRC) is a malignancy of the colon which is the second leading cause of cancer death. The first-line treatment for CRC consists of chemotherapy and monoclonal antibodies that target cell survival. The efficacy of chemotherapy drugs in most cases of CRC still needs to be improved because the cancer cells show that they still have a defense mechanism. In several studies, the active compounds of soursop leaves have several anticancer effects such as cell survival. The drug discovery process requires time, several stages of clinical trials, and large funds so we need a method that can help make them more efficient, one of which is in sillico method. This study used the in sillico method by looking for the active compound of soursop leaves from published scientific articles and also looking for three-dimensional structures, predicting, and analysis of target proteins using several databases. The results of this study found 18 target proteins of soursop leaf active compound is involved in cell survival mechanism of CRC by regulating cell cycle regulation, miRNA transcription regulation, decreasing cell proliferation, triggering apoptosis, decreasing cell invasion and metastasis. The conclusion of this study is that the active substances of soursop leaves have some target proteins that can have some anticancer mechanism, one of which is by suppressing cell survival in CRC. Abstrak. Kanker kolorektal (KKR) merupakan keganasan pada usus besar yang menjadi kanker kedua penyebab kematian tertinggi akibat kanker. Pengobatan lini pertama KKR diantaranya kemoterapi dan antibodi monoklonal yang memiliki target salah satunya mekanisme cell survival. Efikasi obat kemoterapi pada sebagian besar kasus KKR masih perlu ditingkatkan karena sel kanker menunjukkan masih memiliki mekanisme pertahanan. Pada beberapa penelitian, zat aktif daun sirsak memiliki efek sebagai antikanker seperti melalui cell survival. Proses penemuan obat memerlukan waktu, beberapa tahap uji klinis, dan dana yang besar sehingga perlu metode yang membantu agar lebih efisien, salah satunya in sillico. Penelitian ini menggunakan metode in sillico dengan melakukan penelusuran zat aktif daun sirsak dari artikel ilmiah yang terpublikasi dan dilakukan pencarian stuktur tiga dimensi, prediksi, serta analisis protein target menggunakan beberapa database. Hasil dari penelitian ini yaitu ditemukan 18 protein target zat aktif daun sirsak yang terlibat pada mekanisme cell survival KKR dengan mengatur regulasi siklus sel, regulasi transkripsi miRNA, memicu apoptosis, menurunkan proliferasi sel, kemampuan invasi, dan metastasis sel. Kesimpulan pada penelitian ini yaitu zat aktif daun sirsak memiliki protein target yang dapat memiliki mekanisme antikanker salah satunya dengan menekan cell survival pada KKR.
Scoping Review: Potensi Dalbavancin terhadap Kesembuhan Pasien Osteomyelitis Dewasa yang Disebabkan oleh Infeksi Staphylococcus Aureus Muhammad Emir Sidiq; Julia Hartati Hartati; Krishna Pradananta Pradananta
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1839

