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All Journal Damianus Journal of Medicine The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal MedScientiae
Guntur Darmawan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Association between Helicobacter pylori Infection and Graves’ Disease: A Meta-Analysis Guntur Darmawan; Marcellus Simadibrata; Indah Suci Widyahening
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.463 KB) | DOI: 10.24871/182201767-72

Abstract

Background: Helicobacter pylori (H. pylori) infection is proposed to be related with autoimmune diseases, such as Graves’ disease. This study aimed to assess the association between H. pylori infection and Graves’ disease.Method: A systematic literature review was conducted using Pubmed and Cochrane library. The quality of enrolled studies was assessed by the Critical Appraisal Skills Program Oxford. A fixed-effect model approach was used if there was no heterogeneity; otherwise, a random-effect model was used. Heterogeneity was assessed using I2. Publication bias was assessed by funnel plot. All data were analyzed using REVIEW MANAGER 5.3.Results: Six studies from Europe and Asia involving 983 patients were included. Overall H. pylori infection was significantly associated with Graves’ disease (OR = 2.7; 95% CI: 1.47-4.99; p 0.001). In subgroup analysis of 3 studies using non-serological diagnostic method, the prevalence rate of H. pylori infection was higher in Graves’ disease group (78.26% vs. 42.42%) with significant relationship (OR = 4.93; 95% CI: 3.16-7.69; p 0.00001; I2 = 0%). The Cytotoxin associated gene A (CagA) antibody prevalence was significantly higher in Graves’ disease group (46.57% vs. 20.29%; OR = 4.41; 95% CI: 2.65-7.33; p 0.00001; I2 = 56%). No publication bias was observed.Conclusion: Our study showed association between H. pylori infection and Graves’ disease. It might suggest the need of H. pylori examination in Graves’ disease patients and the impact of H. pylori eradication in the treatment of Graves’ disease.
Pancreatic Cancer: Review of Etiology, Clinical Features, Diagnostic Procedures, Treatment and Mesothelin Role Guntur Darmawan; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/121201144-49

Abstract

Pancreatic cancer is one with high mortality cancer in the world. Ninety percent of pancreatic cancer is pancreatic adenocarcinoma. Various factors is associated with an increased risk of pancreatic cancer including age, sex, race, genetic, history of chronic pancreatitis, diabetes mellitus, gallstone, obesity, Helicobacter pylori infection, smoking, diet, and polution exposure. A lot of cases were diagnosed in late stadium due to non-specific early clinical symptoms, and also, until now, there is no examination tool that may screen pancreatic cancer in the earliest stage. Total surgery resection is the therapy of choice in the early stadium of pancreatic cancer, and other therapy modalities are chemotherapy, radiotherapy. Combination of these modalities is frequently used in order to increase the effectiveness of therapy. Mesothelin, a surface glycoprotein on normal mesothelial cells, is overexpressed in pancreatic cancer; therefore, although it is not a cancer specific antigen, it can be used in diagnostic and treatment of pancreatic cancer. Several studies about mesothelin application in pancreatic cancer have been performed; however, more studies are needed to improve the application of mesothelin on pancreatic cancer. Keywords: pancreatic cancer, risk factor, therapy, mesothelin
Acupuncture in the Management of Functional Dyspepsia Anastasia Yoveline; Murdani Abdullah; Guntur Darmawan; Hasan Mihardja; Saleha Sungkar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.501 KB) | DOI: 10.24871/131201249-55

Abstract

Dyspepsia is an uncomfortable sensation or pain in the upper abdomen which is persisting or recurring. Dyspepsia can be classified into functional and organic dyspepsia. Functional dyspepsia is more commonly found compared to the organic type, approximately 60%. Pharmacologic therapy in the management of functional dyspepsia has not shown optimal results, with the multifactorial etiology of functional dyspepsia as the main challenge. Therefore, the management of functional dyspepsia is widened and involves variety treatment modalities, acupuncture being one of them. Acupuncture is a way of treatment by puncturing needles to particular area on the skin to eliminate pain and treat particular diseases. Acupuncture affects stomach motility and gastric acid secretion in functional dyspepsia patients. Two acupuncture points commonly used in functional dyspepsia are ST 36 and PC 6. Acupuncture can restore gastric motility in patients with functional dyspepsia, who have gastric emptying disturbance. Besides, functional dyspepsia complaints, such as epigastric pain, nausea, vomiting, anorexia, burning sensation, and bloating were found to improve after acupuncture therapy. Side effects of acupuncture are not life threatening with low incidence rate. The effectiveness of acupuncture therapy compared to standard medication shows varies results. Further studies are needed to determine the characteristics of functional dyspepsia patients which could have optimal results through acupuncture therapy. Keywords: epigastric pain, gastric motility, ST 36, PC 6
Efektivitas Penggunaan Vitamin B12 dalam Terapi Nyeri Punggung Bawah Darmawan, Guntur; Gianina, Claresta; Liman, Lie Monica Sherine; Hartanto, Hartanto
Bahasa Indonesia Vol 22 No 3 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i3.4394

