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All Journal Majalah Kedokteran Bandung Althea Medical Journal Padjadjaran Journal of Dentistry Cermin Dunia Kedokteran
Nanny Natalia M Soetedjo
Divisi Endokrinologi Dan Metabolik, Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effects of Bengkoang (Pachyrhizus erosus (L) Urb Juice in Hampering Blood Glucose in Rat Models Widyarman, Adrian Dwiputra; Nurdiamah, Emma; Soetedjo, Nanny Natalia Muliani
Althea Medical Journa Vol 1, No 1 (2014)
Publisher : Althea Medical Journa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (520.313 KB)

Abstract

Background : The prevalence of diabetes mellitus in Indonesia tends to increase and is predicted to reach 21.3 millions in 2030. Bengkoang (Pachyrhizus erosus (L) Urb. is one of the traditional medicine frequently used in diabetes treatment.The objective of this study is to assess the effectiveness of bengkoang juice in hampering blood glucose increase. Methods : Fourty alloxan-induced diabetic Wistar rats were used in this study. After 16 hours of fasting, the blood glucose was measured using glucometer EasyTouch Blood Glucose/Cholesterol/Uric Acid Multi-Function Monitoring System. The positive control group was given 7 ml of distilled water and 50% glucose solution with 2.5 g/kg dosage while the study group were given 7 ml of bengkoang juice and 50% glucose solution with 2.5 g/kg dosage. Blood glucose was re-checked after 2 hours. This procedure was performed in October 2012.The results were analyzed using Student’s T-test with α = 0.05.Results: The result shows a significant difference in blood glucose increase between the control and study groups with a score of 121.11 mg/dL and 324.45 mg/dL respectively. This result shows that bengkoang juice increases blood glucose level in Wistar rats.Conclusions: In conclusion, bengkoang (Pachyrhizus erosus (L) Urb. juice has no effect in hampering the blood glucose level increase in Wistar rats. [AMJ.2014;1(1):25–9]Keywords: Alloxan, blood glucose, diabetes mellitus, Pachyrhizus erosus (L) Urb. Pengaruh Bengkoang (Pachyrhizus erosus (L) Urb Juice dalam Menghambat Glukosa Darah pada TikusLatar Belakang: Prevalensi diabetes mellitus di Indonesia cenderung meningkat dan diperkirakan mencapai 21,3 juta pada tahun 2030. Bengkoang (Pachyrhizus erosus ( L ) Urb adalah salah satu obat tradisional yang sering digunakan untuk pengobatan diabetes. Tujuan penelitian ini adalah untuk menilai efektivitas jus bengkoang dalam menghambat peningkatan glukosa darah.Metode: Empat puluh tikus Wistar yang telah diinduksi diabetes aloksan digunakan dalam penelitian ini. Setelah 16 jam puasa, glukosa darah diukur dengan menggunakan glucometer Glukosa Darah EasyTouch / Kolesterol / Asam Urat Monitoring System Multi- Function . Kelompok kontrol positif diberi 7 ml air suling dan larutan glukosa 50 % dengan 2,5 g / kg dosis sedangkan kelompok studi diberi 7 ml jus bengkoang dan larutan glukosa 50 % dengan 2,5 g / kg dosis . Glukosa darah diperiksa kembali setelah 2 jam. Prosedur ini dilakukan pada hasil Oktober 2012 dianalisis menggunakan T -test Student dengan α = 0,05.Hasil: Hasil penelitian menunjukkan perbedaan yang signifikan dalam peningkatan glukosa darah antara kelompok kontrol dan kelompok studi dengan skor 121.11 mg / dL dan 324,45 mg / dL masing-masing . Hasil ini menunjukkan bahwa jus bengkoang meningkatkan kadar glukosa darah pada tikus Wistar .Simpulan: Bengkoang ( Pachyrhizus erosus ( L ) Urb jus tidak berpengaruh dalam menghambat kenaikan kadar glukosa darah pada tikus Wistar .Kata kunci: Aloksan , glukosa darah , diabetes mellitus , Pachyrhizus erosus ( L ) Urb.
Lipid Profile in Type 2-Diabetic Women with Central Obesity and Non-central Obesity Nurvitasari, Scholastica Diana; Natalia MS, Nanny; Yoanita, Yovi
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.857 KB)