Abstract

Abstract. Osteomyelitis is an inflammation of bone structures, cancellous and periosteum in humans and caused by bacterial infection. Antibiotic treatments that are usually used are methicillin, vancomycin, and daptomycin, which often cause resistance nowadays. There is a new antibiotic called dalbavancin that has begun to be used for osteomyelitis treatment. This study aimed to analyze the potency of dalbavancin on adult osteomyelitis patient’s treatment caused by Staphylococcus aureus infection. Scoping review was used as a method for this research by analyzing research articles from four different databases: PubMed, SpringerLink, ScienceDirect and Wiley Online Library. 8.273 articles were generated from the four databases, and after adjusting for inclusion, exclusion, and eligibility criteria, three articles matched the criteria and were further analyzed. Three articles mentioned that the usage of dalbavancin for adult osteomyelitis patients resulted more cured patients and reduction in length-of-stay in dalbavancin group than the control group, but article 1 mentioned dalbavancin group has the same safety outcome and poorer safety outcome in article 2. Dalbavancin has an additional chain of A-40926 which able to bind dalbavancin to bacterial cell membrane so that a strong bond was form to d-alanyl-d-alanine receptors. In conclusion, dalbavancin is effective for adult osteomyelitis patients which caused by S. aureus infection. Abstrak. Osteomyelitis merupakan keadaan terjadinya peradangan pada tulang cancellous dan periosteum diakibatkan oleh infeksi bakteri yang dapat terjadi pada manusia ataupun hewan. Terapi Antibiotik yang paling sering digunakan berupa methicillin, vancomycin dan daptomycin, tetapi kini sering mengalami resistesi. Terdapat antibiotik baru berupa dalbavancin yang mulai digunakan untuk pengobatan osteomyelitis. menganalisis potensi dalbavancin pada pasien osteomyelitis yang disebabkan oleh infeksi Staphylococcus aureus dibandingkan dengan obat standar. Metode yang digunakan dalam penelitian ini berupa scoping review dengan menganalisis artikel ilmiah dari 4 database yaitu PubMed, ScienceDirect, SpringerLink, dan Wiley Online Library. Hasil pencarian awal sebanyak 8.273 artikel, yang setelah disesuaikan dengan kriteria inklusi, eksklusi dan kelayakan menghasilkan 3 artikel yang dapat dianalisis. Hasil analisis dari ketiga artikel menyatakan bahwa dalbavancin menghasilkan potensi yang baik untuk pengobatan osteomyelitis dan menghasilkan angka kesembuhan yang lebih tinggi dan pengurangan lama rawat inap lebih banyak pada grup dalbavancin dibanding pada grup obat standar, sedangkan keamanan dalbavancin dinyatakan sama seperti obat standar pada artikel 1, sementara artikel 2 menyatakan keamanan dalbavancin lebih buruk dibandingkan obat standar. Dalbavancin memiliki struktur rantai A-40926 yang mampu mengikatkan dalbavancin ke membran sel bakteri sehingga terbentuk ikatan kuat terhadap reseptor d-alanyl-d-alanin. Simpulan penelitian ini adalah pemberian dalbavancin efektif terhadap pasien osteomyelitis dewasa yang disebabkan oleh infeksi S. aureus.
Protective Effect of the T1212C Macrophage Mannose Receptor Gene Polymorphism on Pulmonary Tuberculosis Yani Triyani; Julia Hartati; Budiman Budiman; Ida Parwati; Bachti Alisjahbana
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.10706

Abstract

The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandung, from February 2014 to January 2015. The statistical analysis used chi-square and odds ratio. The study’s result has shown the MMR gene polymorphism factor that correlated to the incidence of active pulmonary TB was T1212C (OR=0.253; 95% CI=0.111−0.575; p=0.001). There was an MMR gene in one SNP in the control group (C1323T) only and five single nucleotide polymorphisms (SNPs) in both groups (C1303T, C1221, T1212C, G1186A, and G1195A). Therefore, it can be concluded that MMR gene polymorphism on the T1212C site correlated with the incidence of active pulmonary tuberculosis and was protective.
Keberhasilan Pengobatan Tuberkulosis Paru dengan Komorbid Diabetes Mellitus di RSUD Al Ihsan Bandung Tahun 2020 Rini Nur Islami Dinan; Julia Hartati; Heni Muflihah
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6795

