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All Journal JKPK (Jurnal Kimia dan Pendidikan Kimia) Fullerene Journal of Chemistry JURNAL FARMASIMED (JFM) Oxygenius Journal Of Chemistry Education Jurna Beta Kimia
Anderson Arnold Aloanis
Universitas Negeri Manado
Chemical Engineering, Chemistry & Bioengineering Chemistry Education Medicine & Pharmacology

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Pengembangan Penuntun Praktikum Reaksi Reduksi dan Oksidasi Berbasis Bahan Alam dengan Menggunakan Model ADDIE Ade Wiwit Tahulending; Rymond Rumampuk; Anderson Arnold Aloanis
Oxygenius Journal Of Chemistry Education Vol 1 No 2 (2019): Oxygenius : Journal of Chemistry Education
Publisher : Chemistry Department, Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.692 KB) | DOI: 10.37033/ojce.v1i2.106

Abstract

Penuntun praktikum termasuk salah satu syarat yang sangat penting dalam melaksanakan praktikum agar praktikum dapat berjalan dengan baik. Penelitian ini bertujuan untuk mengembangkan penuntun praktikum materi redoks berbasis bahan alam dengan menggunakan model ADDIE dan untuk mengetahui kelayakan dari penuntun yang dikembangkan. Teknik pengumpulan data yang digunakan adalah metode wawancara, metode observasi, serta metode angket validator dan angket respon siswa. Penelitian ini diujicobakan di kelas X IPA SMA Negeri 2 Tondano dengan jumlah siswa 25. Metode analisis data yang digunakan adalah analisis proses atau pengembangan produk dan analisis data hasil kualitas penuntun praktikum. Berdasarkan persentase dari kedua validator sebagai ahli media dan ahli materi diperoleh skor penilaian persentase rata-rata 92,8% dengan kategori kelayakan sangat layak, sedangkan untuk persentase data respon siswa keseluruhan diperoleh skor penilaian 81,65% dengan kategori kelayakan sangat layak.
Pengembangan Video Pembelajaran Materi Ikatan Kimia Dengan Model ADDIE Sebagai Penunjang Pembelajaran Di Masa Pandemi COVID-19 Meylin Kawete; Dokri Gumolung; Anderson Aloanis
Oxygenius Journal Of Chemistry Education Vol 4 No 1 (2022): Oxygenius : Journal of Chemistry Education
Publisher : Chemistry Department, Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/ojce.v4i1.374

Abstract

The purpose of this study was to develop a Learning Video for Chemical Bonding Materials with the Addie Model as Learning Support during the Covid-19 Pandemic. This research is research and development (Research and Development). This research is a research that refers to the ADDIE model (Analysis, Design, Development or Production, Implementation or Delivery and Evaluations). By following the fifth stage of the ADDIE model, because this is a Video Development research, this research only reaches the fourth stage, namely the Implementation stage. Data collection techniques in this study used a Validation Questionnaire (validation of media experts and validation of material experts) and Student Response Questionnaires. The results of the first material expert validation are included in the "very feasible" criteria with a percentage of 80%. The results from the second validation questionnaire are included in the 'very feasible' criteria with a percentage of 100%, the results from the first media expert validation questionnaire with the 'very feasible' criteria with a percentage of 95.12%, the results from the second validation questionnaire are included in the 'very feasible' criteria with a percentage 86.66% and the results of the student response questionnaires are included in the "very feasible" criteria with a percentage of 90%. Learning videos are declared very suitable for use in the learning process.
Molecular Docking Of Cyclosenegalin A As Anticancer Paat, Vlagia Indira; Aloanis, Anderson Arnold; Najoan, Jessika Maya Jovanka
Jurnal Kimia Fullerene Vol 10 No 1 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i1.713