Abstract

Pendahuluan: Nyeri punggung bawah (NPB) merupakan kondisi nyeri tubuh yang sering dialami oleh manusia yang dapat disebabkan oleh cedera otot atau ligamen. Keadaan nyeri pada punggung bawah biasanya disebabkan oleh cedera mekanik, neurogenik, ataupun penyakit peradangan sistemik. Hingga saat ini terdapat berbagai pilihan modalitas terapi NPB. Tinjauan Pustaka ini ditulis untuk mengevaluasi pemberian vitamin B12 sebagai terapi pada pasien NPB. Metode: Tinjauan pustaka sistematik dilakukan dengan cara pencarian literatur yang bersumber dari Pubmed, Proquest, dan Google Cendekia. Hasil: Terdapat 3 studi dari berbagai negara yang memenuhi kriteria inklusi. Ketiga studi tersebut menunjukkan pemberian vitamin B12 dalam berbagai sediaan menurunkan skala nyeri visual pada pasien NPB. Simpulan: Vitamin B12 memiliki potensi sebagai salah satu modalitas terapi pada pasien NPB.
Korelasi Status Gizi dan Risiko Fraktur pada Lansia Menggunakan FRAX Score di RS Manembo-nembo Desember 2024-Januari 2023 Kalitouw, Praysi Alicia Ferliana; Winaktu, Gracia JMT; Darmawan, Guntur
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3612

Abstract

Fractures in the elderly, especially hip fractures, are a serious health problem because they increase the risk of disability and death. Nutritional status is thought to play a role in fracture risk, but the relationship between the two is still unclear. This study aims to determine the correlation between nutritional status and fracture risk using the FRAX Score. This study used a cross-sectional design with 55 elderly people as a sample, selected using total sampling. Nutritional status was measured using Mid-Upper Arm Circumference (MUAC), while fracture risk was assessed using FRAX Score. Spearman correlation analysis showed a weak negative correlation between nutritional status and the risk of major fracture (r = -0.227; p = 0.096) which was not significant, but there was a significant negative correlation with the risk of hip fracture (r = -0.390; p = 0.003), meaning that the lower the nutritional status, the higher the risk of hip fracture. The conclusion of this study shows that nutritional status is associated with the risk of hip fracture, but not with overall major fracture. Further research with more sensitive methods and larger sample sizes is needed to confirm these results.
Unraveling the Potential Role of Probiotics in Ameliorating Hyperuricemia Darmawan, Guntur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025274-279

Abstract

Hyperuricemia has gained clinical interest due to emerging evidence of its association with various diseases, such as hypertension, diabetes mellitus, cardiovascular disease, chronic kidney disease, and fatty liver. Gut dysbiosis has been suggested to be linked to hyperuricemia, as the gastrointestinal tract is responsible for approximately one-third of the total human uric acid excretion. Alterations in gut microbiota composition have been observed in individuals with hyperuricemia.. Probiotics have regained popularity due to their beneficial health effects, and several studies have shown their potential as a dietary intervention for hyperuricemia. This review aims to examine the intestinal dysbiosis in individuals with hyperuricemia and explore the role of probiotics in ameliorating uric acid levels.
Co-Authors Amaylia Oehadian Anastasia Yoveline Anastasia Yoveline Andini, Dinda Bachti Alisjahbana Bernardo, Margrette Ruth L Bernardo, Margrette Ruth L Dewi, Sumartini Dolvy Girawan Emmy Hermiyanti Pranggono Gianina, Claresta Gracia JMT Winaktu hartanto hartanto Hasan Mihardja Hasan Mihardja Hikmat Permana Indah S. Widyahening Irsan Hasan Kalitouw, Praysi Alicia Ferliana Kusumawardhani, R.N. Yasmin Kusumawati, Maya Laniyati Hamijoyo, Laniyati Liman, Lie Monica Sherine Lisda Amalia Marcellus Simadibrata Marcellus Simadibrata Miftahurachman Miftahurachman, Miftahurachman Muhammad Begawan Bestari Murdani Abdullah Murdani Abdullah Nanny Natalia M Soetedjo Nenny Agustanti Nugraha, Irvan Pranggono, Emmy Hermiyanti Ria Bandiara Ritonga, Ervita Rudi Wisaksana Saleha Sungkar Saleha Sungkar Salvador, David Raymund K Salvador, David Raymund K Subong, Nestor U Subong, Nestor U Trinugroho Heri Fadjari, Trinugroho Heri Usman, Stefanie Yuliana Wijaya, Indra Yudi Wahyudi