Abstract

Background: Type 2 Diabetes Mellitus and central obesity are associated with higher risk of cardiovascular diseases especially in women. Lipid profile may reflect dyslipidemia which includes hypertriglyceridemia, increased level of LDL-C, total cholesterol, and reduced HDL-C level in the blood. Patients with central obesity tend to have dyslipidemia compared to those without central obesity counterpart. The study aimed at comparing lipid profile in central-obese diabetic women and non–central-obese diabetic women. Methods: This study was an analytical study with cross–sectional approach conducted in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2013. A total of 160 data contained of waist circumference (WC) and the level of total cholesterol, triglyceride, HDL-C and LDL-C were obtained from medical record of Diabetic patients within the period of January 2010–January 2012. Women patients whose WC of ≥80 cm were classified as central obesity while WC of <80 cm were classified as non-central obesity. The t-test was used to compare means of different variables, p<0.05 was considered as statistically significant.Results: Central obese diabetic women when compared to non-central obese diabetic women showed statistically significant increase in the level of total cholesterol serum, triglyceride serum and decrease in HDL-C serum level (p<0.05). The LDL-C serum level did not show statistical significant difference in the two groups (p>0.05).Conclusions: Diabetic patients with central obesity tend to have higher level of total cholesterol and triglyceride and lower level of HDL-C compared to diabetic patients without central obesity. [AMJ.2016;3(4):570–6] DOI: 10.15850/amj.v3n4.941
Kadar Hypoxia Inducible Factor-1α pada Penderita Diabetes Melitus Tipe 2 Disertai Mikroalbuminuria dan Retinopati Hoo, Yumilia; Permana, Hikmat; Soetedjo, Nanny Natalia M; Arifin, Augusta Y. L.
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Diabetes melitus tipe 2 (DMT2) sampai saat ini masih menjadi masalah kesehatan karena bersifat progresif dan menimbulkan komplikasi. Menurut data epidemiologi dari International Diabetes Federation (IDF) tahun 2011, dinyatakan bahwa retinopati diabetik sering kali mendahului mikroalbuminuria. Komplikasi tersebut diawali oleh disfungsi endotel yang akan meningkatkan sekresi sitokin yang menginduksi angiogenesis dan limpangiogenesis. Pada keadaan hipoksia akibat perubahan mikrovaskular, hypoxia inducible factor-1 alpha (HIF-1α) disekresikan dan akan merangsang produksi vascular endothelial growth factor (VEGF) yang menginduksi angiogenesis. Penelitian ini bertujuan untuk mengetahui hubungan kadar HIF-1α plasma penderita DMT2 dengan mikroalbuminuria dan retinopati diabetik. Penelitian menggunakan rancangan studi potong lintang terhadap 158 penderita DMT2 yang berobat di poliklinik endokrinologi Rumah Sakit Dr. Hasan Sadikin Bandung periode Juli─Desember 2012. Data dianalisis menggunakan uji-t, Mann Whitney, dan multivariate analysis of variance (MANOVA). Subjek penelitian terdiri atas 82 orang pria (51,9%) dan 76 orang wanita (48,1%). Delapan puluh orang (50,6%) normoalbuminuria dan 78 orang (49,4%) mikroalbuminuria. Pada penelitian ini didapatkan 38 orang dengan retinopati diabetik (24,1%). Median kadar HIF-1α kelompok mikroalbuminuria adalah 0,103 (0,041–0,735) ng/mL dan pada normoalbuminuria 0,144 (0,041–0,481) ng/mL (p=0,257). Median kadar HIF-1α kelompok retinopati positif 0,041 (0,041–0,33) ng/mL, sedangkan kelompok tanpa retinopati 0,167 (0,041–0,735) ng/mL dengan p<0,01. Simpulan, kadar HIF-1α plasma yang rendah atau normal bergantung pada derajat retinopati diabetik. Kadar HIF-1α plasma yang tinggi pada penderita tanpa retinopati diabetik, menunjukkan akan terjadi retinopati diabetik di masa mendatang. [MKB. 2014;46(2):100–5]Kata kunci: Hypoxia inducible factor-1α, mikroalbuminuria, retinopati diabetikHypoxia Inducible Factor-1α in Type 2 Diabetes Mellitus with Microalbuminuria and RetinopathyType 2 diabetes mellitus (T2DM) is still considered a major problem in healthcare, mainly for its progressivity and complications. According to the epidemiological data from the International Diabetes Federation (IDF) in 2011, it is stated that microalbuminuria often precedes the onset of diabetic retinopathy. Complications are preceded by endothelial dysfunction that will increase the secretion of cytokines inducing angiogenesis and limpangiogenesis. In hypoxic conditions induced by microvascular changes, hypoxia inducible factor-1 alpha (HIF-1α) is secreted, stimulating the production of vascular endothelial growth factor (VEGF) which induce angiogenesis. The aim of this study was to know the correlation between plasma HIF-1α concentration with microalbuminuria pattern and diabetic retinopathy in T2DM patients. This cross-sectional study was conducted on 158 T2DM patients in Endocrinology Outpatient Departement of Dr. Hasan Sadikin Hospital during July to December 2012. Data were analyzed using t-test, Mann Whitney, and multivariate analysis of variance (MANOVA) methods. Eighty two males (51.9%) and 76 females (48.1%) participated in the study, making up 158 subjects. Eighty patients (50.6%) had normoalbuminuria and 78 patients (49.4%) had microalbuminuria. Thirty eight patients were found with diabetic retinopathy (24.1%). The median of HIF-1α plasma concentrations was 0.103 (0.041–0.735) ng/mL in the microalbuminuria group and 0.144 (0.041–0.481) ng/mL (p=0.257).in the normoalbuminuria group. The median of HIF-1α plasma concentration in the group with diabetic retinopathy was 0.041 (0.041–0.33) ng/mL, while in the group without diabetic retinopathy the median was 0.167 (0.041–0.735) ng/mL (p<0.01). In conclusion, low or normal HIF-1α plasma levels in patients without diabetic retinopathy predict the grading of diabetic retinopathy, while high levels of plasma HIF-1α suggests the likehood of retinopathy event in the future. [MKB. 2014;46(2):100–5]Key words: Diabetic retinopathy, hypoxia inducible factor-1α, microalbuminuria DOI: 10.15395/mkb.v46n2.281
Pola Penggunaan Antidiabetes Oral Pasien Diabetes MelitusTipe 2 di Bagian Penyakit Dalam RSUD Kota Bandung Tahun 2017 Jonathan, Kevin; -, Kuswinarti; Mulyani Soetedjo, Nanny Natalia
Cermin Dunia Kedokteran Vol 46, No 6 (2019): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (690.028 KB) | DOI: 10.55175/cdk.v46i6.462

