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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School
Hanudse Hartono
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Health Professions Medicine & Pharmacology

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Kadar estradiol serum pada wanita menopause dengan dan tanpa sindroma vasomotor di RSUP H Adam Malik dan RS Jejaring Fakultas Kedokteran Universitas Sumatera Utara Medan Tri Sugeng Hariadi; M. Fidel Ganis Siregar; Hanudse Hartono; Makmur Sitepu; M. Rhiza Z. Tala; Cut Adeya Adella
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background: Physiologic changes from the reproductive to non reproductive phase is characterized by a gradual decline in estrogen levels. In menopausal women decline of estrogen levels can causes various complaints, one of which is the vasomotor syndromeAim: This study was conducted to determine estradiol serum levels in menopausal women with and without vasomotor syndrome and estradiol serum levels in menopausal women based on severity degrees (mild, moderate, and severe).Metode: This analytical cross sectional study involved 60 women, 34 women with vasomotor syndrome and 26 women with non vasomotor syndrome. Serum estradiol levels in every groups were checked. Data were statistically analysed using Anova and Spearmen correlation tests (p<0.05; CI 95%).Results : Non vasomotor syndrome estradiol serum mean rank was significantly higher than vasomotor syndrome estradiol serum mean rank (17.5 vs 47,5 pg/mL). Mean estradiol levels of menopausal vasomotor syndrome subjects based on severity degrees for mild, moderate, and severe degrees are 25.80 ± 2.34 pg/ml; 15.58 ± 2.64 pg/ml; and 11,80 pg/ml (P<0.05). Age, menopausal age, and menopausal length was significantly negatively correlated with estradiol levels with r values of -0.859, - 0.830, and -0.880, respectively. Body Mass Index (BMI) was significantly positively correlated with estradiol levels with a r value of 0.699Conclusion: Serum estradiol levels were lower in vasomotor syndrome women than non vasomotor women. There is significantly differed serum estradiol levels based on severity degress. More severe degrees of vasomotor syndrome will make lowerv serum estradiol levels. Subject characteristics were also significantly associated with serum estradiol levels in menopausal women. Key Words : Menopause, vasomotor syndrome, serum estradiol.
Ekspresigen Homeobox Protein A (HOXA) 10 pada Jaringan Endometrium Penderita Endometriosis yang Infertil Johan Ricardo; Henry Salim; Muhammad Rusda; Letta Lintang; Edi Ardiansyah; Hanudse Hartono
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 48, No 1 (2015): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction :Endometriosis is associated with the abnormality of estrogen and progesterone.Both estrogen and progesterone had a role as strong mitogene in endometrialfocus.One of the mitogene is HOXA10 which was expressed in the nucleus of glandular and stromalcells. Method :This is an analytic study with cross sectionalapproach.40 subjects who fulfilled the inclusion criteria were obtained. lmmunohistochemistry was then performed to evaluate HOXA10 expression.This study was performed from March to April 2015.The obtained data was then analyzed statistically.This study objective is to determine HOXA1O gene expression in endometrialtissue of infertile women with endometriosis Result :Majority of subjects from endometriosis group were fromthe age group of 31-40 years old with 13 subjects (65o/o) and nulliparous with 19 subjects (95%).While from non endometriosis group, majority of subjects were from the age group 41-50 years old with 15 subjects (75%) and parity of 1-3 with 11 subjects (55%). Based on HOXA10 expression intensity, 14 subjects (70%) showed no expression, expression of +1 with 6 subjects (30°/o).While from non endometriosis group, expression of +3 were found in 13 subjects (65o/o), and expression of +2 were found in 7 subjects (35°/o), p<0.05.Conclusion : There is a significant difference of HOXA10 gene expression in endometrialtissue of subject with endometriosis and without endometriosis. Keywords :HOXA10, endometriosis, infertility
Co-Authors CUT ADEYA ADELLA, CUT ADEYA Edi Ardiansyah Henry Salim Johan Ricardo Letta Lintang M. Fidel Ganis Siregar M. Rhiza Z. Tala Makmur Sitepu, Makmur Muhammad Rusda Tri Sugeng Hariadi