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All Journal PHARMACON Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmasipha Jurnal Farmasi Komunitas Duta Pharma Journal Pharmacon: Jurnal Farmasi Indonesia
Clara Ritawany Sinaga
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Kesehatan Dirgahayu Samarinda
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Teresia Delvi; Liniati Geografi; Clara Ritawany Sinaga
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.
Correlation Compliance Antiretroviral Therapy With Levels Viral Load In HIV Patients At Poly Clinic VCT Abdoel Wahab Sjahranie Samarinda Hospital 2022 Mukhlis Agus Setiawan Putra; Liniati Geografi; Clara Ritawany Sinaga
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.47512

Abstract

ABSTRACT Human Immunodeficiency Virus (HIV) is a virus which can attack and infect human white blood cells and cause a decrease in the human immune system. Antiretrovirals (ARVs) have been shown to prevent HIV transmission because ARVs have a mechanism of action to prevent the gradual replication of the HIV virus. Compliance with taking ARV is very necessary, because non-compliance can cause resistance and make the amount of virus in the blood increase. The success of ARV therapy can be determined by monitoring the levels ofviral load. The objectives of the study were to determine the relationship between the level of compliance with the level ofviral loadat 6 and 12 months on ARV. This type of research is observational analytic with research design cross-sectional. The level of adherence was measured using the MMAS-8 questionnaire and the level ofviral loadtaken from medical record data. The data analysis used was Univariate and Bivariate withChi Square. The study showed that from 60 respondents, the results showed that the category of high compliance was 63.4%, the category of moderate compliance was 13.3% and the category of low adherence was 23.3%. The results of the bivariate test showed that the significance value between the level of patient compliance and the level of viral load 6 months (p= 0.027) and 12 months (p= 0.001) <0.05. There is a significant relationship between adherence to taking antiretroviral drugs with levels of viral load HIV patients at the VCT clinic at the Abdoel Wahab Sjahranie Hospital Samarinda in 2022. Keywords: Compliance with taking medication, Viral Load 6 and 12 months, HIV.
Study of Medicine Dosage Adjustments in Inpatients with Chronic Kidney Disease Katharina Kening Weking; Liniati Geografi; Clara Ritawany Sinaga
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88181

Abstract

Background: Decreased kidney function in patients with Chronic Kidney Disease (CKD) necessitates dose adjustment, especially for medicines that have a narrow therapeutic index to avoid unwanted medicine effects.Objectives: The purpose of this study was to determine the medicine dosage adjustments in CKD patients and their therapy outcomes.Methods: This type of research is descriptive with a retrospective approach. The sample in this study is the medical records of inpatient CKD patients at Abdoel Wahab Sjahranie Samarinda Hospital for the period May to November 2022. Calculation of GFR (Glomerular Filtration Rate) uses the MDRD (Modification of Diet in Renal Disease) formula.Results: The results showed that the sex of most patients was male as many as 56.25%. The age of most patients in the range of 53-59 years old as many as 33.75%. Most CKD severity level is stage 5 as many as 91.25%. The most common comorbidities were hypertension (61 patients), diabetes mellitus (15 patients), and edema or pulmonary edema (11 patients). There were 77 patients requiring dose adjustment out of a total of 80 patients. There were 149 (34.89%) medicines requiring dose adjustment out of a total of 427 medicines, with the 5 most medicines being calcium carbonate (24.16%), furosemide (24.16%), metoclopramide (10.74%), paracetamol (10.74%), and ranitidine (7.39%). There were 128 (85.91%) medicines with doses appropriate to the Lexicomp 2023 or Renal Pharmacotherapy 2013. The therapy outcome improved in patients who required dose adjustments by 90.91%.Conclusion: It is recommended to calculate GFR using a new formula such as eGFR using CKD-EPI, and collecting data with a larger number of samples.
Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Delvi, Teresia; Geografi, Liniati; Sinaga, Clara Ritawany
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.
EQ-5D-5L untuk Pengukuran Biaya dan Indeks Utilitas pada Pasien Gagal Ginjal Kronik dengan Hemodialisis Sinaga, Clara Ritawany; Widodo, Gunawan Pamudji; Andayani, Tri Murti
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 14, No 2 (2023): April 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14210