Abstract

DM merupakan penyakit kronis seumur hidup, tidak dapat disembuhkan namun dapat dikontrol dengan intervensi farmakologis, salah satunya antidiabetes oral. Penelitian ini bertujuan untuk mengetahui pola penggunaan antidiabetes oral pada pasien rawat jalan DM tipe 2 di bagian Penyakit Dalam RSUD Kota Bandung pada Januari – Desember 2017. Penelitian ini merupakan penelitian deskriptif dengan desain penelitian potong lintang setiap bulan. Pengambilan sampel secara retrospektif dari data rekam medis pasien dengan menghitung sampel minimal menggunakan rumus Finite Population Correction. Dari 115 sampel meliputi 83 (72,2%) perempuan dan 32 (27,8%) laki-laki, antidiabetes terbanyak terapi tunggal metformin berkisar antara 25 pasien (21,7%) hingga 50 pasien (43,5%)/bulan, diikuti terapi kombinasi 2 antidiabetes metformin dan gliklazid berkisar antara 16 pasien (13,9%) hingga 22 pasein (19,1%)/bulan, dan terapi kombinasi 3 antidiabetes metformin, glikuidon, dan pioglitazon berkisar antara 1 pasien (0,9%) hingga 7 pasien (6,1%)/bulan serta metformin, gliklazid dan akarbose sebanyak 3 pasien (2,6%) hingga 6 pasien (5,2%)/bulan. Obat lain untuk komorbid DMT2 yang terbanyak adalah obat hipertensi sebanyak 57,2%.DM is a chronic disease, controlled pharmacologically, using – among others - oral antidiabetic drugs. This study aims to determine the pattern of use of oral anti-diabetics in DM type 2 outpatients in the Internal Medicine Department of Bandung City Hospital in January - December 2017. This is a descriptive cross-sectional monthly study. Sampling was done retrospectively from the patient's medical record data by calculating the minimum sample using the Finite Population Correction formula. The 115 patients were consisted of 83 women (72.2%) and 32 men (27.8%), the most common single therapy was metformin in range of 25 patients (21,7%) to 50 patients (43,5%)/month, followed by combination of metformin and gliclazide within range of 16 patients (13,9%) to 22 patients (19,1%)/month, and combination of metformin, gliquidone, and pioglitazone within range of 1 patient (0,9%) to 7 patients (6,1%)/month, and metformin, gliclazide, and acarbose between 3 patient (2,6%) to 6 patients (5,2%)/month. Other drugs for comorbidities mostly was hypertension drugs (57,2%).
Effects of Bengkoang (Pachyrhizus erosus (L) Urb Juice in Hampering Blood Glucose in Rat Models Adrian Dwiputra Widyarman; Emma Nurdiamah; Nanny Natalia Muliani Soetedjo
Althea Medical Journal Vol 1, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (520.313 KB)

