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All Journal Medical Journal of Indonesia Bioma : Jurnal Biologi Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Budiningsih Siregar
Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Bioma : Jurnal Biologi Indonesia

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PENILAIAN EKSPRESI PROTEIN MDM2 DAN P53 SEBAGAI PREDIKTOR RESPON RADIOTERAPI PADA KANKER SERVIKS Rahayu, Kun Mardiwati; Siregar, Budiningsih; Kurnia, Iin
Bioma Vol. 12 No. 1 (2016): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.869 KB) | DOI: 10.21009/Bioma12(1).1

Abstract

Cervical cancer is the second most common malignancy in Indonesia, and most of cases were already in advanced stage where radiotherapy is a tratement to given. Apoptosis is one of the markers for survival assessment of therapeutic response. In animal experiments MDM2 expression in various cell types to act as a survival factor by inhibiting the apoptotic function of p53 that is played by apoptosis can lead to malignant transformation and result in resistance to radiotherapy. Therefore, MDM2 is overexpressed due to alleged damage to p53 can also be used to assess the success of radiotherapy. This study aimed to assess the expression of MDM2 and p53 immunohistochemistry in cervical cancer and its relation to radiotherapy response. This study is a retrospective cross-sectional descriptive. The sample consisted of 23 cases of advanced cervical cancer were biopsied, 17 cases with complete response to radiation and 6 cases of partial radiation response. This study showed complete radiotherapy group MDM2 expression was found in 70.59% (12 cases) and p53 expression was found in 94.11% (16 cases), while the expression of MDM2, a partial response was found in 100% (6 cases), while the expression p53 66.67% (4 cases). MDM2 and p53 expression with SPSS 16 chi square test showed no association with response to radiotherapy in cervical cancer.
Co-Authors Abdul B. Saifuddin Achmad Tjarta Andrijono Andrijono Bambang Sutrisna Biran Affandi Dewi Wulandari Diah Rini Handjari Ediwibowo Ambari Harahap, Alida Roswita Hariyono Winarto Iin Kurnia Laila Nuranna M. F. Aziz Mpu Kanoko Pamela Damaledo Abineno Pelupessy, Nugraha Utama Peter A.W. Rogers Rahayu, Kun Mardiwati Rukmini T. Mangunkusumo Santoso Cornain Sigit Purbadi Sugito Wonodirekso Vitantri, Fara Wachju Hadisaputra