Makmur Sitepu, Makmur
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sumatera Utara, Rumah Sakit Umum Pusat H. Adam Malik, Medan, Indonesia

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The status of probiotics supplementation during pregnancy Wibowo, Noroyono; Mose, Johanes C.; Karkata, Made K.; Purwaka, Bangun T.; Kristanto, Herman; Chalid, Maisuri T.; Yusrawati, Yusrawati; Sitepu, Makmur; Kaeng, Juneke J.; Bernolian, Nuswil; Prasmusinto, Damar; Irwinda, Rima
Medical Journal of Indonesia Vol 24, No 2 (2015): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.372 KB) | DOI: 10.13181/mji.v24i2.1223

Abstract

Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.
Description of Pregnant Women's Nutritional Status Based on The Mid-Upper Arm Circumference in Sundari Medan General Hospital In 2019 Franli, David; Sitepu, Makmur; Pasaribu, Hotma Partogi; Martina, Sake Juli
Sumatera Medical Journal Vol. 3 No. 3 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i3.3309

Abstract

Introduction. Chronic energy deficieny (CED) is a condition of a body characterized by low body weight and low energy stores, possibly limited physical capacity due to deprivation of food over a long period time. Ministry of Health ( Kemenkes) showed that in 2015, 305 out of 100.000 death of pregnant women is realated to malnutriotion and CED. Objective. The aim of this study is to determine the overview of pregnant women nutritional status based on mid-upper arm circumference (MUAC) in Sundari Medan General Hospital. Method. The study was an observational descriptive study with a cross sectional design. The samples of this study consists of pregnant women from Sundari Medan Genaral Hospital, who had fulilled the inclusion and esclusion criteria by total sampling. Results.. Among 60 samples, the prevalance of Non-CED woman (85%) was found higher than the mild malnutrition (15%). Conclusion. Prevalance of CED pregnant women was found higher in risky age, middle educated and high income family.  
Descent of Fetal Head into The Pelvic Inlet in Primigravida: Systematic Review Sihotang, Imanuel; Sitepu, Makmur; Rusda, Muhammad
Sumatera Medical Journal Vol. 4 No. 2 (2021): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v4i2.5845

Abstract

Background: Skilled care before, during and after delivery can save the lives of women and newborns. Antenatal care is useful for detecting problems in pregnancy and childbirth, as well as preparing for labor. It is estimated that labor will begin 2-3 weeks after the entry of the fetal head on pelvic inlet. Objective: This study was conducted to determine the prevalence of descending of the fetal head at the pelvic inlet in the primigravida of 34-36 weeks of gestation. Methods: This study uses a systematic review study method with the data used are the results of research that have been circulating in the world. Results: In Weekes and Flynn's (1975) study, the entry of the fetal head into the pelvic cavity and having passed the pelvic inlet with a sample of 422 primigravidas, the prevalence was 34 weeks (2%), 35 weeks (1%). Of the three studies analyzed at 36 weeks' gestation, a prevalence was 4.22%.
RET-HE DALAM DIAGNOSIS SEBAGAI TOLOK UKUR DALAM MENDETEKSI KEKURANGAN ZAT BESI DI IBU HAMIL (Ret-He in Diagnostic Parameter to Detecting Iron Deficiency in Pregnant Women) Imee Surbakti; Adi Koesoema Aman; Makmur Sitepu
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1272