Abstract

Background : The prevalence of diabetes mellitus in Indonesia tends to increase and is predicted to reach 21.3 millions in 2030. Bengkoang (Pachyrhizus erosus (L) Urb. is one of the traditional medicine frequently used in diabetes treatment.The objective of this study is to assess the effectiveness of bengkoang juice in hampering blood glucose increase.Methods : Fourty alloxan-induced diabetic Wistar rats were used in this study. After 16 hours of fasting, the blood glucose was measured using glucometer EasyTouch Blood Glucose/Cholesterol/Uric Acid Multi-Function Monitoring System. The positive control group was given 7 ml of distilled water and 50% glucose solution with 2.5 g/kg dosage while the study group were given 7 ml of bengkoang juice and 50% glucose solution with 2.5 g/kg dosage. Blood glucose was re-checked after 2 hours. This procedure was performed in October 2012.The results were analyzed using Student’s T-test with α = 0.05.Results: The result shows a significant difference in blood glucose increase between the control and study groups with a score of 121.11 mg/dL and 324.45 mg/dL respectively. This result shows that bengkoang juice increases blood glucose level in Wistar rats.Conclusions: In conclusion, bengkoang (Pachyrhizus erosus (L) Urb. juice has no effect in hampering the blood glucose level increase in Wistar rats. [AMJ.2014;1(1):25–9]Keywords: Alloxan, blood glucose, diabetes mellitus, Pachyrhizus erosus (L) Urb. Pengaruh Bengkoang (Pachyrhizus erosus (L) Urb Juice dalam Menghambat Glukosa Darah pada TikusLatar Belakang: Prevalensi diabetes mellitus di Indonesia cenderung meningkat dan diperkirakan mencapai 21,3 juta pada tahun 2030. Bengkoang (Pachyrhizus erosus ( L ) Urb adalah salah satu obat tradisional yang sering digunakan untuk pengobatan diabetes. Tujuan penelitian ini adalah untuk menilai efektivitas jus bengkoang dalam menghambat peningkatan glukosa darah.Metode: Empat puluh tikus Wistar yang telah diinduksi diabetes aloksan digunakan dalam penelitian ini. Setelah 16 jam puasa, glukosa darah diukur dengan menggunakan glucometer Glukosa Darah EasyTouch / Kolesterol / Asam Urat Monitoring System Multi- Function . Kelompok kontrol positif diberi 7 ml air suling dan larutan glukosa 50 % dengan 2,5 g / kg dosis sedangkan kelompok studi diberi 7 ml jus bengkoang dan larutan glukosa 50 % dengan 2,5 g / kg dosis . Glukosa darah diperiksa kembali setelah 2 jam. Prosedur ini dilakukan pada hasil Oktober 2012 dianalisis menggunakan T -test Student dengan α = 0,05.Hasil: Hasil penelitian menunjukkan perbedaan yang signifikan dalam peningkatan glukosa darah antara kelompok kontrol dan kelompok studi dengan skor 121.11 mg / dL dan 324,45 mg / dL masing-masing . Hasil ini menunjukkan bahwa jus bengkoang meningkatkan kadar glukosa darah pada tikus Wistar .Simpulan: Bengkoang ( Pachyrhizus erosus ( L ) Urb jus tidak berpengaruh dalam menghambat kenaikan kadar glukosa darah pada tikus Wistar .Kata kunci: Aloksan , glukosa darah , diabetes mellitus , Pachyrhizus erosus ( L ) Urb. DOI: 10.15850/amj.v1n1.293
Lipid Profile in Type 2-Diabetic Women with Central Obesity and Non-central Obesity Scholastica Diana Nurvitasari; Nanny Natalia MS; Yovi Yoanita
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.857 KB)

