Anderson Arnold Aloanis
Universitas Negeri Manado

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Pengembangan Penuntun Praktikum Reaksi Reduksi dan Oksidasi Berbasis Bahan Alam dengan Menggunakan Model ADDIE Ade Wiwit Tahulending; Rymond Rumampuk; Anderson Arnold Aloanis
Oxygenius Journal Of Chemistry Education Vol 1 No 2 (2019): Oxygenius : Journal of Chemistry Education
Publisher : Chemistry Department, Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.692 KB) | DOI: 10.37033/ojce.v1i2.106

Abstract

Penuntun praktikum termasuk salah satu syarat yang sangat penting dalam melaksanakan praktikum agar praktikum dapat berjalan dengan baik. Penelitian ini bertujuan untuk mengembangkan penuntun praktikum materi redoks berbasis bahan alam dengan menggunakan model ADDIE dan untuk mengetahui kelayakan dari penuntun yang dikembangkan. Teknik pengumpulan data yang digunakan adalah metode wawancara, metode observasi, serta metode angket validator dan angket respon siswa. Penelitian ini diujicobakan di kelas X IPA SMA Negeri 2 Tondano dengan jumlah siswa 25. Metode analisis data yang digunakan adalah analisis proses atau pengembangan produk dan analisis data hasil kualitas penuntun praktikum. Berdasarkan persentase dari kedua validator sebagai ahli media dan ahli materi diperoleh skor penilaian persentase rata-rata 92,8% dengan kategori kelayakan sangat layak, sedangkan untuk persentase data respon siswa keseluruhan diperoleh skor penilaian 81,65% dengan kategori kelayakan sangat layak.
Pengembangan Video Pembelajaran Materi Ikatan Kimia Dengan Model ADDIE Sebagai Penunjang Pembelajaran Di Masa Pandemi COVID-19 Meylin Kawete; Dokri Gumolung; Anderson Aloanis
Oxygenius Journal Of Chemistry Education Vol 4 No 1 (2022): Oxygenius : Journal of Chemistry Education
Publisher : Chemistry Department, Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/ojce.v4i1.374

Abstract

The purpose of this study was to develop a Learning Video for Chemical Bonding Materials with the Addie Model as Learning Support during the Covid-19 Pandemic. This research is research and development (Research and Development). This research is a research that refers to the ADDIE model (Analysis, Design, Development or Production, Implementation or Delivery and Evaluations). By following the fifth stage of the ADDIE model, because this is a Video Development research, this research only reaches the fourth stage, namely the Implementation stage. Data collection techniques in this study used a Validation Questionnaire (validation of media experts and validation of material experts) and Student Response Questionnaires. The results of the first material expert validation are included in the "very feasible" criteria with a percentage of 80%. The results from the second validation questionnaire are included in the 'very feasible' criteria with a percentage of 100%, the results from the first media expert validation questionnaire with the 'very feasible' criteria with a percentage of 95.12%, the results from the second validation questionnaire are included in the 'very feasible' criteria with a percentage 86.66% and the results of the student response questionnaires are included in the "very feasible" criteria with a percentage of 90%. Learning videos are declared very suitable for use in the learning process.
Molecular Docking Of Cyclosenegalin A As Anticancer Paat, Vlagia Indira; Aloanis, Anderson Arnold; Najoan, Jessika Maya Jovanka
Jurnal Kimia Fullerene Vol 10 No 1 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i1.713

Abstract

Cancer is recognized as a leading cause of death globally, responsible for approximately 14.5% of all deaths,. Cyclosenegalin A showed activity against DU-145 human prostate cancer cell line with IC50 of54.92.35μM. This study aims to investigate whether the cyclosenegalin A compound can interact with the target receptors 4IEH and potentially act as an anticancer candidate. The results of the study show that the docking of cyclosenegalin A with the 4IEH receptor yielded the best results, with an affinity value of -8.88 kcal/mol. The hydrogen bonding at the GLY 104, ASP 70, VAL 92, and GLU 95 amino acids was identical to that observed in the standard ligand, n-heteroarilsulfonamides. The interaction between cyclosenegalin A and the target receptor is effective, indicating that cyclosenegalin A holds potential as an anti-cancer candidate.
Physicochemical Properties of Rice Fortified with Payangka Fish Protein Hydrolysate Iskandar, Ashar; Fatimah, Feti; Aloanis, Anderson
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.729

Abstract

Rice is an energy source that is high in carbohydrates and contributes to providing the largest percentage of calories, but rice has a low protein, vitamin and mineral content, so it needs to be fortified to increase the nutritional content of rice, especially protein. This research aims to characterize rice that has been fortified with protein hydrolyzate. Synthesis of Payangka fish protein hydrolyzate was carried out using papain enzyme with concentrations of 2,4 and 6% with an incubation time of 2 hours. The best fortification of rice is done by soaking the rice for 4 hours, then drying it again for 14 hours at a temperature of 50oC. The research results show that Payangka fish hydrolyzate can be obtained through hydrolysis of Payangka fish meat using the Papain enzyme with a concentration of 2-6%. The highest protein content of protein hydrolyzate was obtained when using a Papain enzyme concentration of 6% with a protein content of 3.61%. Fortification of rice with Payangka fish protein hydrolyzate can increase rice protein content, namely from 9.43% (before fortification) to 10.38% (after fortification using protein hydrolyzate with a concentration of 30%)
In Silico Study of the YAKRCFR Peptide Structure and Its Interaction with Human Peroxiredoxin-5 Najoan, Jessika Maya Jovanka; Rumampuk, Rymond Jusuf; Paat, Vlagia Indira; Aloanis, Anderson Arnold
Jurnal Beta Kimia Vol 5 No 2 (2025): Volume 5 Number 2, November 2025
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v5i2.22710

Abstract

The identification of bioactive peptides with therapeutic potential is an emerging focus in drug discovery. In this study, we evaluated the structural stability and binding affinity of the oyster-derived peptide YAKRCFR through molecular modeling and docking simulations against the human peroxiredoxin receptor. Structural prediction using the PEP-FOLD4 server revealed a consistent α-helical conformation across all models, stabilized by key intramolecular hydrogen bonds and favorable sOPEP energy values. Molecular docking was validated with a root mean square deviation (RMSD) of 0.273 Å, confirming the reliability of the docking protocol. The YAKRCFR peptide exhibited a strong binding affinity with the 1HD2 receptor (ΔG = –8.1 kcal/mol), outperforming both ascorbic acid (–6.1 kcal/mol) and the native ligand (–4.862 kcal/mol). Detailed interaction analysis indicated that YAKRCFR forms stable hydrogen bonds and van der Waals interactions with critical residues such as ILE A119 and PHE A120, contributing to its thermodynamic stability and binding specificity. These findings suggest that YAKRCFR holds promise as a lead compound for further development in peptide-based therapeutic strategies, particularly for targets involving the human peroxiredoxin receptor.