Abstract

Treatment of chronic kidney failure requires a large amount of money, especially if the patient has complications, so cost analysis and utility index measurements are needed. This study aimed to determine the effect of complications on cost and utility index in patients with chronic kidney failure on hemodialysis. This research was an observational study that applied a cross-sectional design from the perspective of the service provider. The subjects of the study were 76 outpatients with chronic kidney failure who underwent hemodialysis at the Hemodialysis Unit at the Abdoel Wahab Sjahranie Regional General Hospital, Samarinda from October to November 2020. Complication data were obtained from medical records, financing data were obtained from the finance department, and data on complications the utility index were obtained through direct interviews with patients using the EQ-5D-5L questionnaire. Data were analyzed using the Kruskal-Wallis test. The results of the research showed that the real cost for one month was Rp. 972,540,696 with an average cost of Rp. 12,796,588±120,241. Meanwhile, the real cost per episode of hemodialysis was Rp. 119,582,312 with an average cost of IDR 1,573,451 ± 77,506. The patient utility index was 0.645±0.210. The p-value for the impact of complications on the utility index was 0.012 (<0.05), while the p-value for the impact of complications on costs was 0.095 (>0.05). Thus it could be concluded that complications in chronic renal failure patients had an impact on the utility index.Keywords: chronic kidney failure; hemodialysis; complications; utility index ABSTRAK Penanganan gagal ginjal kronis membutuhkan biaya yang besar, terutama apabila pasien mengalami komplikasi, sehingga diperlukan analisis biaya dan pengukuran indeks utilitas. Penelitian ini bertujuan untuk mengetahui pengaruh komplikasi terhadap biaya dan indeks utilitas pada pasien dengan gagal ginjal kronis dengan hemodialisis. Penelitian ini merupakan studi observasional yang menerapkan rancangan cross-sectional menurut perspektif pemberi layanan. Subyek penelitian adalah 76 pasien rawat jalan dengan gagal ginjal kronis yang menjalani hemodialisis di Unit Hemodialisis Rumah Sakit Umum Daerah Abdoel Wahab Sjahranie, Samarinda pada bulan Oktober sampai November 2020. Data komplikasi diperoleh dari rekam medik, data pembiayaan di peroleh dari bagian keuangan, dan data indeks utilitas diperoleh melalui wawancara secara langsung dengan pasien menggunakan kuesioner EQ-5D-5L. Data dianalisis menggunakan uji Kruskal-Wallis. Hasil penelitian menunjukkan bahwa biaya riil selama satu bulan adalah Rp. 972.540.696 dengan biaya rata-rata Rp. 12.796.588±120.241. Sedangkan biaya riil per episode hemodialisis adalah Rp. 119.582.312 dengan biaya rata-rata Rp.1.573.451±77.506. Indeks utilitas pasien adalah 0,645±0,210. Nilai p untuk dampak komplikasi terhadap indeks utilitas adalah 0,012 (<0,05), sedangkan nilai p untuk dampak komplikasi terhadap biaya adalah 0,095 (>0,05). Dengan demikian bisa disimpulkan bahwa komplikasi pada pasien gagal ginjal kronis berdampak pada indeks utilitas.Kata kunci: gagal ginjal kronis; hemodialisis; komplikasi; indeks utilitas 
Profil Farmakoepidemiologi Suplemen Penambah Darah dan Pengukuran Kualitas Hidup pada Ibu Hamil di UPT Puskesmas Kecamatan Kongbeng Kabupaten Kutai Timur Lujuk, Herlina; Clara Ritawany Sinaga; Wiwi Erwina
Jurnal Farmasi Komunitas Vol. 10 No. 2 (2023): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v10i2.49112