Abstract

Abstract. Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis. In TB patients with Diabetes Mellitus (DM), chronic hyperglycemia impairs immunity and causes prolonged treatment. The aim of this study was to analyze the relationship between DM comorbidities and the success of pulmonary TB treatment. This cross-sectional study used secondary data from the TB information system (SITB) and medical records. The subjects of this study were pulmonary TB patients undergoing treatment at Al Ihsan Hospital during 2020. The inclusion criteria included a minimum age of 19 years, pulmonary TB, and completion of treatment. Research data included TB DM status and treatment outcomes. The end result of complete treatment includes cured and complete. Total TB patients were 1319 people with adult pulmonary TB as many as 634 people who met the inclusion criteria. Most of the pulmonary TB patients were male, 360 people (56.78%) and adults (20-59 years) 455 people (71.77%). Pulmonary TB patients with comorbid DM were 12 people (1.89%) and 622 people without DM (98.11%). There are 10 out of 12 TB DM patients who have incomplete treatment outcomes. There is no relationship between DM comorbidities and the success of pulmonary TB treatment with a P value of 2.517 (P value > 0.05). The conclusion of this study is that there is no relationship between DM comorbidities and treatment success rates. Abstrak. Tuberkulosis (TB) adalah penyakit menular akibat infeksi bakteri Mycobacterium tuberculosis. Pada penderita TB dengan Diabetes Melitus (DM), hiperglikemia kronis merusak imunitas dan menyebabkan lamanya pengobatan.Tujuan penelitian ini menganalisis hubungan komorbid DM dengan keberhasilan pengobatan TB Paru. Penelitian cross sectional ini menggunakan data sekunder sistem informasi TB (SITB) dan rekam medik. Subjek penelitian ini adalah pasien TB paru yang menjalani pengobatan di RSUD Al Ihsan selama tahun 2020. Kriteria inklusi meliputi usia minimal 19 tahun, TB paru, dan menyelesaikan pengobaan. Data penelitian meliputi status TB DM and hasil akhir pengobatan. Hasil akhir pengobatn lengkap meliputi sembuh dan lengkap. Total pasien TB sebanyak 1319 orang dengan TB paru dewasa sebanyak 634 orang yg memenuhi krikteria inklusi. Sebagian besar pasien TB paru memiliki jenis kelamin laki-laki 360 orang (56.78%) dan usia dewasa (20-59 tahun) 455 orang (71.77%). Pasien TB paru dengan komorbid DM 12 orang (1.89%) dan tidak DM 622 orang (98.11%). Terdapat 10 dari 12 orang pasien TB DM memiliki hasil akhir pengobatan tidak lengkap. Tidak terdapat hubungan antara komorbid DM dengan keberhasilan pengobatan TB paru dengan P value 2.517 (P value > 0.05). Simpulan dari penelitian ini adalah tidak terdapat hubungan komorbid DM dengan angka keberhasilan pengobatan.
Studi Literatur: Faktor Risiko Dermatitis Kontak pada Pekerja Putri Dwi Rahmasari; Herri S. Sastramihardja; Julia Hartati
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6439

Abstract

Abstract. Contact dermatitis is inflammation of the skin caused by contact with exogenous substances characterized by itching, redness, scaling, vesicles and papules. Trigger factors for contact dermatitis can come from exposure to chemicals, personal hygiene, duration of contact, and other individual factors. The purpose of this study is to explain the risk factors for contact dermatitis in workers. The method used is a literature study by collecting several previous studies regarding risk factors for contact dermatitis in workers. The results of this study explain contact dermatitis starting from definition, causes, risk factors, pathogenesis, and signs and symptoms. Thus it can be concluded that the risk factors for contact dermatitis can come from exposure to chemicals for a long time, type of work, and other individual factors. Abstrak. Dermatitis kontak adalah inflamasi pada kulit yang disebabkan oleh kontak dengan zat eksogen yang ditandai dengan gatal, kemerahan, bersisik, vesikula, dan papul. Faktor pemicu dermatitis kontak dapat berasal dari paparan bahan kimia, personal hygiene, lama kontak, dan faktor individu lain. Tujuan penelitian ini adalah menjelaskan mengenai faktor risiko dermatitis kontak pada pekerja. Metode yang digunakan adalah studi literatur dengan mengumpulkan beberapa penelitian terdahulu mengenai faktor risiko dermatitis kontak pada pekerja. Hasil dari penelitian ini menjelaskan mengenai dermatitis kontak mulai dari definisi, penyebab, faktor risiko, patogenesis, dan tanda gejala. Dengan demikian dapat disimpulkan faktor risiko dermatitis kontak dapat berasal dari paparan bahan kimia dalam waktu lama, jenis pekerjaan, dan faktor individu lainnya.
Tingkat Stres Berdasarkan Jenis Stresor pada Mahasiswa Tingkat Akhir Fakultas Kedokteran Unisba Afif Januar Ginata; Ratna Dewi Indi Astuti; Julia Hartati
Jurnal Riset Kedokteran Volume 3, No.1, Juli 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1915