Abstract

Background: Type 2 Diabetes Mellitus and central obesity are associated with higher risk of cardiovascular diseases especially in women. Lipid profile may reflect dyslipidemia which includes hypertriglyceridemia, increased level of LDL-C, total cholesterol, and reduced HDL-C level in the blood. Patients with central obesity tend to have dyslipidemia compared to those without central obesity counterpart. The study aimed at comparing lipid profile in central-obese diabetic women and non–central-obese diabetic women. Methods: This study was an analytical study with cross–sectional approach conducted in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2013. A total of 160 data contained of waist circumference (WC) and the level of total cholesterol, triglyceride, HDL-C and LDL-C were obtained from medical record of Diabetic patients within the period of January 2010–January 2012. Women patients whose WC of ≥80 cm were classified as central obesity while WC of <80 cm were classified as non-central obesity. The t-test was used to compare means of different variables, p<0.05 was considered as statistically significant.Results: Central obese diabetic women when compared to non-central obese diabetic women showed statistically significant increase in the level of total cholesterol serum, triglyceride serum and decrease in HDL-C serum level (p<0.05). The LDL-C serum level did not show statistical significant difference in the two groups (p>0.05).Conclusions: Diabetic patients with central obesity tend to have higher level of total cholesterol and triglyceride and lower level of HDL-C compared to diabetic patients without central obesity. [AMJ.2016;3(4):570–6] DOI: 10.15850/amj.v3n4.941
The prevalence of hyposalivation in type 2 diabetes mellitus patients at Endocrinology Department, Internal Medicine Sub Department of RSUP Dr Hasan Sadikin Bandung Sundari, Marini; Dewi, Tenny Setiani; Natalia, Nanny
Padjadjaran Journal of Dentistry Vol 25, No 3 (2013): November 2013
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no3.26813

Abstract

Introduction: The salivary flow rate reduces Hyposalivation. Type 2 diabetes mellitus patient with hyposalivation have a high risk of various oral complications if untreated adequately. The aim of this study was to find the prevalence of hyposalivation in type 2 diabetes mellitus patient at RSUP Dr Hasan Sadikin Bandung. Methods: This study was a descriptive observational with a cross-sectional approach and consecutive sampling method to 30 samples. The study was performed with objective assessment through measuring the unstimulated salivary flow of the whole saliva using spitting method for 5 minutes. Results: The result of this study shows that the prevalence of hyposalivation on type 2 diabetes mellitus patient is 10%. The mean of salivary flow rate sample with hyposalivation is 0,07 mL/minute. Conclusion: The conclusion of this study shows a low prevalence of hyposalivation in type 2 diabetes mellitus patients at RSUP Dr Hasan Sadikin Bandung in October 2011.
Co-Authors Adrian Dwiputra Widyarman Adrian Dwiputra Widyarman Augusta Y. L. Arifin Emma Nurdiamah Emma Nurdiamah Guntur Darmawan Hikmat Permana Jonathan, Kevin Kusumawati, Maya kuswinarti -, kuswinarti Miftahurachman Miftahurachman, Miftahurachman Nurvitasari, Scholastica Diana Ritonga, Ervita Scholastica Diana Nurvitasari Sundari, Marini Tenny Setiani Dewi Yoanita, Yovi Yovi Yoanita Yumilia Hoo