Abstract

Kualitas kesehatan anak yang dikandung sangat dipengaruhi asupan gizi dan kesehatan ibunya. Penelitian ini bertujuan untuk mendiskripsikan profil penggunaan sumplemen penambah darah (jenis dan pola konsumsi;, efek terapi dan efek sampingnya; pengetahuan, sikap dan tindakan terhadap pentingnya mengkonsumsi suplemen penambah darah; dan untuk mengetahui kualitas hidup ibu hamil di Puskesmas Kecamatan Kongbeng Kabupaten Kutai Timur. Penelitian ini merupakan jenis penelitian deskriptif dengan rancangan penelitian cross-sectional. Penelitian ini menggunakan teknik total sampling. Pengambilan data menggunakan metode observasi, wawancara dan lembar kuesioner EQ-5D-5L selama bulan Mei – Juni 2023 pada ibu hamil di wilayah kerja Puskesmas Kecamatan Kongbeng. Teknik analisis data yaitu analisis univariat deskriptif, pola konsumsi suplemen penambah darah, pengetahuan, sikap dan tindakan dalam mengkonsumsi suplemen penambah darah dan  kualitas hidup. Hasil dari penelitian ini diperoleh 70 responden ibu hamil yang mengkonsumsi kombinasi tablet zat besi, dan asam folat sebanyak 77,4 %. Terdapat 87,14 % ibu hamil yang tidak mengalami anemia berdasarkan kadar Hb. Mayoritas ibu hamil merasakan efek samping mual atau muntah (45,71%). Terdapat  72,86 % ibu hamil yang memiliki pengetahuan kurang baik, 78,57 % sikap ibu hamil baik, dan 67,86 % tindakan yang kurang baik. Indeks utilitas ibu hamil yang diukur dengan kuesioner kualitas hidup EQ-5D-5L menunjukkan hasil 0,861  0,155.
Evaluation of Drug Management in the Planning, Procurement, and Distribution Stages at the Hospital Pharmacy Installation Sinaga, Clara Ritawany; Tikes, Roivelisko; Simanullang, Raymon
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.6395

Abstract

Pharmacy department is a very important part of the hospital because it is the center of drug management and a source of hospital income. This study aims to determine drug management at the planning, procurement, and distribution stages at the Hospital Pharmacy Installation. This type of research is a descriptive evaluative research with qualitative methods. Data collection was carried out retrospectively on drug management indicators at the planning, procurement, and distribution stages, prospectively by conducting direct interviews and using random sampling methods. Data analysis uses and according to the Indonesian Ministry of Health in 2008, WHO in 1993 and Pudjaningsih in 1996. The validity test used is expert judgment. The results of the study showed that the conformity of drug items with the National Formulary was 18%, the frequency of procurement of each drug item was 5,6x/year, 13% invoice errors, the frequency of delayed payments by the hospital against the specified time was 70%, the level of drug availability was 46 months, the percentage of dead stock was 1%, the compatibility between drugs and stock cards was 100%. This shows that the indicators of drug management at the planning, procurement, and distribution stages are still not efficient, because there are still several indicators that do not comply with the established standards so that improvements need to be made.
Antihypercholesterolemic Activity of Tahongai Leaf infusion (Kleinsovia hospita L.) In Mice (Mus musculus L.) Sianturi, Sister; Sinaga, Clara Ritawany; Leswana, Nurillahi Febria; Butar-Butar, Maria Elvina Tresia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.233-238

Abstract

Tahongai (Kleinhovia hospita L.) is an indigenous plant of East Kalimantan known for its health benefits, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. This study evaluates the antihypercholesterolemic activity of Tahongai leaf infusion in hypercholesterolemic mice (Mus musculus L.), induced by egg yolk. The test groups included a positive control (simvastatin), a negative control (distilled water), and three treatment groups with Tahongai leaf infusion at concentrations of 15%, 30%, and 60%. The results indicated that the highest reduction in cholesterol levels was observed in the P1 group (15% infusion) with an average decrease of 30.84%, followed by P2 (30% infusion) at 24.79%, and P3 (60% infusion) at 9.31%. The positive control group showed an average reduction of 8.64%. Statistical analysis using One-Way ANOVA revealed a significant difference (p<0.05) in cholesterol level reduction among the treatment groups.
HUBUNGAN KEPATUHAN PENGGUNAAN OBAT HIPERTENSI DENGAN JARAK TEMPUH KE PUSKESMAS SEKOLAQ DARAT KABUPATEN KUTAI BARAT Annafiatuzakiah; Sinaga, Clara Ritawany; Elvinda, Esty; Oktaviya, Hana
Duta Pharma Journal Vol. 5 No. 1 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v5i1.4910

