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Januarsih Januarsih
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Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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EFEKTIFITAS EKSTRAK PUNICA GRANATUM TERHADAP KADAR NITRICT OXYDE PADA KULTUR HUVECS YANG DIPAPAR PLASMA PREEKLAMPSI Megawati Megawati; Januarsih Januarsih; Fitria Jannatul Laili
Jurnal_Kebidanan Vol. 15 No. 2 (2025): Jurnal Kebidanan Volume 15 Nomor 2 Tahun 2025
Publisher : STIKES Panca Bhakti Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33486/jurnalkebidanan.v15i2.384

Abstract

Preeclampsia is one of the leading causes of maternal morbidity and mortality, with pathogenesis involving oxidative stress due to increased free radicals and decreased antioxidant activity. Red pomegranate (Punica granatum) contains polyphenols, anthocyanins, and tannins, which act as natural antioxidants. This study aimed to investigate the effect of Punica granatum extract on Nitric Oxide (NO) levels in Human Umbilical Vein Endothelial Cells (HUVECs) exposed to preeclampsia plasma. An experimental study with a post-test only control group design was conducted with five groups: negative control (HUVECs + normal plasma), positive control (HUVECs + preeclampsia plasma), and three treatment groups with Punica granatum extract at 14 ppm, 28 ppm, and 56 ppm. NO levels were measured using the ELISA method after 24 hours of incubation. The results showed significant differences among groups (p < 0.05). The 56 ppm extract dose resulted in the most significant decrease in NO levels (20.3 µM), comparable to the normal control group (18.4 µM). This study is at TRL 3–4, representing a proof-of-concept based on in vitro testing. In conclusion, Punica granatum extract has potential as a natural antioxidant and a complementary therapy candidate for preeclampsia, although further studies in animal models and clinical trials are required.
Perbedaan Kadar Hemoglobin Ibu Hamil antara Wilayah Endemis dan Non-Endemis Cacing Buski di Kabupaten Hulu Sungai Utara Januarsih Januarsih; Rita Kirana; Agus Rachmadi
Jurnal Skala Kesehatan Vol. 17 No. 1 (2026): Jurnal Skala Kesehatan Edisi Januari 2026
Publisher : Politeknik Kementerian Kesehatan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jsk.v17i1.518

Abstract

Anemia during pregnancy remains a major public health issue in Indonesia. One of the contributing factors is intestinal parasitic infection, such as (buski fluke), particularly in areas with poor sanitation and raw aquatic plant consumption. To compare hemoglobin levels among pregnant women in endemic and non-endemic areas of Fasciolopsis buski. This was a comparative cross-sectional study involving 124 pregnant women, consisting of 62 from endemic and 62 from non-endemic regions. Data were obtained through interviews, observations, and hemoglobin measurements using Hemocue®. Data were analyzed using an independent t-test at a 0.05 significance level. The mean hemoglobin level among pregnant women in endemic areas was 10.7 ± 1.1 g/dL, while in non-endemic areas it was 11.6 ± 1.0 g/dL. The t-test revealed a significant difference between the two groups (p = 0.001). The prevalence of anemia was 61.3% in endemic and 29.0% in non-endemic areas. There is a significant difference in hemoglobin levels between pregnant women living in endemic and non-endemic areas of Fasciolopsis buski. Endemicity of parasitic infection may contribute to higher anemia risk among pregnant women in endemic regions.
Co-Authors Agus Rachmadi Fitria Jannatul Laili Megawati Megawati Rita Kirana