Abstract

Abstract. Stress is a common phenomenon and cannot be avoided by everyone. Stress is an unpleasant condition and can elicit a response be it mental, physical, emotional, and spiritual of a person. The occurrence of stress is caused by a stimulus called a stressor. A person who experiences stress brings up signs according to their stress level, be it mild, moderate, or severe levels. The aims of study to determine the picture of stress levels based on the type of stressor assessed using the Medical Student Stressor Questionnaire in final year students of the academic stage of the Faculty of Medicine Unisba. This research is a descriptive study with a cross sectional approach with the number of samples is 130 students. The results of this study found that the level of stress in general most occurs in moderate stress reaching 46.92%, the level of stress based on Academic Related Stressor most occurs in severe stress reaching 40.77%, stress levels based on Interpersonal and Intrapersonal Related Stressors, Teaching and Learning Related Stressors, Social Related Stressors, and Group Activities Related Stressor is dominated by moderate stress, the level of stress based on Drive & Desire Related Stressor occurs the most in mild stress reaching 37.69%. The occurrence of differences in stress levels in each individual is due to several influencing factors such as the ability of individuals to perceive stressors, the time of exposure to stressors, and the number of stressors that must be faced in the same period of time. Abstrak. Stres merupakan fenomena umum dan tidak dapat dihindari oleh setiap orang. Stres adalah kondisi yang tidak menyenangkan dan dapat menimbulkan respon baik itu mental, fisik, emosional, dan spiritual seseorang. Terjadinya stres disebabkan oleh suatu stimulus yang disebut sebagai stresor. Seseorang yang mengalami stres memunculkan tanda-tanda sesuai dengan tingkat stresnya, baik itu tingkat ringan, sedang, maupun berat. Penelitian ini bertujuan untuk mengetahui gambaran tingkat stres berdasarkan jenis stresor yang dinilai menggunakan Medical Student Stressor Questionnaire pada mahasiswa tingkat akhir tahap akademik Fakultas Kedokteran Unisba. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional dengan jumlah sampel sebanyak 130 mahasiswa. Hasil penelitian ini didapatkan bahwa tingkat stres secara umum paling banyak terjadi pada stres sedang mencapai 46,92%, tingkat stres berdasarkan Academic Related Stressor paling banyak terjadi pada stres berat mencapai 40,77%, tingkat stres berdasarkan Interpersonal and Intrapersonal Related Stressor, Teaching and Learning Related Stressor, Social Related Stressor, dan Group Activities Related Stressor didominasi dengan stres sedang, tingkat stres berdasarkan Drive & Desire Related Stressor paling banyak terjadi pada stres ringan mencapai 37,69%. Terjadinya perbedaan tingkatan stres pada masing-masing individu disebabkan karena adanya beberapa faktor yang mempengaruhi seperti kemampuan individu dalam mempersepsikan stresor, waktu paparan stresor, dan banyaknya stresor yang harus di hadapi dalam jangka waktu yang bersamaan.
Tingkat Stres Berdasarkan Jenis Stresor pada Mahasiswa Tingkat Akhir Fakultas Kedokteran Unisba Afif Januar Ginata; Ratna Dewi Indi Astuti; Julia Hartati
Jurnal Riset Kedokteran Volume 3, No.1, Juli 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1915