Abstract

Varieties of the laboratory test can be applied in the detecting of iron status. These test are divided into conventional hematologicindex and biochemical iron serum. With the development of an hematological analyzer, new parameter has been found to monitor theiron status with reticulocytes hemoglobin analysis (Ret-He). To know the diagnostic accuracy of Ret-He and to conclude whether Ret-Hecan be used as a parameter to detect iron deficiency in pregnant women by obtaining certain information. This study used analyticalcross sectional was conducted at Haji Adam Malik Hospital Medan, in March−June 2013. The Applying samples consisted of 64 thirdtrimester pregnant women which divided into two (2) groups: the noniron deficiency group using 28 subjects and in the iron deficiency36 subjects. In this study, the researchers found AUC for Ret-He about 77.7% with the best cut off value of <31.4 pg. Using the cut offvalue the researchers obtained the sensitivity about 61.1%, specificity 75.0%, Positive Predictive Value (PPV) 75.8%, Negative PredictiveValue (NPV) 60.0%, Likehood Ratio (LR) (+) 2.44 and LR (–) 0.51%. Based on this study, can be concluded, that the diagnostic accuracyRet-He is a good parameter to detect iron deficiency in the pregnant women.
Kadar estradiol serum pada wanita menopause dengan dan tanpa sindroma vasomotor di RSUP H Adam Malik dan RS Jejaring Fakultas Kedokteran Universitas Sumatera Utara Medan Tri Sugeng Hariadi; M. Fidel Ganis Siregar; Hanudse Hartono; Makmur Sitepu; M. Rhiza Z. Tala; Cut Adeya Adella
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background: Physiologic changes from the reproductive to non reproductive phase is characterized by a gradual decline in estrogen levels. In menopausal women decline of estrogen levels can causes various complaints, one of which is the vasomotor syndromeAim: This study was conducted to determine estradiol serum levels in menopausal women with and without vasomotor syndrome and estradiol serum levels in menopausal women based on severity degrees (mild, moderate, and severe).Metode: This analytical cross sectional study involved 60 women, 34 women with vasomotor syndrome and 26 women with non vasomotor syndrome. Serum estradiol levels in every groups were checked. Data were statistically analysed using Anova and Spearmen correlation tests (p<0.05; CI 95%).Results : Non vasomotor syndrome estradiol serum mean rank was significantly higher than vasomotor syndrome estradiol serum mean rank (17.5 vs 47,5 pg/mL). Mean estradiol levels of menopausal vasomotor syndrome subjects based on severity degrees for mild, moderate, and severe degrees are 25.80 ± 2.34 pg/ml; 15.58 ± 2.64 pg/ml; and 11,80 pg/ml (P<0.05). Age, menopausal age, and menopausal length was significantly negatively correlated with estradiol levels with r values of -0.859, - 0.830, and -0.880, respectively. Body Mass Index (BMI) was significantly positively correlated with estradiol levels with a r value of 0.699Conclusion: Serum estradiol levels were lower in vasomotor syndrome women than non vasomotor women. There is significantly differed serum estradiol levels based on severity degress. More severe degrees of vasomotor syndrome will make lowerv serum estradiol levels. Subject characteristics were also significantly associated with serum estradiol levels in menopausal women. Key Words : Menopause, vasomotor syndrome, serum estradiol.
Calcium serum concentration among pregnant women in a tertiary hospital and its satellite hospital in Medan, Indonesia Muhammad Agung Khoiri; Sarma N Lumbanraja; Duddy Aldiansyah; M. Fidel Ganis Siregar; Makmur Sitepu; M. Rhiza Tala
Majalah Obstetri & Ginekologi Vol. 30 No. 2 (2022): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I22022.78-83

Abstract

HIGHLIGHTS 1. Serum calcium concentration in pregnant women who took prenatal appointments in the general hospital and its satellite hospitals were evaluated.2. It was found that serum calcium concentration in those pregnant women who made the prenatal appointments were normal.   ABSTRACT Objectives: This study aimed to evaluate serum calcium concentration in pregnant women who made prenatal appointments to Obstetric and Gynecologic Outpatient Clinics at Adam Malik General Hospital, Medan, Indonesia, and its satellite hospitals. Materials and Methods: This study was a descriptive study with a case series approach. The case series of the study included 35 pregnant women in their second or third trimester chosen by consecutive sampling method. Results: The mean calcium serum level of pregnant women in the second and third trimester was 9.12±0.49 mg/dl and 8.97±0.26 mg/dl, respectively. The mean calcium level of pregnant women aged <20, 20-35, and >35 years old were 9.0±0.28 mg/dl, 9.07±0.44 mg/dl, and 8.96±0.06 mg/dl, respectively. Conclusion: This study found that the mean calcium serum level of pregnant women who took prenatal appointments in Haji Adam Malik General Hospital, Medan, Indonesia, was normal.
Serological description of neonatal umbilical cord blood from pregnant women confirmed with positive COVID-19 by RT-PCR at Rumah Sakit Umum Pusat H. Adam Malik, Medan, Indonesia Benjamin Sihite; Makmur Sitepu; Khairani Sukatendel; Sarma Nursani Lumbanraja; Iman Helmi Effendi; Rizki Yaznil; Edy Ardiansyah
Majalah Obstetri & Ginekologi Vol. 30 No. 3 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I32022.128-133

