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All Journal Jurnal Penelitian Farmasi dan Herbal Jurnal Pengabdian Masyarakat Putri Hijau
Pintata Sembiring
Institut Kesehatan Deli Husada
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GELUGUR (Garcinia atroviridis Griff ex. T Anderson)TERHADAP TIKUS JANTAN PUTIH (Rattus norvegicus) DENGAN LOPERAMIDE SEBAGAI PEMBANDING Pintata Sembiring
Jurnal Penelitian Farmasi & Herbal Vol 4 No 1 (2021): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v4i1.761

Abstract

Gelugur leaf (Garcinia atroviridis Griff ex T. Anderson) is a kind of nadir is believed to origanate from the wild forest of Peninsular Malaysia. Gelugur leaves have antidiarrheal compounds in the shapes of tannins and flavonoids to reduce diarrhea. The purpose of this study was to find out the antidiarrheal activity of the ethanolic extract of gelugur leaf in white male rats. The antidiarrheal effect was tested on 15 white male rats with 5 treatment groups, namely, a negative control group of 1% CMC Na, a positive control group of loperamidee hcl, and a treatment group of ethanol extract of gelugur leaves at a dose of 150 miligrams/kgBW, a dose of 300 miligrams/kgBW, and 600 miligrams/kg body weight. Each group was given oral treatment and observations were made on the onset of diarrhea, frequency of diarrhea, and stool consistency. Tests were carried out using an experimental method. The ethanol extract of gelugur leaves was made by maceration method using 96% ethanol. The results of the study on the onset of diarrhea were EEDG 600 miligrams/kgBB (60 minutes), a good decrease in diarrhea frequency was indicated by EEDG 600 miligrams/kgBB (4 times), a good decrease in stool weight was shown by EEDG 600 miligrams/ kgBB (0,7757 grams), good consistency was also shown in the EEDG 600 miligrams/kgBB (soft stools. The data were statistically analyzed using One Way Anova. The results of data analysis from the three EEDG groups affected the decrease in diarrhea because the sig value <0.05 Based on One Way Anova analysis, the five most effective treatments were loperamidee, 600 miligrams/kgBB, EEDG at 300 miligrams/kgBB, EEDG at 150 miligrams/kgBB, and CMC Na 1%. The conclusion in this study is that EEDG 600 miligrams/kgBB has antidiarrheal activity induced by oleum recini when compared with EEDG concentrations of 150 miligrams/kgBB and 300 miligrams/kgBB.
EDUKASI PEMANFAATAN DAUN BENALU DUKU (Dendrophthoe pentandra (L.) Miq) DAN DAUN SUKUN (Artocarpus altilis) SEBAGAI ANTIDIABETES di RSU SEMBIRING Deli Tua Anggun Syafitri; Linta Meliala; Masria Phetheresia Sianipar; Pintata Sembiring; Viktor Edyward Marbun; Sofia Eliasari Br Bangun
Jurnal Pengabdian Masyarakat Putri Hijau Vol 3 No 2 (2023): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v3i2.1189

Abstract

Diabetes melitus merupakan penyakit gangguan metabolik yang disebabkan oleh gagalnya organ pankreas dalam memproduksi hormon insulin secara memadai. Terapi farmakologi diabetes melitus saat ini masih terbatas pada penggunaan obat-obatan seperti hipoglikemik oral (OHO) dan masyarakat yang menderita diabetes sebagian besar melakukan swamedikasi dengan obat tradisonal yang digunakan bersamaan dengan obat antidiabetes sintesis. Salah satu contoh tanaman yang dapat menurunkan kadar glukosa darah adalah daun benalu duku dan daun sukun yang memiliki kandungan flavonoid untuk menurunkan glukosa darah dengan cara meningkatkan sensitivitas sel terhadap insulin dan merangsang pelepasan insulin pada sel β pancreas. Tujuan dari kegiatan ini adalah untuk memberikan edukasi kepada pasien rawat jalan di RSU Sembiring Deli Tua tentang obat antidiabetes yang berasal dari bahan alam yaitu daun benalu duku dan daun sukun. Setelah mengikuti kegiatan ini peserta memiliki pengetahuan yang baru tentang cara pengolahan bahan alam seperti daun benalu duku dan daun sukun sebagai terapi pengobatan diabetes melitus yang aman dan efektif
Co-Authors Anggun Syafitri Linta Meliala Masria Phetheresia Sianipar Sofia Eliasari Br Bangun Viktor Edyward Marbun