Abstract

Cancer is recognized as a leading cause of death globally, responsible for approximately 14.5% of all deaths,. Cyclosenegalin A showed activity against DU-145 human prostate cancer cell line with IC50 of54.92.35μM. This study aims to investigate whether the cyclosenegalin A compound can interact with the target receptors 4IEH and potentially act as an anticancer candidate. The results of the study show that the docking of cyclosenegalin A with the 4IEH receptor yielded the best results, with an affinity value of -8.88 kcal/mol. The hydrogen bonding at the GLY 104, ASP 70, VAL 92, and GLU 95 amino acids was identical to that observed in the standard ligand, n-heteroarilsulfonamides. The interaction between cyclosenegalin A and the target receptor is effective, indicating that cyclosenegalin A holds potential as an anti-cancer candidate.
Physicochemical Properties of Rice Fortified with Payangka Fish Protein Hydrolysate Iskandar, Ashar; Fatimah, Feti; Aloanis, Anderson
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.729

Abstract

Rice is an energy source that is high in carbohydrates and contributes to providing the largest percentage of calories, but rice has a low protein, vitamin and mineral content, so it needs to be fortified to increase the nutritional content of rice, especially protein. This research aims to characterize rice that has been fortified with protein hydrolyzate. Synthesis of Payangka fish protein hydrolyzate was carried out using papain enzyme with concentrations of 2,4 and 6% with an incubation time of 2 hours. The best fortification of rice is done by soaking the rice for 4 hours, then drying it again for 14 hours at a temperature of 50oC. The research results show that Payangka fish hydrolyzate can be obtained through hydrolysis of Payangka fish meat using the Papain enzyme with a concentration of 2-6%. The highest protein content of protein hydrolyzate was obtained when using a Papain enzyme concentration of 6% with a protein content of 3.61%. Fortification of rice with Payangka fish protein hydrolyzate can increase rice protein content, namely from 9.43% (before fortification) to 10.38% (after fortification using protein hydrolyzate with a concentration of 30%)
In Silico Study of the YAKRCFR Peptide Structure and Its Interaction with Human Peroxiredoxin-5 Najoan, Jessika Maya Jovanka; Rumampuk, Rymond Jusuf; Paat, Vlagia Indira; Aloanis, Anderson Arnold
Jurnal Beta Kimia Vol 5 No 2 (2025): Volume 5 Issue 2, November 2025
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v5i2.22710

Abstract

The identification of bioactive peptides with therapeutic potential is an emerging focus in drug discovery. In this study, we evaluated the structural stability and binding affinity of the oyster-derived peptide YAKRCFR through molecular modeling and docking simulations against the human peroxiredoxin receptor. Structural prediction using the PEP-FOLD4 server revealed a consistent α-helical conformation across all models, stabilized by key intramolecular hydrogen bonds and favorable sOPEP energy values. Molecular docking was validated with a root mean square deviation (RMSD) of 0.273 Å, confirming the reliability of the docking protocol. The YAKRCFR peptide exhibited a strong binding affinity with the 1HD2 receptor (ΔG = –8.1 kcal/mol), outperforming both ascorbic acid (–6.1 kcal/mol) and the native ligand (–4.862 kcal/mol). Detailed interaction analysis indicated that YAKRCFR forms stable hydrogen bonds and van der Waals interactions with critical residues such as ILE A119 and PHE A120, contributing to its thermodynamic stability and binding specificity. These findings suggest that YAKRCFR holds promise as a lead compound for further development in peptide-based therapeutic strategies, particularly for targets involving the human peroxiredoxin receptor.
In silico Study of the Antidiabetic Potential of Alkaloid Compounds from the Roots of Acalypha indica: Molecular Docking and ADMET Prediction Lakasan, Ahmad Chandra; Duengo, Suleman; Arviani; Musa, Wenny JA; Aloanis, Anderson Arnold; Botutihe, Deasy Natalia
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j5150f91