Abstract

HIGHLIGHTS 1. COVID-19 raises concern in regard with its effect on pregnancy.2. The serological descriptions of umbilical cord of neonates born from mothers suffering from COVID-19 were identified.3. Most of the serology was non-reactive IgG and IgM, followed was reactive IgG and the least was the reactive IgM.   ABSTRACT Objective: To evaluate the serological description of the neonatal umbilical cord in COVID-19 mothers confirmed by RT-PCR at Rumah Sakit Umum Pusat (RSUP) H. Adam Malik Medan in January-June 2021. Materials and Methods: This study was an observational study with a case series approach where the cases were mothers infected with SARS CoV-2 confirmed by RT-PCR. The study was conducted at Universitas Sumatera Utara (USU) Hospital Laboratory and RSUP H. Adam Malik for 6 months, from January 2021 to June 2021. The data collected were analyzed using descriptive statistics. If the data were normally distributed, they were presented as mean + SD; otherwise, they were presented as median (min-max) for each variable. The Statistical Package for Social Sciences version 22.0 (IBM SPSS Corp.; Armonk, NY, USA) was used for statistical analysis. Results: Neonatal umbilical cord serology results (IgM and IgG) were predominantly non-reactive, where IgM was non-reactive in 43 neonates (97.7%) and IgG was non-reactive in 37 neonates (84.1%). In mothers without COVID-19 symptoms, neonate umbilical cord serology results were dominated by non-reactive IgM (88.6%) and IgG (79.5%). In mothers who recovered from COVID-19, neonate umbilical cord serology results were also dominated by non-reactive IgM (95.5%) and IgG (81.8%). Conclusion: The neonatal umbilical cord serology results from the mother confirmed with positive COVID-19 were nonreactive IgG and IgM in the majority of 35 (79%) samples, reactive IgG in 7 (15.9%), and reactive IgM in 1 (2%) sample.
Comparison of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio levels in ovarian cyst among epithelial ovarian cancer patients at RSUP H. Adam Malik Medan, Indonesia Sari Dewi, Mega; Yustin Simanjuntak, Roy; Sari Lintang, Letta; Fahdhy, Muhammad; Edianto, Deri; Sitepu, Makmur
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.117-122

Abstract

HIGHLIGHTS Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) have potential as independent prognostic markers for ovarian cancer. This research was to evaluate NLR and PLR levels in ovarian cysts with epithelial ovarian cancer patients at RSUP H. Adam Malik Medan, Indonesia.   ABSTRACT Objective: To assess Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as independent prognostic markers in epithelial ovarian cancer patients at RSUP H. Adam Malik Medan, Indonesia, considering the disease's common occurrence and typically late-stage diagnosis with a poor prognosis due to inflammatory processes implicated in malignancy mechanisms. Materials and Methods: A comparative case-control study was conducted at the Department of Obstetrics and Gynecology, RSUP H. Adam Malik Medan, from December 2019 to February 2020. The study included 40 patients each diagnosed with ovarian cysts and epithelial ovarian cancer. Bivariate analysis was conducted using independent T-test for normally distributed data and the Mann-Whitney test for non-normally distributed data. Significance was established at p <0.05. Results: The median NLR in the ovarian cancer group was 2.45 (1.06 to 38.44) and in the ovarian cysts group was 2.34 (1.44 to 3.78). Median PLR levels in ovarian cancer were 12813.94 (3178.08 to 19040.0) and in ovarian cysts were 11138.15 (5026.18 to 22839.51). Statistical analysis revealed no significant difference in NLR and PLR levels between ovarian cancer and ovarian cysts (p >0.05). Conclusion: NLR and PLR levels demonstrated no significant difference between ovarian cancer and ovarian cyst patients at RSUP H. Adam Malik Medan, Indonesia. However, NLR and PLR can still serve as valuable markers for identifying malignant processes in patients suspected of malignancy.
Overview of Knowledge Levels and Risk Factors for Scabies and Pediculosis capitis among Female Students in Darularafah Raya Islamic Boarding School Bella Yofrisanda; Dewi Saputri; Makmur Sitepu; Milahayati Daulay
Sumatera Medical Journal Vol. 8 No. 3 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i3.19069

Abstract

Background: Scabies and pediculosis capitis infections remain common parasitic issues, particularly in densely populated living environments such as boarding schools. The high incidence of these infections is influenced by the level of knowledge and risk-related behaviors within the population. Objective: This research was conducted to understand the level of knowledge and risk factors for scabies and pediculosis capitis infections among female students at Darularafah Raya Islamic Boarding School. Methods: This descriptive research was conducted with eleventh-grade female students, with a sample size of 58 participants selected using systematic random sampling techniques. Data were collected through questionnaires assessing knowledge levels and risk factors. Results: Research data indicate a prevalence of scabies of 22.4% and pediculosis capitis of 55.4%. A total of 31 respondents (53.4%) demonstrated a good level of knowledge about scabies, while 52 respondents (89.7%) showed a good level of knowledge about pediculosis capitis. The primary risk factors for scabies observed among respondents were sharing clothing and sharing beds. For pediculosis capitis, the prevalent risk factors include using communal prayer garments and sharing bedding equipment. Conclusion: Most respondents possess good knowledge; however, the incidence of scabies and pediculosis capitis infections remains relatively high.