Abstract

Abstract. Stress is a common phenomenon and cannot be avoided by everyone. Stress is an unpleasant condition and can elicit a response be it mental, physical, emotional, and spiritual of a person. The occurrence of stress is caused by a stimulus called a stressor. A person who experiences stress brings up signs according to their stress level, be it mild, moderate, or severe levels. The aims of study to determine the picture of stress levels based on the type of stressor assessed using the Medical Student Stressor Questionnaire in final year students of the academic stage of the Faculty of Medicine Unisba. This research is a descriptive study with a cross sectional approach with the number of samples is 130 students. The results of this study found that the level of stress in general most occurs in moderate stress reaching 46.92%, the level of stress based on Academic Related Stressor most occurs in severe stress reaching 40.77%, stress levels based on Interpersonal and Intrapersonal Related Stressors, Teaching and Learning Related Stressors, Social Related Stressors, and Group Activities Related Stressor is dominated by moderate stress, the level of stress based on Drive & Desire Related Stressor occurs the most in mild stress reaching 37.69%. The occurrence of differences in stress levels in each individual is due to several influencing factors such as the ability of individuals to perceive stressors, the time of exposure to stressors, and the number of stressors that must be faced in the same period of time. Abstrak. Stres merupakan fenomena umum dan tidak dapat dihindari oleh setiap orang. Stres adalah kondisi yang tidak menyenangkan dan dapat menimbulkan respon baik itu mental, fisik, emosional, dan spiritual seseorang. Terjadinya stres disebabkan oleh suatu stimulus yang disebut sebagai stresor. Seseorang yang mengalami stres memunculkan tanda-tanda sesuai dengan tingkat stresnya, baik itu tingkat ringan, sedang, maupun berat. Penelitian ini bertujuan untuk mengetahui gambaran tingkat stres berdasarkan jenis stresor yang dinilai menggunakan Medical Student Stressor Questionnaire pada mahasiswa tingkat akhir tahap akademik Fakultas Kedokteran Unisba. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional dengan jumlah sampel sebanyak 130 mahasiswa. Hasil penelitian ini didapatkan bahwa tingkat stres secara umum paling banyak terjadi pada stres sedang mencapai 46,92%, tingkat stres berdasarkan Academic Related Stressor paling banyak terjadi pada stres berat mencapai 40,77%, tingkat stres berdasarkan Interpersonal and Intrapersonal Related Stressor, Teaching and Learning Related Stressor, Social Related Stressor, dan Group Activities Related Stressor didominasi dengan stres sedang, tingkat stres berdasarkan Drive & Desire Related Stressor paling banyak terjadi pada stres ringan mencapai 37,69%. Terjadinya perbedaan tingkatan stres pada masing-masing individu disebabkan karena adanya beberapa faktor yang mempengaruhi seperti kemampuan individu dalam mempersepsikan stresor, waktu paparan stresor, dan banyaknya stresor yang harus di hadapi dalam jangka waktu yang bersamaan.
Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities Hartati, Julia; Damayanti, Meta Maulida; Nur, Ismet Muchtar; Furqaani, Annisa Rahmah; Sari, Ajeng Kartika; Rachmawati, Meike; Siddiq, Tita Barriah; Fakih, Taufik Muhammad; Radina, Faqih
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.12916

Abstract

The growth of micro-organisms that acquire resistance to most commercially available antibiotics is occurring rapidly. Consequently, a pressing necessity exists to identify and detect new antimicrobial substances. This study aimed to analyze the antioxidant and antibacterial activity of nanoemulsion clove extract and grape seed oil. This research was conducted in June 2023 using experimental methods at the Research Laboratory of the Universitas Islam Bandung Pharmaceutical Study Program by developing a nanoemulsion preparation containing clove extract (Syzygium aromaticum L.) and grape seed oil (Vitis vinifera L.). Antioxidant activity was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antibacterial activity was tested using the agar diffusion method by measuring the growth inhibitory diameter of Staphylococcus aureus and Streptococcus mutans bacteria and divided into four groups formulas based on the addition of clove extract with different concentrations in the nanoemulsion base (FA=0.25%, FB=0.5%, FC=0.75%, and FD=1%) to see the best results. The result shows nanoemulsion preparations have antioxidant properties in the DPPH test. The FA formula has the highest IC50, namely 1,117.56 ppm. The antibacterial activity of Staphylococcus aureus and Streptococcus mutans has an inhibition zone, although it is still in the category of inhibiting bacterial growth, but does not kill growth. The nanoemulsion formulation, comprising clove extract and grape seed oil, has exhibited exceptional antioxidant properties and substantial antimicrobial efficacy against prevalent oral bacterial strains.
Co-Authors A, Atikah Afiati, Farida Afif Januar Ginata Amma, Salsabila Shafa Muradi Annisa Rahmah Furqaani Bachti Alisjahbana Budiman , Budiman Eka Hendyanny Eka Hendyanny, Eka Eka Nurhayati Fadhilah, Nur Syafrina Febriani, Nelly Heni Muflihah Herri S. Sastramihardja Hidayat, Wahid Humaira, Khansa Hur'iynazzahra Kariima Romli Ida Parwati Irna Herliani Irna Herliani, Irna Ismet Muchtar Nur Krishna Pradananta Pradananta Lelly Yuniarti Meike Rachmawati Meta Maulida Damayanti Muhammad Emir Sidiq N, Nurlaila Neni Sawitri Nurul Patrisia Nurul Patrisia, Nurul Putri Dwi Rahmasari Putri, Nafisya Nur Adiba Purnomo Radina, Faqih Ratna Dewi Indi Astuti Rini Nur Islami Dinan Roselowati, Yessy Rahma Sadiah Achmad Sari, Ajeng Kartika Siddiq, Tita Barriah Siti Fatimah Az'zahra Taufik Muhammad Fakih Yani Triyani