Abstract

Oral Type 2 Diabetes Mellitus (T2DM) therapy gastrointestinal side effects encouraged bioactive alternative exploration via Acalypha indica root alkaloids. This study aimed to evaluate Acalypha indica root alkaloids detected by LC-HRMS against α-glucosidase using molecular docking and ADMET evaluation. Ligand structures were optimized via ChemDraw 3D while 2QMJ receptor preparation was conducted using Discovery Studio Client and AutoDock Tools. Parameters were validated through redocking with RMSD <2 Å. Molecular docking was performed using AutoDock Vina with interaction visualization via Discovery Studio Visualizer and PyMOL while pharmacokinetic profiles were predicted using ADMETlab. Results identify compound (1) as the most potent inhibitor with ΔG -9.47 kcal/mol surpassing acarbose stability. Visualizations confirm hydrophobic interaction strengthening at key catalytic residues Asp443 and Asp542 indicating a competitive inhibition mechanism. Compound (1) selection as the primary candidate is based on high affinity and genotoxic safety due to mutagenicity absence in AMES parameters. Compound (1) ADMET characteristics show low intestinal permeability advantageous for local action in the intestinal lumen similar to acarbose. This study recommends compound (1) as a potential antidiabetic candidate for further testing although structural optimization is required to mitigate organ toxicity risks at advanced clinical stages.
Total Synthesis and Potential Bioactivity of Linear Peptide LSAVTPG Aloanis, Anderson Arnold; Paat, Vlagia Indira; Duengo, Suleman
Jurnal Kimia Fullerene Vol 11 No 2: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i2.790

Abstract

The total synthesis of the linear peptide LSAVTPG was successfully carried out using the solid-phase peptide synthesis (SPPS) method. The synthesis employed the Fmoc/tBu protection strategy on a 2-chlorotrityl chloride resin as the solid support. Following chain assembly, the final peptide was cleaved from the resin using 95% trifluoroacetic acid (TFA), affording the target peptide with a yield of 81.6%. Structural confirmation was performed by high-resolution mass spectrometry (HRMS), which showed an observed ion at m/z 644.3621, consistent with the calculated value of m/z 644.3619 for C₂₈H₅₀N₇O₁₀. Purity and retention characteristics were further analyzed using analytical HPLC, where the peptide exhibited a retention time of 13.536 minutes. These results demonstrate that the SPPS method with Fmoc/tBu chemistry is an efficient strategy for the synthesis of the LSAVTPG peptide with high yield and analytical confirmation. The potential bioactivity screened computationally and showed some potential such as spanning oncology, cardiometabolic regulation, neurodegeneration, immunology, and inflammation.
Total Synthesis and Molecular Docking study of Peptide AWVDY as an Anti-inflamation Agent Aloanis, Anderson Arnold; Najoan, Jessika Maya Jovanka; Paat, Vlagia Indira; Rumengan, Stefan Marco; Rumampuk, Rymond Jusuf
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 10, No 2 (2025): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v10i2.103623

Abstract

Bioactive peptides are known for their diverse biological functions, many of which support health and well-being. In this study, we synthesized and evaluated the anti-inflammatory potential of the peptide AWVDY, derived from oyster (Crassostrea rivularis). The synthesis was performed using the solid-phase peptide synthesis (SPPS) method, applying the Fmoc strategy on 2-chlorotrityl chloride (2-CTC) resin, and achieved a high yield of 95.83%. The resulting peptide was characterized using Time-of-Flight Mass Spectrometry (TOF-MS), which detected a peak at m/z [M+H⁺] 653.1418, consistent with the expected molecular formula C₃₂H₄₀N₆O₉. This was further validated by analytical HPLC, showing a retention time of 22.596 minutes. Molecular docking studies indicated that AWVDY binds favorably to the pro-inflammatory cytokines TNF-α and Interleukin-6, with binding affinities of -10.360, -10.430, and -8.960 kcal/mol, respectively. These findings suggest that AWVDY may act as a dual-target peptide capable of modulating inflammatory pathways, highlighting its potential as a promising candidate for the development of new anti-inflammatory therapeutics. 
Co-Authors Ade Wiwit Tahulending Andre Karundeng Arviani Deasy Natalia Botutihe Dokri Gumolung Esti Purnamasari Fahriana Fahriana Feti Fatimah Haryadi Haryadi Hotma Rotua Br. Simbolon Iskandar, Ashar Kristiyani Teke Lakasan, Ahmad Chandra Marlina Karundeng Meylin Kawete Musa, Wenny JA Najoan, Jessika Maya Jovanka nia yuniar kandou Paat, Vlagia Indira Rymond Jusuf Rumampuk Sanusi Gugule Stefan Marco Rumengan Suleman Duengo Syahriyani Timin Tri Reksa Saputra