Abstract

Bagi pasien hipertensi kepatuhan dalam menjalani pengobatan dapat mempengaruhi kesembuhan pasien. Faktor yang mempengaruhi kepatuhan pasien hipertensi adalah jarak rumah dengan fasilitas kesehatan seperti Puskesmas, Rumah Sakit, dan fasilitas lainnya. Penelitian ini bertujuan untuk mengetahui hubungan kepatuhan penggunaan obat pasien hipertensi dengan jarak tempuh ke Puskesmas Sekolaq Darat Kabupaten Kutai Barat. Penelitian ini dilaksanakan pada periode Mei-Juni 2023 dengan metode observasional analitik dengan pendekatan cross sectional. Pengambilan sampel menggunakan metode Non- probability sampling dengan teknik Purposive Sampling, alat ukur yang digunakan adalah kuesioner medication Adherence Report Scale MARS-5 dan di analisis menggunakan metode univariat dan bivariat dengan skala linkert dan data di analisis menggunakan SPSS 26.0 dengan menggunakan uji Chi-Square. Sampel yang diteliti sebanyak 80 responden yang terdiri dari pasien hipertensi yang tercatat di Puskesmas Sekolaq Darat. Hasil penelitian menunjukan kategori kepatuhan tinggi sebanyak 35%, kategori kepatuhan sedang sebanyak 65%, dan kategori kepatuhan rendah sebanyak 0%. Hasil uji bivariat didapatkan bahwa nilai antara kepatuhan penggunaan obat hipertensi dengan jarak tempuh ke Puskesmas (p = 0,940) >0,05. Tidak terdapat hubungan yang signifikan antara kepatuhan penggunaan obat hipertensi dengan jarak tempuh ke Puskesmas Sekolaq Darat Kabupaten Kutai Barat.
PENGUKURAN INDEKS UTILITAS MENGGUNAKAN INSTRUMEN EORTC QLQ-CX24 DAN EQ-5D-5L PASIEN KANKER SERVIKS YANG MENJALANI KEMOTERAPI Sinaga, Clara Ritawany; Annafiatuzakiah; Elvinda, Esty; Allunan, Febyola Sascia
Duta Pharma Journal Vol. 5 No. 1 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v5i1.4916

Abstract

Kanker serviks adalah suatu kondisi yang merupakan pertumbuhan sel abnormal dalam tubuh menjadi sel kanker, sehingga kanker serviks termasuk penyakit kronis dan untuk mempertahankan kualitas hidupnya penderita menjalani pengobatan kemoterapi. Pengukuran indeks utilitas perlu dilakukan, terutama apabila pasien mengalami komplikasi. Tujuan dari penelitian adalah untuk mengetahui indeks utilitas, dan hubungan komplikasi terhadap indeks utilitas pada pasien kanker serviks dengan kemoterapi. Penelitian ini merupakan penelitian deskriptif dengan rancangan penelitian cross sectional. Subyek penelitian adalah pasien kanker serviks yang menjalani kemoterapi rawat jalan di RSUD Abdoel Wahab Sjahranie Samarinda periode Maret – Mei 2023. Metode pengambilan data dilakukan dengan pengambilan data di rekam medik, dan wawancara langsung dengan menggunakan instrumen EORTC QLQ- CX24 dan EQ-5D-5L. Analisis yang digunakan adalah Chi-square. Hasil penelitian diperoleh nilai indeks utilitas pasien yang diukur dengan EORTC QLQ-CX24 pada skala fungsional sebesar 63,33±19,959 dan skala gejala 24,537±10,892. Sedangkan hasil penelitian yang diukur dengan EQ-5D-5L diperoleh nilai indeks utilitas pasien sebesar 0,696±0,198. Hasil uji statistik menujukkan nilai signifikansi >0,05 pada indeks kualitas hidup yang berarti bahwa tidak terdapat hubungan antara komplikasi terhadap indeks utilitas baik pada instrumen EORTC QLQ- CX24 maupun EQ-5D-5L.
Co-Authors Allunan, Febyola Sascia Andayani, Tri Murti Annafiatuzakiah Delvi, Teresia Dewanti, Christy Alma Esty Elvinda Gunawan Pamudji Widodo Katharina Kening Weking Liniati Geografi Lujuk, Herlina Maria Elvina Tresia Butar-Butar Mukhlis Agus Setiawan Putra Nurillahi Febria Leswana Oktaviya, Hana Simanullang, Raymon Sister Sianturi Teresia Delvi Tikes, Roivelisko Wiwi Erwina